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| 1 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 2 | Dihedral influence on lateral–directional dynamic stability on large aspect ratio tailless flying wing aircraft显示文摘The influence of dihedral layout on lateral–directional dynamic stability of the tailless flying wing aircraft is discussed in this paper. A tailless flying wing aircraft with a large aspect ratio is selected as the object of study, and the dihedral angle along the spanwise sections is divided into three segments. The influence of dihedral layouts is studied. Based on the stability derivatives calculated by the vortex lattice method code, the linearized small-disturbance equations of the lateral modes are used to determine the mode dynamic characteristics. By comparing 7056 configurations with different dihedral angle layouts, two groups of stability optimized dihedral layout concepts are created. Flight quality close to Level 2 requirements is achieved in these optimized concepts without any electric stability augmentation system. | Song Lei Yang Hua Zhang Yang Zhang Haoyu Huang Jun | 2014 | Chinese Journal of Aeronautics2014，27，5： | 4 |
| 3 | Trace Elements in Sphalerite from the Dadongla Zn-Pb Deposit, Western Hunan-Eastern Guizhou Zn-Pb Metallogenic Belt, South China显示文摘The western Hunan-eastern Guizhou Zn-Pb metallogenic belt is one of the important Zn-Pb mineralization regions in China.The Dadongla deposit,located in the northeast of Guizhou Province,is one of the typical Zn-Pb deposits in the region and has estimated resources more than 12 million metric tons(Mt)with an average grade of 4.11 wt%Zn+Pb.Its orebodies are hosted in the lower Cambrian Aoxi Formation dolomite,occurring as bedded,para-bedded in shape,and in conformity with the wall rock.The ore mineral assemblage is simple,dominated by sphalerite with minor pyrite and galena,and the gangue minerals are composed of dolomite,calcite with minor bitumen and barite.In view of the lack of geological and geochemical researches,the genesis of Zn-Pb ore is still unclear.Laser ablation-inductively coupled plasma mass spectrometry(LA-ICPMS)spot and mapping analyses were used to obtain sphalerite trace element chemistry in the Dadongla Zn-Pb deposit in Guizhou,China,aiming to constrain its ore genesis.The results show that sphalerite is characterized by the enrichment of Cd,Fe,Ge and Hg,corresponding with that of typical MVT deposits.Four zones were identified in the sphalerite crystal from Dadongla from the center to margin according to the color bands.in which the zone in the center,representing the early ore-stage sphalerite,is characterized by enrichment of Cd relatively,while the zone forming at late ore-stage is enriched in Ge and Hg relatively.The finding was controlled by differential leached metals content in ore-forming fluid from its source rock.Notably,critical element Ge trends to be enriched at the late ore-stage and follows a substitution of 2 Zn^2+(?)Ge^4++□(vacancy).Moreover,the calculated ore-forming temperature ranges from 79.9℃to 177.6℃by the empirical formula,which is similar to that of typical Mississippi Valley-type(MVT)deposits.Compared with the features of trace elements in sphalerite from different types of deposits,together with the geology,the Dadongla deposit belongs to an MVT Zn-Pb deposit. | HU Yusi YE Lin WEI Chen LI Zhenli HUANG Zhilong WANG Haoyu | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 3 |
| 4 | Water boosted CO_(2)/C_(2)H_(2)separation in L-arginine functionalized metal–organic framework显示文摘The separation of CO_(2)/C_(2)H_(2)mixture by CO_(2)-selective sorbents is an energy-efficient C_(2)H_(2)purification technique,but is strategically challenging due to their similar molecular size and physicochemical properties.Meanwhile,water is inevitable in CO_(2)/C_(2)H_(2)mixture and it is usually a significant barrier because of its competitive adsorption with CO_(2).To address this challenge,herein,we report the first example of metal–organic framework(MOF)that exhibits water-boosted CO_(2)adsorption and CO_(2)/C_(2)H_(2)separation by anchoring L-arginine(ARG)on the Zr6 cluster of MOF-808.The CO_(2)affinity and capacity in the resulting MOF-808-ARG are markedly facilitated by the presence of water,while the C_(2)H_(2)adsorption is significantly suppressed.Specifically,CO_(2)adsorption capacities in adsorption isotherm and breakthrough measurement are increased to 143%and 184%,respectively.In addition,the wet MOF-808-ARG exhibits the record CO_(2)/C_(2)H_(2)selectivity of 1,180 under zero coverage.Breakthrough experiments reveal that CO_(2)/C_(2)H_(2)mixture can be completely separated