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| 1 | Effects of protein sources and levels in antibiotic-free diets on diarrhea,intestinal morphology, and expression of tight junctions in weaned piglets显示文摘This study examined effects of dietary protein sources and levels on intestinal health of 21 to 35 d-old weaned piglets fed antibiotics-free diets. A total of 150 weaned piglets(21 d of age) were allotted to 5 dietary treatment groups. Diets were formulated, based on corn-soybean meal, with different protein sources(fish meal and soy protein concentrate) to provide different dietary CP levels. Piglets within 5 dietary treatments were fed diets as follows, respectively: 1) control diet of 17% CP(control); 2) 19% CP diets formulated with more soy protein concentrate(SPC19); 3) fish meal(FM19); 4) 23.7% CP diets formulated with more soy protein concentrate(SPC23); 5) fish meal(FM23). The results showed that piglets from control group had higher ADG and lower incidence of diarrhea compared with those of other groups(P < 0.05). The incidence of diarrhea of piglets in FM19 group was lower than those from SPC23 group and FM23 group(P < 0.05). With the higher CP levels, villous height and villous height to crypt depth ratio of piglets in the duodenum and jejunum were decreased(P < 0.05), but crypt depth was increased(P < 0.05). Comparing control group and other groups, we found the expression of inflammatory cytokines interleukin-1β(IL-1β) and interferon-γ(IFN-γ) were increased(P < 0.05) in the jejunum and colon of piglets, as did cystic fibrosis transmembrane conductance regulators(CFTR) in the distal colon. The relative transcript abundance of Zonula occludens-1(ZO-1) in the jejunum, and occludin in the jejunum and ileum of piglets fed 23.7% CP diets were reduced compared with those fed control diet(P < 0.05). In conclusion, the 17% CP diet without in-feed antibiotics helped improve growth performance and relief of diarrhea of 21 to 35 d-old weaned piglets. Dietary CP level, rather than its source(either fish meal or soy protein concentrate), has more significant impacts on the growth performance and intestinal health of 21 to 35 d-old weaned piglets when fed antibiotics-free diets. | Yunpeng Wu Zongyong Jiang Chuntian Zheng Li Wang Cui Zhu Xuefen Yang Xiaolu Wen Xianyong Ma | 2015 | Animal Nutrition2015，，3： | 22 |
| 2 | Fecal scores and microbial metabolites in weaned piglets fed different protein sources and levels显示文摘This experiment studied the effects of dietary protein sources and levels on the gut health of piglets,p H value,and concentrations of microbial metabolites(ammonia-N,volatile fatty acids [VFA],and polyamines) in the distal colonic and proximal colonic digesta of piglets weaned at 21 d of age.A total of 150 early-weaned piglets were allotted randomly to 5 diets: 1) control diet(CT; 17% CP),2) CT formulated with more soy protein concentrate(SPC19; 19% CP),3) more fish meal(FM19; 19% CP),4) CT formulated with more soy protein concentrate(SPC23; 23% CP),and 5) more fish meal(FM23; 23%CP).Results showed high protein level increased fecal score(P < 0.05),but different protein sources did not(P > 0.05).The p H value and ammonia-N concentration of digesta in the proximal and distal colon of FM23 were significantly higher(P < 0.05) than those of CT.Acetic acid,propionic acid,butyric acid and valeric acid concentrations in the proximal colon of FM23 exceeded those of CT,SPC19,and FM19(P < 0.05);however,isobutyric acid and isovaleric acid were not affected(P > 0.05).Histamine and spermidine concentrations of FM23 were higher than those of other treatments(P < 0.05).Propionic acid and butyric acid concentrations in the distal colon were higher of FM23 than of FM19(P < 0.05); putrescine,histamine and spermidine were higher of FM23 than of LP and FM19(P < 0.05).It was concluded that high dietary CP content increased microbial metabolites(ammonia-N,histamine,putrescine) in colonic digesta and aggravated piglets' diarrhea. | Xiaolu Wen Li Wang Chuntian Zheng Xuefen Yang Xianyong Ma Yunpeng Wu Zhuang Chen Zongyong Jiang | 2018 | Animal Nutrition2018，，1： | 14 |
