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| 1 | Adsorption behavior of phosphate on Lanthanum(Ⅲ) doped mesoporous silicates material显示文摘A series of lanthanum doped meosoporous MCM-41(LaxM41,x is Si/La molar ratio) was prepared by sol-gel method.The surface structure of the materials was investigated with X-ray diffraction and N2 adsorption/desorption technique.The content of La in the materials was determined by ICP.It was found that the La content of La25M41,La50M41 and La100M41 was 7.53%,3.89% and 2.32%,respectively.The phosphate adsorption capacities increased with increasing amount of La incorporation.With 0.40 g La25M41 99.7% phosphate could be removed.The effects of Si/La molar ratio,LaxM41 dose,pH,initial concentration of phosphate solution,co-ions on phosphate adsorption were also evaluated.The phosphate adsorption kinetics of LaxM41 could be well-described by the pseudo second-order model,and Langmuir isotherm fit equilibrium data much better than the Freundlich isotherm. | Jianda Zhang Zhemin Shen Wenpo Shan Ziyan Chen Zhijian Mei Yangming Lei Wenhua Wang | 2010 | Journal of Environmental Sciences2010，22，4： | 18 |
| 2 | Notch signaling in blood vessels: from morphogenesis to homeostasis显示文摘Notch signaling is an evolutionarily conserved intercellular signaling pathway that plays numerous crucial roles in vascular development and physiology.Compelling evidence indicates that Notch signaling is vital for vascular morphogenesis including arterial and venous differentiation and endothelial tip and stalk cell specification during sprouting angiogenesis and also vessel maturation featured by mural cell differentiation and recruitment.Notch signaling is also required for vascular homeostasis in adults by keeping quiescent phalanx cells from re-entering cell cycle and by modulating the behavior of endothelial progenitor cells.We will summarize recent advances of Notch pathway in vascular biology with special emphasis on the underlying molecular mechanisms. | ZHANG Ping YAN XianChun CHEN Yan YANG ZiYan HAN Hua | 2014 | Science China(Life Sciences)2014，57，8： | 15 |
| 3 | Three-dimensional cooperative guidance strategy and guidance law for intercepting highly maneuvering target显示文摘Cooperative interception of the target with strong maneuverability by multiple missiles with weak maneuverability in the three-dimensional nonlinear model is studied.Firstly,the three-dimensional nonlinear model of cooperative guidance is established.The three-dimensional reachable region is represented composed of lateral acceleration and longitudinal acceleration in the two-dimensional coordinate system.Secondly,the problem of the multiple missile’s reachable coverage area is transformed into the problem of cooperative coverage.A cooperative coverage strategy is proposed and an algorithm for quickly calculating the number of required missiles is designed.Then,the guidance law based on the cooperative coverage strategy is proposed,and it is proved that cooperative interception of the target can be achieved under the acceleration limit.Moreover,the relations among the number of missiles,the initial array position of terminal guidance and the coverage area of the target’s large maneuver are analyzed.The dynamic adjustment strategy of guidance parameters is proposed to reduce the guidance error.Finally,simulation results show that multiple missiles with low maneuverability can achieve effective interception of target with strong maneuverability through the proposed cooperative strategy and cooperative guidance method. | Ziyan CHEN Jianglong YU Xiwang DONG Zhang REN | 2021 | Chinese Journal of Aeronautics2021，34，5： | 7 |
