|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy显示文摘Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic burdens.Intra-articular administration of agents is clinically used for pain management.However,the effectiveness is inapparent caused by the rapid clearance of agents.To overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents.Given the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders.In this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release.Then,we review the interactions of nanoparticles with cartilage microenvironment and the rational design.Furthermore,we highlight advances in the therapeutic schemes according to the pathology signals.Finally,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals.We anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation. | Xu Li Bingyang Dai Jiaxin Guo Lizhen Zheng Quanyi Guo Jiang Peng Jiankun Xu Ling Qin | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 2 | A study on dynamic shear strength on frozen soil-concrete interface显示文摘Using newly developed dynamic shearing devices, the dynamic shearing strength of frozen soil-concrete interface was studied experimentally. By placing concrete blocks in the lower half of the shear box and frozen soil sample in the upper part, a series of dynamic shear tests on their interfaces were carried out. The obtained results are summarized and the main influencing factors are revealed. | Peng Lv JianKun Liu YingHui Cui | 2013 | Research in Cold and Arid Regions2013，5，4： | 5 |
| 3 | Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity显示文摘IL-15 is a promising cytokine to expand NK and CD8'T cells for cancer immunotherapy,but its application is limited by dose-limiting,on-target off-tumor toxicity.Here,we have developed a next-generation IL 15 that is activated inside the tumor microenvironment(TME).This pro-IL-15 has the extracellular domain of IL-15RP fused to the N-terminus of slL-15-Fc through a tumor-enriched Matrix Metalloproteinase(MMP)cleavable peptide linker to block its activity.Unlike slL-15-Fc,pro-IL-15 does not activate the peripheral expansion of NK cells and T cells,thus reducing systemic toxicity,but it still preserves efficient anti-tumor abilities.In various mouse tumors,the anti-tumor effect of pro-IL-15 depends on intratumoral CD8'T cells and IFN-y-Pro-IL-15 increases the stem-like TCF1^(+)Tim-3 CD8^(+)T cells within tumor tissue and helps overcome immune checkpoint blockade(ICB)resistance.Moreover,pro-IL-15 synergizes with current tyrosine kinase inhibitor(TKI)targeted-therapy in a poorly inflamed TUBO tumor model,suggesting that pro-IL-15 helps overcome targeted-therapy resistance.Our results demonstrate a next-generation IL-15 cytokine that can stimulate potent anti-tumor activity without severe toxicity. | Jingya Guo Yong Liang Diyuan Xue Jiao Shen Yueqi Cai Jiankun Zhu Yang-Xin Fu Hua Peng | 2021 | Cell Research2021，31，11： | 2 |
| 4 | The Active Sites and Corresponding Stability Challenges of the M-N-C Catalysts for Proton Exchange Membrane Fuel Cell显示文摘Proton exchange membrane fuel cells(PEMFCs)as promising alternatives to traditional internal combustion engines have attracted massive concerns to promote their wide application in society.However,the biggest challenge to the commercialization of PEMFCs remains the high cost due to the adoption of the platinum group metal(PGM)catalysts in the cathode. | Ruolin Peng Zhongkun Zhao Hongmin Sun Yongping Yang Tinglu Song Yao Yang Jiankun Shao Haibo Jin Hongtao Sun Zipeng Zhao | 2023 | Chinese Journal of Chemistry2023，41，6： | 1 |
| 5 | Functionalized Hydrogels for Articular Cartilage Tissue Engineering显示文摘Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints.AC defects are common in the knees of young and physically active individuals.Because of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage adequately.With rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating behaviors.They can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of cartilage.This article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC repair.Finally,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation. | Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin | 2022 | Engineering2022，8，6： | 1 |
| 6 | Macroscopic, Flexible, High-Performance Graphene Ribbons显示文摘 | Sun Jiankun Li Yanhui Peng Qingyu | 2013 | ACS Nano2013，7，10： | 1 |
