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| 1 | Similarity criteria and coal-like material in coal and gas outburst physical simulation显示文摘 | Bo Zhao Guangcai Wen Haitao Sun Dongling Sun Huiming Yang Jie Cao Linchao Dai Bo Wang | 2018 | International Journal of Coal Science & Technology2018，5，2： | 17 |
| 2 | Hybrids perfluorosulfonic acid ionomer and silicon oxide membrane for application in ion-exchange polymer-metal composite actuators显示文摘This paper reports a new technique to fabricate an ion-exchange polymer-metal composite (IPMC) actuator. This technique is based on a hybrid organic-inorganic composite membrane. In the fabrication course, silica oxide particles, prepared from hydrolysis of tetraethyl orthosilicate in situ with sol-gel reaction, co-crystallize with perfluorosulfonate acid (PFSA) ionomer. Attenuated total reflectance fourier transform infrared spectroscopy (ATR-FTIR) analyses demonstrate that a highly water-saving hybrid membrane is formed. Measurements of mechanical properties reveal that elastic modulus and hardness of the hybrid membrane are about 2 times compared to a commercial PFSA membrane. Scanning electron microscopy (SEM) results show that the hybrid membrane has a high porosity. Inside the membrane pores, there exists a great quantity of micro scale channels in the range of 100―300 nm. After fabrication of IPMC actuator, an electric current sensor, a force sensor, and a high speed camera are assembled and used to evaluate IPMC performance. It is shown that, compared to an IPMC actuator made from a commercial membrane, the electromechanical performance of the new actuator increases 6―8 times; when it is actuated in air, its stable non-water working time is prolonged for 6―7 times. | GUO DongJie DING HaiTao WEI HaiJu HE QingSong YU Min DAI ZhenDong | 2009 | Science China(Technological Sciences)2009，52，10： | 10 |
| 3 | Experimental Study and Model Analysis of the Performance of IPMC Membranes with Various Thickness显示文摘 | Qingsong He Min Yu Linlin Song Haitao Ding Xiaoqing Zhang Zhendong Dai | 2011 | Journal of Bionic Engineering2011，8，1： | 10 |
| 4 | Effect of gas emissions from Tianchi volcano (NE China) on environment and its potential volcanic hazards显示文摘The Tianchi volcano in the Changbai Mountains is located on the boundary between China and North Korea. There are many times of eruptions of the Tianchi volcano during the Holocene. One of its large eruptions occurred around 1000 years ago dated by 14C method and historical records. Composition of products of the largest Tianchi volcanic eruption studied is characterized by comendi- tic Plinian fallout and unwelded ignimbrite, which are mainly distributed in China and North Korea. Caldera is about 4.4 km long and 3.4 km wide, which had filled with water (e.g. Tianchi Lake). The Tianchi volcanic cone is about 2700 m high above sea level. The Tianchi Lake is located on the summit of the volcanic cone, that is also highest peak of the Changbai Mountains in northeastern China. This study analyzed Cl, F, S and H2O concentrations of melt inclusions in the phenocryst min- erals (anorthoclase and quartz) and co-existing matrix glasses using the electron microprobe and estimated environmental effect of Tianchi volcanic gases. The authors proposed a new method to evaluate future eruption of active volcano and estimate potential volcanic hazards based on contents of volatile emissions. Using this method, we made a perspective of future volcanic hazard in this re- gion. | GUO Zhengfu LIU Jiaqi HAN Jingtai HE Huaiyu DAI Guoliang YOU Haitao | 2006 | Science China Earth Sciences2006，49，3： | 9 |
| 5 | Grey-matter volume as a potential feature for the classification of Alzheimer's disease and mild cognitive impairment: an exploratory study显示文摘Specific patterns of brain atrophy may be helpful in the diagnosis of Alzheimer's disease(AD). In the present study, we set out to evaluate the utility of grey-matter volume in the classification of AD and amnestic mild cognitive impairment(aMCI) compared to normal control(NC) individuals. Voxel-based morphometric analyses were performed on structural MRIs from 35 AD patients, 27 aMCI patients, and 27 NC participants. A two-sample two-tailed t-test was computed between the NC and AD groups to create a map of abnormal grey matter in AD. The brain areas with significant differences were extracted as regions of interest(ROIs), and the