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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Cardiac Na^(+)-Ca^(2+) exchanger 1(ncx1h)is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish显示文摘Ca^(2+) signaling is critical for heart development;however,the precise roles and regulatory pathways of Ca^(2+) transport proteins in cardiogenesis remain largely unknown.Sodium-calcium exchanger 1(Ncx1)is responsible for Ca^(2+) efflux in cardiomyocytes.It is involved in cardiogenesis,while the mechanism is unclear.Here,using the forward genetic screening in zebrafish,we identified a novel mutation at a highly-conserved leucine residue in ncx1 gene(mutant^(LDD353)/ncx1h^(L154P))that led to smaller hearts with reduced heart rate and weak contraction.Mechanistically,the number of ventricular but not atrial cardiomyocytes was reduced in ncx1h^(L154P) zebrafish.These defects were mimicked by knockdown or knockout of ncx1h.Moreover,ncx1h^(L154P) had cytosolic and mitochondrial Ca^(2+) overloading and Ca^(2+) transient suppression in cardiomyocytes.Furthermore,ncx1h^(L154P) and ncx1h morphants downregulated cardiac transcription factors hand2 and gata4 in the cardiac regions,while overexpression of hand2 and gata4 partially rescued cardiac defects including the number of ventricular myocytes.These findings demonstrate an essential role of the novel 154th leucine residue in the maintenance of Ncx1 function in zebrafish,and reveal previous unrecognized critical roles of the 154th leucine residue and Ncx1 in the formation of ventricular cardiomyocytes by at least partially regulating the expression levels of gata4 and hand2. | Liming Chu Huimin Yin Lei Gao Li Gao Yu Xia Chiyuan Zhang Yi Chen Tingxi Liu Jijun Huang Kenneth R.Boheler Yong Zhou Huang-Tian Yang | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 3 | Intravascular Brachytherapy Versus Drug-Eluting Stents for the Treatment of Patients With Drug-Eluting Stent Restenosis显示文摘 | Rebecca Torguson Manel Sabate Regina Deible Kimberly Smith William W. Chu Kenneth M. Kent Augusto D. Pichard William O. Suddath Lowell F. Satler Ron Waksman | 2006 | The American Journal of Cardiology2006，，： | 1 |
| 4 | Determination of the structure of chlorobutyl and bromobutyl rubber by NMR spectroscopy显示文摘 | Chu Chia Yeh Watson Kenneth Norman Vukov Rastko | 1987 | Rubber Chemistry and Technology1987，60，4： | 1 |
| 5 | Radiological prognosticators of hepatocellular carcinoma treated by hepatectomy显示文摘BACKGROUND: Hepatectomy is the main curative treatment for hepatocellular carcinoma (HCC), but postoperative long- term survival is poor. Preoperative radiological features of HCC displayed by computed tomography or magnetic resonance imaging could serve as additional prognostic factors. This study aimed to identify preoperative radiological features of HCC that may be of prognostic significance in hepatectomy. METHODS: Ninety-two patients who underwent hepatectomy for HCC were included in this study. Preoperative radiological features including tumor number, size, location (peripheral, middle, central), portal vein invasion, hepatic vein invasion, and presence of pseudo-capsule were analyzed in relation to survival. RESULTS: With a median follow-up period of 41.7 months, the 1-, 3- and 5-year overall survival rates were 85%, 65% and 58%, respectively. Univariate analysis showed that portal vein invasion and absence of pseudo-capsule were significant prognostic factors for overall survival, while all the examined radiological features were prognostic factors for disease-free survival. Multivariate analysis for overall survival found no significant factor. On multivariate analysis for disease-free survival, patients who had tumors with portal vein invasion had poorer survival with a hazard ratio of 2.26 (95% CI, 1.05-4.91; P=0.038) and patients with single nodular HCC or pseudo-capsulated HCC had better survival with a hazard ratio of 0.50 (95% CI, 0.27-0.94; P=0.032) and 0.38 (95% CI, 0.14-0.99; P=0.048), respectively. CONCLUSIONS: Demonstrable pseudo-capsule of HCC and solitary HCC on imaging and absence of portal vein invasionare features associated with better disease-free survival after hepatectomy. These features may guide treatment planning for HCC. | Kevin KW Chu See Ching Chan Sheung Tat Fan Kenneth SH Chok Tan To Cheung William W Sharr Albert CY Chan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，6： | 1 |
