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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function显示文摘Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes development.TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains unclear.In our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD mice.Mechanistic investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin production.Moreover,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T cells.In addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B cells.Our data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T cells.Therefore,therapeutically targeting TLR7 may prove beneficial for disease protection. | Juan Huang Jian Peng James Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou F.Susan Wong Li Wen | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | A non-wetting and conductive polyethylene dioxothiophene hole transport layer for scalable and flexible perovskite solar cells显示文摘The regulated crystallization of perovskite and highly repeatable preparation are decisive challenges for large-scale flexible perovskite solar cells(PSCs).Herein,we synthesize an oil-soluble poly(3,4-ethylenedioxythiophene)(Oil-PEDOT)as a hole transport layer(HTL).The non-wetting Oil-PEDOT HTL can promote the quality of large-area flexible perovskite films because of its optimized crystallinity and printability.The Oil-PEDOT layer also delivers desirable conductivity and charge transport without a complex doping.Consequently,the flexible PSCs with Oil-PEDOT HTL achieve an efficiency of 19.51%and 16.70%based on 1.05 and 22.50 cm^(2),respectively.Moreover,these large-scale flexible PSCs demonstrate remarkable mechanical robustness,and the efficiency exhibits 93%retention after 7,000 bending cycles.These results show that the Oil-PEDOT is a potentially efficient HTL for fabricating efficient large-scale flexible PSCs. | Chenxiang Gong Lin Zhang Xiangchuan Meng Zhi Xing Li Rao Hongyu Wang Zengqi Huang Licheng Tan Ting Hu Xiaotian Hu Yiwang Chen | 2021 | Science China Chemistry2021，64，5： | 1 |
| 4 | Fabrication and characterization of graphene-reinforced waterborne polyurethane nanocomposite coatings by the sol–gel method显示文摘 | Xin Wang Weiyi Xing Lei Song Hongyu Yang Yuan Hu Guan Heng Yeoh | 2012 | Surface & Coatings Technology2012，，23： | 1 |
| 5 | Determining the sum of flexoelectric coefficients in nematic liquid crystals by the ca- pacitance method 显示文摘 | Ye Wenjiang Xing Hongyu Cui Wenjing | 2014 | Chin Phys B2014，23，11： | 1 |
| 6 | Determining the sum of flexoelectric coefficients in nematic liquid crystals using the capacitance method显示文摘 | Ye Wenjiang Xing Hongyu Cui Wenjing | 2014 | Chin Phys B2014，23，11： | 1 |
| 7 | Covalent functionalization of graphene with organosilane and its use as a reinforcement in epoxy composites显示文摘 | Xin Wang Weiyi Xing Ping Zhang Lei Song Hongyu Yang Yuan Hu | 2012 | Composites Science and Technology2012，，6： | 1 |
| 8 | Genome-wide signatures of the geographic expansion and breeding of soybean显示文摘Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the genome sequences of 2,214 soybeans and proposed a soybean evolutionary route, i.e., the expansion of annual wild soybean(Glycine soja Sieb. & Zucc.) from southern China and its domestication in central China, followed by the expansion and local breeding selection of its landraces(G. max(L.) Merr.). We observed that the genetic introgression in soybean landraces was mostly derived from sympatric rather than allopatric wild populations during the geographic expansion. Soybean expansion and breeding were accompanied by the positive selection of flowering time genes, including GmSPA3c. Our study sheds light on the evolutionary history of soybean and provides valuable genetic resources for its future breeding. | Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu | 2023 | Science China(Life Sciences)2023，66，2： | 1 |