grey-matter volumes in the ROIs of the aMCI patients were included to evaluate the patterns of change across different disease severities. Next, correlation analyses between the grey-matter volumes in the ROIs and all clinical variables were performed in aMCI and AD patients to determine whether they varied with disease progression. The results revealed significantly decreased grey matter in the bilateral hippocampus/parahippocampus, the bilateral superior/middle temporal gyri, and the right precuneus in AD patients.The grey-matter volumes were positively correlated with clinical variables. Finally, we performed exploratory linear discriminative analyses to assess the classifying capacity of grey-matter volumes in the bilateral hippocampus and parahippocampus among AD, aMCI, and NC. Leave-one-out crossvalidation analyses demonstrated that grey-matter volumes in hippocampus and parahippocampus accurately distinguished AD from NC. These findings indicate that grey-matter volumes are useful in the classification of AD. | Yane Guo Zengqiang Zhang Bo Zhou Pan Wang Hongxiang Yao Minshao Yuan Ningyu An Haitao Dai Luning Wang Xi Zhang Yong Liu | 2014 | Neuroscience Bulletin2014，30，3： | 7 |
| 6 | Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer显示文摘Curcumin (淫液) ,主要 polyphenolic curcuminoid,从沉金根茎姜黄 longa 获得了,最近被报导在 vitro 并且在 vivo 有潜在的 antitumor 效果。Docetaxel (文档) 为非小的房间肺癌症的治疗被认为化疗同样首要。这里,我们第一次报导淫液能 synergistically 提高在里面 vitro 并且在对肺癌症的文档的 vivo antitumor 功效。在当前的学习,联合索引(CI ) 在 vitro 并且在 vivo 研究是打算的在里面决定在淫液和文档之间的相互作用。在里面在里面 vitro cytotoxicity 测试,中等效果的分析清楚地在某些集中显示了在淫液和文档之间的一个 synergistic 相互作用。而且,在 vivo,评估进一步在确定的 A549 与由静脉内的交货独自一个的文档相比表明了淫液 + 文档的优异 anticancer 功效移植异种皮移植模型。结果证明淫液 synergistically 在 4 天起始的治疗以后立即增加了文档的功效。另外,淫液和文档的同时的管理几乎没在治疗学的剂量包括骨头髓和肝显示出很少毒性到正常纸巾。因此,在 vitro 并且在 vivo,评估在传统的化疗对肺癌症和淫液的介绍表明了淫液和文档的令人满意的 synergistic antitumor 功效是阻止非小的房间肺癌症的传播的一个很有希望的方法。 | Haitao Yin Rui Guo Yong Xu Yulong Zheng Zhibo Hou Xinzheng Dai Zhengdong Zhang Donghui Zheng Hua'e Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 4 |
| 7 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 8 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 9 | Gene expression profiling under different photoperiod/temperature conditions in a photoperiod-/thermo-sensitive genic male sterile line of rice(Oryza sativa L.)显示文摘Peiai 64S is a photoperiod- and thermo- sensitive genic male sterile (PTSGMS) line of rice, which is male sterile at long day/high temperature and partial fertile at short day/low temperature. A cDNA array representing 3328 unique rice genes was used to profile the gene expression patterns in the young panicles of Peiai 64S under these two condi- tions. The statistical data showed that up to 14.60% of genes exhibited up-or down-regulated expressions in the plants at long day/high temperature compared with plants at short day/low temperature. Only four genes were up-regulated while 482 genes down-regulated. Real-time PCR with all the up-regulated and 9 randomly selected down-regulated genes confirmed the differential expressions detected by the array, indicating that the constructed cDNA array is reliable. These differently expressed genes participated in almost all cell biological responses. Analysis of up- and down-regulated genes revealed distinctive changes between the mRNA abundances of MMK1 and MMK2, both of which are analogs ofMAPK, and significant down-regulation of several transcription factors. It was suggested that changes that occurred in the MAPK signal transduction path- way might disturb the transcription control necessary for morphogenesis of pollens and corresponding phys- iological functions. | GUO Xiaoqin DONG Haitao ZHENG Kangle LUO Hongmei TAN Xuelin FANG Yongqi WANG Yanqin DENG Ye DAI Chengen LOU Yichun SHAO Jing SHI Wenqin ZHAO Dong LI Debao | 2006 | Chinese Science Bulletin2006，51，2： | 2 |
| 10 | Characteristics of LCoS phase only spatial light modulator and its application 显示文摘 | DAI Haitao LIU Yanjun WANG Xin | 2004 | SPIE2004，5280，： | 1 |
