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| 1 | Load Profiling and Its Application to Demand Response: A Review显示文摘The smart grid has been revolutionizing electrical generation and consumption through a two-way flow of power and information. As an important information source from the demand side, Advanced Metering Infrastructure(AMI) has gained increasing popularity all over the world. By making full use of the data gathered by AMI, stakeholders of the electrical industry can have a better understanding of electrical consumption behavior. This is a significant strategy to improve operation efficiency and enhance power grid reliability. To implement this strategy,researchers have explored many data mining techniques for load profiling. This paper performs a state-of-the-art,comprehensive review of these data mining techniques from the perspectives of different technical approaches including direct clustering, indirect clustering, clustering evaluation criteria, and customer segmentation. On this basis, the prospects for implementing load profiling to demand response applications, price-based and incentivebased, are further summarized. Finally, challenges and opportunities of load profiling techniques in future power industry, especially in a demand response world, are discussed. | Yi Wang Qixin Chen Chongqing Kang Mingming Zhang Ke Wang Yun Zhao | 2015 | Tsinghua Science and Technology2015，20，2： | 17 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Advances in optical engineering for future telescopes显示文摘Significant optical engineering advances at the University of Arizona are being made for design, fabrication, and construction of next generation astronomical telescopes. This summary review paper focuses on the technological advances in three key areas. First is the optical fabrication technique used for constructing next-generation telescope mirrors. Advances in ground-based telescope control and instrumentation comprise the second area of development. This includes active alignment of the laser truss-based Large Binocular Telescope(LBT) prime focus camera, the new MOBIUS modular cross-dispersion spectroscopy unit used at the prime focal plane of the LBT, and topological pupil segment optimization. Lastly, future space telescope concepts and enabling technologies are discussed. Among these, the Nautilus space observatory requires challenging alignment of segmented multi-order diffractive elements. The OASIS terahertz space telescope presents unique challenges for characterizing the inflatable primary mirror, and the Hyperion space telescope pushes the limits of high spectral resolution, far-UV spectroscopy. The Coronagraphic Debris and Exoplanet Exploring Pioneer(CDEEP) is a Small Satellite(Small Sat) mission concept for high-contrast imaging of circumstellar disks and exoplanets using vector vortex coronagraph. These advances in optical engineering technologies will help mankind to probe, explore, and understand the scientific beauty of our universe. | Daewook Kim Heejoo Choi Trenton Brendel Henry Quach Marcos Esparza Hyukmo Kang Yi-Ting Feng Jaren NAshcraft Xiaolong Ke Tianyi Wang Ewan SDouglas | 2021 | Opto-Electronic Advances2021，4，6： | 10 |
| 4 | Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naive Adult Patients显示文摘 | Xian-Hui Kang Fang-Ping Bao Hong-Gang Zhang Dan-Jun Yu Ke Ha Qing Xie Sheng-Mei Zhu | 2018 | Chinese Medical Journal2018，，16： | 10 |
| 5 | Causes of immune dysfunction in hyperbilirubinemia model rats显示文摘Objective:To explore the causes of immune dysfunction in neonatal rats with hyperbilirubinemia.Methods:A total of 60 newborn SD rats were equally randomized into normal saline(NS) group,LPS control group,bilirubin control group,low-dose group and high-dose group.After anesthesia,0.1 mL NS was given to the NS and LPS control group and different doses of bilirubin for the other groups;1 h later,the NS and bilirubin control group received the intraperitoneal injection of 0.05 mL NS and 1mg/kg LPS for the other groups.After 5 or 24 hours of model establishment,spleens were collected for detecting the expression levels of MyD88 and p-TAK1 protein and the spleen cells apoptosis by immunohistochemmistry and TUNEL method.After 24 hours of model establishment,scrum inflammatory factors levels and T cell subsets distribution were determined by ELISA and flow