| 9 | Efficient Removal of Lead from Washing Effluent of Lead-contaminated Soil with Garlic Peel显示文摘 | CHEN Xing YIN Lipu ZHOU Hongyu LIU Junyou LI Xiaohui AI Xianbin HUANG Kai | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 10 | Structure,far-infrared spectroscopy,microwave dielectric properties,and improved low-temperature sintering characteristics of tri-rutile Mg_(0.5)Ti_(0.5)TaO_(4) ceramics显示文摘In this study,tri-rutile type Mg_(0.5)Ti_(0.5)TaO_(4) ceramics were synthesized,where the structure–property relationship,especially the structural configuration and intrinsic dielectric origin of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics,and the low-firing characteristics were studied.It is found that the tri-rutile structural type is unambiguously identified through the Rietveld refinement analysis,the selected area electron diffraction(SAED),and the high-resolution transmission electron microscopy(HRTEM)along the[110]zone axis.With the increase in sintering temperature,the densification and uniformity of crystal growth play important roles in regulating the microwave dielectric properties of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics.Intrinsically,theoretical dielectric properties calculated by the far-infrared reflective spectra approached the experimental values,indicating the importance of structural features to dielectric properties.Furthermore,a glass additive with high matching relevance with ceramics has been developed to decrease the high sintering temperature of Mg_(0.5)Ti_(0.5)TaO_(4) ceramics,where 2–4 wt%Li_(2)O–MgO–ZnO–B_(2)O_(3)–SiO_(2)(LMZBS)glass frit was adopted to reduce the suitable temperature from 1275 to 1050℃ without significantly deteriorating the microwave dielectric characteristics.Specifically,Mg_(0.5)Ti_(0.5)TaO_(4) ceramics containing 2 wt% glass addition sintered at 1050℃for 4 h possess excellent microwave dielectric properties:dielectric constant(ε_(r))=44.3,quality factor multiplied by resonant frequency(Q×f)=23,820 GHz(f=6.2 GHz),and the temperature coefficient of resonant frequency(τ_(f))=123.2 ppm/℃. | Hongyu YANG Liang CHAI Guangchao LIANG Mengjiang XING Zixuan FANG Xing ZHANG Tianying QIN Enzhu LI | 2023 | Journal of Advanced Ceramics2023，12，2： | 1 |
| 11 | Mechanical and thermal properties of phenolic / glass fiber foam modified with phosphorus - containing polyurethane prepolymer显示文摘 | Yuan Haixia Xing Weiyi Yang Hongyu | 2013 | Polymer International2013，62，2： | 1 |
| 12 | Synthesis and characterization of a DOPO-substitued organophosphorus oligomer and its application in flame retardant epoxy resins显示文摘 | Xin Wang Yuan Hu Lei Song Hongyu Yang Weiyi Xing Hongdian Lu | 2011 | Progress in Organic Coatings2011，，1： | 1 |
| 13 | An Arabidopsis Promoter Microarray and its Initial Usage in the Identification of HY5 Binding Targets in Vitro显示文摘 | Ying Gao Jinming Li Elizabeth Strickland Sujun Hua Hongyu Zhao Zhangliang Chen Lijia Qu Xing Wang Deng | 2004 | Plant Molecular Biology2004，，5： | 1 |
| 14 | Plant pan-genomics:recent advances,new challenges,and roads ahead显示文摘Pan-genomics can encompass most of the genetic diversity of a species or population and has proved to be a powerful tool for studying genomic evolution and the origin and domestication of species,and for providing information for plant improvement.Plant genomics has greatly progressed because of improvements in sequencing technologies and the rapid reduction of sequencing costs.Nevertheless,pangenomics still presents many challenges,including computationally intensive assembly methods,high costs with large numbers of samples,ineffective integration of big data,and difficulty in applying it to downstream multi-omics analysis and breeding research.In this review,we summarize the definition and recent achievements of plant pan-genomics,computational technologies used for pan-genome construction,and the applications of pan-genomes in plant genomics and molecular breeding.We also discuss challenges and perspectives for future pan-genomics studies and provide a detailed pipeline for sample selection,genome assembly and annotation,structural variation identification,and construction and application of graph-based pan-genomes.The aim is to provide important guidance for plant pan-genome research and a better understanding of the genetic basis of genome evolution,crop domestication,and phenotypic diversity for future studies. | Wei Li Jianan Liu Hongyu Zhang Ze Liu Yu Wang Longsheng Xing Qiang He Huilong Du | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 15 | Automated detection on the security of the linked-list operations显示文摘1 Introduction As measures taken by OS(operation system)to mitigate exploit getting more perfect,the stack-related vulnerabilities are reduced gradually and heap-related vulnerabilities have become increasingly prominent in most C/C++memory vulnerabilities.As is known,software program is a fusion of data structures and algorithms.Therefore,if unsafe operations are performed on data,unintended results may occur. | Hongyu KUANG Jian WANG Ruilin LI Chao FENG YunFei SU Xing ZHANG | 2022 | Frontiers of Computer Science2022，16，2： | 0 |
