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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis. | QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan | 2015 | Science China(Information Sciences)2015，58，9： | 12 |
| 3 | Inflammation and tumor progression:signaling pathways and targeted intervention显示文摘Cancer development and its response to therapy are regulated by inflammation,which either promotes or suppresses tumor progression,potentially displaying opposing effects on therapeutic outcomes.Chronic inflammation facilitates tumor progression and treatment resistance,whereas induction of acute inflammatory reactions often stimulates the maturation of dendritic cells(DCs)and antigen presentation,leading to anti-tumor immune responses.In addition,multiple signaling pathways,such as nuclear factor kappa B(NF-kB),Janus kinase/signal transducers and activators of transcription(JAK-STAT),toll-like receptor(TLR)pathways,cGAS/STING,and mitogen-activated protein kinase(MAPK);inflammatory factors,including cytokines(e.g.,interleukin(IL),interferon(IFN),and tumor necrosis factor(TNF)-a),chemokines(e.g.,C-C motif chemokine ligands(CCLs)and C-X-C motif chemokine ligands(CXCLs)),growth factors(e.g.,vascular endothelial growth factor(VEGF),transforming growth factor(TGF)-P),and inflammasome;as well as inflammatory metabolites including prostaglandins,leukotrienes,thromboxane,and specialized proresolving mediators(SPM),have been identified as pivotal regulators of the initiation and resolution of inflammation.Nowadays,local irradiation,recombinant cytokines,neutralizing antibodies,small-molecule inhibitors,DC vaccines,oncolytic viruses,TLR agonists,and SPM have been developed to specifically modulate inflammation in cancer therapy,with some of these factors already undergoing clinical trials.Herein,we discuss the initiation and resolution of inflammation,the crosstalk between tumor development and inflammatory processes.We also highlight potential targets for harnessing inflammation in the treatment of cancer. | Huakan Zhao Lei Wu Guifang Yan Yu Chen Mingyue Zhou Yongzhong Wu Yongsheng Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 11 |
| 4 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
| 5 | Stem cell lineage in body layer specialization and vascular patterning of rice root and leaf显示文摘Since the first appearance of vascular plants during evolution, the plant body has become specialized for adaption to land conditions. Much of our knowledge of plant body specialization and the origins of tissues from stem cells have been obtained from studies on the dicot Arabidopsis thaliana. However, less is known about plant body specialization in monocots, another important branch of angiosperms. In this study, we analyzed stem cell lineage and differentiation during development of the root and leaf of the monocot model plant rice(Oryza sativa). Our results showed that three body layers of rice are established from stem cells accompanied by progressively reduced pluripotency. Layer 1(L1) is a single-cell layer of epidermis; L2 is the cortex/endodermis in the root and the mesophyll in the leaf; and L3 is the site of vascular initiation. At least two common steps in vascular development are shared between rice root and leaf. The preprocambium divides to form the procambium and root pericycle or leaf outer sheath. The procambium further differentiates into the xylem, phloem and circumambient cells. We found that the outer sheath of leaf vascular bundles originates not only from the preprocambium of L3,but also from the mesophyll precursor cells of L2. In addition, WUSCHEL-RELATED HOMEOBOX(WOX)genes are expressed in not only the stem cell niche but also metaxylem precursor in rice. This pattern differs from that of homologs in Arabidopsis, suggesting that WOX functions have been recruited in different stem cells in dicots and monocots. | Minhuan Zeng Bo Hu Jiqin Li Guifang Zhang Ying Ruan Hai Huang Hua Wang Lin Xu | 2016 | Science Bulletin2016，61，11： | 5 |