cytometry.Results:In contrast to low-dose bilirubin,high-dose bilirubin could induce spleen cells apoptosis in coordination with LPS.After 5 hours of model establishment,compared with NS group.MyD88 expression level in low-dose group elevated while p-TAK1 level in high-dose group reduced(P<0.05).In high-dose group,inflammotory factors levels and CD8^+T cells percentage were all higher than LPS control and NS group(P<0.05),while CD4^+ T cells percentage was lower than NS group(P<0.05).Conclusions:High-concentration plasma bilirubin in coordination with LPS could inhibit NF- κB signal pathways activation and aggravate inflammatory reaction,thus caused immunosuppression with inflammation cascade,which resulted in the immune dysfunction. | Xiao-Min Sun Ping Kang Ke Tao | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 8 |
| 6 | Effect of source location on particle dispersion in displacement ventilation rooms显示文摘A proposed computer model for predicting aerosol particle dispersion in indoor spaces was validated with experimental data found in th literature,and is then used to study the effect of the area and point source locations on particle dispersion in displacement ventilation(DV) rooms The results show that aerosol source location has a strong impact on the spatial distribution and removal rate of indoor particles.Particle remova performance depends strongly on ventilation efficiency and particle deposition rate on indoor surfaces.Important consideration for both relativ ventilation efficiency and deposition rate consists of the position of the aerosol source relative to the main airflow pattern and the occupied zone. | Ke Zhong Yanming Kang Youjun Wang | 2008 | Particuology2008，6，5： | 7 |
| 7 | Magnetic resonance evaluation of transplanted mesenchymal stem cells after myocardial infarction in swine显示文摘Objectives To trace and evaluate intracoronary transplanted mesenchymal stem cells(MSCs) labeled with superparamagnetic iron oxide(SPIO) by using magnetic resonance imaging(MRI) in a swine model of myocardial infarction (MI).Methods MSCs were transfected with a lentiviral vector carrying the gene encoding green fluorescent protein (GFP) and labeled in vitro with SPIO.Two weeks after MI, swine were randomized to intracoronary transplantation of dual -labeled MSCs(n = 10),MSCs-GFP(n = 10) and saline(n = 5).MRI examination was performed with a 1.5T clinical scanner at 24 hours,3 weeks and 8 weeks after cells transplantation. Signal intensity(SI) changes,cardiac function and MI size were measured using MRI.Correlation between MR findings and histomorphologic findings was also investigated. Results The labeling efficiency at a combination of 25μg Fe/ml SPIO and 0.8 pi/ml Lipofectamine 2000 reached 100%.SPIO labeling did not affect GFP fluorescence and dual-labeling did not affect cell proliferation(P>0.05). Multipotentiality was not affected especially for cardiomyocyte-like cells differentiation.Cardiac cell marker of a-MHC and actinin were positively expressed by immunofluorescence staining after induction.SI on T2 * WI decreased substantial- ly in the interventricular septum 24 hours after injection of MSCs.The intensity of hypo-intense signals appeared to increase throughout the later time points.Changes in SI at 24 hours,3 weeks and 8 weeks were 52.98%±10.74%,21.53%±5.40%and 6.23%±2.01%,respectively(P<0.01).DE-MRI demonstrated both dual-labeled MSCSs and MSCs-GFP could dramatically reduce the size of MI and improve cardiac function. Histological data revealed that prussian blue stain-positive cells were found mainly in the border zone which also showed green fluorescence but negative for macrophage marker(CD68).Gross pathologic examination revealed that engrafted MSCs dramatically reduce the extent of necrotic myocardium and promote the regeneration of new,contractile myocardium along the subendocardial surface of the MI. Conclusions MSCs could be efficiently and safely labeled with SPIO and GFP,and could be detected reproducibly and noninvasively in vivo using cardiac MRI.Intracoronary transplantation of dual-labeled MSCs could increase cardiac function and reduce the size of MI. | KE Yang~1,PENG Chao-quan~1,XIANG Peng~1,ZHANG Cheng-xi~1, ZOU Li-yuan~1,WU Xiao~1,YA Gao~1,KANG Z huang~2,HE Ke-ke~2,LIU Jin-lai~1 (1.Department of Cardiology,The Third Affiliated Hospital, Sun Yat-sen University,Guangzhou 2.Department of Radiology, the Third Affiliated Hospital,Sun Yat-sen University, Guangzhou 5100630 3.Center for Stem Cell Biology and Tissue Engineering,Sun Yat-sen University,Guangzhou 5100120) | 2011 | 岭南心血管病杂志2011，17，S1： | 7 |