and the result of mass spectrometry indicates that the C_(2)H_(2)purity in the outlet is up to 99.9%.In situ infrared(IR)results and density functional theory(DFT)calculations reveal the water-promoted CO_(2)adsorption mechanism that the formation of bicarbonate products in the presence of water is thermodynamically and kinetically more favorable than that without water.Moreover,MOF-808-ARG also possesses excellent water stability and excellent regeneration of CO_(2)adsorption.This work provides a new paradigm by transforming the negative effects of water into positive ones for CO_(2)/C_(2)H_(2)separation. | Hejin Zhu Wenjuan Xue Hongliang Huang Lvyun Chen Haoyu Liu Chongli Zhong | 2023 | Nano Research2023，16，5： | 2 |
| 5 | A self-standing,UV-cured semi-interpenetrating polymer network reinforced composite gel electrolytes for dendrite-suppressing lithium ion batteries显示文摘A self-standing,flexible and lithium dendrite growth-suppressing composite gel polymer electrolyte membrane was designed for the use of room-temperature lithium ion batteries.The multi-functional composite semi-interpenetrating polymer network(referred to as“Cs-IPN”)electrolyte membrane was fabricated by combining a UV-cured ethoxylated trimethylolpropane triacrylate(ETPTA)macromer with alumina nanoparticles in the presence of liquid electrolyte and thermoplastic linear poly(ethylene oxide)(PEO).The polymer electrolyte membrane exhibits a semi-interpenetrating polymer network structure and a higher room temperature ionic conductivity,which impart the electrolyte with a significant cycling(120 mAh g^(-1)after 200 cycles)and a remarkable rate(137 mAh g^(-1)at 0.1℃,130 mAh g^(-1)at 0.5℃,119 mAh g^(-1)at 1℃ and 100 mAh g^(-1)at 2℃)performance in Li/LiFePO4 battery.More importantly,the polymer electrolyte possesses superior ability to inhibit the growth of lithium dendrites,which makes it promising for next generation lithium ion batteries. | Ruiping Liu Zirui Wu Peng He Haoyu Fan Zeya Huang Lei Zhang Xinshuang Chang Hang Liu Chang-an Wang Yutao Li | 2019 | Journal of Materiomics2019，5，2： | 2 |
| 6 | Principle and numerical demonstration of high power all-fiber coherent beam combination based on self-imaging effect in a square core fiber显示文摘The self-imaging effect in a square core fiber has been investigated, and an integrated all-fiber combiner has been proposed based on a large mode area double clad fiber, which can be employed to construct high power coherent beam combining sources in the all-fiber format. The influence of various parameters on beam quality(M^(2)) and efficiency of the all-fiber coherent beam combiner has been studied numerically, which reveals that the near diffraction-limited laser beam can be achieved. A principle demonstration of the self-imaging effect has been carried out experimentally in a square core fiber, which proves the feasibility of beam combining with the square fiber, and that it is a promising way to develop high power coherent beam combination sources. | Yuefang Yan Yu Liu Haoyu Zhang Yue Li Yuwei Li Xi Feng Donglin Yan Jianjun Wang Honghuan Lin Feng Jing Wenhui Huang Rumao Tao | 2022 | Photonics Research2022，10，2： | 2 |
| 7 | Comparison of Dextran Perfusion and GSI-B4 Isolectin Staining in a Mouse Model of Oxygen-induced Retinopathy显示文摘Purpose: Oxygen-induced retinopathy(OIR) is a robust and widely used animal model for the study of retinal neovascularization(NV). Dextran perfusion and Griffonia simplicifolia isolectin B4(GSI-B4) staining are two common methods for examining the occurrence and extent of OIR. This study provides a quantitative comparison of the two for OIR detection.Methods: At postnatal day 7(PN7), fifteen C57 BL / 6J mice were exposed to a 75% hyperoxic condition for 5 days and then returned to room air conditions. At PN17, the mice received intravitreal injection of GSI-B4 Alexa Fluor 568 conjugate. After 10 hours, they were infused with FITC-dextran conjugate via the left ventricle. Retinal flat mounts were photographed by confocal microscopy. Areas with fluorescent signals and the total retinal areas were quantified by Image J software.Results:Both GSI-B4 and dextran detected the peripheral neovascular area. The mean hyper fluorescence area was 0.33 ±0.14% of whole retinal area determined by GSI-B4 staining and 0.25±0.28% determined by dextran perfusion. The difference between the two measures was 0.08%(95% CI:-0.59%,0.43%)..The Pearson correlation coefficient between the two methods was 0.386,P =0.035..The mean coincidence rates were 14.3 ±13.4% and 24.9 ±18.5% for GSI-B4 and dextran staining, respectively.Conclusion:.Both methods can complement each other indemonstrating and quantitatively evaluating retinal NV. A poor agreement was found between the two methods;.GSI-B4 isolectin was more effective than FITC-dextran perfusion in evaluating the extent of retinal NV in a mouse model of OIR. | Shaofen Huang Jiajian Liang Gary Hin-Fai Yam Zhihao Lu Chi Pui Pang Haoyu Chen | 2015 | Eye Science2015，30，2： | 2 |