| 6 | Expression of human soluble TRAIL in Chlamydomonas reinhardtii chloroplast显示文摘Tumor necrosis factor-related apop-tosis-inducing ligand (TRAIL) induces selectively apoptosis in various tumor cells and virus-infected cells, but rarely in normal cells. A chloroplast expres-sion vector, p64TRAIL, containing the cDNA coding for the soluble TRAIL (sTRAIL), was constructed with clpP-trnL-petB-chlL-rpl23-rpl2 as Chlamydomonas reinhardtii plastid homologous recombinant frag-ments and spectinomycin-resistant aadA gene as a select marker. The plasmid p64TRAIL was trans-ferred into the chloroplast genome of C. reinhardtii by the biolistic method. Three independently trans-formed lines were obtained by 100 mg/L spectino-mycin selection. PCR amplification, Southern blot analysis of the sTRAIL coding region DNA and culti-vation cells in the dark all showed that the exogenous DNA had been integrated into chloroplast genome of C. reinhardtii. Western blot analysis showed that human soluble TRAIL was expressed in C. reinhardtii chloroplast. The densitometric analysis of Western blot indicated that the expressed human sTRAIL protein in the chloroplasts of C. reinhardtii accounted for about 0.43%―0.67% of the total soluble proteins. These experimental results demonstrated the possi-bility of using transgenic chloroplasts of green alga as bioreactors for production of biopharmaceuticals. | YANG Zongqi LI yinü CHEN Feng LI Dong ZHANG Zhifang LIU Yanxin ZHENG Dexian WANG Yong SHEN Guifang | 2006 | Chinese Science Bulletin2006，51，14： | 4 |
| 7 | F-box gene FOA2 regulates GA-and ABA-mediated seed germination in Arabidopsis显示文摘Dear Editor,GA and ABA antagonize each other in controlling seed germination,but the molecular mechanism is not fully understood.The F-box proteins act as the most important SCF(SKP1,cullin/CDC53,F-box protein)complex subunit | Reqing Hei Dashi Yu Xinmei Li Guifang Duan Yunxuan Zhang Dongying Tang Xiaoying Zhao Xuanming Liu | 2016 | Science China(Life Sciences)2016，59，11： | 3 |
| 8 | Ultra-flat dispersion in an integrated waveguide with five and six zero-dispersion wavelengths for mid-infrared photonics显示文摘We propose a new type of dispersion flattening technology, which can generate an ultra-flat group velocity dispersion profile with five and six zero-dispersion wavelengths(ZDWs). The dispersion value varies from-0.15 to 0.35 ps/(nm·km) from 4 to 8 μm, which to the best of our knowledge is the flattest one reported so far, and the dispersion flatness is improved by more than an order of magnitude. We explain the principle of producing six ZDWs. Mode distribution in this waveguide is made stable over a wide bandwidth. General guidelines to systematically control the dispersion value, sign, and slope are provided, and one can achieve the desired dispersion by properly adjusting the structural parameters. Fabrication tolerance of this waveguide is also examined. | Yuhao Guo Zeinab Jafari Lijuan Xu Changjing Bao Peicheng Liao Guifang Li Anuradha M.Agarwal Lionel C.Kimerling Jurgen Michel Alan E.Willner Lin Zhang | 2019 | Photonics Research2019，7，11： | 3 |
| 9 | Optical fiber amplifiers for space-division multiplexing显示文摘最近,空间部门 multiplexing (SDM ) 技术使用多核心纤维(MCF ) 和很少模式纤维(FMF ) 被介绍了进光纤维通讯增加传播能力。光纤维放大器的二种主要类型基于 Erbiumdoped 纤维(EDF ) 和拉曼效果被开发了在 MCF 和 FMF 放大信号。在这份报纸,我们考察了这些放大器的原则和配置。 | Dagong JIA Haiwei ZHANG Zhe JI Neng BAI Guifang LI | 2012 | Frontiers of Optoelectronics2012，5，4： | 3 |