| 11 | Community Characteristics and Species Diversity of Wetland Plants in the Yangguan Nature Reserve of Dunhuang显示文摘As a typical inland wetland, Yangguan nature reserve wetland in Dunhuang is one of the important stops of migratory route for birds, which is vulnerable and particular. Study on the community characteristics and species diversity of wetland has great signifi cance for biodiversity protection. Based on the fi eld investigation, the fl oristic composition, geographical elements and species diversity of wetland plants were studied in Yangguan reserve of Dunhuang. The results showed that 26 families, 56 genera and 74 species were recorded in the study area. The largest families were the Gramineae and Chenopodiaceae, accounting for 29.73% of the total. Herbs were the most abundant life-form, accounting for 77.03% of the total. The fl oral geographical elements of the plants were mainly composed of temperate zone distribution type. By using two way indicator species analysis(TWINSPAN), the vegetation in 36 sampling plots could be classifi ed into 8 communities. The species diversity indexes of communities were relatively low, but had large differences among each other. According to the importance value, the Margalef richness index(Rm) ranged from 0 to 4.200. Simpson diversity index(D) was between 0 and 0.512; Shannon diversity index(H) ranged from 0 to 1.400, and Pielou evenness index(J) was within the range of 0.538 to 1.000. The results indicated that the plant species were relatively rare and simple in general, the species diversity of communities was low, and the ecological environment was fragile in Yangguan nature reserve of Dunhuang. | DAI Xueling ZHAO Tingwei MA Shoushi LIU Xingwen YANG Jinwu MA Haitao HE Wenli YANG Jing DUAN Hongling XIE Jianping | 2016 | Journal of Landscape Research2016，8，2： | 1 |
| 12 | Global Identification of Significantly Expressed Genes in Developing Endosperm of Rice by Expression Sequence Tags and cDNA Array Approaches显示文摘Rice endosperm plays a very important role in seedling germination and determines the qualities of rice grain. Although studies on specific gene categories in endosperm have been carried out, global view of gene expression at a transcription level in rice endosperm is still limited. To gain a better understanding of the global and tissue-specific gene expression profiles in rice endosperm, a cDNA library from rice endosperm of immature seeds was sequenced. A cDNA array was constructed based on the tentative unique transcripts derived from expression sequence tag (EST) assembling results and then hybridized with cDNAs from five different tissues or organs including endosperm, embryo, leaf, stem and root of rice. Significant redundancy was found for genes encoding prolamin, glutelin, allergen, and starch synthesis proteins, accounting for ~34% of the total ESTs obtained. The cDNA array revealed 87 significantly expressed genes in endosperm compared with the other four organs or tissues. These genes included 13 prolamin family proteins, 17 glutelin family proteins, 12 binding proteins, nine catalytic proteins and four ribosomal proteins, indicating a complicated biological processing in rice endosperm. In addition, Northern verification of 1,4-alpha-glucan branching enzyme detected two isoforms in rice endosperm, the larger one of which only existed in endosperm. | Qichao Tu Haitao Dong Haigen Yao Yongqi Fang Cheng'en Dai Hongmei Luo Jian Yao Dong Zhao Debao Li | 2008 | Journal of Integrative Plant Biology2008，50，9： | 0 |
| 13 | Establishment of an animal model of extra-vertebral foramen cervical nerve entrapment by local electrical stimulation and selection of suitable stimulation parameters显示文摘A rat model of extra-vertebral foramen cervical nerve entrapment was established according to the following parameters:stimulation intensity 20 V;frequency 50 Hz;pulse width 200 μs;duration 333 ms/s for a total of 8 hours.After the electrical stimulation,rats exhibited mild muscle fiber atrophy,mild inflammatory exudates,connective tissue local fibrosis and chondrocyte metaplasia.Mean muscle fiber cross-sectional area was reduced.The nerve myelin sheath continuity was partially demyelinated.The microstructure of nerve cells was disrupted and these symptoms worsened with prolongation of the stimulation.The shoulder,neck and upper extremity muscles on the tested side demonstrated positive sharp waves and fibrillations.The severity increased with continuation of the stimulation.High amplitude and polyphasic motor unit potentials gradually appeared.Similar findings were seen in the contralateral side,but at a less severe level. | Jinwu Wang Juliet Hou Qi Li Jian Tang Biyu Rui Shangchun Guo Haitao Jiang Cunyi Fan You Wang Zhenan Zhu Kerong Dai Guang H Yue | 2011 | Neural Regeneration Research2011，6，29： | 0 |
