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| 1 | Application of the CRISPR-Cas System for Efficient Genome Engineering in Plants显示文摘 | Mao, Yanfei Zhang, Hui Xu, Nanfei Zhang, Botao Gou, Feng Zhu, Jian-Kang | 2013 | Molecular Plant2013，6，6： | 132 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Effect of anaphylatoxin C3a, C5a on the tubular epithelial-myofibroblast transdifferentiation in vitro显示文摘背景 Tubulointerstitial 肾的纤维变性是进步的肾疾病的普通结束点,并且管状的 epithelial-myofibroblast transdifferentiation ( TEMT )在 tubulointerstitial 的进步起一个关键作用肾的 fibrosis.Anaphylatoxin C3a 和 C5a 在肾的疾病并且作为这研究的潜在的新治疗学的 targets.The 目的作为新奇 profibrotic 因素被识别是调查是否 C3a , C5a 能由转变生长 factor-31 ( TGF-1 ) /connective 织物生长因素调整 TEMT 控制组, 10 ng/ml TGF-31 组, 50 nmol/L C5a 组,加 2.5 mol/L C5aRA 的 50 nmol/L C5a group.TGF-1 受体对手( TGF-1 RA ) 10 g/ml 被用来调查 导致C3a 、 导致C5a 的 TEMT.Electron 的机制显微镜学被用来观察染色的词法 changes.Immunocytochemistry ,即时 PCR 并且西方的弄污被用来检测光滑的肌肉肌动朊的表情( -SMA),E-cadherin,Col-I,C3a 受体( C3aR ), C5aR , CTGF 和与 C3a 和 C5a fo 有教养的 TGF-1.Results HK-2 | LIU Fang GOU Rong HUANG Jun FU Ping CHEN Feng FAN Wen-xing HUANG You-qun ZANG Li WU Min QIU Hong-yu WEI Da-peng | 2011 | Chinese Medical Journal2011，，23： | 15 |
| 4 | Persistence of side population cells with high drug efflux capacity in pancreatic cancer显示文摘AIM: To investigate the persistence of side population (SP) cells in pancreatic cancer and their role and mechanism in the drug resistance. METHODS: The presentation of side population cells in pancreatic cancer cell line PANC-1 and its proportion change when cultured with Gemcitabine, was detected by Hoechst 33342 staining and FACS analysis. The expression of ABCB1 and ABCG2 was detected by real- time PCR in either SP cells or non-SP cells. RESULTS: SP cells do exist in PANC-1, with a median of 3.3% and a range of 2.1-8.7%. After cultured with Gemcitabine for 3 d, the proportion of SP cells increased significantly (3.8% ± 1.9%, 10.7% ± 3.7%, t = 4.616, P = 0.001 < 0.05). ABCB1 and ABCG2 expressed at higher concentrations in SP as compared with non-SP cells (ABCB1: 1.15 ± 0.72, 5.82 ± 1.16, t = 10.839, P = 0.000 < 0.05; ABCG2: 1.16 ± 0.75, 5.48 ± 0.94, t = 11.305, P = 0.000 < 0.05), which may contribute to the efflux of fluorescent staining and drug resistance. CONCLUSION: SP cells with inherently high resistance to chemotherapeutic agents do exist in pancreatic cancers, which may be candidate cancer stem cells contributing to the relapse of the tumor. | Jing Zhou Chun-You Wang Tao Liu Bin Wu Feng Zhou Jiong-Xin Xiong He-Shui Wu Jing Tao Gang Zhao Ming Yang Shan-Miao Gou | 2008 | World Journal of Gastroenterology2008，14，6： | 13 |
| 5 | High-Resolution Records of the Holocene Paleoenvironmental Variation Reflected by Carbonate and Its Isotopic Compositions in Bosten Lake and Response to Glacial Activities显示文摘The Early Holocene paleoclimate in Bosten Lake on the northern margin of the Tarim Basin, southern Xinjiang, is reconstructed through an analysis of a 953 cm long core (BSTC2000) taken from Bosten Lake. Multiple proxies of this core, including the mineral components of carbonate, carbonate content, stable isotopic compositions of carbonate, Ca/Sr, TOC and C/N and C/S of organic matter, are used to reconstruct the climatic change since 8500 a B.P. The chronology model is made by nine AMS 14C ages of leaves, seeds and organic matter contained in two parallel cores. The climate was cold and wet during 8500 to 8100 a B.P. Temperature increased from 8100 to 6400 a B.P., the climate was warm and humid, and the lake expanded. The lake level was highest during this stage. Then from 6400 to 5100 a B.P., the climate became cold and the lake level decreased slightly. During