| 8 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 9 | A Second-Order Sliding Mode Controller of Quad-Rotor UAV Based on PID Sliding Mode Surface with Unbalanced Load显示文摘Quad-rotor unmanned aerial vehicle(UAV)is a typical multiple-input-multiple-output underactuated system with couplings and nonlinearity.Usually,the flying environment is very complex,so that it is impossible for the UAV to avoid effects derived from disturbances and uncertainties.In order to improve the reliability of flight control,we established the dynamic model of quad-rotor UAV by Newton-Euler equation in unbalanced load conditions.Considering external disturbances in the attitude,a second-order sliding mode controller was designed with PID sliding mode surface and Extended State Observer(ESO).The simulation experiments have got good control performance,illustrating the effectiveness of our controller.Meanwhile,the controller was implemented in a quadrotor UAV,which carried a pan-tilt camera for aerial photography.The actual flight experiments proved that this paper dealt with the high stabilization flight control problem for the quad-rotor UAV,which laid a good foundation for autonomous flight of the UAV. | KANG Bing MIAO Yan LIU Fu DUAN Jilu WANG Ke JIANG Shoukun | 2021 | Journal of Systems Science & Complexity2021，34，2： | 5 |
| 10 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 11 | Effects of supply air temperature and inlet location on particle dispersion in displacement ventilation rooms显示文摘The effects of supply temperature and vertical location of inlet air on particle dispersion in a displacement ventilated (DV) room were numerically modeled with validation by experimental data from the literature. The results indicate that the temperature and vertical location of inlet supply air did not greatly affect the air distribution in the upper parts of a DV room, but could signiflcantly influence the airflow pattern in the lower parts of the room, thus affecting the indoor air quality with contaminant sources located at the lower level, such as particles from working activities in an offlce. The numerical results also show that the inlet location would slightly influence the relative ventilation efflciency for the same air supply volume, but particle concentration in the breathing zone would be slightly lower with a low horizontal wall slot than a rectangular diffuser. Comparison of the results for two different supply temperatures in a DV room shows that, although lower supply temperature means less incoming air volume, since the indoor flow is mainly driven by buoyancy, lower supply temperature air could more efflciently remove passive sources (such as particles released from work activities in an offlce). However, in the breathing zone it gives higher concentration as compared to higher supply air temperature. To obtain good indoor air quality, low supply air temperature should be avoided because concentration in the breathing zone has a stronger and more direct impact on human health. | Yanming Kang Youjun Wang Ke Zhong | 2011 | Particuology2011，9，6： | 5 |
| 12 | EFFECTS OF ENTERAL AND PARENTERAL NUTRITION ON GASTROENTERIC HORMONES AND GASTRIC MOTILITY AFTER SUBTOTAL GASTRECTOMY显示文摘Objective To investigate the effects of enteral nutrition(EN)and parenteral nutrition(PN)on gastric motility and gastroenteric hormones after subtotal gastrectomy.Methods Forty-one patients underwent gastrectomy were randomly divided into EN group(n=20)and PN group(n=21).From the first postoperative day to the seventh day,patients received either EN(EN group)or PN(PN group)with isocaloric(84.9 kJ·kg-1·d-1)and isonitrogenous(0.11 g·kg-1·d-1)intake.Serum gastrin(GAS),plasma motilin(MTL),and plasma cholecystokinin(CCK)were measured on preoperative day,the first and seventh postoperative day.Electrogastrography(EGG)was measured on preoperative day and the seventh postoperative day.Results Compared with preoperation,blood GAS,MTL,and CCK levels of 41 patients decreased significantly on the first day after subtotal gastrectomy(P<0.001),but returned to the preoperative levels one week later.EGG