|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Hydrographic field investigations in the Northern South China Sea by open cruises during 2004-2013显示文摘 | Lili Zeng Qiang Wang Qiang Xie Ping Shi Lei Yang Yeqiang Shu Ju Chen Dandan Sui Yunkai He Rongyu Chen Dongxiao Wang | 2015 | Science Bulletin2015，60，6： | 10 |
| 3 | LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer显示文摘 | Yang Yang Wei Huang Rongfang Qiu Ruiqiong Liu Yi Zeng Jie Gao Yu Zheng Yongqiang Hou Shuang Wang Wenqian Yu Shuai Leng Dandan Feng Yan Wang | 2018 | Journal of Molecular Cell Biology2018，10，4： | 10 |
| 4 | Modeling stationary and moving cracks in shells by X-FEM with CB shell elements显示文摘The continuum-based(CB)shell theory is combined with the extended finite element method(X-FEM)in this paper to model crack propagation in shells under static and dynamic situations.Both jump function and asymptotic crack tip solution are adopted for describing the discontinuity and singularity of the crack in shells.Level set method(LSM)is used to represent the crack surface and define the enriched shape functions.Stress intensity factors(SIFs)are calculated by the displacement interpolation technique to prove the capability of the method and the maximum strain is applied for the fracture criterion.Also,an efficient integration scheme for the CB shell element with cracks is proposed. | ZENG QingLei LIU ZhanLi XU DanDan ZHUANG Zhuo | 2014 | Science China(Technological Sciences)2014，57，7： | 7 |
| 5 | Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS显示文摘The activity and stability of the adapter protein MAVS (also known as VISA, Cardif and IPS-1), which critically mediates cellular antiviral responses, are extensively regulated by ubiquitination. However, the process whereby MAVS is deubiquitinated is unclear. Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) targets MAVS for deubiquitination. Viral infection leads to the IRF3/7-dependent upregulation of OTUD4 which interacts with MAVS to remove K48-linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling. Knockout or knockdown of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-κB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo. Consistently, Cre-ER Otud4fl/fl or Lyz2-Cre Otud4fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit increased sensitivity to VSV infection compared to their control littermates. In addition, reconstitution of MAVS into OTUD4-deficient cells restores virus-induced expression of downstream genes and cellular antiviral responses. Together, our findings uncover an essential role of OTUD4 in virus-triggered signaling and contribute to the understanding of deubiquitination-mediated regulation of innate antiviral responses. | Tianzi Liuyu Keying Yu Liya Ye Zhidong Zhang Man Zhang Yujie Ren Zeng Cai Qiyun Zhu Dandan Lin Bo Zhong | 2019 | Cell Research2019，29，1： | 7 |
| 6 | Heptanuclear brucite disk with cyanide bridges in a cocrystal and tracking its pyrolysis to an efficient oxygen evolution electrode显示文摘The development of efficient oxygen evolution reaction(OER)catalysts is still lacking in exploration of the mechanism of controlled pyrolysis of precursors among new material platforms.Here,a novel Co-based coordination molecular cluster has been first introduced as precursor to obtain metallic cobalt core shelled by N-doped carbon(Co@NC)structure which operates as an oxygen evolution electrode.Specifically,a new cocrystal compound,[Co7II(l3-CN)6(mmimp)6][CoIICl3N(CN)2]á3CH3OH(Co7+1,mmimp=2-methoxy-6-((methylimino)-methyl)phenol),was isolated consisting of Brucite disks of cobalt where the usual bridging l3-OH is replaced by l3-CN produced by the in-situ decomposition of dicyanamide(NC-N-CNà).The cobalt atoms are bonded through the nitrogen atom of the cyanide.Remarkably,time dependent thermogravimetric-mass spectrometry(TG-MS)analysis was utilized to track its pyrolysis process.It allowed us to propose a possible formation process of the Co@NC structure from Co7+1.Interestingly,an extremely superior OER electrode is optimized for Co@NC-600 having the lowest overpotential of257 m V at 10 m A/cm2in 1 mol/L KOH solution.The present study pins down the importance of clusters of transition metals on realizing distinct nanostructures operating as highly efficient OER electrocatalyst. | Jian-Qiang Zhao Dandan Cai Jun Dai Mohamedally Kurmoo Xu Peng Ming-Hua Zeng | 2019 | Science Bulletin2019，64，22： | 4 |