the late mid-Holocene, the climate was hot and dry from 5100 to 3100 a B.P., but there was a short cold period during 4400 to 3800 a B.P. At this temporal interval, a mass of ice and snow melting water supplied the lake at the early time and made the lake level rise. The second highest lake level stage occurred during 5200 to 3800 a B.P. The climate was cool and wet during 3100 to 2200 a B.P., when the lake expanded with decreasing evaporation. The lake had the last short-term high level during 3100 to 2800 a B.P. After this short high lake level period, the lake shrank because of the long-term lower temperature and reduced water supply. From 2200 to 1200 a B.P., the climate was hot and dry, and the lake shrank greatly. Although the temperature decreased somewhat from 1200 a B.P. to the present, the climate was warm and dry. The lake level began to rise a little again, but it did not reach the river bed altitude of the Konqi River, an outflow river of the Bosten Lake. | ZHANG Chengjun ZHENG Mianping Alexander PROKOPENKO Steffen MISCHKE GOU Xiaohui YANG Qili ZHANG Wanyi FENG Zhaodong | 2009 | Acta Geologica Sinica(English Edition)2009，83，6： | 10 |
| 6 | Pharmacological Inhibition of Macrophage Toll-like Receptor 4/Nuclear Factor-kappa B Alleviates Rhabdomyolysis-induced Acute Kidney Injury显示文摘 | Rong-Shuang Huang Jiao-Jiao Zhou Yu-Ying Feng Min Shi Fan Guo Shen-Ju Gou Stephen Salerno Jr. Liang Ma Ping Fu | 2017 | Chinese Medical Journal2017，，18： | 9 |
| 7 | Effect of Yang-activating and stasis-eliminating decoction from Traditional Chinese Medicine on intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium显示文摘OBJECTIVE: To evaluate the effect of decoction prepared with Yang-activating and stasis-eliminating medicinals from Traditional Chinese Medicine(TCM) on the intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium(DSS).METHODS: Totally 55 male Wistar rats(body weight of 170-190 g) were randomly divided into the blank group(n = 10) and the model duplication group(n = 45). The blank group was not intervened, while the other was modeled with 5% dextran sulfate sodium by gavaging in a dosage of4 m L per day to induce ulcerative colitis, a total of7 days. Then, the model rats were divided into model blank group, mesalazine group and TCM group,and each group was consisted of 15 rats. They were given retention enema 10 min with normal saline,mesalazine enema(0.036 g/m L), and Yang-activating and stasis-eliminating decoction [0.54 g/m L of a decoction boiled by Puhuang(Pollen Typhae), Xiebai(Bulbus Allii Macrostemonis) and Wulingzhi(Faeces Trogopteri)] for 10 days respectively. Afterwards,all of the rats were evaluated by disease activity index(DAI), histological changes of distal colon, expression of occludin protein and ultrastructure of intestinal epithelial cells. Furthermore, ratio of lactulose to mannitol(L/M) discharged in urine was evaluated.RESULTS: Comparing the results between TCM and model control groups, scores of DAI and histological lesions decreased significantly(P = 0.000 <0.01), ultrastructures of intestinal epithelial cells and tight junctions were more complete. The expression of occludin protein(P = 0.001 < 0.01) increased while the L/M value decreased significantly(P = 0.000 < 0.01) in TCM group. There was no statistical difference between the TCM and mesalazine groups in results of each item(P > 0.05).CONCLUSION: The decoction prepared with Yang-activating and stasis-eliminating TCM medicianls can restore intestinal mucosal epithelial cells and tight junctions the model rats with ulcerative colitis; it can reduce histological lesions and protect the permeability of intestinal mucosa barrier in the rats as well. | Shi Lijie Shi Lei Liu Leilei Feng Xiuxian Wang Jing Yang Qiang Chai Shiwei Gou Jing Zang Fenglin He Sufei | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 7 |
