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| 1 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 2 | Climatic and lake environmental changes in the Serling Co region of Tibet over a variety of timescales显示文摘The Serling Co region is located at the transitional zone of the interaction between the Indian monsoon and the westerlies over the Tibetan Plateau. The Serling Co lake covers a water area of2,389 km2(June 2017) in a 45,530 km2drainage basin. Under the dramatic hydro-meteorological changes on the Tibetan Plateau in recent decades, and complex hydrological compositions of rivers and lakes in the basin, the lake area expanded by 43%, from1,667 km2in 1976, to 2,389 km2in 2017 (1)In 2014 it surpassed Nam Co as the largest lake on the Tibetan Plateau [2], and exerts significant effect on regional environmental conditions. | Liping Zhu Junbo Wang Jianting Ju Ning Ma Yinsheng Zhang Chong Liu Boping Han Linshan Liu Mingda Wang Qingfeng Ma | 2019 | Science Bulletin2019，64，7： | 13 |
| 3 | Broken Rotor Bar Fault Diagnosis of Induction Motors Using a Hybrid Bare-bones Particle Swarm Optimization Algorithm显示文摘在传统定子电流频谱分析中,感应电机转子断条故障特征经常被基波分量淹没而无法准确检测。针对该问题,提出一种基于混合骨干微粒群优化算法的转子断条故障诊断新方法。该方法首先根据电流信号与单位余弦基函数的内积最大准则,利用混合骨干微粒群算法强大的全局搜索能力,准确估计出基波波形参数;然后利用波形参数构造出基波表达式,并将其从原电流信号中剔除,达到突出故障特征的目的。针对微粒群算法在进化后期收敛缓慢的缺点,通过K–均值聚类方式,引入单纯形法对其进行改进,使整个算法的广度探索与深度开发能力得到了有效均衡。最后,对模拟数据和实测信号进行实验,结果验证了所提方法的有效性和优越性。 | WANG Panpan SHI Liping ZHANG Yong HAN Li | 2012 | 中国电机工程学报2012，32，30： | 10 |
| 4 | Pd/activated carbon sorbents for mid-temperature capture of mercury from coal-derived fuel gas显示文摘Higher concentrations of Hg can be emitted from coal pyrolysis or gasification than from coal combustion, especially elemental Hg. Highly efficient Hg removal technology from coal-derived fuel gas is thus of great importance. Based on the very excellent Hg removal ability of Pd and the high adsorption abilities of activated carbon(AC) for H2 S and Hg, a series of Pd/AC sorbents was prepared by using pore volume impregnation, and their performance in capturing Hg and H2 S from coal-derived fuel gas was investigated using a laboratory-scale fixed-bed reactor. The effects of loading amount, reaction temperature and reaction atmosphere on Hg removal from coal-derived fuel gas were studied. The sorbents were characterized by N2 adsorption, X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The results indicated that the efficiency of Hg removal increased with the increasing of Pd loading amount, but the effective utilization rate of the active component Pd decreased significantly at the same time. High temperature had a negative influence on the Hg removal. The efficiency of Hg removal in the N2–H2S–H2–CO–Hg atmosphere(simulated coal gas) was higher than that in N2–H2S–Hg and N2–Hg atmospheres, which showed that H2 and CO, with their reducing capacity, could benefit promote the removal of Hg. The XPS results suggested that there were two different ways of capturing Hg over sorbents in N2–H2S–Hg and N2–Hg atmospheres. | Dekui Li Jieru Han Lina Han Jiancheng Wang Liping Chang | 2014 | Journal of Environmental Sciences2014，26，7： | 8 |
| 5 | A Hybrid Simplex Search and Modified Bare-bones Particle Swarm Optimization显示文摘 | WANG Panpan SHI Liping ZHANG Yong HAN Li | 2013 | Chinese Journal of Electronics2013，22，1： | 6 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | Study on the quantitative structureactivity relation-ship of C-10 substituted artemisinin(QHS)’s derivatives using rough set theory显示文摘The structure-activity relationship study of C-10 substituted artemisinin (QHS) derivatives that are used as antimalarial was performed with the RS (rough sets) method. An RS process is a concise nonlinear process, and it has broad application foreground in the data mining of nonlinear life courses. In this work, initially the parameters of C-10 substituted QHS’s derivatives were computed with the quantum chemistry method, and the information table was constructed