| 4 | Strain hardening behavior of Mg-Y alloys after extrusion process显示文摘The strain hardening is an effective mode of enhancing mechanical properties in alloys.In this work,the strain hardening behaviors of Mg-xY(x=1,2,and 3 wt%)after extrusion process was investigated using uniaxial tensile tests.Results suggest that the Mg-xY alloys are composed ofα-Mg with a little amount of Mg24Y5 phase.The average grain size reduces from 19.8μm to 12.2μm as the Y content adds from 1 wt%to 2 wt%.Nevertheless,when Y content reaches 3 wt%,the grain size reaches to 12.9μm,which is close to that of Mg-2Y.The strain hardening rate decreases from 883 MPa to 798 MPa at(σ-σ0.2)=40 MPa,and Mg-2Y and Mg-3Y have the similar strain hardening response.Moreover,Mg-1Y shows an obvious ascending stage after the steep decreasing stage,which is mainly caused by the activation of twinning.The strain hardening behavior of Mg-xY is explained based on understanding the roles of the deformation mechanisms via deformation microstructure analysis and Visco-Plastic Self Consistent(VPSC)model.The variation of strain hardening characteristics with increasing Y content is related to the effects of grain size and texture. | Chaoyue Zhao Ziyan Li Jiahui Shi Xianhua Chen Teng Tu Zhu Luo Renju Cheng Andrej Atrens Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 5 | Bias-drift-free Mach–Zehnder modulators based on a heterogeneous silicon and lithium niobate platform显示文摘Optical modulators have been and will continue to be essential devices for energy-and cost-efficient optical communication networks.Heterogeneous silicon and lithium niobate modulators have demonstrated promising performances of low optical loss,low drive voltage,and large modulation bandwidth.However,DC bias drift is a major drawback of optical modulators using lithium niobate as the active electro-optic material.Here,we demonstrate high-speed and bias-drift-free Mach–Zehnder modulators based on the heterogeneous silicon and lithium niobate platform.The devices combine stable thermo-optic DC biases in silicon and ultra-fast electro-optic modulation in lithium niobate,and exhibit a low insertion loss of 1.8 d B,a low half-wave voltage of 3 V,an electro-optic modulation bandwidth of at least 70 GHz,and modulation data rates up to 128 Gb/s. | SHIHAO SUN MINGBO HE MENGYUE XU SHENGQIAN GAO ZIYAN CHEN XIAN ZHANG ZILIANG RUAN XIONG WU LIDAN ZHOU LIN LIU CHAO LU CHANGJIAN GUO LIU LIU SIYUAN YU XINLUN CAI | 2020 | Photonics Research2020，8，12： | 5 |
| 6 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 7 | BURST-LDA: A NEW TOPIC MODEL FOR DETECTING BURSTY TOPICS FROM STREAM TEXT显示文摘Topic models such as Latent Dirichlet Allocation(LDA) have been successfully applied to many text mining tasks for extracting topics embedded in corpora. However, existing topic models generally cannot discover bursty topics that experience a sudden increase during a period of time. In this paper, we propose a new topic model named Burst-LDA, which simultaneously discovers topics and reveals their burstiness through explicitly modeling each topic's burst states with a first order Markov chain and using the chain to generate the topic proportion of documents in a Logistic Normal fashion. A Gibbs sampling algorithm is developed for the posterior inference of the proposed model. Experimental results on a news data set show our model can efficiently discover bursty topics, outperforming the state-of-the-art method. | Qi Xiang Huang Yu Chen Ziyan Liu Xiaoyan Tian Jing Huang Tinglei Wang Hongqi | 2014 | Journal of Electronics(China)2014，31，6： | 3 |
| 8 | Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress显示文摘Ulcerative colitis(UC)is a chronic and recurrent inflammatory bowel disease(IBD)that has become a major gastroenterologic problem during recent decades.Numerous complicating factors are involved in UC development such as oxidative stress,inflammation,and microbiota disorder.These factors exacerbate damage to the intestinal mucosal barrier.Spirulina platensis is a commercial alga with various biological activity that is widely used as a functional ingredient in food and beverage products.However,there have been few studies on the treatment of UC using S.platensis aqueous extracts(SP),and the underlying mechanism of action of SP against UC has not yet been elucidated.Herein,we aimed to investigate the modulatory effect of SP on microbiota disorders in UC mice and clarify the underlying mechanisms by which SP alleviates damage to the intestinal mucosal barrier.Dextran sulfate sodium(DSS)was used to establish a normal human colonic epithelial cell(NCM460)injury model and UC animal