| 10 | Mode demultiplexing hybrids for mode-division multiplexing coherent receivers显示文摘We propose a mode demultiplexing hybrid(MDH) that integrates mode demultiplexing, local oscillator power splitting, and optical 90-deg mixing using multi-plane light conversion(MPLC). We demonstrate the realization of a three-mode MDH using four phase plates, one more than what is required for an MPLC-based mode demultiplexer, via numerical simulations. The performance of the three-mode MDH is comparable to that of commercial single-mode 90-deg hybrids. This multiple-functionality device enables simplification of the coherent optical front end of mode-division multiplexing receivers. | HE WEN HUIYUAN LIU YUANHANG ZHANG PENG ZHANG GUIFANG LI | 2019 | Photonics Research2019，7，8： | 3 |
| 11 | Fabrication of nanozyme@DNA hydrogel and its application in biomedical analysis显示文摘Nanozymes 由于容易的准备和低费用的优点收到了大注意。不同于乐意地适应生理的环境的自然的酶,人工的 nanozymes 是容易的在复杂临床的样品使钝化(例如,浆液) ,它可以损坏催化能力并且因而在生物医学的分析限制申请。为了征服这个问题,在这研究,我们由把 nanozymes 合并到纯 DNA hydrogel 制作了新奇 nanozyme@DNA hydrogel 建筑学。金 nanoparticles (AuNPs ) 作为模型 nanozyme 被采用。当他们被 hydrogel 保护,结果显示在 DNA hydrogel 合并的 AuNPs 在浆液保留他们的催化能力,而 AuNPs 完全独自在浆液失去催化能力。在浆液的氢过氧化物和葡萄糖的察觉基于 AuNPs@DNA hydrogel 的催化作用被完成。分别地,各个的察觉限制到达 1.7 和 38 M 它等于用自然的酶获得的价值。除机制以外,一些另外的优点例如再循环能力和可获得性,也被探索了。这 nanozyme@DNA hydrogel 体系结构可以在复杂生理的样品为生物医学的分析象 nanozymes 的申请一样为 nanozymes 的利用有一个大潜力。 | Xiaoli Zhu Xiaoxia Mao Zihan Wang Chang Feng Guifang Chen Genxi Li | 2017 | Nano Research2017，10，3： | 2 |
| 12 | Effect of ebosin on modulating interleukin-1β-induced nflammatory responses in rat fibroblast-like synoviocytes显示文摘 | Yang Zhang Lifei Wang Liping Bai Rong Jiang Lianhong Guo Jianbo Wu Guifang Cheng Ren-Zhang Yuan Li | 2016 | Cellular & Molecular Immunology2016，13，5： | 2 |
| 13 | Neutron activation analysis and Mdssbauer spectroscopy research on coloring mechanism of ancient Chinese Guan porcelain显示文摘The content of 30 kinds of coloring elements in Guan porcelain in the Southern Song Dynasty has been determined by neutron activation analysis (NAA). Iron is the major coloring element. Mossbauer spectroscopy has shown that the iron of the glaze exists in the form of structural iron (Fe2+, Fe3+). The quantitative relationship between the main wavelength of every color glaze and the relative content (Fe2+/Fe3+) of structural iron has been determined. Thus the coloring mechanism of Guan porcelain in the Southern Song Dynasty has been revealed entirely. | ZHAO Weijuan, LI Guoxia, GAO Zhengyao, ZHANG bin, LI Rongwu, WU Xiaoli, YAO Guifang, JIA Xiuqin, HAN Song & HUANG Zhongxiang1. Department of Physics, Zhengzhou University, Zhengzhou 450052, China 2. Department of Architecture, Zhengzhou Technology University, Zhengzhou 450002, China 3. Department of Physics, Beijing Normal University, Beijing 100875, China 4. Hangzhou Museum of Guan kiln, Hangzhou 310008, China 5. Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100080, China | 2000 | Chinese Science Bulletin2000，45，20： | 2 |
| 14 | Interaction between curcumin and mimetic biomembrane显示文摘Curcumin,a major bioactive compound in turmeric,has a broad spectrum of antioxidant,anticarcinogenic,antimutagenic and anti-inflammatory properties.At the molecular level,curcumin modulates many structurally unrelated membrane proteins through several signaling pathways.Curcumin has been suggested to change the properties of cell membranes and affect the membrane-bound proteins indirectly;however,the detailed mechanism has yet to be investigated.In this paper,self-assembled bilayer lipid membranes are artificially constructed on the surface of a gold electrode to mimic biomembranes,and