from the parameters (condition attributes) and biological activity (decision attributes). Based on the analysis of rough set theory, the core and reduction of attributes sets were obtained. Then the decision rules were extracted and the struc-ture-activity relationship was analyzed. As a nonlinear system, RS theory can extract the special rela-tion in the database. It has the advantage of being nonlinear over multiple linear regression (MLR), principal component analysis (PCA), partial least square (PLS), etc., and the advantage of obtaining results with unambiguous physical meanings over artificial neuron networks (ANNs), etc. The result obtained in this study is instructive to the study of pharmacodynamics, resistance mechanism of QHS and development of QHS’s derivatives. | LIU Hao QU LingBo GAO HongBin WANG JinXiang HAN LiPing XIANG BingRen | 2008 | Science China Chemistry2008，51，10： | 5 |
| 8 | Rb Protein is Essential to the Senescence-Associated Heterochromatic Foci Formation Induced by HMGA2 in Primary WI38 Cells显示文摘细胞的老朽是提供一个障碍给肿瘤的转变的房间周期拘捕的一张不可逆的表格。Rb (Retinoblastoma ) 小径的正直为为衰老的状态的稳定性提供一个分子的基础的联系老朽的 heterochromatin foci (SAHF ) 的形成是必要的。令人惊讶地,尽管高活动性组 A2 蛋白质(HMGA2 ) 能支持 tumorigenesis 并且在肿瘤房间禁止 Rb 功能, HMGA2 的高级表示是足够的在主要房间导致 SAHF 形成。决定 Rb 蛋白质是否在导致 HMGA2 的 SAHF 形成是必要的因此变得重要。在这研究,我们由 HMGA2,典型衰老的标记在被看见的宫外的表示建立了细胞的老朽和 SAHF 汇编 WI38 房间模型,包括 p53, p21 和 p16 的著名 upregulation,并且提高了 SA -- 和 E2F 目标基因的 downregulation 染色的牛乳糖。我们然后证明 Rb 小径禁止者 E7 蛋白质能部分在 WI38 房间在 HMGA2 表示以后废除 SAHF 形成的能力,显示 Rb 是为导致 HMGA2 的 SAHF 形成的一个关键因素。然而, Rb 弄空完全没救 HMGA2 导致的房间生长拘捕,建议 Rb 不是为在 WI38 房间的导致 HMGA2 的老朽的一条独占的小径。 | Xi Shi Baoqing Tian Lingxia Liu Yanyan Gao Chi Ma Namusamba Mwichie Wenlong Ma Liping Han Baiqu Huang Jun Lu Yu Zhang | 2013 | Journal of Genetics and Genomics2013，40，8： | 4 |
| 9 | Loss of Wip1 aggravates brain injury after ischaemia/reperfusion by overactivating microglia显示文摘Background and purpose The inflammatory response mediated by microglia/macrophages is closely related to cerebral ischaemia/reperfusion injury.Wild-type p53-induced protein phosphatase 1(Wip1),a serine/threonine phosphatase,is expressed in various tissues.A growing number of reports have suggested that Wip1 is a negative regulator of inflammation in peripheral tissue;however,its role in the central nervous system(CNS)remains unclear.This study aimed to clarify whether Wip1 can inhibit CNS inflammation by regulating microglia/macrophage functions after ischaemic injury.Methods A model of middle cerebral artery occlusion and reperfusion was established in mice.CNS inflammation was simulated by lipopolysaccharide treatment of primary microglia.Laser speckle imaging was used to monitor regional cerebral blood flow.Behavioural outcomes were assessed with a TreadScan gait analysis system.TTC staining was used to evaluate the infarct volume,and western blotting and immunofluorescence staining were applied to detect the phenotypical transformation of microglia.ELISA was performed to detect the levels of inflammatory factors.Results Wip1 expression was increased after ischaemia/reperfusion.Wip1-knockout(KO)mice displayed more severe brain injury than wild-type mice,as indicated by aggravated motor dysfunction,greater brain infarct volumes and higher expression of inflammatory cytokines(interleukin-6 and tumour necrosis factor alpha)in the brain.We also found that Wip1 depletion increased microglial/macrophage activation in both in vitro and in vivo models,which all showed activation of microglia/macrophages.Lentivirus-Ppm1d reversed the injury induced by Wip1-KO.Conclusions Our results suggest that Wip1 may inhibit neuroinflammation by inhibiting microglial/macrophage activation after brain ischaemia/reperfusion injury. | Feng Yan Xiang Cheng Ming Zhao Shenghui Gong Ying Han Liping Ding Di Wu Yumin Luo Wei Zuo Lingling Zhu Ming Fan Xunming Ji | 2021 | Stroke & Vascular Neurology2021，6，3： | 4 |