| 3 | Growth, photosynthesis and podophyllotoxin accumulation of Dysosma versipellis in response to a light gradient and conservation implications显示文摘Dysosma versipellis (Hance) M. Cheng ex Ying (Berberidaceae) is a rare and vulnerable, perennial herb endemic to China with pharmaceutical significance. Increasing habitat loss and over-exploitation of the plant has severely affected the plant's in situ conservation, necessitating ex situ conservation and commercial cultivation. The light regime is a critical environmental factor contributing to successful ex situ conservation via efficient production of biomass and secondary metabolites. We investigated the responses of 2-year-old D. versipellis plants to a light gradient in terms of leaf morphology, growth, biomass production, photo- synthesis and podophyllotoxin (PTOX) accumulation. D. versipellis responded to the light gradient in terms of plant height, leaf size, leaf photosynthesis and PTOX accumulation. Plants demonstrated optimal vegetative growth, photosynthetic capability, and PTOX production, under a light intensity equal to 30% full sunlight. Half full sunlight led to the lowest production of PTOX despite having no obviously different effects on growth. Full sunlight was able to cause leaf death in mid-summer (July), although these plantlets did not significantly differ in growth or biomass production before July and new leaves emerged in August. D. versipellis is therefore proposed to be a shade-tolerant plant, well adapted to variations in irradiance. Irradiance of 10%-50%, particularly ca. 30% full sunlight is strongly recommended for ex situ conservation and commercial cultivation. | ZHAO YunPeng GONG HuaDong LU WeiQiang JIANG WeiMei ZHOU XiaoLong FU ChengXin | 2011 | Chinese Science Bulletin2011，56，24： | 6 |
| 4 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 5 | Aerodynamic force and moment measurement of 10°half-angle cone in JF12 shock tunnel显示文摘An aerodynamic force and moment measurement was conducted in JF12 long-testduration detonation-driven shock tunnel of Institute of Mechanics,Chinese Academy of Sciences.The test duration of JF12 is 100–130 ms.The nominal Mach number is 7.0 and the exit diameter of the contoured nozzle is 2.5 m.The total enthalpy is 2.5 MJ/kg which duplicates the hypersonic flight conditions of Mach number 7.0 at 35 km altitude.The test model is the standard aerodynamic force model of 10° half-angle sharp cone.The length of the test model is 1500 mm and the weight is 57 kg.The aerodynamic forces were measured with a six-component strain balance.The angles of attack were set to be à5°,0°,5°,10° and 14°,respectively.The experimental results show that in the 100–130 ms test duration,the signals of strain balance have 3–4 complete vibration cycles.So,the aerodynamic forces and moments can be obtained directly by averaging the signals of balance without acceleration compensation.The force measurement error of repeatability of JF12 is less than 2%.The aerodynamic force coefficients of JF12 are in good agreement with those of conventional hypersonic wind tunnels.For this test model at Mach number 7.0 and total enthalpy of 2.5 MJ/kg,the real-gas effects on aerodynamic force characteristics are not very evident. | Yunfeng LIU Yunpeng WANG Chaokai YUAN Changtong LUO Zonglin JIANG | 2017 | Chinese Journal of Aeronautics2017，30，3： | 5 |
| 6 | Environment controls on Mesoproterozoic thrombolite morphogenesis:A case study from the North China Platform显示文摘Thrombolites are widespread in the Mesoproterozoic Wumishan Formation in the North China Platform.This study shows that they mainly concentrated in subtidal carbonate facies with relatively low hydrodynamic conditions,rather than in intertidal zone as suggested previously.From the deep lower to the shallow upper subtidal facies,the thrombolites show evident changes in morphology from dominantly domal to tabular forms,likely suggestive of environmental controls on their morphogenesis and distribution.As the most important component in thrombolites,mesoclots typically consist of organic-rich micritic nuclei and organic-poor fibrous aragonite rims.Mesoclots may vary considerably in their morphology,but a type of specifically shaped mesoclots tends to concentrate predominantly in a particular group of thrombolites.The proportion of the fibrous aragonite rims in mesoclots decrease as the depositional environments become shallower,likely suggesting that the environmental changes also have controls on the internal fabrics of thrombolites.Putative filamentous bacterial colonies are well preserved in some aragonite fans in the matrix between mesoclots,invoking rapid precipitation and aragonite-supersaturated conditions in the ambient waters.It seems that a suboxic to anoxic environment,highly alkaline seawater and relatively low hydrodynamic conditions were among the important factors that facilitated the development and preservation of thrombolites in the Mesoproterozoic epeiric sea on the North China Platform. | Tang Dongjie Shi Xiaoying Jiang Ganqing Pei Yunpeng Zhang Wenhao | 2013 | Journal of Palaeogeography2013，2，3： | 5 |