| 16 | Effects of Hydroxyl Groups in Organic Ammonium Counterions on the Properties of Fluorinated Surfactants显示文摘The surface tension, foaming and viscosity for C_7F_(15)COO^-N^+H(C_2H_4OH)_x(C_2H_5)_(3-x) and C_8F_(17)SO_3^-N^+H(C_2H_4OH)_x(C_2H_5)_(3-x)(x=0, 1,2, 3) were measured to systematically study the effects of hydroxyl groups in organic ammonium counterions on the properties of perfluorooctanoates and perfluorooctanesulfonates. The results showed that the critical micelle concentration (cmc) and the surface tension at cmc (γ_(cmc)) were both increased with the increase of number of hydroxyl groups (x) in the two series. The perfluorooctanesulfonate had smaller cmc but higherγ_(cmc) than perfluorooctanoate with the same counterion. The minimum molecular area of surface adsorption (A_(min)) of C_8F_(17)SO_3^-N^+H(C_2H_4OH)_x(C_2H_5)_(3-x) were 0.64, 0.57, 0.63 and 0.72 nm^2 while the A_(min) values of C_7F_(15)COO^-N^+H(C_2H_4OH)_x(C_2H_5)_(3-x) were 0.61, 0.62, 0.61 and 0.71 nm_2 when x=0, 1, 2 and 3,respectively. For the investigated systems of surfactants, the results of foam expansion ratio agreed with those of surface activity, while the 25% drainage time were consistent with the results of viscosity. | Zhang Tiantian Zhou Hongyu Wu Bowan Xiao Jinxin Xing Hang | 2017 | China Detergent & Cosmetics2017，2，4： | 0 |
| 17 | Effect of extracellular matrix stiffness on the progression of renal fibrosis显示文摘Medical University,Shenyang 110122,China.The mechanical microenvironment of cells is recently reported to associate with the progression of renal fibrosis.However,the mechanism has not been fully elucidated.In the present study,based on the precision measurement of atom force microscope(AFM),hydrogel substrates of various stiffness were prepared to simulate the hardness of extracellular matrix(ECM)in normal and fibrotic kidney tissue.Renal mesangial cells were then cultured on the hydrogel matrix with different hardness. | Fu Yuanyuan Wan Pengzhi Wang Kaiyue Xing Jia Zou Yu Li Xue Chen Hongyu Zhai Xiaoyue | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 18 | Effect of Doped Alkali Metal Ions on the SO_(2) Capture Performance of MnO_(2) Desulfurization Materials at Low Temperature显示文摘Sulfur dioxide(SO_(2))emissions from diesel exhaust pose a serious threat to the environment and human health.Thus,desulfurization technology and the performance of desulfurization materials must be improved.In this study,MnO_(2) was modified with various alkali metal ions using the impregnation method to enhance its SO_(2) capture performance.The composites were characterized intensively by scanning electron microscopy,energydispersive X-ray spectroscopy,X-ray diffraction spectroscopy,and Brunauer-Emmett-Teller theory.The SO_(2) capture performance of these composites were measured via thermogravimetry,and the effect of doping with alkali metal ions on the SO_(2) capture performance of MnO_(2) was investigated.Results showed that the SO_(2) capture performance of MnO_(2) could be enhanced by doping with alkali metal ions,and the MnO_(2) composite doped with LiOH(2.0 mol/L)had the best SO_(2) capture capacity(124 mgSO_(2)/gMaterial),which was 18%higher than that of pure MnO_(2).Moreover,the type and concentration of alkali metal ions had varying effects on the SO_(2) capture performance of MnO_(2).In our experiment,the SO_(2) capture performance of the MnO_(2) doped with NaOH,LiCl,Na2CO3,K2CO3,and Li2CO3 composites were worse than that of pure MnO_(2).Therefore,the influences of the type and concentration of alkali metal ions to be doped into desulfurization materials must be considered comprehensively. | Xing Li Yugo Osaka Hongyu Huang Takuya Tsujiguchi Akio Kodama | 2021 | Journal of Renewable Materials2021，9，9： | 0 |
