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| 1 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 2 | Geochronology and Geochemistry of Metallogenetic Porphyry Bodies from the Nongping Au-Cu Deposit in the Eastern Yanbian Area, NE China: Implications for Metallogenic Environment显示文摘The metallogenetic porphyry bodies in the Nongping Au-Cu deposit, in the eastern Yanbian area, mainly include porphyritic granodiorite and biotite granodiorite porphyry. They are featured with high silicon and enrichment in sodium, and classified into sodic rocks of low-K tholeiitic basalt series. Except slightly low Sr content, the rock basically has the geochemical characteristics of the adakite: relatively high A12O3 content, relatively low MgO content, depletion in Y and Yb; relative enrichment in large ion lithophile elements (LILEs) and light rare-earth elements (LREEs), relatively low content of high field strength elements (HFSEs); positive Eu anomaly or weak negative Eu anomaly. In situ zircon dating technology LA-MC-ICP-MS was used to conduct single-grain zircon dating of biotite granodiorite porphyry, and the results show that the age of metallogenetic porphyry body is 100.04±0.88 Ma, indicating that the porphyry bodies were emplaced in the late Cretaceous period. According to the regional tectonic setting and the comparison with the same kind of deposits, we think that the metallogenetic porphyry bodies in the Nongping Au-Cu deposit have a close genetic connection with the subduction of the Pacific plate in the late Yanshanian period. The adakitic magma generated from partial melting of the subducting plate has high formation temperature, high oxygen fugacity, and volatile constituents' enrichment, so it is helpful for enrichment of metallogenetic elements and plays an important role in the formation of porphyry Au-Cu deposits in this region. | REN Yunsheng JU Nan ZHAO Hualei WANG Hui HOU Kejun LIU Shen | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 7 |
| 3 | Bone Loss Induced by Simulated Microgravity,Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats显示文摘Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley(SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase(b ALP), osteocalcin(OCN), and tartrate-resistant acid phosphatase-5 b(TRAP-5 b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone. | ZHANG Ya Nan SHI Wen Gui LI He HUA Jun Rui FENG Xiu WEI Wen Jun WANG Ju Fang HE Jin Peng LEI Su Wen | 2018 | Biomedical and Environmental Sciences2018，31，2： | 4 |
| 4 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 5 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 6 | Overlying strata movement of recovering standing pillars with solid backfilling by physical simulation显示文摘To analyze the overlying strata movement law of recovering room mining standing pillars with solid backfilling.Physical simulation experiments with sponge and wood as the backfilling simulation material were tested.The results show that:(i) The covering-rock mechanics of the overly strata comes from 'two-arch structures + hinged girder + bend beam' to 'backfilling material + hinged girder + bent beam' by increasing the fill ratio from 0%to 85%,the beginning of overlying strata movement appears later and the total duration of subsidence velocity increased from zero to the highest value increases.The trend of 'single polarization' of the subsidence velocity curves becomes noticeable and the velocity variation trend becomes stable,(ii) The equiponderate aeolian sand was added to improve the anti-pressure ability of the loess,and the corresponding ground processing & transportation system was designed. | An Baifu Miao Xiexing Zhang Jixiong Ju Feng Zhou Nan | 2016 | International Journal of Mining Science and Technology2016，26，2： | 3 |