| 8 | Design of an eddycurrent array probe for crack sizing in steam generator tubes显示文摘 | Haoyu Huang Nozomu Sakurai | 2003 | NDT&E International2003，，36： | 1 |
| 9 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 10 | De sign of an eddy-current array probe for crack sizingin steam generator tubes显示文摘 | Nozomu Sakurai Toshiyuki Takagi etc | 2003 | NDT&E International2003，36，： | 1 |
| 11 | Highly stretchable,soft and sticky PDMS elastomer by solvothermal polymerization process显示文摘Siloxane rubber shows attractive properties of high stability,elasticity and transparency.Besides,the regulation of its properties renders it widely used in many application fields.However,most of the reported performance improvement methods of siloxane rubber focus on the change of chemical composition of siloxane rubber,including the design of molecular chain and the introduction of other compounds,etc.Such a strategy is still faced with many limitations in practical application.In this work,on the premise of not changing the chemical composition of siloxane rubber,we propose a facile solvothermal polymerization process to change the structure of cross-linking networks,so as to obtain the siloxane rubber with controllable mechanical properties.Compared to the normal curing method,we realized polydimethylsiloxane elastomer(PDMS)with maximum elongation of more than 3,000%(>10 times of normally cured one)and tensile modulus lower than 0.15 MPa(<1/10 of normally cured one).In addition to superior stretchability,it gains extra high softness,stickiness and sensitive response to organic solvents.Based on our solvothermal cured PDMS,its applications in oil collection and organic solvent sensor have been demonstrated.It is expected that this method can be readily utilized widely and shows great application potentials. | Jin Huang Yuchun Cai Chengyuan Xue Jin Ge Haoyu Zhao Shu-Hong Yu | 2021 | Nano Research2021，14，10： | 1 |
| 12 | Synthesis, characterization and biological activities of schiff base complexes derived from methyl-substituted salicylaldehyde and D-glucosamine,ML2显示文摘 | Huang Yonghua Shen Haoyu Long Shu | 2002 | Synthesis & Reactivity in Inorganic & Metal-Organic Chemistry2002，32，9： | 1 |
| 13 | Evaluation of surface temperature and pressure derived from MERRA-2 and ERA5 reanalysis datasets and their applications in hourly GNSS precipitable water vapor retrieval over China显示文摘Temperature and pressure play key roles in Global Navigation Satellite System(GNSS) precipitable water vapor(PWV) retrieval. The National Aeronautics and Space Administration(NASA) and European Center for Medium-Range Weather Forecasts(ECMWF) have released their latest reanalysis product: the modern-era retrospective analysis for research and applications, version 2(MERRA-2) and the fifthgeneration ECMWF reanalysis(ERA5), respectively. Based on the reanalysis data, we evaluate and analyze the accuracy of the surface temperature and pressure products in China using the the measured temperature and pressure data from 609 ground meteorological stations in 2017 as reference values.Then the accuracy of the two datasets and their performances in estimating GNSS PWV are analyzed. The PWV derived from the pressure and temperature products of ERA5 and MERRA-2 has high accuracy. The annual average biases of pressure and temperature for ERA5 are-0.07 hPa and 0.45 K, with the root mean square error(RMSE) of 0.95 hPa and 2.04 K, respectively. The annual average biases of pressure and temperature for MERRA-2 are-0.01 hPa and 0.38 K, with the RMSE of 1.08 h Pa and 2.66 K, respectively.The accuracy of ERA5 is slightly higher than that of MERRA-2. The two reanalysis data show negative biases in most regions of China, with the highest to lowest accuracy in the following order: the south,north, northwest, and Tibet Plateau. Comparing the GNSS PWV calculated using MERRA-2(GNSS MERRA-2 PWV) and ERA5(GNSS ERA5 PWV) with the radiosonde-derived PWV from 48 co-located GNSS stations and the measured PWV of the co-location radiosonde stations, it is found that the accuracy of GNSS ERA5 PWV is better than that of GNSS MERRA-2 PWV. These results show the different applicability of surface temperature and pressure products from MERRA-2 and ERA5 data, indicating that both have important applications in meteorological research and GNSS water vapor monitoring in China. | Liangke Huang Xiaoyang Fang Tengxu Zhang Haoyu Wang Lei Cui Lilong Liu | 2023 | Geodesy and Geodynamics2023，14，2： | 1 |