| 19 | The genome of okra (Abelmoschus esculentus) provides insights into its genome evolution and high nutrient content显示文摘Okra(Abelmoschus esculentus)is an important vegetable crop with high nutritional value.However,the mechanism underlying its high nutrient content remains poorly understood.Here,we present a chromosome-scale genome of okra with a size of 1.19 Gb.Comparative genomics analysis revealed the phylogenetic status of A.esculentus,as well as whole-genome duplication(WGD)events that have occurred widely across the Malvaceae species.We found that okra has experienced three additional WGDs compared with the diploid cotton Gossypium raimondii,resulting in a large chromosome number(2n=130).After three WGDs,okra has undergone extensive genomic deletions and retained substantial numbers of genes related to secondary metabolite biosynthesis and environmental adaptation,resulting in significant differences between okra and G.raimondii in the gene families related to cellulose synthesis.Combining transcriptomic and metabolomic analysis,we revealed the relationship between gene expression and metabolite content change across different okra developmental stages.Furthermore,the sinapic acid/S-lignin biosynthesis-related gene families have experienced remarkable expansion in okra,and the expression of key enzymes involved in the sinapic acid/S-lignin biosynthesis pathway vary greatly across developmental periods,which partially explains the differences in metabolite content across the different stages.Our study gains insights into the comprehensive evolutionary history of Malvaceae species and the genetic basis that underlies the nutrient content changes in okra,which will facilitate the functional study and genetic improvement of okra varieties. | Ruyu Wang Wei Li Qiang He Hongyu Zhang Meijia Wang Xinyuan Zheng Ze Liu Yu Wang Cailian Du Huilong Du Longsheng Xing | 2023 | Horticulture Research2023，10，8： | 0 |
| 20 | High-quality Fagopyrum esculentum genome provides insights into the flavonoid accumulation among different tissues and self-incompatibility显示文摘Common buckwheat(Fagopyrum esculentum)and Tartary buckwheat(Fagopyrum tataricum),the two most widely cultivated buckwheat species,differ greatly in flavonoid content and reproductive mode.Here,we report the first high-quality and chromosome-level genome assembly of common buckwheat with 1.2 Gb.Comparative genomic analysis revealed that common buckwheat underwent a burst of long terminal repeat retrotransposons insertion accompanied by numerous large chromosome rearrangements after divergence from Tartary buckwheat.Moreover,multiple gene families involved in stress tolerance and flavonoid biosynthesis such as multidrug and toxic compound extrusion(MATE)and chalcone synthase(CHS)underwent significant expansion in buckwheat,especially in common buckwheat.Integrated multi-omics analysis identified high expression of catechin biosynthesis-related genes in flower and seed in common buckwheat and high expression of rutin biosynthesis-related genes in seed in Tartary buckwheat as being important for the differences in flavonoid type and content between these buckwheat species.We also identified a candidate key rutindegrading enzyme gene(Ft8.2377)that was highly expressed in Tartary buckwheat seed.In addition,we identified a haplotype-resolved candidate locus containing many genes reportedly associated with the development of flower and pollen,which was potentially related to self-incompatibility in common buckwheat.Our study provides important resources facilitating future functional genomics-related research of flavonoid biosynthesis and selfincompatibility in buckwheat. | Qiang He Dan Ma Wei Li Longsheng Xing Hongyu Zhang Yu Wang Cailian Du Xuanzhao Li Zheng Jia Xiuxiu Li Jianan Liu Ze Liu Yuqing Miao Rui Feng Yang Lv Meijia Wang Hongwei Lu Xiaochen Li Yao Xiao Ruyu Wang Hanfei Liang Qinghong Zhou Lijun Zhang Chengzhi Liang Huilong Du | 2023 | Journal of Integrative Plant Biology2023，65，6： | 0 |
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