| 7 | PDMS microchannel fabrication technique based on microwire-molding显示文摘Micro-flow channel is basic functional component of microfluidic chip,and every step-forward of its construction technique has been receiving concern all over the world.This article presents a not-complicated but flexible method for fabrication of micro-flow channels.This method mainly utilizes the conventional molding capability of polydimethylsiloxane(PDMS) and widespread commercial microwires as templates.We have fabricated out some conventional types of microchannels with different topological shapes,as examples for the demonstration of this flexible fabrication route which was not dependent on the stringent demands of photolithographical or microelectromechanical system(MEMS) techniques.The smooth surface,high-intensity,and high flexibility of the wires made it possible to create many types of topological structures of the two-dimensional or three-dimensional microchannel or channel array.The geometric shape of the cross-section of thus forming microchannel in PDMS was the negative of that of embedded-in microwire,in high-fidelity if suitable measures were taken.More-over,such a microchannel fabrication process can easily integrate the conductivity and low resistivity of the metal wire to create micro-flow devices that are suitable for the electromagnetic control of liquid or the temperature regulation in the microchannel.Furthermore some preliminary optical analysis was provided for the observation of thus forming rounded microchannel.Based on this molding strategy,we even made some prototypes for functional microflow application,such as microsolenoids chip and temperature control gadgets.And an experiment of forming a droplet in the cross channel further confirmed the feasibility and applicability of this flexible microchannel forming technique. | JIA YueFei JIANG JiaHuan MA XiaoDong LI Yuan HUANG HeMing CAI KunBao CAI ShaoXi WU YunPeng | 2008 | Chinese Science Bulletin2008，53，24： | 5 |
| 8 | pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging显示文摘The emerging technique of photoacoustic imaging,especially in the near infra-red(NIR)window,permits high resolution,deep-penetration,clinically reliable sensing.However,few contrast agents are available that can specifically respond to intricate biological environments,and which are biodegradable and biocompatible.Herein,we in troduce a new class of pH-sensitive orga nic photoacoustic con trast age nt that operates in the second NIR window(NIR-II,960-1,700 nm),which is derived from the self-assembled charge-transfer nanocomplex(CTN)by 3,3',5,5'-tetramethylbenzidine(TMB)and its dication structure(TMB++).The unique NIR-ll-responsive CTN can specifically respond to pH change in the physiological range and allows noninvasive and sensitive visualization of the tumor acidic microenvironment(e.g.at pH5)in mice with higher signal-to-noise ratio.The CTN is biodegradable under physiological conditions(e.g.pH 7.4),which alleviates the biosafety concern of nan oparticle accumulati on in vivo.These results clearly show the pote ntial of the TMB/TMB++-based CTN as a promisi ng pH-activated and biodegradable molecular probe for specific tumor photoacoustic imaging in the NIR-II region. | Zhimin Wang Paul Kumar Upputuri Xu Zhen Ruochong Zhang Yuyan Jiang Xiangzhao Ai Zhijun Zhang Ming Hu Zhenyu Meng Yunpeng Lu Yuanjing Zheng Kanyi Pu Manojit Pramanik Bengang Xing | 2019 | Nano Research2019，12，1： | 3 |
