|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Hyperglycemia induces protein nonenzymeatic glycosylation in brain neurons of diabetic rats at early stage显示文摘BACKGROUND: Protein nonenzymatic glycosylation is supposed to be one of mechanisms for chronic complications development in diabetes mellitus, and therefore, might play an important role in the neuronal degeneration. OBJECTIVE: To study the protein nonenzymatic glycosylation in brain neurons of diabetic rats, and to analyze the pathway of neuronal degeneration at the early stage of hyperglymecia. DESIGN: Randomized controlled animal experiment. SETTING: Department of Endocrinology, First hospital Affiliated to General Hospital of Chinese PLA and Beijing Laboratory for Brain Aging, Xuanwu Hospital Affiliated to Capital Medical University. MATERIALS: Thirty-five male Wistar rats (grade Ⅱ), aged 3 months old, and 11 male purebred Kunming mice (grade Ⅲ) without special pathogen, aged 3 months old, were provided by the Animal Room of Capital Medical University. METHODS: This experiment was carried out in the Beijing Laboratory for Brain Aging, Xuanwu Hospital Affiliated to Capital Medical University in 1998. The rats in the diabetic model group were intraperitoneally injected into 10 g/L STZ according to 60 mg/kg to establish rat models of diabetes mellitus. The blood glucose and body mass of rats in each group were determined respectively at 1, 2 and 3 months after modeling. The antibodies of advanced glycosylation end products (AGEs) of bovine serum albumin (anti-BSA) were self-prepared: ①The antigen of AGEs-BSA was prepared.②Eleven male Kuming mice (grade Ⅱ) of 3 months old without special pathogen were selected to inoculate AGEs-BSA. ③ The animals were immunized. ④Primary purification and detection of poly-antibodies of AGEs: the AGEs were performed immunohistochemical examination at 1 month after diabetic modeling by ELISA method. MAIN OUTCOME MEASURES: ① Detection results of blood glucose and body mass of rats in two groups at different time points. ② Determination of polyclonal antibody titer of AGEs-BSA. ③ Changes in immunohistochemical image of AGEs in brain tissue of rats in two groups. RESULTS: Thirteen rats in the diabetic model group and fifteen rats in the normal model group entered the stage of final analysis. ①Changes of blood glucose and body mass: At 1, 2 and 3 months after modeling, the blood glucose of rats in the diabetic model group were respectively(28.8±2.8),(23.1±5.5),(25.4± 5.1) mmol/L, which were significantly higher than those in the normal control group [(6.2±0.9),(6.1±0.8), (6.1±0.7) mmol/L,P < 0.01]; At 1, 2 and 3 months after modeling, the body mass of rats in the diabetic model group were respectively (250.1±52.2),(263.8±50.0),(261.5±42.6) g, which were significantly lower than those in the normal control group [(422.6±36.2),(462.6±39.0),(485.0±28.8) g,P < 0.01]. ②Determination of antibody titer of immune serum: The mice were treated by AGEs-BSA of different concentrations twice. After that, the titer of AGEs -BSA was determined, and the results of which indicated that a higher absorbance existed at 1∶1 000. ③Determination of antigen concentration: The final titer of antibody in the abdominal dropsy was determined, and the results of which suggested that there was a much higher absorbance in the AGEs-BSA at the concentration of 5–50 mg/L. ④Determination of antibody titer in abdominal dropsy: The antibody titer in abdominal dropsy was detected by ELISA method with antigen at 20 mg/L, which indicated that the maximum absorbance (1.265±0.039) existed at 1∶4 000, and very larger absorbance (0.982±0.067) at 1∶20 000. The polyclonal antibody of AGEs-BSA was successfully prepared. ⑤Immunohistochemical detection results: The immunohistochemical staining of AGEs showed there were positive neurons in the first month in the diabetic model group, whereas it was not significant in the normalcontrol group. The positive substances were found mainly in the cytoplasm. CONCLUSION: Hyperglycemia at the early stage of diabetes mellitus (1 month after modeling) can lead to protein nonenzymeatic glycosylation in brain neurons, and no obvious reactions mentioned above are found in the normal control group. It suggests that the degenerative changes of tissue structure of central nervous system are related with protein nonenzymeatic glycosylation caused by hyperglycemia. | Jingsheng Hu Xueyi Ma Shuli Sheng | 2007 | Neural Regeneration Research2007，2，1： | 2 |
| 3 | Mapping of the Ogura fertility restorer gene Rfo and development of Rfo allele-specific markers in canola (Brassica napus L.)显示文摘 | Xueyi Hu Mandy Sullivan-Gilbert Tom Kubik Jason Danielson Nathan Hnatiuk Wesley Marchione Thomas Greene Steven A. Thompson | 2008 | Molecular Breeding2008，，4： | 1 |