model.The mitochondrial membrane potential assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and staining with Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)and Hoechst 33258 were carried out to determine the effects of SP on the NCM460 cell injury model.Moreover,hematoxylin and eosin(H&E)staining,transmission electron microscopy(TEM),enzyme-linked immunosorbent assay(ELISA),quantitative real-time polymerase chain reaction(qPCR),western blot,and 16S ribosomal DNA(rDNA)sequencing were used to explore the effects and underlying mechanisms of action of SP on UC in C57BL/6 mice.In vitro studies showed that SP alleviated DSS-induced NCM460 cell injury.SP also significantly reduced the excessive generation of intracellular reactive oxygen species(ROS)and prevented mitochondrial membrane potential reduction after DSS challenge.In vivo studies indicated that SP administration could alleviate the severity of DSS-induced colonic mucosal damage compared with the control group.Inhibition of inflammation and oxidative stress was associated with increases in the activity of antioxidant enzymes and the expression of tight junction proteins(TJs)post-SP treatment.SP improved gut microbiota disorder mainly by increasing antioxidant enzyme activity and the expression of TJs in the colon.Our findings demonstrate that the protective effect of SP against UC is based on its inhibition of pro-inflammatory cytokine overproduction,inhibition of DSS-induced ROS production,and enhanced expression of antioxidant enzymes and TJs in the colonic mucosal barrier. | Jian WANG Liqian SU Lun ZHANG Jiali ZENG Qingru CHEN Rui DENG Ziyan WANG Weidong KUANG Xiaobao JIN Shuiqing GUI Yinghua XU Xuemei LU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，6： | 3 |
| 9 | Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies显示文摘Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders. | Ziyan Xie Junye Chen Chenyu Wang Jiahao Zhang Yanxiang Wu Xiaowei Yan | 2021 | Journal of Molecular Cell Biology2021，13，2： | 2 |
| 10 | 19.34 cm2 large-area quaternary organic photovoltaic module with 12.36% certified efficiency显示文摘In this study, a quaternary blending strategy was applied in the fabrication of organic photovoltaic devices and large-area modules. As a result, the ultimate quaternary organic solar cells(OSCs) deliver 16.71% efficiency for small-area devices and 13.25% for large-area(19.34 cm2) modules(certified as 12.36%), which is one of the highest efficiencies for organic solar modules to date. Our results have proved the synergistic effects of multiple components in OSCs, providing an effective strategy for achieving high-performance organic photovoltaic devices and modules. | Ziyan Jia Zeng Chen Xu Chen Jizhong Yao Buyi Yan Rui Sheng Haiming Zhu Yang(Michael)Yang | 2021 | Photonics Research2021，9，3： | 2 |
| 11 | A Comparative Analysis on Weibo and Twitter显示文摘Weibo is the Twitter counterpart in China that has attracted hundreds of millions of users. We crawled an almost complete Weibo user network that contains 222 million users and 27 billion links in 2013. This paper analyzes the structural properties of this network, and compares it with a Twitter user network. The topological properties we studied include the degree distributions, connected components, distance distributions, reciprocity,clustering coefficient, Page Rank centrality, and degree assortativity. We find that Weibo users have a higher diversity index, higher Gini index, but a lower reciprocity and clustering coefficient for most of the nodes. A surprising observation is that the reciprocity of Weibo is only about a quarter of the reciprocity of the Twitter user network. We also show that Weibo adoption rate correlates with economic development positively, and Weibo network can be used to quantify the connections between provinces and regions in China. In particular, point-wise mutual information is shown to be accurate in quantifying the strength of connections. We developed an interactive analyzing software framework for this study, and released the data and code online. | Wentao Han Xiaowei Zhu Ziyan Zhu Wenguang Chen Weimin Zheng Jianguo Lu | 2016 | Tsinghua Science and Technology2016，21，1： | 2 |