interaction between the supported membranes and curcumin is studied electrochemically.Results show that curcumin interacts with the membranes strongly,in a concentration-dependent manner.At low concentrations,curcumin tends to insert into the outer monolayer only,while at high concentrations,it may also begin to penetrate the inner monolayer.The results obtained in this work may enhance our understanding of the effect of curcumin,and possibly flavonoids,on cell membranes and membrane proteins. | CHEN GuiFang CHEN YangYang YANG NaNa ZHU XueJun SUN LiZhou LI GenXi | 2012 | Science China(Life Sciences)2012，55，6： | 2 |
| 15 | Scalable non-mode selective Hermite–Gaussian mode multiplexer based on multi-plane light conversion显示文摘Non-mode-selective(NMS) multiplexers(muxes) are highly desirable for coherent power combining to produce a high-power beam with a shaped profile(wavefront synthesis) from discrete, phase-locked emitters. We propose a design for a multi-plane light conversion(MPLC)-based NMS mux, which requires only a few phase masks for coherently combining hundreds of discrete input beams into an output beam consisting of hundreds of Hermite–Gaussian(HG) modes. The combination of HG modes as a base can further construct a beam with arbitrary wavefront. The low number of phase masks is attributed to the identical zero-crossing structure of the Hadamard-coded input arrays and of the output HG modes, enabling the practicality of such devices. An NMS mux supporting 256 HG modes is designed using only seven phase masks, and achieves an insertion loss of-1.6 d B, mode-dependent loss of 4.7 d B, and average total mode crosstalk of-4.4 d B. Additionally, this design,featuring equal power for all input beams, enables phase-only control in coherent power combining, resulting in significant simplifications and fast convergence compared with phase-and-amplitude control. | HE WEN YUANHANG ZHANG RACHEL SAMPSON NICOLAS K.FONTAINE NING WANG SHENGLI FAN GUIFANG LI | 2021 | Photonics Research2021，9，2： | 2 |
| 16 | Few-mode fibre-optic microwave photonic links显示文摘The fibre-optic microwave photonic link has become one of the basic building blocks for microwave photonics.Increasing the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic range.Even though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude lower.In this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial modes.Using specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed transmission.This work represents the first step in few-mode microwave photonics.The spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics. | He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose Enrique Antonio Lopez Rodrigo Amezcua Correa Guifang Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 17 | Green fluorescent protein as a vital elimination marker to easily screen marker-free transgenic progeny derived from plants co-transformed with a double T-DNA binary vector system显示文摘 | Songbiao Chen Xugang Li Xiang Liu Hongling Xu Kun Meng Guifang Xiao Xiaoli Wei Feng Wang Zhen Zhu | 2005 | Plant Cell Reports2005，，9： | 1 |
| 18 | Photo1 properties of YAG: Tb nano - powders under vacuum ultraviolet excitation 显示文摘 | Guifang Li Quanxi Cao Zhimin Li Yunxia Huang Yunge Wei Junyan Shi | 2009 | Journal of Alloys and Compounds2009，485，12： | 1 |
| 19 | Chromatic dispersion and polarization- mode dispersion monitoring for RZ-DPSK signals based on asynchronous amplitude-histogram evaluation 显示文摘 | Li Zhihong Li Guifang | 2006 | Journal of Lightwave Technology2006，24，7： | 1 |
| 20 | Recent advances in coherent optical communication显示文摘 | Guifang Li | | 0，，： | 1 |
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