| 10 | δ^(13)C and water-use efficiency indicated by δ^(13)C of different plant functional groups on Changbai Mountains, Northeast China显示文摘Leaf δ13C of different plant functional groups (trees, shrubs and forbs; evergreen and deciduous; annual, biennial and perennial) were examined on the Changbai Mountains, China. Life form has a significant influence on plant δ13C, suggesting that leaf δ13C is also ideal for distinguishing functional groups species in temperate and frigid zones with high humidity. Additionally, the difference of water-use efficiency (WUE) is significant among different plant functional groups. δ13C and WUE are in the following order of forbs < shrubs < trees. Within shrubs, δ13C and WUE are higher for evergreen shrubs than deciduous shrubs. Differences in δ13C and WUE are significant among different lifespan herbs, and δ13C and WUE follow the order of annual herbs > biennial herbs > perennial herbs, not in accordance with the pattern obtained by previous studies in deserts, suggesting that the ranking of δ13C and WUE among annual, biennial and perennial herbs may be dependent on local water availability. | TAN WenBing WANG GuoAn HAN JiaMao LIU Min ZHOU LiPing LUO Ting CAO ZiYu CHENG ShuZhi | 2009 | Chinese Science Bulletin2009，54，10： | 4 |
| 11 | Effects of ultrasound on the desulfurization performance of hot coal gas over Zn-Mn-Cu supported on semi-coke sorbent prepared by high-pressure impregnation method显示文摘Zn-Mn-Cu/SC(U) sorbent was hydrothermally synthesized by ultrasound-assisted high-pressure impregnation method with semi-coke(SC)as support and the mixed solution of zinc nitrate,manganese nitrate and copper nitrate as active component precursors.The desulfurization performances of hot coal gas on the prepared sorbent at a mid-temperature of 500°C were tested in fixed-bed reactor.Morphology and pore structure of the prepared sorbent were also characterized by TEM,N2adsorption/desorption isotherms and XRD.For comparison,the sorbent of Zn-Mn-Cu/SC prepared by conventional high-pressure impregnation was also evaluated and characterized in order to study the effects of ultrasound treatment.Zn-Mn-Cu/SC(U) sorbent prepared by high-pressure impregnation under ultrasound-assisted condition showed a better desulfurization performance than Zn-Mn-Cu/SC.It could remove H2 S from 1000×10-6m3/m3 to 0.1×10-6m3/m3 at 500°C and maintained for 12.5 h with the sulfur capacity of 7.74%,in which both the breakthrough time and sulfur capacity were about 32% and 51% higher than those of Zn-Mn-Cu/SC sorbent.The introduction of ultrasound during high-pressure impregnation process greatly improved the morphology and pore structure of the sorbent.The ultrasonic treatment made particle size of active components smaller and made them more evenly disperse on semi-coke support,which provided more opportunities to contact with H2S in coal-based gases.However,there were no any difference in compositions and existing forms of active components on the Zn-Mn-Cu/SC and Zn-Mn-Cu/SC(U) sorbents. | Xiaoyang Zhang Xianrong Zheng Peng Han Ze Liu Liping Chang | 2015 | Journal of Energy Chemistry2015，24，3： | 4 |
| 12 | Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression显示文摘Shuyusan, a traditional Chinese medicine, was shown to improve depression symptoms and behavioral scores, as well as increase 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan levels, in a rat model of chronic stress-induced depression. However, dopamine, noradrenalin, and 3-methoxy-4-hydroxyphenylglycol expressions remained unchanged following Shuyusan treatment. Compared with the model group, the number of 5-HT-positive neurons in layers 4-5 of the frontal cortex, as well as hippocampal CA1 and CA3 regions, significantly increased following Shuyusan treatment. These results suggested that Shuyusan improved symptoms in a rat model of chronic stress-induced depression with mechanisms that involved 5-HT, 5-HT metabolite, 5-HT precursor expressions. | Yuanyuan Zhang Jianjun Jia Liping Chen Zhitao Han Yulan Zhao Honghong Zhang Yazhuo Hu | 2011 | Neural Regeneration Research2011，6，33： | 4 |