| 7 | ELANE:an emerging lane to selective anticancer therapy显示文摘Recently,Cui et al.1 revealed that neutrophil elastase(ELANE)can selectively kill a wide range of cancer cells while sparing proximal non-cancer cells and significantly attenuate tumorigenesis,suggesting a promising selective and broad anticancer strategy. | Boqiang Peng Jiankun Hu Xianghui Fu | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 1 |
| 8 | One Single Amino Acid for Estimation the Content of Total Free Amino Acids in Qingkailing Injection Using High-Performance Liquid Chromatography-Diode Array Detection显示文摘 | Li Zhang Xue Wang Jiankun Su Haiyu Liu Zhixin Zhang Lingling Qin Cheng He Long Peng Mingxing Guo Xiaoyan Gao Shuang-Qing Zhang | 2014 | Journal of Analytical Methods in Chemistry2014，，： | 1 |
| 9 | Study on temperature field and settlement of thawing soil under static and dynamic loading显示文摘A series of tests were conducted to analyze temperature field distribution and thawing settlement of a thawing soil under static and dynamic loading at various cooling and thawing temperatures. The results demonstrate:(1) the temperature field distribution of the thawing soil was not significantly influenced by the loading form under the tested loading conditions;similar results were obtained for samples at different dynamic loading frequencies and different dynamic loading amplitudes, which verified the independence of loading form and temperature field;(2) changed temperature field distributions were found in thawing soil with different cooling and thawing temperatures, and the cooling and thawing temperature of the samples were the main factors affecting their temperature distributions;(3) under the tested conditions, thawing settlements were little influenced by the thawing temperature and the dynamic loading frequency; and(4) a linear relationship existed between the thawing settlement and the cooling temperature, and a logarithmic function could be used to describe the relationship between the thawing settlement and the loading amplitude. | LiYun Peng JianKun Liu | 2013 | Research in Cold and Arid Regions2013，5，5： | 0 |
| 10 | A Deep Reinforcement Learning Based Car Following Model for Electric Vehicle显示文摘Car following (CF) models are an appealing research area because they fundamentally describe longitudinal interactions of vehicles on the road, and contribute significantly to an understanding of traffic flow. There is an emerging trend to use data-driven method to build CF models. One challenge to the data-driven CF models is their capability to achieve optimal longitudinal driven behavior because a lot of bad driving behaviors will be learnt from human drivers by the supervised learning manner. In this study, by utilizing the deep reinforcement learning (DRL) techniques trust region policy optimization (TRPO), a DRL based CF model for electric vehicle (EV) is built. The proposed CF model can learn optimal driving behavior by itself in simulation. The experiments on following standard driving cycle show that the DRL model outperforms the traditional CF model in terms of electricity consumption. | Yuankai Wu Huachun Tan Jiankun Peng Bin Ran | 2019 | 智能城市应用2019，2，5： | 0 |
| 11 | Recognition for avian influenza virus proteins based on support vector machine and linear discriminant analysis显示文摘Total 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy (Ria) for training samples is 99.8% and Ria by leave one out cross validation is 99.5%. Both Ria of 99.8% for training samples and Ria of 99.3% by leave one out cross validation are obtained using SVM model, respectively. External 200 HA proteins of influenza virus were used to validate the external predictive power of the resulting model. The external Ria for them is 95.5% by LDA and 96.5% by SVM, respectively, which shows that HA proteins of AIVs are preferably recognized by SVM and LDA, and the performances by SVM are superior to those by LDA. | LIANG GuiZhao CHEN ZeCong YANG ShanBin MEI Hu ZHOU Yuan YANG Li ZHOU Peng YANG ShengXi SHU Mao LIAO ChunYang WU ShiRong LI GenRong HE Liu GAO JianKun Gan MengYu LI DeJing CHEN GuoPing WANG GuiXue LONG Sha JING JuHua ZHENG XiaoLin ZENG Hui ZHANG QiaoXia ZHANG MengJun YANG Qi TIAN FeiFei TONG JianBo WANG JiaoNa LIU YongHong LI Bo QIU LiangJia CAI ShaoXi ZHAO Na YANG Yan SU XiaLi SONG Jian CHEN MeiXia ZHANG XueJiao SUN JiaYing LI JingWei CHEN GuoHua CHEN Gang DENG Jie PENG ChuanYou ZHU WanPing XU LuoNan WU YuQuan LIAO LiMin LI Zhi LI Jun LU DaJun SU QinLiang HUANG ZhengHu ZHOU Ping LI ZhiLiang | 2008 | Science China Chemistry2008，51，2： | 0 |