| 14 | Interface dipole enhancement effect and enhanced Rayleigh scattering显示文摘一纳米或亚纳米的光效果包围象围单人赛的碳 nanotubes (SWCNT ) 那样的单个 nanomaterials 的压缩分子的界面的层理论上并且试验性地被学习了。当由光照亮了时,这界面的层作为一个光偶极子格子表现并且贡献在附近的原子,分子,或 nanomaterials 上提高本地地的一块即时近的地,它可以接着导致提高的瑞利散布,散布的拉曼,和荧光。这接口偶极子的理论提高了效果(IDEE ) 预言那在 nanomaterials 和界面的层的飞机之间的更小的距离,或到包围媒介的界面的层的绝缘的常数的更大的比率,将导致一个更大的领域改进因素。这预言被 SWCNT 以及在逐渐地控告的 SWCNT 散布的 situ 瑞利散布的提高的瑞利的几实现进一步试验性地验证。接口偶极子提高了散布的瑞利不仅启用真彩 nanomaterials 的即时成像,而且提供一个有效工具凝视进微妙的界面的现象。 | Wenyun Wu Jingying Yue Dongqi Li Xiaoyang Lin Fangqiang Zhu Xue Yin Jun Zhu Xingcan Dai Peng Liu Yang Wei Jiaping Wang Haitao Yang Lina Zhang Qunqing Li Shoushan Fan Kaili Jiang | 2015 | Nano Research2015，8，1： | 0 |
| 15 | Effects of coal-fired power plants on soil microbial diversity and community structures显示文摘Long-term deposition of atmospheric pollutants emitted from coal combustion and their effects on the eco-environment have been extensively studied around coal-fired power plants.However,the effects of coal-fired power plants on soil microbial communities have received little attention through atmospheric pollutant deposition and coal-stacking.Here,we collected the samples of power plant soils(PS),coal-stacking soils(CSS)and agricultural soils(AS)around three coal-fired power plants and background control soils(BG)in Huainan,a typical mineral resource-based city in East China,and investigated the microbial diversity and community structures through a high-throughput sequencing technique.Coal-stacking significantly increased(p<0.05)the contents of total carbon,total nitrogen,total sulfur and Mo in the soils,whereas the deposition of atmospheric pollutants enhanced the levels of V,Cu,Zn and Pb.Proteobacteria,Actinobacteria,Thaumarchaeota,Thermoplasmata,Ascomycota and Basidiomycota were the dominant taxa in all soils.The bacterial community showed significant differences(p<0.05)among PS,CSS,AS and BG,whereas archaeal and fungal communities showed significant differences(p<0.01)according to soil samples around three coal-fired power plants.The predominant environmental variables affecting soil bacterial,archaeal and fungal communities were Mo-TN-TS,Cu-V-Mo,and organic matter(OM)-Mo,respectively.Certain soil microbial genera were closely related to multiple key factors associated with stacking coal and heavy metal deposition from power plants.This study provided useful insight into better understanding of the relationships between soil microbial communities and long-term disturbances from coal-fired power plants. | Bowen Sun Renbin Zhu Yu Shi Wanying Zhang Zeming Zhou Dawei Ma Runfang Wang Haitao Dai Chenshuai Che | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 16 | Spermidine mediated PLGA nanoparticles containing fluorofenidone for treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF) is a progressive, fatal lung disease with poor survival. The advances made in deciphering IPF have led to the approval of different anti-fibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles(liposomes, nanoparticles, microspheres, nanopolymersomes and nanoliposomes) modified with different functional groups have demonstrated improvement in lung targeted drug delivery. In the present study, we prepared, characterized, and evaluated spermidine(SPD) modified poly-lactic-co-glycolide nanoparticles(SPD-AKF-PLGA/NPs) as carriers for fluorofenidone(AKF) in order to improve the anti-fibrotic efficacy of this drug in lung. SPD-AKF-PLGA/NPs were prepared and functionalized by modified solvent evaporation method with spermidine(SPD), poly-lactic-co-glycolide-polyethylene glycol(PEG-PLGA) groups. The size of SPD-AKF-PLGA/NPs was 172.5±4.3 nm. The AKF release from nanoparticles was shown to be fit Higuchi model. The A549 cellular uptake of the SPD-Cou-6-NPs group was found to be almost 2-fold higher than that of the Cou-6-NPs group. Free SPD and DFMO were pre-incubated in A549 cells to further prove that the uptake of SPD-Cou-6-PLGA/NPs via PTS. As a result, the uptake of SPD-Cou-6-PLGA/NPs significantly decreased with the increase of SPD concentrations in incubation. At the higher SPD concentrations in 50 and 500 μM, the uptake of SPD-Cou-6-PLGA/NPs reduced 0.34 and 0.49-fold than that without SPD pretreatment. After pretreatment with DFMO for 36 h, the cellular uptake of SPD-Cou-6-NPs reached 1.26-fold compared to untreated DFMO group. In biodistribution study, the drug targeting