| 7 | Contrasting dynamic characteristics of shear turbulence and Langmuir circulation in the surface mixed layer显示文摘Large eddy simulation(LES) is used to investigate contrasting dynamic characteristics of shear turbulence(ST)and Langmuir circulation(LC) in the surface mixed layer(SML). ST is usually induced by wind forcing in SML. LC can be driven by wave-current interaction that includes the roles of wind, wave and vortex forcing. The LES results show that LC suppresses the horizontal velocity and greatly modifies the downwind velocity profile, but increases the vertical velocity. The strong downwelling jets of LC accelerate and increase the downward transport of energy as compared to ST. The vertical eddy viscosity Km of LC is much larger than that of ST. Strong mixing induced by LC has two locations. They are located in the 2ds–3ds(Stokes depth scale) and the lower layer of the SML,respectively. Its value and position change periodically with time. In contrast, maximum Km induced by ST is located in the middle depth of the SML. The turbulent kinetic energy(TKE) generated by LC is larger than that by ST. The differences in vertical distributions of TKE and Km are evident. Therefore, the parameterization of LC cannot be solely based on TKE. For deep SML, the convection of large-scale eddies in LC plays a main role in downward transport of energy and LC can induce stronger velocity shear(S2) near the SML base. In addition, the large-scale eddies and S2 induced by LC is changing all the time, which needs to be fully considered in the parameterization of LC. | LI Guojing WANG Dongxiao CHEN Ju YAO Jinglong ZENG Lili SHU Yeqiang SUI Dandan | 2015 | Acta Oceanologica Sinica2015，34，5： | 2 |
| 8 | Preference of online users and personalized recommendations显示文摘 | Yuan Guan Dandan Zhao An Zeng Ming-Sheng Shang | 2013 | Physica A: Statistical Mechanics and its Applications2013，，： | 1 |
| 9 | Synoptic-scale disturbances over the northern South China Sea and their responses to El Nio显示文摘Using surface and aerological meteorological observations obtained at the Xisha Automatic Weather Station and three moored buoys along the continental slope, characteristics of the synoptic-scale disturbances over the northern South China Sea (NSCS) are extensively studied. The power spectra of surface and aerological observations suggest a synoptic feature with a pronounced energy peak at a period of 5-8 d and a weak peak at 3-4 d. The standard deviation of the synoptic temperature component derived at Xisha Station from 1976 to 2011 indicates that the strongest variability normally exists in August all through the whole troposphere. At the interannual scale, it is found that El Nin o plays an important role in regulating the synoptic disturbances of atmosphere. The vertical synoptic disturbances have a double active peak following El Nin o condition. The first peak usually occurs during the mature phase of El Nin o, and the second one occurs in the summer of decay year. Comparing with the summer of developing years, the summer of the decaying year of El Nin o has more active and stronger synoptic disturbances, especially for the 5-8 d period variations. | ZENG Lili LI Xixi DU Yan SHI Rui YAO Jinglong WANG Dongxiao SUI Dandan | 2012 | Acta Oceanologica Sinica2012，31，5： | 1 |
| 10 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor显示文摘 | Xun Xu Yong Hou Xuyang Yin Li Bao Aifa Tang Luting Song Fuqiang Li Shirley Tsang Kui Wu Hanjie Wu Weiming He Liang Zeng Manjie Xing Renhua Wu Hui Jiang Xiao Liu Dandan Cao Guangwu Guo Xueda Hu Yaoting Gui Zesong Li Wenyue Xie Xiaojuan Sun Min Shi Zhiming | 2012 | Cell2012，，5： | 1 |