| 7 | Molecular Characterization of Human Respiratory Adenovirus Infection in Children from November 2016 to October 2017 in Xining City, China显示文摘Human adenoviruses (HAdVs) belong to the genus Mastadenovirus, family Adenoviridae, and can cause respiratory tract and gastrointestinal tract infections, as well as ocular infections in humans[1]. Till date, a total of 84 unique genotypes of AdVs have been identified and classified as human Mastadenovirus species A to G, and specific types are often associated with certain clinical symptoms, epidemiological settings, and demographic risk groups[2]. Among these species, members of the species HAdV-B (HAdV-3, HAdV-7, HAdV-11, HAdV-16, HAdV-21, HAdV-34, HAdV-35, HAdV-50, etc), HAdV-C (HAdV-1, HAdV-2, HAdV-5, and HAdV-6), and HAdV-E (HAdV-4) have been generally associated with respiratory infections[3]. HAdV infections are mild and self-limited in healthy individuals, whereas they can result in high mortality rates in immunocompetent and immunocompromized patients[4]. | YU Juan LI Hong LU Nan Nan LEI You Ju JIANG Shuang Ying ZHAO Sheng Cang RAO Hua Xiang | 2019 | Biomedical and Environmental Sciences2019，32，1： | 3 |
| 8 | Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice显示文摘BACKGROUND Although expression of interleukin(IL)-34 is upregulated in active ulcerative colitis(UC),the molecular function and underlying mechanism are largely unclear.AIM To investigate the function of IL-34 in acute colitis,in a wound healing model and in colitis-associated cancer in IL-34-deficient mice.METHODS Colitis was induced by administration of dextran sodium sulfate(DSS),and carcinogenesis was induced by azoxymethane(AOM).Whether the impact of IL-34 on colitis was dependent on macrophages was validated by depletion of macrophages in a murine model.The association between IL-34 expression and epithelial proliferation was studied in patients with active UC.RESULTS IL-34 deficiency aggravated murine colitis in acute colitis and in wound healing phase.The effect of IL-34 on experimental colitis was not dependent on macrophage differentiation and polarization.IL-34-deficient mice developed more tumors than wild-type mice following administration of AOM and DSS.No significant difference was shown in degree of cellular differentiation in tumors between wild-type and IL-34-deficient mice.IL-34 was dramatically increased in the active UC patients as previously reported.More importantly,expression of IL-34 was positively correlated with epithelial cell proliferation in patients with UC.CONCLUSION IL-34 deficiency exacerbates colonic inflammation and accelerates colitis-associated carcinogenesis in mice.It might be served as a potential therapeutic target in UC. | Zhao-Xiu Liu Wei-Jie Chen Yang Wang Bing-Qian Chen Yi-Cun Liu Tiao-Chun Cheng Lei-Lei Luo Lin Chen Lin-Ling Ju Yuan Liu Ming Li Nan Feng Jian-Guo Shao Zhao-Lian Bian | 2022 | World Journal of Gastroenterology2022，28，47： | 3 |
| 9 | Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome显示文摘Background and Aims:The effect of ginsenoside Rb1 on D-galactosamine(D-GalN)/lipopolysaccharide(LPS)-induced acute liver injury(ALI)is unknown.The aim of this study was to evaluate the effect of ginsenoside Rb1 on ALI and its underlying mechanisms.Methods:Mice were pretreated with ginsenoside Rb1 by intraperitoneal injection for 3 days before D-GalN/LPS treatment,to induce ALI.The survival rate was monitored every hour for 24 h,and serum biochemical parameters,hepatic index and histopathological analysis were evaluated to measure the degree of liver injury.ELISA was used to detect oxidative stress and inflammatory cytokines in hepatic tissue and serum.Immunohistochemistry staining,RT-PCR and western blotting were performed to evaluate the expression of toll-like receptor 4(TLR4),nuclear factorkappa B(NF-κB),and NLR family,pyrin domain-containing 3 protein(NLRP3)in liver tissue and Kupffer cells(KCs).Results:Ginsenoside Rb1 improved survival with D-GalN/LPS-induced ALI by up to 80%,significantly ameliorated the increased alanine and aspartate transaminase,restored the hepatic pathological changes and reduced the levels of oxidative stress and inflammatory cytokines altered by D-GalN/LPS.Compared to the control group,the KCs were increased in the D-GalN/LPS groups but did not increase significantly with Rb1 