| 12 | Ribonuclease H-like gene SMALL GRAIN2 regulates grain size in rice through brassinosteroid signaling pathway显示文摘Grain size is a key agronomic trait that determines the yield in plants.Regulation of grain size by brassinosteroids(BRs)in rice has been widely reported.However,the relationship between the BR signaling pathway and grain size still requires further study.Here,we isolated a rice mutant,named small grain2(sg2),which displayed smaller grain and a semi-dwarf phenotype.The decreased grain size was caused by repressed cell expansion in spikelet hulls of the sg2 mutant.Using map-based cloning combined with a Mut Map approach,we cloned SG2,which encodes a plant-specific protein with a ribonuclease H-like domain.SG2 is a positive regulator downstream of GLYCOGEN SYNTHASE KINASE2(GSK2)in response to BR signaling,and its mutation causes insensitivity to exogenous BR treatment.Genetical and biochemical analysis showed that GSK2 interacts with and phosphorylates SG2.We further found that BRs enhance the accumulation of SG2 in the nucleus,and subcellular distribution of SG2 is regulated by GSK2 kinase activity.In addition,Oryza sativa OVATE family protein 19(OsOFP19),a negative regulator of grain shape,interacts with SG2 and plays an antagonistic role with SG2 in controlling gene expression and grain size.Our results indicated that SG2 is a new component of GSK2-related BR signaling response and regulates grain size by interacting with Os OFP19. | Yunshuai Huang Hui Dong Changling Mou Ping Wang Qixian Hao Min Zhang Hongmin Wu Fulin Zhang Tengfei Ma Rong Miao Kai Fu Yaping Chen Ziyan Zhu Cheng Chen Qikai Tong Zhuoran Wang Shirong Zhou Xi Liu Shijia Liu Yunlu Tian Ling Jiang Jianmin Wan | 2022 | Journal of Integrative Plant Biology2022，64，10： | 1 |
| 13 | Lagrangian duality and saddle points for sparse linear programming显示文摘The sparse linear programming(SLP) is a linear programming problem equipped with a sparsity constraint, which is nonconvex, discontinuous and generally NP-hard due to the combinatorial property involved.In this paper, by rewriting the sparsity constraint into a disjunctive form, we present an explicit formula of the Lagrangian dual problem for the SLP, in terms of an unconstrained piecewise-linear convex programming problem which admits a strong duality under bi-dual sparsity consistency. Furthermore, we show a saddle point theorem based on the strong duality and analyze two classes of stationary points for the saddle point problem. At last,we extend these results to SLP with the lower bound zero replaced by a certain negative constant. | Chen Zhao Ziyan Luo Weiyue Li Houduo Qi Naihua Xiu | 2019 | Science China Mathematics2019，62，10： | 1 |
| 14 | An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development显示文摘Genetic composition plays critical roles in the pathogenesis of autism spectrum disorder(ASD).Especially,inherited and de novo intronic variants are often seen in patients with ASD.However,the biological significance of intronic variants is difficult to address.Here,among a Chinese ASD cohort,we identified a recurrent inherited intronic variant in the CHD7 gene,which is specifically enriched in East Asian populations.CHD7 has been implicated in numerous developmental disorders including CHARGE syndrome and ASD.To investigate whether the ASD-associated CHD7 intronic variant affects neural development,we established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to control.Upon differentiation towards the forebrain neuronal lineage,we found that neural cells carrying the CHD7 intronic variant exhibited developmental delay and maturity defects.Importantly,we found that TBR1,a gene also implicated in ASD,was significantly increased in neurons carrying the CHD7 intronic variant,suggesting the intrinsic relevance among ASD genes.Furthermore,the morphological defects found in neurons carrying CHD7 intronic mutations were rescued by knocking down TBR1,indicating that TBR1 may be responsible for the defects in CHD7-related disorders.Finally,the CHD7 intronic variant generated three abnormal forms of transcripts through alternative splicing,which all exhibited loss-of-function in functional assays.Our study provides crucial evidence supporting the notion that the intronic variant of CHD7 is potentially an autism susceptibility site,shedding new light on identifying the functions of intronic variants in genetic studies of autism. | Ran Zhang Hui He Bo Yuan Ziyan Wu Xiuzhen Wang Yasong Du Yuejun Chen Zilong Qiu | 2021 | Neuroscience Bulletin2021，37，8： | 1 |