| 13 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 14 | Identification of Nonstructural Protein 8 as the N-Terminus of the RNA-Dependent RNA Polymerase of Porcine Reproductive and Respiratory Syndrome Virus显示文摘Porcine reproductive and respiratory syndrome virus (PRRSV) is a member within the family Arteriviridae of the order Nidovirales. Replication of this positive-stranded RNA virus within the host cell involves expression of viral replicase proteins encoded by two ORFs, namely ORF1 a and ORF1 b. In particular, translation of ORF1 b depends on a-1-ribosomal frameshift strategy. Thus, nonstructural protein 9 (nsp9), the first protein within ORF1 b that specifies the function of the viral RNA-dependent RNA polymerase, is expressed as the C-terminal extension of nsp8, a small nsp that is encoded by ORF1 a. However, it has remained unclear whether the mature form of nsp9 in virus-infected cells still retains nsp8,addressing which is clearly critical to understand the biological function of nsp9. By taking advantage of specific antibodies to both nsp8 and nsp9, we report the following findings. (1) In infected cells, PRRSV nsp9 was identified as a major product with a size between 72 and 95 k Da (72–95 KDa form), which exhibited the similar mobility on the gel to the in vitro expressed nsp8–9 ORF1 b, but not the ORF1 b-coded portion (nsp9 ORF1 b). (2) The antibodies to nsp8, but not to nsp7 or nsp10, could detect a major product that had the similar mobility to the 72–95 KDa form of nsp9. Moreover, nsp9 could be co-immunoprecipitated by antibodies to nsp8, and vice versa. (3) Neither nsp4 nor nsp2 PLP2 was able to cleave nsp8–nsp9 in vitro. Together, our studies provide experimental evidence to suggest that nsp8 is an N-terminal extension of nsp9.Our findings here paves way for further charactering the biological function of PRRSV nsp9. | Yuanyuan Liu Yunhao Hu Yue Chai Liping Liu Jiangwei Song Shaochuan Zhou Jia Su Lei Zhou Xinna Ge Xin Guo Jun Han Hanchun Yang | 2018 | Virologica Sinica2018，33，5： | 3 |
| 15 | Anti-porcine circovirus type 2(PCV2) antibody placental barrier leakage from sow to fetus: impact on the diagnosis of intra-uterine PCV2 infection显示文摘Dear Editor,Fetuses develop antibodies when they are infectedwith porcine circovirus type 2(PCV2).At abortion orbirth,both PCV2 and/or anti-PCV2 antibodies can thenbe detected.Finding anti-PCV2 antibodies in aborted fe-tuses or stillborn piglets is generally used as evidence ofan intra-uterine PCV2 infection.However,a recent anal-ysis of fetuses sent in for PCV2 diagnosis and caesare-an-derived,colostrum-deprived pigs revealed that | Dipongkor Saha Rubén Del Pozo Sacristán Nicolaas Van Renne Liping Huang Ruben Decaluwe Annelies Michiels Alfonso Lopez Rodriguez Maria José Rodrí-guez Margarita García Durán Ilse Declerk Dominiek Maes Hans J. Nauwynck | 2014 | Virologica Sinica2014，29，2： | 3 |
| 16 | Balancing method without trial weights for rotor systems based on similitude scale model显示文摘 | Ruiduo YE Liping WANG Xiaojie HOU Zhong LUO Qingkai HAN | 2018 | Frontiers of Mechanical Engineering2018，13，4： | 3 |
| 17 | Tribological study of N-containing borate derivatives and their synergistic antioxidation effects with T531显示文摘Two N-containing borates, BTES and BMES, were synthesized with dodecyl phenol, 2-(N-containing heterocyclic) ethan-1-ol, boric acid, and dibutylamine, and their tribological properties in rapeseed oil(RSO) were investigated using a four-ball tester. The results showed that the load-carrying ability(P_B value) of RSO can be improved by 40.9% and 67.9%, respectively, when using 0.5 wt% BTES and BMES. Moreover, the antiwear and friction-reducing performances of the additive-containing oils increased with the additive concentration. The X-ray photoelectron spectroscopy results of the worn steel ball surfaces showed that BTES and BMES formed protective films, which contained boron oxide, iron oxide, ferrous sulfate, ferrous