| 14 | 50th anniversary of artemisinin:From the discovery to allele-aware genome assembly of Artemisia annua显示文摘Over the past half century,the fight against malaria has been a resounding success mainlydue to thediscoveryof artemisinin.According to the World Health Organization(WHO),morbidity and mortality due to malaria have been cut by half since the promotion of artemisinin-based combination therapy(WHO,2020). | Jiang Xu Baosheng Liao Ling Yuan Xiaofeng Shen Xuejiao Liao Jigang Wang Haoyu Hu Zhihai Huang Li Xiang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 1 |
| 15 | Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization显示文摘Background:Immunosuppressive M2 macrophages in the tumor microenvironment(TME)can mediate the therapeutic resistance of tumors,and seriously affect the clinical efficacy and prognosis of tumor patients.This study aims to develop a novel drug delivery system for dual-targeting tumor and macrophages to inhibit tumor and induce macrophage polarization.Methods:The anti-tumor effects of methyltransferase like 14(METTL14)were investigated both in vitro and in vivo.The underlying mechanisms of METTL14 regulating macrophages were also explored in this study.We further constructed the cyclic(Arg-Gly-Asp)(cRGD)peptide modified macrophage membrane-coated nanovesicles to co-deliver METTL14 and the TLR4 agonist.Results:We found that METTL14 significantly inhibits the growth of tumor in vitro.METTL14 might downregulate TICAM2 and inhibit the Toll-like receptor 4(TLR4)pathway of macrophages,meanwhile,the combination of METTL14 and the TLR4 agonist could induce M1 polarization of macrophages.Macrophage membrane-coated nanovesicles are characterized by easy modification,drug loading,and dual-targeting tumor and macrophages,and cRGD modification can further enhance its targeting ability.It showed that the nanovesicles could improve the in vivo stability of METTL14,and dual-target tumor and macrophages to inhibit tumor and induce M1 polarization of macrophages.Conclusions:This study anticipates achieving the dual purposes of tumor inhibition and macrophage polarization,and providing a new therapeutic strategy for tumors. | Xin Huang Lutong Wang Haoyu Guo Weiyue Zhang | 2023 | Bioactive Materials2023，，5： | 1 |
| 16 | Knowledge expression,numerical modeling and optimization application of ethylene thermal cracking:From the perspective of intelligent manufacturing显示文摘Applications of process systems engineering(PSE)in plants and enterprises are boosting industrial reform from automation to digitization and intelligence.For ethylene thermal cracking,knowledge expression,numerical modeling and intelligent optimization are key steps for intelligent manufacturing.This paper provides an overview of progress and contributions to the PSE-aided production of thermal cracking;introduces the frameworks,methods and algorithms that have been proposed over the past10 years and discusses the advantages,limitations and applications in industrial practice.An entire set of molecular-level modeling approaches from feedstocks to products,including feedstock molecular reconstruction,reaction-network auto-generation and cracking unit simulation are described.Multilevel control and optimization methods are exhibited,including at the operational,cycle,plant and enterprise level.Relevant software packages are introduced.Finally,an outlook in terms of future directions is presented. | Kexin Bi Shuyuan Zhang Chen Zhang Haoran Li Xinye Huang Haoyu Liu Tong Qiu | 2021 | Chinese Journal of Chemical Engineering2021，34，10： | 1 |
| 17 | Design of an eddy-current array probe for crack sizing in steam generator tubes显示文摘 | Haoyu Huang Nozomu Sakurai Toshiyuki Takagi Tetsuya Uchimoto | 2003 | NDT and E International2003，，7： | 1 |
| 18 | The efficacy assessment of convalescent plasma therapy for COVID-19 patients:a multi-center case series显示文摘Convalescent plasma(CP)transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections.However,the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019(COVID-19).We aimed to explore the potential efficacy of CP therapy,and to assess the possible factors associated with its efficacy.We enrolled eight critical or severe COVID-19 patients from four centers.Each patient was transfused with 200–400mL of CP from seven recovered donors.The primary indicators for clinical efficacy assessment were the changes of clinical symptoms,laboratory parameters,and radiological image after CP transfusion.CP donors had a wide range of antibody levels measured by serology tests