| 15 | Whole-genome Duplication Reshaped Adaptive Evolution in A Relict Plant Species,Cyclocarya paliurus显示文摘Cyclocarya paliurus is a relict plant species that survived the last glacial period and shows a population expansion recently.Its leaves have been traditionally used to treat obesity and diabetes with the well-known active ingredient cyclocaric acid B.Here,we presented three C.paliurus genomes from two diploids with different flower morphs and one haplotype-resolved tetraploid assembly.Comparative genomic analysis revealed two rounds of recent whole-genome duplication events and identified 691 genes with dosage effects that likely contribute to adaptive evolution through enhanced photosynthesis and increased accumulation of triterpenoids.Resequencing analysis of 45 C.paliurus individuals uncovered two bottlenecks,consistent with the known events of environmental changes,and many selectively swept genes involved in critical biological functions,including plant defense and secondary metabolite biosynthesis.We also proposed the biosynthesis pathway of cyclocaric acid B based on multi-omics data and identified key genes,in particular gibberellinrelated genes,associated with the heterodichogamy in C.paliurus species.Our study sheds light on evolutionary history of C.paliurus and provides genomic resources to study the medicinal herbs. | Yinquan Qu Xulan Shang Ziyan Zeng Yanhao Yu Guoliang Bian Wenling Wang Li Liu Li Tian Shengcheng Zhang Qian Wang Dejin Xie Xuequn Chen Zhenyang Liao Yibin Wang Jian Qin Wanxia Yang Caowen Sun Xiangxiang Fu Xingtan Zhang Shengzuo Fang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 1 |
| 16 | Effect of magnesium on the electrochemical behavior of lithium anode in LiOH aqueous solution used for lithium-water battery 显示文摘 | Zhang Ziyan Chen Kanghua Ni Erfu | 2010 | Electro Chimica Acta2010，55，： | 1 |
| 17 | Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis显示文摘Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of △^(9)-tetrahydrocannabinol;however,recently,the perspective has changed with the recognition of additional therapeutic values,particularly the pharmacological potential of cannabidiol.A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis resources.Here,we comprehensively review the historical usage of Cannabis,biosynthesis of trichome-specific cannabinoids,regulatory network of trichome development,and synthetic biology of cannabinoids.This review provides valuable insights into the efficient biosynthesis and green production of cannabinoids,and the development and utilization of novel Cannabis varieties. | Ziyan Xie Yaolei Mi Lingzhe Kong Maolun Gao Shanshan Chen Weiqiang Chen Xiangxiao Meng Wei Sun Shilin Chen Zhichao Xu | 2023 | Horticulture Research2023，10，9： | 1 |
| 18 | Uncovering CO_(2) emission drivers under regional industrial transfer in China’s Yangtze River Economic Belt: a multi-layer LMDI decomposition analysis显示文摘With the relocation of heavy industries moving from downstream region to upstream and midstream regions in the Yangtze River Economic Belt(YREB),it is critical to encourage coordinated low carbon development in different regions within the YREB.This paper uncovers the evolution of CO_(2) emissions in different regions within the YREB for the period of 2000–2017.It decomposes regional CO_(2) emission changes using the temporal and cross-regional three-layer logarithmic mean Divisia index(LMDI)method.Besides,it decomposes industrial CO_(2) emission changes using the temporal two-layer LMDI method.The research results show that economic growth is the major driver for regional CO_(2) emission disparities.The mitigation drivers,such as energy intensity and energy structure,lead to a more decreased CO_(2) emission in the downstream region than in the upstream and midstream regions.In addition,it proposes several policy recommendations based upon the local realities,including improving energy efficiency,optimizing energy structure,promoting advanced technologies and equipment transfers,and coordinating the development in the upstream,midstream and downstream regions within the YREB. | Huijuan JIANG Yong GENG Xu TIAN Xi ZHANG Wei CHEN Ziyan GAO | 2021 | Frontiers in Energy2021，15，2： | 1 |