| 12 | Development of a dynamic load direct shear apparatus for the study of permafrost显示文摘The dynamic parameters of permafrost are crucial to and directly affect the accuracy of engineering design and numerical simulation. This paper describes a new dynamic load direct shear apparatus that was developed to measure these parameters. The power systems and measurement and control systems of the device are described, as is a successful validation experiment. The results show that this dynamic load direct shearing device can accurately derive dynamic shear parameters within a certain range of frequencies and amplitudes of shear load. | YingHui Cui JianKun Liu Peng Lv | 2013 | Research in Cold and Arid Regions2013，5，4： | 0 |
| 13 | FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke显示文摘Few studies have investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. Presently, the extent of the involvement of these plentiful sEVs in the onset and progression of ischemic stroke remains an unresolved question. Our study systematically identified the characteristics of sEVs derived from neurons under hypoxic conditions (HypEVs) by physical characterization, sEV absorption, proteomics and transcriptomics analysis. The effects of HypEVs on neurites, cell survival, and neuron structure were assessed in vitro and in vivo by neural complexity tests, magnetic resonance imaging (MRI), Golgi staining, and Western blotting of synaptic plasticity-related proteins and apoptotic proteins. Knockdown of Fused in Sarcoma (FUS) small interfering RNA (siRNA) was used to validate FUS-mediated HypEV neuroprotection and mitochondrial mRNA release. Hypoxia promoted the secretion of sEVs, and HypEVs were more easily taken up and utilized by recipient cells. The MRI results illustrated that the cerebral infarction volume was reduced by 45% with the application of HypEVs, in comparison to the non- HypEV treatment group. Mechanistically, the FUS protein is necessary for the uptake and neuroprotection of HypEVs against ischemic stroke as well as carrying a large amount of mitochondrial mRNA in HypEVs. However, FUS knockdown attenuated the neuroprotective rescue capabilities of HypEVs. Our comprehensive dataset clearly illustrates that FUS-mediated HypEVs deliver exceptional neuroprotective effects against ischemic stroke, primarily through the maintenance of neurite integrity and the reduction of mitochondria-associated apoptosis. | Yousheng Wu Xiaoxiong Huang Zefeng Tan Jiankun Zang Min Peng Niu He Tao Zhang Hongcheng Mai Anding Xu Dan Lu | 2023 | Bioactive Materials2023，，11： | 0 |
| 14 | A theoretical framework for thawing soil显示文摘This paper puts forward the coupling model of the heat-moisture-stress field based on the governing equation of non-stationary heat transfer, moisture movement and the basic differential equations of deformation problem by displacement under axisymmetric conditions. Using a detailed calculation example for the section of the Xiang Pi Mountain in 109th National Highway, a mechanical model of the cylinder made by typical silty clay soil is simulated. Results show that in the coupling process, dynamic stress pays little contribution to the distribution of temperature field along different depths, and the amount of thawing deformation increased with dynamic loading time under the same frequency and amplitude. | Feng Shi JianKun Liu LiYun Peng | 2013 | Research in Cold and Arid Regions2013，5，4： | 0 |
| 15 | Only Sunda and Chinese pangolin(Pholidota)are naturally distributed in China显示文摘INTRODUCTION Pangolin is the common name for animals in the Family Pholidota,Mammalia,which consists of eight extant species.All pangolin species have been listed as critically endangered(CR),endangered(EN),or vulnerable(VU)species in the International Union for Conservation of Nature(IUCN)Red List of Threatened Species(Challender et al.2020).In June 2020,the Chinese government upgraded the Chinese pangolin(Manis pentadactyla Linnaeus,1758)from a national second-class protected animal to a national first-class protected animal.In February 2021,the Sunda pangolin(Manis javanica Desmarest,1822)and the Indian pangolin(Manis crassicaudata Geoffroy,1803)were added to the list of national first-class protected animals.However,the number of species of pangolins naturally distributed in China varies in the literature:Some sources have recorded only one species,namely the Chinese pangolin(Nowak&Paradiso 1983;Sheng 1999),while most have recorded two species,namely the Chinese pangolin and Indian pangolin(Allen 1938;Zhang 1997;Wang 2003;Wu et al.2005a;Hu&Hu 2017). | Peng CEN Jiankun SUN Qiaoyan WANG Fuhua ZHANG Lianxian MO Amna MAHMOOD Jiaqi LI Yifu WANG Shibao WU | 2023 | Integrative Zoology2023，18，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员