which were to some degree correlated with the neutralizing antibody(NAb)level.No adverse events were observed during and after CP transfusion.Following CP transfusion,six out of eight patients showed improved oxygen support status;chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days;the viral load was decreased to a negative level in five patients who had the previous viremia;other laboratory parameters also tended to improve,including increased lymphocyte counts,decreased C-reactive protein,procalcitonin,and indicators for liver function.The clinical efficacy might be associated with CP transfusion time,transfused dose,and the NAb levels of CP.This study indicated that CP might be a potential therapy for severe patients with COVID-19. | Hao Zeng Dongfang Wang Jingmin Nie Haoyu Liang Jiang Gu Anne Zhao Lixin Xu Chunhui Lang Xiaoping Cui Xiaolan Guo Changlong Zhou Haibo Li Bin Guo Jinyong Zhang Qiang Wang Li Fang Wen Liu Yishan Huang Wei Mao Yaokai Chen Quanming Zou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 19 | Acclimation of CH_(4)emissions from paddy soil to atmospheric CO_(2)enrichment in a growth chamber experiment显示文摘Elevated levels of atmospheric CO_(2)(eCO_(2))promote rice growth and increase methane(CH_(4))emissions from rice paddies,because increased input of plant photosynthate to soil stimulates methanogenic archae.However,temporal trends in the effects of eCO_(2)on rice growth and CH_(4)emissions are still unclear.To investigate changes in the effects of eCO_(2)over time,we conducted a two-season pot experiment in a walk-in growth chamber.Positive effects of eCO_(2)on rice leaf photosynthetic rate,biomass,and grain yield were similar between growing seasons.However,the effects of eCO_(2)on CH_(4) emissions decreased over time.Elevated CO_(2)increased CH_(4)emissions by 48%-101%in the first growing season,but only by 28%-30%in the second growing season.We also identified the microbial process underlying the acclimation of CH4 emissions to atmospheric CO_(2)enrichment:eCO_(2)stimulated the abundance of methanotrophs more strongly in soils that had been previously exposed to eCO_(2)than in soils that had not been.These results emphasize the need for long-term eCO_(2)experiments for accurate predictions of terrestrial feedbacks. | Haoyu Qian Yaguo Jin Jin Chen Shan Huang Yunlong Liu Jun Zhang Aixing Deng Jianwen Zou Genxing Pan Yanfeng Ding Yu Jiang Kees Jan van Groenigen Weijian Zhang | 2022 | The Crop Journal2022，10，1： | 1 |
| 20 | Moxibustion modulates working memory in patients with amnestic mild cognitive impairment:a functional magnetic resonance imaging study显示文摘OBJECTIVE:To investigate the correlation between changes in brain activity associated with working memory and assessment scales of memory scores in amnestic mild cognitive impairment(aMCI)before and after moxibustion therapy.METHODS:aMCI patients were randomized into the moxibustion treatment(MT)group and the placebo moxibustion(PM)group.Each group received either moxibustion therapy or a placebo moxibustion for eight weeks.Neuropsychological performance and functional brain responses to a working memory task were assessed at baseline and at the end of treatment.Memory function was evaluated individually by the Rivermead behavioral memory test(RBMT),and working memory was assessed by the N-back task.RESULTS:Compared with the PM group,RBMT score changes were significant(P<0.05).In the MT group,the accuracy of the N-back texts increased compared with those before the intervention.After moxibustion intervention,the right insula,postcentral gyrus,precentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,calcarine sulcus,posterior cingulate gyrus,middle frontal gyrus and anterior frontal gyrus were significantly activated(P=0.01,Cluster-level Family-Wise Error=0.05).Pearson correlation analysis showed that the insula,lingual gyrus and posterior cingulate gyrus were associated with changes in N-back score.Spearman correlation analysis showed that the postcentral gyrus,superior temporal gyrus,thalamus,lingual gyrus,and posterior cingulate gyrus were correlated with RBMT score changes.CONCLUSION:Moxibustion treatment improved memory in aMCI patients and was associated with the activation of the brain region of the insula,lingual gyrus,posterior cingulate gyrus,postcentral gyrus,superior temporal gyrus,and thalamus,which may be an important mechanism by which moxibustion improves the memory function. | LI Xingjie LIU Qiqi XIA Rui LIU Jun WANG Dan SHI Jiao KUANG Yuxing DAI Yalan HUANG Haoyu TANG Wei CHEN Shangjie | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 1 |
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