| 19 | Current climate overrides past climate change in explaining multi-site beta diversity of Lauraceae species in China显示文摘Background:We aimed to characterise the geographical distribution of Sørensen-based multi-site dissimilarity(β_(sor))and its underlying true turnover(β_(sim))and nestedness(βsne)components for Chinese Lauraceae and to analyse their relationships to current climate and past climate change.Methods:We used ensembles of small models(ESMs)to map the current distributions of 353 Lauraceae species in China and calculated β_(sor) and its β_(sim) and β_(sne) components.We tested the relationship between β_(sor),β_(sne) and β_(sim) with current climate and past climate change related predictors using a series of simultaneous autoregressive(SAR_(err))models.Results:Spatial distribution of β_(sor)of Lauraceae is positively correlated with latitude,showing an inverse rela-tionship to the latitudinalα-diversity(species richness)gradient.High β_(sor) occurs at the boundaries of the warm temperate and subtropical zones and at the Qinghai-Tibet Plateau due to high β_(sne).The optimized SAR_(err) model explainsβ_(sor) andβ_(sne) well,but notβ_(sim).Current mean annual temperature determinesβ_(sor) and β_(sne) of Lauraceae more than anomalies and velocities of temperature or precipitation since the Last Glacial Maximum.Conclusions:Current low temperatures and high climatic heterogeneity are the main factors explaining the high multi-siteβ-diversity of Lauraceae.In contrast to analyses of the β-diversity of entire species assemblages,studies of single plant families can provide complementary insights into the drivers of β-diversity of evolutionarily more narrowly defined entities. | Ziyan Liao Youhua Chen Kaiwen Pan Mohammed A.Dakhil Kexin Lin Xianglin Tian Fengying Zhang Xiaogang Wu Bikram Pandey Bin Wang Niklaus E.Zimmermann Lin Zhang Michael P.Nobis | 2022 | Forest Ecosystems2022，9，2： | 1 |
| 20 | Exploring the nonlinear piezoresistive effect of 4HSiC and developing MEMS pressure sensors for extreme environments显示文摘Microelectromechanical system(MEMS)pressure sensors based on silicon are widely used and offer the benefits of miniaturization and high precision.However,they cannot easily withstand high temperatures exceeding 150 ℃ because of intrinsic material limits.Herein,we proposed and executed a systematic and full-process study of Sic-based MEMS pressure sensors that operate stably from-50 to 300 ℃.First,to explore the nonlinear piezoresistive effect,the temperature coefficient of resistance(TCR)values of 4H-SiC piezoresistors were obtained from-50 to 500 ℃.A conductivity variation model based on scattering theory was established to reveal the nonlinear variation mechanism.Then,a piezoresistive pressure sensor based on 4H-SiC was designed and fabricated.The sensor shows good output sensitivity(3.38 mVN/MPa),accuracy(0.56%FS)and low temperature coefficient of sensitivity(TCS)(-0.067%FS/℃)in the range of-50 to 300 ℃.In addition,the survivability of the sensor chip in extreme environments was demonstrated by its anti-corrosion capability in H_(2)SO_(4) and NaOH solutions and its radiation tolerance under 5 W X-rays.Accordingly,the sensor developed in this work has high potential to measure pressure in high-temperature and extreme environments such as are faced in geothermal energy extraction,deep well dilling,aeroengines and gas turbines. | Chen Wu Xudong Fang Qiang Kang Ziyan Fang Junxia Wu Hongtao He Dong Zhang Libo Zha Bian Tian Ryutaro Maedai Zhuangde Jjang | 2023 | Microsystems & Nanoengineering2023，9，2： | 1 |
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