| 9 | Thioperamide treats neonatal hypoxic-ischemic encephalopathy by postsynaptic H1 receptors显示文摘Thioperamide, a selective histamine H3 receptor antagonist, can increase histamine content in the brain, improve brain edema, and exert a neuroprotective effect. This study aimed to examine the mechanism of action of thioperamide during brain edema in a rat model of neonatal hypoxicischemic encephalopathy. Our results showed that thioperamide significantly decreased brain water content and malondialdehyde levels, while significantly increased histamine levels and superoxide dismutase activity in the hippocampus. This evidence demonstrates that thioperamide could prevent oxidative damage and attenuate brain edema following neonatal hypoxic-ischemic encephalopathy. We further observed that changes in the above indexes occurred after combined treatment of thioperamide with the H1 receptor antagonist, pyrilamine, and the H2 receptor antagonist, cimetidine. Experimental findings indicated that pyrilamine reversed the effects of thioperamide; however, cimetidine had no significant influence on the effects of thioperamide. Our present findings suggest that thioperamide can increase brain histamine content and attenuate brain edema and oxidative damage by acting in combination with postsynaptic H1 receptors in a rat model of neonatal hypoxic-ischemic encephalopathy. | Feiyong Jia Lin Du Yunpeng Hao Shicheng Liu Ning Li Huiyi Jiang | 2013 | Neural Regeneration Research2013，8，19： | 3 |
| 10 | Advances in critical technologies for hypersonic and high-enthalpy wind tunnel显示文摘Hypersonic and high-enthalpy wind tunnels and their measurement techniques are the cornerstone of the hypersonic flight era that is a dream for human beings to fly faster,higher and further.The great progress has been achieved during the recent years and their critical technologies are still in an urgent need for further development.There are at least four kinds of hypersonic and high-enthalpy wind tunnels that are widely applied over the world and can be classified according to their operation modes.These wind tunnels are named as air-directly-heated hypersonic wind tunnel,light-gas-heated shock tunnel,free-piston-driven shock tunnel and detonation-driven shock tunnel,respectively.The critical technologies for developing the wind tunnels are introduced in this paper,and their merits and weakness are discussed based on wind tunnel performance evaluation.Measurement techniques especially developed for high-enthalpy flows are a part of the hypersonic wind tunnel technology because the flow is a chemically reacting gas motion and its diagnosis needs specially designed instruments.Three kinds of the measurement techniques considered to be of primary importance are introduced here,including the heat flux sensor,the aerodynamic balance,and optical diagnosis techniques.The techniques are developed usually for conventional wind tunnels,but further improved for hypersonic and high-enthalpy tunnels.The hypersonic ground test facilities have provided us with most of valuable experimental data on high-enthalpy flows and will play a more important role in hypersonic research area in the future.Therefore,several prospects for developing hypersonic and high-enthalpy wind tunnels are presented from our point of view. | Zonglin JIANG Zongmin HU Yunpeng WANG Guilai HAN | 2020 | Chinese Journal of Aeronautics2020，33，12： | 3 |
| 11 | Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10显示文摘Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid (Aβ) 1-42] vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 × Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ3-10 is a promising vaccine for AD. | Rong Guo Kui Huang Tongzi Jiang Jian Li Yu Li Xiaona Xing Yunpeng Cao | 2011 | Neural Regeneration Research2011，6，26： | 2 |
| 12 | Electrochemical CO_(2) mineralization for red mud treatment driven by hydrogen-cycled membrane electrolysis显示文摘CO_(2)mineralization as a promising CO_(2)mitigation strategy can employ industrial alkaline solid wastes to achieve net emission reduction of atmospheric CO_(2).The red mud is a strong alkalinity waste residue produced from the aluminum industry by the Bayer process which has the potential for the industrial CO_(2)large scale treatment.However,limited by complex components of red mud and harsh operating conditions,it is challenging to directly mineralize CO_(2)using red mud to recover carbon and sodium resources and to produce mineralized products simultaneously with high economic value efficiently.Herein,we propose a novel electrochemical CO_(2)mineralization strategy for red mud treatment driven by hydrogen-cycled membrane electrolysis,realizing mineralization of CO_(2)efficiently and recovery