after gastrectomy showed that gastric basal electrical rhythm was significantly restrained(P<0.001).On the seventh day after subtotal gastrectomy,plasma MTL and CCK levels in EN group were higher than those in PN group(P<0.05).There was no difference in GAS level between two groups.EGG in EN group was better than that in PN group postoperatively.Conclusions The levels of gastroenteritic hormones and the gastric motility decrease significantly after subtotal gastrectomy.In contrast with PN,EN can accelerate the recovery of MTL,CCK,and gastric motility after subtotal gastrectomy. | Wei-ming Kang Jian-chun Yu Qun Zhang Mei-yun Ke Jia-ming Qian | 2008 | Chinese Medical Sciences Journal2008，23，2： | 4 |
| 13 | Group VB transition metal dichalcogenides for oxygen reduction reaction and strain-enhanced activity governed by p-orbital electrons of chalcogen显示文摘Developi ng alter native oxyge n reducti on reactio n (ORR) catalysts to replace precious Pt-based metals with abundant materials is the key challe nge of commercial application of fuel cells. Owing to their various compositi ons and tun able electronic properties, transition metal dichalcogenides (TMDs) have the great potential to realize high-efficiency catalysts for ORR. Here, various 3R-phase dichalcogenides of group VB and VIB transition metals (MX2, M = Nb, Ta, Mo, W;X = S, Se, Te) are investigated for ORR catalysts by using density functional theory calculations. The computed over-potentials of group VB TMDs are much less than those of group VIB TMDs. For group VB TMDs, a volcano-type plot of ORR catalytic activity is established on the adsorption energies of *OH, and NbS2 and TaTe2 exhibit best ORR activity with an oveepotential of 0.54 V. To achieve even better activity, strain engineering is performed to tune ORR catalytic activity, and the minimum over-potential of 0.43 V can be realized. We further dem on strate that the shift of p orbital center of surface chalcoge n elements under strain is responsible for tuning the catalytic activity of TMDs. | Shuyang Zhao Ke Wang Xiaolong Zou Lin Gan Hongda Du Chengjun Xu Feiyu Kang Wenhui Duan Jia Li | 2019 | Nano Research2019，12，4： | 4 |
| 14 | The utilization status of aspirin for the secondary prevention of ischemic stroke显示文摘背景现在的学习被瞄准为 ischemic 击的第二等的预防调查阿司匹林的用法,评估相关因素,并且分析为不服并且不规则地拿阿司匹林的原因。在这的病人组织的方法都是先前在我们的医院里与服的梗塞或短暂 ischemic 攻击(TIA ) 被诊断了的击幸存者。我们在三年的 periodfollowing 上调查了他们阿司匹林的使用他们的住院。根据病人的阿司匹林用法,他们被划分成治疗和非处理组。另外,为不服或不规则地拿阿司匹林的原因在二个组被分析。1240 个病人全部的结果 A 被学习,包括 367 (29.60%) 在治疗组织并且 873 (70.40%) 在非处理的案例组织。另外, 201 (16.20%) 在治疗组的案例定期一直在服阿司匹林(阿司匹林日报的 50-325 mg ) 1 ~ 3 年了或更长。结果证明为不在这研究服阿司匹林的主要原因与病人的 concems 考虑有关服阿司匹林(46.45%) 的副作用,以及医生是在通知他们的病人服阿司匹林(38.71%) 的机能不全。为不规则地服阿司匹林是医生没通知长度到他们的病人(41.57%) 阿司匹林用法,并且那搀的病人的主要原因没在病人的后续访问(26.51%) 之上开阿司匹林。为阿司匹林消费增加病人的依从的最有效的方法是为中风治疗支持指南并且在中风治疗中继这些进展到病人的结论。 | KE Xian-jun YU Yong-fei GUO Zhen-li XU Kang HAI Hong ZHANG Ai-he JIANG Hong PENG Hong | 2009 | Chinese Medical Journal2009，，2： | 4 |
| 15 | RELATIVE LEVELS OF INDOOR AND OUTDOOR PARTICLE NUMBER CONCENTRATIONS IN A RESIDENTIAL BUILDING IN XI'AN显示文摘The time series of indoor and outdoor particle number concentrations in a naturally ventilated residential building in Xi’an were tested simultaneously for 7 days in summer. The relationships between indoor and outdoor con-centrations were examined and discussed, and linear regression analysis was employed to correlate the indoor and outdoor concentrations. The diurnal cycles of indoor and outdoor particle concentrations of different particle size ranges all showed positive correlations between indoor and outdoor number concentrations. The I/O ratios of number concen-trations varied with the increase of particle size in the range of 0.89 (±0.19) to 0.99 (±0.15). | Yanming Kang Ke Zhong Shun-Cheng Lee | 2006 | China Particuology2006，4，6： | 3 |
| 16 | Histological and cytological investigations of the infection and colonization of apple bark by Valsa mali var. mali显示文摘 | Xiwang Ke Lili Huang Qingmei Han Xiaoning Gao Zhengsheng Kang | 2013 | Australasian Plant Pathology2013，，1： | 3 |