| 4 | Fault diagnosis of bearings based on deep separable convolutional neural network and spatial dropout显示文摘Bearing pitting,one of the common faults in mechanical systems,is a research hotspot in both academia and industry.Traditional fault diagnosis methods for bearings are based on manual experience with low diagnostic efficiency.This study proposes a novel bearing fault diagnosis method based on deep separable convolution and spatial dropout regularization.Deep separable convolution extracts features from the raw bearing vibration signals,during which a 3×1 convolutional kernel with a one-step size selects effective features by adjusting its weights.The similarity pruning process of the channel convolution and point convolution can reduce the number of parameters and calculation quantities by evaluating the size of the weights and removing the feature maps of smaller weights.The spatial dropout regularization method focuses on bearing signal fault features,improving the independence between the bearing signal features and enhancing the robustness of the model.A batch normalization algorithm is added to the convolutional layer for gradient explosion control and network stability improvement.To validate the effectiveness of the proposed method,we collect raw vibration signals from bearings in eight different health states.The experimental results show that the proposed method can effectively distinguish different pitting faults in the bearings with a better accuracy than that of other typical deep learning methods. | Jiqiang ZHANG Xiangwei KONG Xueyi LI Zhiyong HU Liu CHENG Mingzhu YU | 2022 | Chinese Journal of Aeronautics2022，35，10： | 1 |
| 5 | Use of STSs and SSRs as rapid and reliable preselection tools in a marker-assisted selection-backcross scheme显示文摘 | Jean-Marcel Ribaut Xueyi Hu David Hoisington Diego González-de-León | 1997 | Plant Molecular Biology Reporter1997，，2： | 1 |
| 6 | Important safeguard of work safety for enterprises in China 显示文摘 | Maohua Zhong Tiemin Liu Yunfeng Deng Congling Shi Tairan Fu Xueyi Hu Safety evaluation | 2006 | Jouma| of Loss Prevention in the Process Industries2006，19，6： | 1 |
| 7 | Mapping of the loci controlling oleic and linolenic acid contents and development of fad2 and fad3 allele-specific markers in canola (Brassica napus L.)显示文摘 | Xueyi Hu Mandy Sullivan-Gilbert Manju Gupta Steven A. Thompson | 2006 | Theoretical and Applied Genetics2006，，3： | 1 |
| 8 | Vercytochalasins A and B: Two unprecedented biosynthetically related cytochalasins from the deep-sea-sourced endozoic fungus Curvularia verruculosa显示文摘Vercytochalasins A(1) and B(2), two biosynthetically related cytochalasins featuring novel structure and substituents, were isolated from the endozoic fungus Curvularia verruculosa which was associated with the deep-sea squat lobster Shinkaia crosnieri collected from the cold seep environment in South China sea. Their structures were elucidated by detailed interpretation of NMR spectroscopic and mass spectrometric data. The absolute configurations were confirmed by NOESY experiments as well as by DP4+ and ECD calculations. Differed from common cytochalasins, compound 1 is an uncommon secocytochalasin featuring the ester group cleaved between C-9 and C-23, and incorporating an additional oxygenated C4 unit which coupled with C-20 and C-22 to form a new substituted cyclohexenone moiety, while compound 2 contains an unusual 2–hydroxy-3-oxobutan-2-yl unit at C-22. Both compounds are distinctive from the commonly described cytochalasins. Compound 1 exhibited potent activity against angiotensinI-converting enzyme(ACE) whereas compound 2 showed antibacterial activity. Molecular docking simulations were performed to explore the intermolecular interaction of compounds 1 and 2 with ACE. | Xueyi Hu Xiaoming Li Suiqun Yang Xin Li Bingui Wang Linghong Meng | 2023 | Chinese Chemical Letters2023，34，2： | 1 |
| 9 | Study on potential evapotranspiration and wet-dry condition in the seasonal frozen soil region of northern Tibetan Plateau显示文摘This study was based on the CEOP/CAMP-Tibet observed data at AWS (Automatic Weather Station) of MS3478 in the seasonal frozen soil region of northern Tibetan Plateau from March 2007 to February 2008.The variation characteristics of PE (potential evapotranspiration) were analyzed based on the Penman-Monteith method recommended by FAO (the Food and Agriculture Organization of the United Nations).The contributions of dynamic,thermal and water factors to PE were discussed,and the wet-dry condition of the plateau region was further studied.The results indicated that daily PE was between 0.52 mm and 6.46 mm for the whole year.Monthly PE was over 107 mm from May to September,but decreased to less than 41 mm from November to February.Annual PE was 1,037.8 mm.In the summer,thermal PE was significantly more than dynamic PE,but conversely in the winter.Annual variation of thermal PE was of sine wave pattern.In addition,drought and semi-drought climate lasted for a long time while semi-humid climate was short.The effect of water and dynamic factors on PE varied considerably with the seasons.Annual variation of thermal PE was of sine wave pattern. | HuiGen He ZeYong Hu XueYi Xun Jun Sun Li Hao LiJiao Xu Wen Peng | 2011 | Research in Cold and Arid Regions2011，3，2： | 1 |