of carbon and sodium resources with economic value.The system utilizes H_(2)as the redox-active proton carrier to drive the cathode and anode to generate OH^(-) and H^(+) at low voltage,respectively.The H^(+) plays as a neutralizer for the alkalinity of red mud and the OH^(-) is used to mineralize CO_(2)into generate highpurity NaHCO_(3)product.We verify that the system can effectively recover carbon and sodium resources in red mud treatment process,which shows that the average electrolysis efficiency is 95.3%with highpurity(99.4%)NaHCO_(3)product obtained.The low electrolysis voltage of 0.453 V is achieved at10 mA·cm^(-2) in this system indicates a potential low energy consumption industrial process.Further,we successfully demonstrate that this process has the ability of direct efficient mineralization of flue gas CO_(2)(15%volume)without extra capturing,being a novel potential strategy for carbon neutralization. | Heping Xie Yunpeng Wang Tao Liu Yifan Wu Wenchuan Jiang Cheng Lan Zhiyu Zhao Liangyu Zhu Dongsheng Yang | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 2 |
| 13 | Interaction of Irregular Waves with Vertical Breakwater and Characteristics of Secondary Wave Generated by Overtopping显示文摘This study investigated the interaction between irregular waves and vertical breakwater.The main goal was to determine the wave force on the breakwater for different depths,along with the evolution of the secondary wave generated by overtopping.The open source code DualSPHysics was used in the simulation.Wavelet transform was employed to remove the acoustic components from the weakly compressible smoothed particle hydrodynamics pressure solution.The results of the experiments and simulations showed that although the wave height at the low water level(case 2 was smaller than that at the high water level(case 1,the horizontal and uplifting force of case 2 was higher than that of case 1.In case 2,a large impact pressure occurred because of the plunging wave and wave breaking effects.As the water level was close to the breakwater top in case 1,the secondary wave generated by overtopping was studied.Results indicated that wave and breakwater interactions transfer wave energy from the leading wave component to higher harmonics.Two main harmonics were identified in the secondary wave.The first harmonic was the incident peak frequency,which was still the dominant component.During the wave propagation behind the breakwater,the frequencies of harmonics remained unchanged,but the amplitude of the first harmonic showed an obvious change.Under the same wave condition,the first and second harmonics did not change with depth. | HAN Xinyu JIANG Yunpeng DONG Sheng | 2021 | Journal of Ocean University of China2021，20，6： | 2 |
| 14 | A novel method to calculate the thrust of linear induction motor based on instantaneous current value显示文摘Because of the end effect, a linear induction motor (LIM) runs in an asymmetrical state even though the winding of each phase is symmetric. Based on the basic principle of the LIM, a new approach was proposed to calcu-late the thrust of the LIM using the instantaneous current value. A three-phase LIM model with 12 slots and a single-layer winding was designed to validate this method. The experiments show that when the current is small, the calculated results basically agree with the experiments. The agreement becomes worse with the increase of the current because of the saturation of the primary iron core. The proposed formula is suitable when the iron core of the LIM primary is in an unsaturated state. | Jiaqing MA Yunpeng ZHU Jing JIANG | 2012 | Journal of Modern Transportation2012，20，2： | 2 |
| 15 | Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease显示文摘 | Jiang Changtao Xie Cen Li Fei Zhang Limin Nichols Robert G Krausz Kristopher W Cai Jingwei Qi Yunpeng Fang Zhong-Ze Takahashi Shogo Tanaka Naoki Desai Dhimant Amin Shantu G Albert Istvan Patterson Andrew D Gonzalez Frank J | 2015 | Journal of Clinical Investigation2015，，1： | 1 |
| 16 | Identification of natural splice variants of SAMHD1 in virus-infectedHCC显示文摘 | Yunpeng Shi Guoyue Lv Zhe Chu Liling Piao Xingkai Liu Tuo Wang Yanfang Jiang Ping Zhang | 2014 | Oncology Reports2014，，2： | 1 |