pretreatment.D-GalN/LPS could upregulate while Rb1 pretreatment could downregulate the expression of interleukin(IL)-1β,IL-18,NLRP3,apoptosis associated specklike protein containing CARD(ASC)and caspase-1 in isolated KCs.Furthermore,ginsenoside Rb1 inhibited activation of the TLR4/NF-κB signaling pathway and NLRP3 inflammasome induced by D-GalN/LPS administration.Conclusions:Ginsenoside Rb1 protects mice against D-GalN/LPS-induced ALI by attenuating oxidative stress and the inflammatory response through the TLR4/NF-κB signaling pathway and NLRP3 inflammasome activation. | Yimei Liu Ninghua Liu Yujing Liu Hongyu He Zhe Luo Wenjun Liu Nan Song Minjie Ju | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 2 |
| 10 | Complete thoracoscopic ablation of the left atrium via the left chest for treatment of lone atrial fibrillation显示文摘 | Ju Mei Nan Ma Fangbao Ding Yin Chen Zhaolei Jiang Fengqing Hu Haibo Xiao | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 2 |
| 11 | Comparison of the Outcomes of Modified Artificial Chordae Technique for Mitral Regurgitation through Right Minithoracotomy or Median Sternotomy显示文摘 | Zhao-Lei Jiang Xiao-Yuan Feng Nan Ma Jia-Quan Zhu Li Zhang Fang-Bao Ding Chun-Rong Bao Ju Mei | 2016 | Chinese Medical Journal2016，，18： | 2 |
| 12 | 显示文摘 | Shan Jingning Yao Nan Ju Yiguang | 2010 | J Nanopart Res2010，12，4： | 1 |
| 13 | Pretreatment research in solid backfill material in fully mechanized backfilling coal mining technology显示文摘 | ZHOU Nan ZHANG Qiang JU Feng | 2013 | Disaster Ad- vances2013，6，2： | 1 |
| 14 | The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer显示文摘 | Jia Zhou Wei-Yu Zhao Xu Ma Rui-Jun Ju Xiu-Ying Li Nan Li Meng-Ge Sun Ji-Feng Shi Cheng-Xiang Zhang Wan-Liang Lu | 2013 | Biomaterials2013，，： | 1 |
| 15 | Interactive effects of water stress and powdery mildew(Blumeria graminis)on the alkaloid production of Achnatherum inebrians infected by Epichlo?endophyte显示文摘Dear Editor,Achnatherum inebrians,also known as drunken horse grass(DHG),is a toxic perennial bunch grass that can be infected by Epichlo?gansuensis or E.inebrians(Chen et al.,2015).It is well known that Epichlo?fungal endophytes can protect their host plants from herbivores by producing different classes of alkaloids.A recent trial demonstrated that sheep exhibited notable toxicity symptoms by directly feeding with endophyte-infected(E+)A.inebrians(Liang et al.,2017). | Nana Li Chao Xia Rui Zhong Yawen Ju Zhibiao Nan Michael J Christensen Xingxu Zhang | 2018 | Science China(Life Sciences)2018，61，7： | 1 |
| 16 | Higher rates of nitrogen fertilization decrease soil enzyme activities, microbial functional diversity and nitrification capacity in a Chinese polytunnel greenhouse vegetable land显示文摘 | Weishou Shen Xiangui Lin Weiming Shi Ju Min Nan Gao Huayong Zhang Rui Yin Xinhua He | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 17 | Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice显示文摘Differentially expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.The results showed that 21 peptides were down-regulated,with peptides of mass-to-charge ratio 758.772 5 and mass-to-charge ratio 5 432.206 9,demonstrating the most significant decreases.These finding suggest that these peptides are candidate biomarkers and may play an important role in the pathogenesis of prion disease. | Xiangyu Liao Jiayu Wan Wensen Liu Xin Tang Wufei Zhu Na XU Jing Xu Nan Li Yaping Chang Chuanjing Ju | 2011 | Neural Regeneration Research2011，6，23： | 1 |
| 18 | Transgenic tomato overexpressing ath-miR399d has enhanced phosphorus accumulation through increased acid phosphatase and proton secretion as well as phosphate transporters显示文摘 | Nan Gao Yanhua Su Ju Min Weishou Shen Weiming Shi | 2010 | Plant and Soil (-)2010，，1： | 1 |
| 19 | Genetic Algorithm Coupled with the Neural Network for Fatigue Properties of Welding Joints Predicting显示文摘 | Nan Zhou Jixiong Zhang Feng Ju Shaojie Liu | 2012 | Journal of Computers2012，，8： | 1 |
| 20 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
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