| 8 | Pancreas duodenal homeobox-1 expression and significance in pancreatic cancer显示文摘AIM: To study the correlations of Pancreas duodenal homeobox-1 with pancreatic cancer characteristics, including pathological grading, TNM grading, tumor metastasis and tumor cell proliferation. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect PDX-1 mRNA expression in pancreatic cancer tissue and normal pancreatic tissue. The expression of PDX-1 protein was measured by Western blot and immunohistochemistry. Immunohistochemistry was also used to detect proliferative cell nuclear antigen (PCNA). Correlations of PDX-1 with pancreatic cancer characteristics, including pathological grading, TNM grading, tumor metastasis and tumor cell proliferation, were analyzed by using χ2 test. RESULTS: Immunohistochemistry showed that 41.1% of pancreatic cancers were positive for PDX-1 expression, but normal pancreatic tissue except islets showed no staining for PDX-1. In consistent with the result of imunohistochemistry, Western blot showed that 37.5% of pancreatic cancers were positive for PDX-1. RT-PCR showed that PDX-1 expression was significantly higher in pancreatic cancer tissues than normal pancreatic tissues (2-3.56 ± 0.35 vs 2-8.76 ± 0.14, P < 0.01). Lymph node metastasis (P < 0.01), TNM grading (P < 0.05), pathological grading (P < 0.05) and tumor cell proliferation (P < 0.01) were significantly correlated with PDX-1 expression levels. CONCLUSION: PDX-1 is re-expressed in pancreatic cancer, and PDX-1-positive pancreatic cancer cells show more malignant potential compared to PDX-1-negative cells. Therefore, PDX-1-positive cells may be tumor stemcells and PDX-1 may act as alternate surface marker of pancreatic cancer stem cells. | Tao Liu Shan-Miao Gou Chun-You Wang He-Shui Wu liong-Xin Xiong Feng Zhou | 2007 | World Journal of Gastroenterology2007，13，18： | 6 |
| 9 | Relationship between plant canopy characteristics and photosynthetic productivity in diverse cultivars of cotton(Gossypium hirsutum L.)显示文摘Genotype and plant type affect photosynthetic production by changing the canopy structure in crops.To analyze the mechanism of action of heterosis and plant type on canopy structure in cotton(Gossypium hirsutum L.),we had selected two cotton hybrids(Shiza 2,Xinluzao 43) and two conventional varieties(Xinluzao 13,Xinluzao 33) with different plant types in this experiment.We studied canopy characteristics and their correlation with photosynthesis in populations of different genotypes and plant types during yield formation in Xinjiang,China.Canopy characteristics including leaf area index(LAI),mean foliage tilt angle(MTA),canopy openness(DIFN),and chlorophyll relative content(SPAD).The results showed that LAI and SPAD peak values were higher and their peak values arrived later,and the adjustment capacity of MTA during the flowering and boll-forming stages was stronger in Xinluzao 43,with the normal-leaf,pagoda plant type,than these values in other varieties.DIFN of Xinluzao 43 remained between0.09 and 0.12 during the flowering and boll-forming stages,but was lower than that in the other varieties during the boll-opening stage.Thus,these characteristics of Xinluzao 43 were helpful for optimizing the light environment and maximizing light interception,thereby increasing photosynthetic capability.The photosynthetic rate and photosynthetic area were thus affected by cotton genotype as changes in the adjustment range of MTA,increases in peak values of LAI and SPAD,and extension of the functional stage of leaves.Available photosynthetic area and canopy light environment were affected by cotton plant type as changes in MTA and DIFN.Heterosis expression and plant type development were coordinated during different growth stages,the key to optimizing the canopy structure and further increasing yield. | Guoyi Feng Honghai Luo Yali Zhang Ling Gou Yandi Yao Yongzeng Lin Wangfeng Zhang | 2016 | The Crop Journal2016，4，6： | 6 |