| 6 | The effect of surface passivation on microwave characteristics of undoped AlGaN/gaN HEMT's显示文摘 | chu Kenneth K Chumbes E Martin | 2000 | IEEE Electron Device Leff2000，21，： | 1 |
| 7 | Role of Prophylactic Intra-Aortic Balloon Pump in High-Risk Patients Undergoing Percutaneous Coronary Intervention显示文摘 | Sundeep Mishra William W. Chu Rebecca Torguson Roswitha Wolfram Regina Deible William O. Suddath Augusto D. Pichard Lowell F. Satler Kenneth M. Kent Ron Waksman | 2006 | The American Journal of Cardiology2006，，5： | 1 |
| 8 | Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘 | Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 9 | Relationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds显示文摘 | Xiangmei Liu Shuilin Wu Kelvin W.K. Yeung Y.L. Chan Tao Hu Zushun Xu Xuanyong Liu Jonathan C.Y. Chung Kenneth M.C. Cheung Paul K. Chu | 2010 | Biomaterials2010，，2： | 1 |
| 10 | Role of Prophylactic Intra-Aortic Balloon Pump in High-Risk Patients Undergoing Percutaneous Coronary Intervention显示文摘 | Sundeep Mishra William W. Chu Rebecca Torguson Roswitha Wolfram Regina Deible William O. Suddath Augusto D. Pichard Lowell F. Satler Kenneth M. Kent Ron Waksman | 2006 | The American Journal of Cardiology2006，，5： | 1 |
| 11 | Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events: A Prospective Assessment With MRI—Initial Results显示文摘 | Norihide Takaya Chun Yuan Baocheng Chu Tobias Saam Hunter Underhill Jianming Cai Nam Tran Nayak L. Polissar Carol Isaac Marina S. Ferguson Gwenn A. Garden Steven C. Cramer Kenneth R. Maravilla Beverly Hashimoto Thomas S. Hatsukami | 2006 | Stroke2006，，3： | 1 |
| 12 | Electrochemiluminescence of Bare Glassy Carbon with Benzoyl Peroxide as the Coreactant in N,N-Dimethylformamide显示文摘The electrochemiluminescence(ECL)properties of many carbon materials have been reported with glassy carbon(GC),Pt,Au or indium tin oxide(ITO)as the working electrode(WE).As one type of carbon materials,GC itself can generate ECL signal.Some research groups have already noticed the ECL signal from GC WE and reported the results of GC WE with respect to their luminophores.However,comprehensive analyses of ECL properties of GC WE are rare.Herein,the ECL properties of GC WE in organic electrolyte with benzoyl peroxide as the coreactant are reported.Our results are of great importance to distinguish the true ECL data of luminophores from that of GC. | ShuiJian He Kenneth Chu Jonathan Michael Wong Liu-Qing Yang Jonathan Ralph Adsetts Rui-Zhong Zhang Yan-Hua Chen Zhi-Feng Ding | 2020 | Journal of Analysis and Testing2020，4，4： | 1 |
| 13 | A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants显示文摘 | Hoi Man Wong Kelvin W.K. Yeung Kin On Lam Vivian Tam Paul K. Chu Keith D.K. Luk Kenneth M.C. Cheung | 2009 | Biomaterials2009，，8： | 1 |
| 14 | De- termination of the structure of chlorobutyl and bromobutyl rub- ber by NMR spectroscopy显示文摘 | Chia Yeh Chu Kenneth Norman Watson Rastko Vukov | 1987 | Rubber Chemistry and Technol- ogy1987，63，4： | 1 |
| 15 | Low-modulus Mg/PCL hybrid bone substitute for osteoporotic fracture fixation显示文摘 | Hoi Man Wong Shuilin Wu Paul K. Chu Shuk Han Cheng Keith D.K. Luk Kenneth M.C. Cheung Kelvin W.K. Yeung | 2013 | Biomaterials2013，，29： | 1 |
| 16 | Protocols for Calibrating Multibearn Sonar 显示文摘 | KENNETH G FOOTE DEZHANG CHU TERENCE R HAMMAR | 2005 | Acoustical Society of America2005，，4： | 1 |
| 17 | 金属有机框架材料在电化学/电化学发光免疫分析中的应用显示文摘设计和研制具有超灵敏、高精度、选择性好的免疫传感器对于疾病的早期诊断和筛查以及疾病治疗过程的监测具有十分重要的意义。其中,电化学免疫分析法和电化学发光(ECL)免疫分析法,由于具有稳定性好、灵敏度高、线性范围宽、可控性好等优点而备受关注,已成为当前的研究热点之一。金属有机框架(MOFs)作为一类新型的多孔晶体材料,由于其具有比表面积大、化学稳定性好、孔径和纳米级骨架结构可调节等优点,在电化学和ECL免疫传感器的制备中得到了广泛的应用。MOFs不仅可以作为固定生物识别分子的敏感平台,还可以用于富集痕量分析物和信号分子来放大分析信号,提高电化学或ECL免疫分析的灵敏度。目前,科研人员已合成各种各样具有不同性能和形貌的MOFs纳米材料,并用于开发高性能的电化学免疫传感器和ECL免疫传感器。本文综述了不同类型的基于MOFs纳米材料的电化学/ECL免疫传感器的制备及其在免疫分析中的检测应用。研究表明,MOFs不仅可以作为电极表面修饰的基底、信号探针(包括电活性标记分子和电化学发光发光标记探针)、催化活性标记物,还可以作为负载各种生物分子、纳米材料的载体,最终可用于灵敏的电化学和ECL检测。此外,本综述还讨论了未来发展功能化MOFs纳米材料的挑战和机遇,并为未来设计和制造基于MOFs的高性能免疫传感器提出了一些指导性意见。 | 覃晓丽 詹子颖 Sara Jahanghiri Kenneth Chu 张丛洋 丁志峰 | 2023 | 电化学2023，29，6： | 1 |
| 18 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 19 | Metamorphosis of larvae of Crassostrea virginica fed microencapsulated diets显示文摘 | Chu F L Kenneth L | 1987 | Aquac1987，64，： | 1 |
| 20 | Modeling decomposition of unconfined rigid polyurethane foam显示文摘 | Michael L. Hobbs Kenneth L. Erickson Tze Y. Chu | 2000 | Polymer Degradation and Stability2000，，1： | 1 |
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