sulfide(for BMES), and other organic nitrogen compounds, on the metal surfaces. The better load-carrying and antiwear performances of BMES than those of BTES might be due to their different sulfur contents, which result in different tribochemical reaction films on the contact surfaces. The oxidation stability tests showed that BTES and BMES possessed synergistic antioxidation activity with N-phenyl-α-naphthylamine(T531), and consequently, the oxidation activation energy of the oil sample increased by 77.85% and 82.19%, respectively, compared with that of RSO when the oil sample contained 0.05 wt% BTES/BMES and 0.25% T531. | Liping XIONG Zhongyi HE Jian LIU Jianqiang HU Xu XIN Sheng HAN Yinglei WU Shaoming YANG | 2019 | Friction2019，7，5： | 3 |
| 18 | Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer显示文摘Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past decades.Localized targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic cancer.An injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via EUS-FNI.Here,a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was developed.This hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological temperature.Both in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery system.Synergistic cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel system.After a single intratumoral injection,the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP combination.In addition,a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel composites.The obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs,for use in a variety of inoperable solid tumors. | Kun Shi Bingxin Xue Yanpeng Jia Liping Yuan Ruxia Han Fan Yang Jinrong Peng Zhiyong Qian | 2019 | Nano Research2019，12，6： | 3 |
| 19 | High-quality industrial n-type silicon wafers with an efficiency of over 23% for Si heterojunction solar cells显示文摘展示更长的少数搬运人一生和某些金属污染的更高的忍耐的 n 类型 CZ-Si 晶片能提供最好的基于 Si 的太阳能电池之一。在这研究,在顶与不同晶片被制作的 Si heterojuction ( SHJ )太阳能电池,中间和铸块锭的尾巴位置,展出了稳定的高效率>22%尽管有抵抗力和一生的各种各样的侧面,它表明了n类型铸块锭的高材料利用。为有效地把日光变换成电力,另外,金字塔尺寸,金字塔密度和 Cz-Si 晶片的表面的粗糙被扫描电子显微镜(SEM ) 和传播电子显微镜(TEM ) 调查。而且, SHJ 太阳能电池的依赖表面地形学上的开电路的电压被讨论,它显示表面金字塔的一致性帮助改进开电路的电压和变换效率。而且,模拟表明 SHJ 太阳能电池的最高的效率能被晶片与 100 m 的厚度完成。幸好,有 100 m 的晶片厚度的 SHJ 太阳能电池的超过 23% 变换效率在飞行员生产线基于房间制造过程的系统的优化被获得。显然,两 n 类型铸块锭的大可获得性和更薄的晶片强烈支持了高效率 SHJ 太阳能电池的更低的费用制造。 | Fanying MENG Jinning LIU Leilei SHEN Jianhua SHI Anjun HAN Liping ZHANG Yucheng LIU Jian YU Junkai ZHANG Rui ZHOU Zhengxin LIU | 2017 | Frontiers in Energy2017，11，1： | 3 |
| 20 | Effect of pulsatile perfusion during cardiopulmonary bypass in terms of radial artery sphygmogram显示文摘OBJECTIVE: To investigate a quantitative method for using radial artery pulse waveforms to assess the effect of pulsatile flow during cardiopulmonary bypass(CPB).METHODS: A total of 34 adults with heart disease who underwent open-heart surgery between April2010 and January 2011 were randomized into a pulsatile perfusion group(n=17) and a non-pulsatile perfusion group(n=17). Radial arterial pulse waveforms of pulsatile and non-pulsatile perfusion patients were observed and compared before and during CPB.RESULTS: No pulse waveform could be detected at patients' radial artery in both groups when the aorta was cross-clamped. Pulse waveforms could be detected at pulsatile perfusion patients' radial artery, but could not be detected at non-pulsatile perfusion patients' radial artery during CPB. Additionally, patients' pulse waveforms during pulsatile perfusion were lower than those before the operation.CONCLUSION: Our findings indicate that radial artery sphygmogram can be used as a valid indicator to evaluate the effectiveness of pulsatile perfusion during CPB. | Zhifeng Zhang Jiatuo Xu Enyuan Zhu Qi Zhang Lu Yu Yongbing Qiu Jianguo Tang Zhaofu Fei Xin Li Liping Tu Chouping Han Ying Liu Zhen Guo Changle Zhou Meiyu Shi Yingxin Qian Yimin Bao Xinming Ji | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
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