| 11 | Sinoatrial node pacemaker cells share dominant biological properties with glutamatergic neurons显示文摘Activation of the heart normally begins in the sinoatrial node(SAN).Electrical impulses spontaneously released by SAN pacemaker cells(SANPCs)trigger the contraction of the heart.However,the cellular nature of SANPCs remains controversial.Here,we report that SANPCs exhibit glutamatergic neuron-like properties.By comparing the single-cell transcriptome of SANPCs with that of cells from primary visual cortex in mouse,we found that SANPCs co-clustered with cortical neurons.Tissue and cellular imaging confirmed that SANPCs contained key elements of glutamatergic neurotransmitter system,expressing genes encoding glutamate synthesis pathway(G/s),ionotropic and metabotropic glutamate receptors(Grina,Gria3,Grm1 and Grm5)t and glutamate transporters(Slc17a7).SANPCs highly expressed cell markers of glutamatergic neurons(Snap25 and S/-c17a7)t whereas Gad1,a marker of GABAergic neurons,was negative.Functional studies revealed that inhibition of glutamate receptors or transporters reduced spontaneous pacing frequency of isolated SAN tissues and spontaneous Ca2+transients frequency in single SANPC.Collectively,our work suggests that SANPCs share dominant biological properties with glutamatergic neurons,and the glutamatergic neurotransmitter system may act as an intrinsic regulation module of heart rhythm,which provides a potential intervention target for pacemaker cell-associated arrhythmias. | Dandan Liang Zhigang Xue Jinfeng Xue Duanyang Xie Ke Xiong Huixing Zhou Fulei Zhang Xuling Su Guanghua Wang Qicheng Zou Yi Liu Jian Yang Honghui Ma Luying Peng Chunyu Zeng Gang Li Li Wang Yi-Han Chen | 2021 | Protein & Cell2021，12，7： | 1 |
| 12 | Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders显示文摘Neuroplastin 65(Np65) is an immunoglobulin superfamily cell adhesion molecule involved in synaptic formation and plasticity. Our recent study showed that Np65-knockout(KO) mice exhibit abnormal cognition and emotional disorders. However, the underlying mechanisms remain unclear. In this study, we found 588 differentiallyexpressed genes in Np65-KO mice by microarray analysis.RT-PCR analysis also revealed the altered expression of genes associated with development and synaptic structure,such as Cdh1, Htr3 a, and Kcnj9. In addition, the expression of Wnt-3, a Wnt protein involved in development, was decreased in Np65-KO mice as evidenced by western blotting. Surprisingly, MRI and DAPI staining showed a significant reduction in the lateral ventricular volume of Np65-KO mice. Together, these findings suggest that ablation of Np65 influences gene expression, which may contribute to abnormal brain development. These results provide clues to the mechanisms underlying the altered brain functions of Np65-deficient mice. | Huanhuan Li Jiujiang Zeng Liang Huang Dandan Wu Lifen Liu Yutong Liu Qionglan Yuan | 2018 | Neuroscience Bulletin2018，34，5： | 1 |
| 13 | Study of the volatile composition of tomato during storage by a combination sampling method coupled with gas chromatography/mass spectrometry显示文摘 | ZHANG Zhuoming ZENG Dandan LI Gongke | 2008 | J Sci Food Agric2008，88，： | 1 |
| 14 | Effects of salt stress on the growth, physiological responses, and glycoside con- tents of Stevia rebaudiana Bertoni 显示文摘 | Zeng Jianwei Chen Aimeng Li Dandan | 2013 | Journal of Agricultural and Food Chemistry2013，61，24： | 1 |
| 15 | Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment显示文摘For coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),15–30%of patients are likely to develop COVID-19-related acute respiratory distress syndrome(ARDS).There are still few effective and well-understood therapies available.Novel variants and short-lasting immunity are posing challenges to vaccine efficacy,so finding antiviral and antiinflammatory treatments remains crucial.Here,tripterin(TP),a traditional Chinese medicine,was encapsulated into liposome(TP lipo)to investigate its antiviral and antiinflammatory effects in severe COVID-19.By using two severe COVID-19 models in human ACE2-transgenic(hACE2)mice,an analysis of TP lipo’s effects on pulmonary immune responses was conducted.Pulmonary pathological alterations and viral burden were reduced by TP lipo treatment.TP lipo inhibits SARS-CoV-2 replication and hyperinflammation in infected cells and mice,two crucial events in severe COVID-19 pathophysiology,it is a promising drug candidate to treat SARS-CoV-2-induced ARDS. | Haiying Que Weiqi Hong Tianxia Lan Hao Zeng Li Chen Dandan Wan Zhenfei Bi Wenyan Ren Min Luo Jingyun Yang Cai He Ailing Zhong Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 1 |