index of SPD-AKF-PLGA/NPs in lung was 3.62 and 4.66-fold than that of AKF-PLGA/NPs and AKF solution, respectively. It was suggested that the SPD-AKF-PLGA/NPs could accumulate effectively in the lung. The lung histopathology changes and collagen deposition were observed by HE staining and Masson staining in efficacy study. In SPD-AKF-PLGA/NPs group, the damage was further improved compared to that of the AKFPLGA/NPs group and AKF solution group. The results indicated that SPD-AKF-PLGA/NPs could be effective nanocarriers for antipulmonary fibrosis therapy. | Jing Tang Jianming Li Guo Li Haitao Zhang Ling Wang Dai Lid Jinsong Ding | 2019 | 长沙医学院学报2019，，1： | 0 |
| 17 | Key Intrinsic Security Technologies in 6G Networks显示文摘Intrinsic security is a hot topic in the research of 6G network security.A revolution from the traditional“pluginbased”and“patchbased”network security protection mechanism to a self-sensing,self-adaptive and self-growing network immunity system is a general view of 6G intrinsic security in the industry.Massive connection security,physical-layer security,blockchain,and other 6G candidate intrinsic security technologies are analyzed based on 6G applications,especially hot scenarios and key technologies in the ToB(oriented to business)field. | LU Haitao YAN Xincheng ZHOU Qiang DAI Jiulong LI Rui | 2022 | ZTE Communications2022，20，4： | 0 |
| 18 | Waveguide-integrated optical modulators with two-dimensional materials显示文摘Waveguide-integrated optical modulators are indispensable for on-chip optical interconnects and optical computing.To cope with the ever-increasing amount of data being generated and consumed,ultrafast waveguide-integrated optical modulators with low energy consumption are highly demanded.In recent years,two-dimensional(2D)materials have attracted a lot of attention and have provided tremendous opportunities for the development of high-performance waveguide-integrated optical modulators because of their extraordinary optoelectronic properties and versatile compatibility.This paper reviews the state-of-the-art waveguide-integrated optical modulators with 2D materials,providing researchers with the developing trends in the field and allowing them to identify existing challenges and promising potential solutions.First,the concept and fundamental mechanisms of optical modulation with 2D materials are summarized.Second,a review of waveguide-integrated optical modulators employing electro-optic,all-optic,and thermo-optic effects is provided.Finally,the challenges and perspectives of waveguide-integrated modulators with 2D materials are discussed. | Haitao Chen Hongyuan Cao Zejie Yu Weike Zhao Daoxin Dai | 2023 | Journal of Semiconductors2023，44，11： | 0 |
| 19 | Sharp recanalization using Chiba biopsy needle for the treatment of biliary occlusion after radiofrequency ablation显示文摘Introduction Biliary stricture is a less common complication after hepatic radiofrequency ablation(RFA)[1,2].Patients with biliary stricture often present with recurrent jaundice,fever or chills,and require endoscopic or percutaneous biliary drainage,and in some cases recanalization of the biliary tract[3].Establishing guide-wire passage through the stricture is essential for biliary recanalization.However,in some cases of complete biliary obstruction,a more aggressive technique is needed when ordinarymethods fail to establish.Herein,we report a novel technique of extraluminal recanalization for biliary strictures using a Chiba biopsy needle,which is similar to sharp endovascular recanalization. | Bin Chen Haitao Dai Keyu Tang Run Lin Yonghui Huang | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 20 | Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss显示文摘Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with HO.Moreover,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 dpi.Correcting immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass loss.We further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to immunosuppression.Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss.Collectively,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO. | Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing Wang Rui Chen Jia Liu Xiangyue Meng Wei Wang Guiling Li Jiao Zhou Ya Zhang Wanbo Zhu Shiyuan Fang Haiming Wei Hong Zheng Siying Wang Fang Ni | 2022 | Bone Research2022，10，4： | 0 |
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