| 10 | Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat显示文摘The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. This study is designed to investigate the bioactive components on increasing peak bone mass (PBM) by exploring the spectrum-effect relationship between chromatography fingerprints and effect. Multiple indicators are selected to evaluate the pharmacological activity. In fingerprints, 21 common peaks are obtained, five of which are identified. Furthermore, gray relational analysis (GRA) is a quantitative method of gray system theory and is used to describe the correlation degree of common peaks and pharmacological activities with relational value. 21 components are then divided into three different regions, of which ononin and calycosin play an extremely significant role in increasing PBM. In addition, factor analysis and hierarchical cluster analysis (HCA) are used to screen the optimal producing area for Radix Hedysari. This provides a comprehensive and efficient method to improve the quality evaluation of Radix Hedysari, confirming the bioactive components for PBM-enhancement and further develop its medicinal value. | Xin-Yue Chen San-Hu Gou Zhi-Qiang Shi Zhi-Yuan Xue Shi-Lan Feng | 2019 | Journal of Pharmaceutical Analysis2019，9，4： | 6 |
| 11 | Prostate cancer prediction forest algorithm that takes using the random into account transrectal ultrasound findings, age, and serum levels of prostate-specific antigen显示文摘这研究的目的是评估在预言前列腺癌的前列腺特定的抗原的 transrectal 超声调查结果,年龄,和浆液层次上联合数据的随机的森林算法的能力。Clinico 人口统计的数据为 941 个病人被分析,前列腺疾病在我们的医院对待,包括基于前列腺的指导超声的针活体检视的年龄,前列腺特定的抗原铺平的浆液, transrectal 超声调查结果,和病理诊断。这些数据用 Chi 平方测试有或没有前列腺癌症在病人之间被比较,然后进入了随机的森林模型预言诊断。有或没有前列腺癌症的病人在前列腺特定的抗原铺平的年龄和浆液显著地不同(P < 0.001 ) ,以及在所有 transrectal 超声特征(P < 0.05 ) 除了不平的回响(P = 0.609 ) 。随机的森林模型与 83.10% 的精确性基于年龄,前列腺特定的抗原和超声预言了前列腺癌症, 65.64% 的敏感,和 93.83% 的特性。积极预兆的价值是 86.72% ,并且否定预兆的价值是 81.64% 。由集成年龄,前列腺特定的抗原层次和 transrectal 超声调查结果,随机的森林算法比也为前列腺癌症显示出更好诊断的性能诊断指示物自己。这个算法可以帮助由为活体检视在高风险识别病人改进疾病的诊断。 | Li-Hong Xiao Pei-Ran Chen Zhong-Ping Gou Yong-Zhong Li Mei Li Liang-Cheng Xiang Ping Feng | 2017 | Asian Journal of Andrology2017，19，5： | 5 |
| 12 | Analysis and Suppression of Beat Phenomenon for Railway Traction Converters and Motors显示文摘交直交传动系统广泛应用于高速铁路牵引领域。由于单相脉冲整流器的工作特性,其输出直流电压含有频率为2倍电网频率的脉动分量。该分量在牵引电机侧会引起拍频现象,尤其当牵引逆变器工作频率接近2倍电网频率时最为严重。首先详细分析了直流电压脉动分量的来源和拍频现象产生的本质。然后,在取消LC谐振电路并考虑直流侧脉动电压幅值和相角变化的情况下,研究了一种基于频率补偿的无拍频控制算法,并应用于间接转子磁场定向矢量控制系统。通过在转速环注入脉动分量,补偿牵引逆变器工作频率,抑制牵引电机拍频电流。最后,仿真结果和硬件在回路实验结果验证了该算法的有效性。 | GOU Bin FENG Xiaoyun SONG Wensheng HAN Kun, GE Xinglai | 2013 | 中国电机工程学报2013，33，9： | 5 |
| 13 | Remedy or Poison: Impacts of China's Outward Direct Investment on Its Exports显示文摘在过去的十年期间,中国是向外直接的投资(ODI ) ,出口经历了快速的生长,引起到在他们之间的关系的增加的注意。在 2003-2012 期间在中国的 ODI 和贸易上基于面板数据使用严肃模型到 174 个国家和区域,现在的纸在出口上调查中国的 ODI 的影响。我们发现中国到一个主人国家的 ODI 显著地与那经济支持中国的贸易:ODI 存货的 10 百分比增加能在出口,进口的 2.07 百分比增加和网出口的 2.87 百分比增加导致 2.14 百分比增加。主人国家到中国的经济,它的基础结构和它的距离的规模也在中国的出口上有重要影响。因此,在 ODI 的生长将便于中国的贸易和集成进全球经济,并且提高由在国外转移低端的工业的在中国的工业升级。 | Xiaoguang Liu Qin Gou Feng Lu | 2015 | China & World Economy2015，23，6： | 5 |