| 16 | Microfiltration performance of regenerated cellulose membrane prepared at low temperature for wastewater treatment显示文摘 | Liu Shilin Zeng Jian Tao Dandan | 2010 | Cellulose2010，17，6： | 1 |
| 17 | Fusarium-produced vitamin B6 promotes the evasion of soybean resistance by Phytophthora sojae显示文摘Plants can be infected by multiple pathogens concurrently in natural systems. However,pathogen–pathogen interactions have rarely been studied. In addition to the oomycete Phytophthora sojae, fungi such as Fusarium spp. also cause soybean root rot. In a 3-year field investigation, we discovered that P. sojae and Fusarium spp. frequently coexisted in diseased soybean roots. Out of 336 P. sojae–soybean–Fusarium combinations,more than 80% aggravated disease. Different Fusarium species all enhanced P. sojae infection when co-inoculated on soybean. Treatment with Fusarium secreted non-proteinaceous metabolites had an effect equal to the direct pathogen coinoculation. By screening a Fusarium graminearum mutant library, we identified Fusarium promoting factor of Phytophthora sojae infection 1(Fpp1),encoding a zinc alcohol dehydrogenase. Fpp1 is functionally conserved in Fusarium and contributes to metabolite-mediated infection promotion, in which vitamin B6(VB6) produced by Fusarium is key. Transcriptional and functional analyses revealed that Fpp1 regulates two VB6 metabolism genes, and VB6 suppresses expression of soybean disease resistance-related genes. These results reveal that co-infection with Fusarium promotes loss of P. sojae resistance in soybean, information that will inform the sustainable use of diseaseresistant crop varieties and provide new strategies to control soybean root rot. | Shuchen Wang Xiaoyi Zhang Zhichao Zhang Yun Chen Qing Tian Dandan Zeng Miao Xu Yan Wang Suomeng Dong Zhonghua Ma Yuanchao Wang Xiaobo Zheng Wenwu Ye | 2023 | Journal of Integrative Plant Biology2023，65，9： | 1 |
| 18 | Contents list available at SciVerse Science Direct显示文摘 | Yuan Guan Dandan Zhao An Zeng | 2013 | Physica A2013，392，： | 1 |
| 19 | Study on interaction between induced and natural fractures by extended finite element method显示文摘Fracking is one of the kernel technologies in the remarkable shale gas revolution. The extended finite element method is used in this paper to numerically investigate the interaction between hydraulic and natural fractures, which is an important issue of the enigmatic fracture network formation in fracking. The criteria which control the opening of natural fracture and crossing of hydraulic fracture are tentatively presented. Influence factors on the interaction process are systematically analyzed, which include the approach angle, anisotropy of in-situ stress and fluid pressure profile. | DanDan Xu ZhanLi Liu Zhuo Zhuang QingLei Zeng Tao Wang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 0 |
| 20 | Wide spectrum and rapid calculation model for atmospheric radiative transfer in limb remote sensing显示文摘We proposed a wide spectrum and rapid calculation model FALTRAN( Fast Atmospheric Limb TRANsmission),to solve the problems of current radiative transfer model in limb remote sensing. In FALTRAN:( 1) Band model algorithm was employed and the molecular spectroscopy database was based on HITRAN2008.( 2) Limb radiative transfer equation consists of scattering and thermal radiation was established,and according to the limb geometry characteristic,a Hemisphere Radiation Adding( HRA) approach based on finite difference method was proposed to solve it. We investigated the atmospheric limb radiations under typical atmospheric modes in several commonly used remote sensing bands. Moreover,radiation contribution by two hemispheres was quantitative analyzed as well. Validation results show that the relative differences between FALTRAN and Combining Differential-Integral( CDI) model are within 2%,and calculation results by FALTRAN have good agreement with Michelson Interferometer for Passive Atmospheric Sounding( MIPAS) measurements. FALTRAN is proven to be reliable in the limb radiative transfer calculation. | GUO Jing YANG Chunping ZENG Dandan YE Yutang RAO Changhui | 2015 | 遥感学报2015，19，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员