| 17 | Comprehensive identification and analyses of the Hsf gene family in the whole-genome of three Apiaceae species显示文摘Apiaceae is a major family from Apiales and includes many important vegetable and medicinal crops.Heat shock transcription factors(Hsf)play important roles in heat tolerance during plant development.Here,we conducted systematic analyses of the Hsf gene family in three Apiaceae species,including 17 Apium graveolens(celery),32 Coriandrum sativum(coriander),and 14 Daucus carota(carrot).A total of 73 Hsf genes were identified in three representative species,including Arabidopsis thaliana,Vitis vinifera,and Lactuca sativa.Whole-genome duplication played important roles in the Hsf gene family’s expansion within Apiaceae.Interestingly,we found that coriander had more Hsf genes than celery and carrot due to greater expansion and fewer losses.Twenty-seven branches of the phylogenetic tree underwent considerable positive selection in these Apiaceae species.We also explored the expression patterns of Hsf genes in three plant organs.Collectively,this study will serve as a rich gene resource for exploring the molecular mechanisms of heat tolerance.Additionally,this is the first study to report on the Hsf gene family in Apiaceae;thus,our research will provide guidance for future comparative and functional genomic studies on the Hsf gene family and others in Apiaceae. | Qiaoying Pei Tong Yu TongWu Qihang Yang Ke Gong Rong Zhou Chunlin Cui Ying Yu Wei Zhao Xi Kang Rui Cao Xiaoming Song | 2021 | Horticultural Plant Journal2021，7，5： | 3 |
| 18 | Efficient computation method for two-dimensional nonlinear waves显示文摘The theory and simulation of fully-nonlinear waves in a truncated two-dimensional wave tank in time domain are presented. A piston-type wave-maker is used to generate gravity waves into the tank field in finite water depth. A damping zone is added in front of the wave-maker which makes it become one kind of absorbing wave-maker and ensures the prescribed Neumann condition. The efficiency of numerical tank is further enhanced by installation of a sponge layer beach (SLB) in front of downtank to absorb longer weak waves that leak through the entire wave train front. Assume potential flow, the space- periodic irrotational surface waves can be represented by mixed Euler-lagrange particles Solving the integral equation at each time step for new normal velocities, the instantaneous free surface is integrated following time history by use of fourth-order Runge- Kutta method. The double node technique is used to deal with geometric discontinuity at the wave- body intersections. Several precise smoothing methods have been introduced to treat surface point with high curvature. No saw-tooth like instability is observed during the total simulation. The advantage of proposed wave tank has been verified by comparing with linear theoretical solution and other nonlinear results, excellent agreement in the whole range of frequencies of interest has been obtained. | Wang Ke ,Kang Haigui (1. State Key Laboratory of Ocean & Offshore, Department of Civil Engineering, Dalian University of Technology, Dalian 116023, China) | 2001 | Acta Oceanologica Sinica2001，20，2： | 3 |
| 19 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 20 | Adhesive anastomosis for organ transplantation显示文摘The recent development of tough tissue adhesives has stimulated intense interests among material scientists and medical doctors.However,these adhesives have seldom been tested in clinically demanding surgeries.Here we demonstrate adhesive anastomosis in organ transplantation.Anastomosis is commonly conducted by dense sutures and takes a long time,during which all the vessels are occluded.Prolonged occlusion may damage organs and even cause death.We formulate a tough,biocompatible,bioabsorbable adhesive that can sustain tissue tension and pressurized flow.We expose the endothelial surface of vessels onto a gasket,press two endothelial surfaces to the adhesive using a pair of magnetic rings,and reopen the bloodstream immediately.The time for adhesive anastomosis is shortened compared to the time for sutured anastomosis.We have achieved adhesive anastomosis of a great vein in transplanting the liver of a pig.After the surgery,the adhesive is absorbed,the vein heals,and the pig lives for over one month. | Kang Liu Hang Yang Gaobo Huang Aihua Shi Qiang Lu Shanpei Wang Wei Qiao Haohua Wang Mengyun Ke Hongfan Ding Tao Li Yanchao Zhang Jiawei Yu Bingyi Ren Rongfeng Wang Kailing Wang Hui Feng Zhigang Suo Jingda Tang Yi Lv | 2022 | Bioactive Materials2022，7，7： | 3 |
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