| 14 | Source of blood supply of liver cavernous hemangioma and sclerosis and embolization treatment显示文摘SourceofbloodsupplyoflivercavernoushemangiomaandsclerosisandembolizationtreatmentLIGouWei1,ZHAOZhongRong2,LIBaoSheng1,LI... | LI Gou Wei 1, ZHAO Zhong Rong 2, LI Bao Sheng 1, LIU Xiao Gong 1, WANG Zhi Liang 1 and LIU Qing Feng 1 | 1997 | World Journal of Gastroenterology1997，3，3： | 4 |
| 15 | Efficacy and safety of alcohol sclerotherapy involving single-session multiple injections to treat simple renal cysts: a multicenter, prospective, randomized, controlled trial显示文摘 | LI Yong-zhong LI Ming-xing WANG Tao YANG Li-chuan FENG Ping GOU Zhong-ping YUAN Jia-ying ZHANG Wei | 2013 | Chinese Medical Journal2013，，5： | 4 |
| 16 | YR36/WKS1-Mediated Phosphorylation of PsbO,an Extrinsic Member of Photosystem Ⅱ,Inhibits Photosynthesis and Confers Stripe Rust Resistance in Wheat显示文摘Wheat stripe rust,due to infection by Puccinia striiformis f.sp.tritici(Pst),is a devastating disease that causes significant global grain yield losses.Yr36,which encodes Wheat Kinase START1(WKS1),is an effec-tive high-temperature adult-plant resistance gene and confers resistance to a broad spectrum of Pst races.We previously showed that WKS1 phosphorylates the thylakoid ascorbate peroxidase protein and reduces its ability to detoxify peroxides,which may contribute to the accumulation of reactive oxygen species(ROS).WKS1-mediated Pst resistance is accompanied by leaf chlorosis in Pst-infected regions,but the un-derlying mechanisms remain elusive.Here,we show that WKS1 interacts with and phosphorylates PsbO,an extrinsic member of photosystem Ⅱ(PS Ⅱ),to reduce photosynthesis,regulate leaf chlorosis,and confer Pst resistance.A point mutation in PsbO-A1 or reduction in its transcript levels by RNA interference resulted in chlorosis and reduced Pst sporulation.Biochemical analyses revealed that WKS1 phosphorylates PsbO at two conserved amino acids involved in physical interactions with PS Ⅱ and reduces the binding affinity of PsbO with PS Ⅱ.Presumably,phosphorylated PsbO proteins dissociate from the PS Ⅱ complex and then un-dergo rapid degradation by cysteine and aspartic proteases.Taken together,these results demonstrate that perturbations of wheat PsbO by point mutation or phosphorylation by WKS1 reduce the rate of photo-synthesis and delay the growth of Pst pathogen before the induction of ROS. | Shuai Wang Qiu-Ping Li Jianfeng Wang Yan Yan Guo-Liang Zhang Yan Yan Huifei Zhang Jiajie Wu Feng Chen Xiaojie Wang Zhensheng Kang Jorge Dubcovsky Jin-Ying Gou | 2019 | Molecular Plant2019，12，12： | 3 |
| 17 | Enhanced damping capacity of ferromagnetic Fe-Ga alloys by introducing structural defects显示文摘The irreversible motion of magnetic domain walls in ferromagnets can dissipate a large portion of the elastic energy,and the associated damping capacity is proportional to the magnetostriction constant.In contrast,here we found that the damping capacity of the large magnetostriction Fe-Ga alloys can be enhanced by 2-3 times through introducing structural defects including interfacial dislocations and stacking faults,despite that these defects deteriorate the magnetostriction.These structural defects were introduced by aging the BCC(body-centered-cubic)solution-treated precursor,for which the formation of mechanically harder FCT(face-centered-tetragonal)and/or FCC(face-centered-cubic)phases can result in high-density partial dislocations at the semi-coherent phase interfaces and quasi-periodically stacked nano-layer substructure inside the FCC variants.The structural defects act as extra damping sources besides the magnetic domain walls because the structural accommodation of the semi-coherent phase interfaces between BCC and FCT/FCC nanoprecipitates with different elastic moduli and the nano-layer substructure towards long-range ordered periodical stacking can dissipate a large portion of mechanical energy.These findings suggest that introducing structural defects provides fresh freedom to design high damping ferromagnetic materials. | Ruihua Qiao Junming Gou Tianzi Yang Yiqun Zhang Feng Liu Shanshan Hu Tianyu Ma | 2021 | Journal of Materials Science & Technology2021，，25： | 3 |