| 17 | Condition-based switching and replacement policies for a two-unit warm standby redundant system subject to non-instantaneous switchover显示文摘This study investigates condition-based switching and replacement policies for a two-unit warm standby redundant system subject to non-instantaneous switchover. The system consists of two identical units: one is operating unit, while the other is standby unit. Two units are under continuous monitoring and degradation described by Gamma processes. Both switching and replacement policies are based on the degradation level of the operating unit. The switching and replacement thresholds are decision variables decided by minimizing the long-run expected cost rate. We first setup the mathematical optimization model and then analyze the global optimal solution of replacement threshold, as well as the existence and uniqueness condition for the local optimal solution of switching threshold(STH). Finally, we find that the optimal replacement threshold is ‘‘the bigger the better'', but the optimal STH depends on some optimal conditions which can be easily computed. Numerical examples are provided to verify the policies, and the effects of noninstantaneous switchover and cost ratio on optimal STHs are numerically discussed. | Yunpeng Jiang Maoyin Chen Donghua Zhou | 2014 | Chinese Science Bulletin2014，59，33： | 1 |
| 18 | Design and Experiments of Ultrasound Image-Guided Multi-DOF Robot System for Brachytherapy显示文摘To implant radioactive seeds through a needle precisely and safely, a novel multi-DOF surgical robotic system is presented in this paper for percutaneous prostate intervention through the patient's perineum under real-time ultrasound image guidance. The proposed robot, which is designed with 9-DOF, consists of a 3-DOF automatic location platform for position adjustment, 2-DOF for automatic ultrasonic probe adjustment mounted with electromagnetic trackers, and 4-DOF for manually adjusting the guided template. Meanwhile, a new registration method based on the quaternion algorithm and least square method is developed, and the needle insertion is performed under the realtime guidance of a navigation system. Furthermore, the robot system has undergone some preliminary experiments with a laser tracker to evaluate the repeatability and accuracy of the robot system. The location error of the puncture needle tip can be controlled under 0.7 mm in air for the whole robotic system. The acquired results endorse the precision of the robot system for prostate seed implantation brachytherapy. | Shan Jiang Yunpeng Yang Zhiyong Yang Zhen Zhang Sheng Liu | 2017 | Transactions of Tianjin University2017，23，5： | 1 |
| 19 | Study of the effect of particle size on the effective modulus of polymeric composites on the basis of the molecular chain network microstructure显示文摘 | Yunpeng Jiang Keiichiro Tohgo Hui Yang | 2010 | Computational Materials Science2010，49，： | 1 |
| 20 | Improving Language Translation Using the Hidden Markov Model显示文摘Translation software has become an important tool for communication between different languages.People’s requirements for translation are higher and higher,mainly reflected in people’s desire for barrier free cultural exchange.With a large corpus,the performance of statistical machine translation based on words and phrases is limited due to the small size of modeling units.Previous statistical methods rely primarily on the size of corpus and number of its statistical results to avoid ambiguity in translation,ignoring context.To support the ongoing improvement of translation methods built upon deep learning,we propose a translation algorithm based on the Hidden Markov Model to improve the use of context in the process of translation.During translation,our Hidden Markov Model prediction chain selects a number of phrases with the highest result probability to form a sentence.The collection of all of the generated sentences forms a topic sequence.Using probabilities and article sequences determined from the training set,our method again applies the Hidden Markov Model to form the final translation to improve the context relevance in the process of translation.This algorithm improves the accuracy of translation,avoids the combination of invalid words,and enhances the readability and meaning of the resulting translation. | Yunpeng Chang Xiaoliang Wang Meihua Xue Yuzhen Liu Frank Jiang | 2021 | Computers, Materials & Continua2021，，6： | 1 |
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