| 10 | Nonmacrocyclic Iron(II)Soluble Redox Mediators Leading to High-Rate Li-O_(2)Battery显示文摘The lithium-oxygen(Li-O_(2))battery is highly promising but suffers from poor cycling life,especially at high rates;hence,the need for high-efficient accelerating agents is crucial.Recently macrocyclic Fe-based redox mediators,such as iron(II)phthalocyanine(FePc)and heme,have been developed and anticipated to be ideal due to their bifunctional charge and superoxide shuttling capabilities.However,they still operate far below expectations,which could result from the low concentrations in electrolyte due to the strongπ-πinteraction at carbon cathode.Herein,the authors report a new type of nonmacrocyclic Fe-based redox mediators,iron(II)acetylacetonate[Fe(acac)2]and iron(II)glycinate[Fe(gly)2],which have weakπ-πinteraction with the carbon cathode,thus,remain at high concentrations in the electrolyte.The Fe(gly)2@Li-O_(2)battery reaches a long life of 321 cycles at 0.5 A g^(−1),which is much superior to the counterpart with the typical macrocyclic FePc,and particularly exhibits a long life of 167 cycles at 2.0 A g^(−1)and 136 cycles at ultrahigh 5.0 A g^(−1).This study demonstrates an efficient strategy to achieve a high-rate performance of Li-O_(2)batteries by developing nonmacrocyclic Fe-based redox mediators with high-efficient electron and superoxide shuttling. | Baoxing Wang Xiao Wang Xueyi Cheng Jing Zhang Minglei Yan Guochang Li Lijun Yang Qiang Wu Xizhang Wang Zheng Hu | 2021 | CCS Chemistry2021，3，5： | 0 |
| 11 | Antioxidant bisabolane-type sesquiterpenoids from algalderived fungus Aspergillus sydowii EN-434显示文摘A new aromatic bisabolene-type sesquiterpenoid(7 S,8 S)-8-hydroxysydowic acid(1),together with a pair of new bisabolene derivative(±)-(7 R*,10 R*)-10-hydroxysydowic acid(2),as well as two known analogues hydroxysydonic acid(3)and sydowic acid(4)were isolated and identifi ed from the endophytic fungal strain Aspergillus sydowii EN-434 that was obtained from the marine red alga Symphyocladia latiuscula.Their structures were elucidated by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),and quantum chemical electronic circular dichroism(ECD)calculations as well as comparison of the data with literature reports.Compound 1 exhibited potent DPPH free radical scavenging activity with IC 50 value of 113.5μmol/L. | HU Xueyi LI Xiaoming MENG Linghong WANG Bingui | 2020 | Journal of Oceanology and Limnology2020，38，5： | 0 |
| 12 | Highly reinforce the interface stability using 2-Phenyl-1H-imidazole-1-sulfonate electrolyte additive to enhance the high temperature performance of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)/graphite batteries显示文摘This work develops 2-Phenyl-1H-imidazole-1-sulfonate(PHIS)as a multi-functional electrolyte additive for H2O/HF scavenging and film formation to improve the high temperature performance of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)/graphite batteries.After 450 cycles at room temperature(25℃),the discharge capacity retentions of batteries with blank and PHIS-containing electrolyte are 56.03%and 94.92%respectively.After 230 cycles at high temperatures(45℃),their values are 75.30%and 88.38%respectively.The enhanced electrochemical performance of the batteries with PHIS-containing electrolyte is supported by the spectroscopic characterization and theoretical calculations.It is demonstrated that this PHIS electrolyte additive can facilitate the construction of the electrode interface films,remove the H2O/HF in the electrolyte,and improve the electrochemical performance of the batteries.This work not only develops a sulfonate-based electrolyte but also can stimulate new ideas of functional additives to improve the battery performance. | Xin He Yiting Li Wenlian Wang Xueyi Zeng Huilin Hu Haijia Li Weizhen Fan Chaojun Fan Jian Cai Zhen Ma Junmin Nan | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
| 13 | Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses显示文摘Establishment of vaginal immune defenses at the mucosal interface layer through gene vaccines promise to prevent infectious diseases among females.Mucosal barriers composed of a flowing mucus hydrogel and tightly conjugated epithelial cells(ECs),which represent the main technical difficulties for vaccine development,reside in the harsh,acidic human vaginal environment.Different from frequently employed viral vectors,two types of nonviral nanocarriers were designed to concurrently overcome the barriers and induce immune responses.Differing design concepts include the charge-reversal property(DRLS)to mimic a virus that uses any cells as factories,as well as the addition of a hyaluronic acid coating(HA/RLS)to directly target dendritic cells(DCs).With a suitable size and electrostatic neutrality,these two nanoparticles penetrate a mucus hydrogel with similar diffusivity.The DRLS system expressed a higher level of the carried human papillomavirus type 16 L1 gene compared to HA/RLS in vivo.Therefore it induced more robust mucosal,cellular,and humoral immune responses.Moreover,the DLRS applied to intravaginal immunization induced high IgA levels compared with intramuscularly injected DNA(naked),indicating timely protection against pathogens at the mucus layer.These findings also offer important approaches for the design and fabrication of nonviral gene vaccines in other mucosal systems. | Qunjie Bi Xu Song Yangyang Zhao Xueyi Hu Huan Yang Rongrong Jin Yu Nie | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员