| 18 | Thermal behavior of the HTR-10 under combined PLOFC and ATWS condition initiated by unscrammed control rod withdrawal显示文摘Two tests initiated by unscrammed control rod withdrawal were performed on the High Temperature GasCooled Reactor-Test Module(HTR-10) in November 2003 after the reactor achieved its full power, and the test conditions represented a typical transient scenario of modular high-temperature reactors(HTRs), called pressurized loss of forced cooling, and anticipated transient without scram.Based on the test parameters, the HTR-10 thermal behaviors under the test conditions were studied with the help of the system analysis code THERMIX. The combination of the test results and the investigation results makes the HTR-10 safety potential better understood. Key phenomena, such as the helium natural circulation and the temperature redistribution in the reactor, were revealed. As the safety feature of most significance, there is a large margin between the maximum fuel temperature and its safety limit in each test. Temperatures of thermocouples in different components were calculated by THERMIX and compared with the test values. The applicability of the code was verified by good agreement obtained from the comparison. | Feng Gou Yuan Liu Fu-Bing Chen Yu-Jie Dong | 2018 | Nuclear Science and Techniques2018，29，9： | 3 |
| 19 | In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells显示文摘AIM: To observe whether pancreatic and duodenal homeobox factor-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells in vitro. METHODS: Rat pancreatic tissue was submitted to digestion by collegenase, ductal epithelial cells were separated by density gradient centrifugation and then cultured in RPMI1640 medium with 10% fetal bovine serum. After 3-5 passages, the cells were incubated in a six-well plate for 24 h before transfection of recombination plasmid XlHbox8VP16. Lightcycler quantitative real-time RT-PCR was used to detect the expression of PDX-1 and insulin mRNA in pancreatic epithelial cells. The expression of PDX-1 and insulin protein was analyzed by Western blotting. Insulin secretion was detected by radioimmunoassay. Insulin- producing cells were detected by dithizone-staining. RESULTS: XlHbox8 mRNA was expressed in pancreatic ductal epithelial cells. PDX-1 and insulin mRNA as well as PDX-1 and insulin protein were signifi cantly increased in the transfected group. The production and insulin secretion of insulin-producing cells differentiated from pancreatic ductal epithelial cells were higher than those of the untransfected cells in vitro with a significant difference (1.32 ± 0.43 vs 3.48 ± 0.81, P < 0.01 at 5.6 mmol/L; 4.86 ± 1.15 vs 10.25 ± 1.32, P < 0.01 at 16.7 mmol/L). CONCLUSION: PDX-1 can differentiate rat pancreaticductal epithelial cells into insulin-producing cells in vitro. In vitro PDX-1 transfection is a valuable strategy for increasing the source of insulin-producing cells. | Tao Liu Chun-You Wang Feng Yu Shan-Miao Gou He-Shui Wu Jiong-Xin Xiong Feng Zhou | 2007 | World Journal of Gastroenterology2007，13，39： | 3 |
| 20 | Two-state energy model and experimental study of coal adsorb methane显示文摘 | Zeng-Chao FENG Dong ZHAO Zhi-Xiang LIU Yan-Qi WANG Hong-Qiang GOU | 2013 | Journal of Coal Science & Engineering(China)2013，19，4： | 2 |
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