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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Dynamic response of utility tunnel during the passage of Rayleigh waves显示文摘The modeling methodologies and calculation of dynamic response of underground structure under Rayleigh waves is investigated in this paper. First the free field responses under Rayleigh waves are analyzed and the numerical results agree well with the theoretical results. Then, the approximate Rayleigh waves are put forward based on the preliminary re-search, and Rayleigh wave field is obtained through fast Fourier transform technique. Taking a utility tunnel as an example, its dynamic responses under Rayleigh waves is calculated by ABAQUS. The results demonstrate that bending deformation is the main component of structural deformation and the deformation at the top of the structure is about twice as much as that at bottom of the structure. The effect of soil-structure interface and the buried depth of underground structure are also investi-gated via parameter analysis. For the shallow buried underground structures, Rayleigh waves can be the key factor to control the responses and damage of the structure. | Jie Li Qingxia Yue Jun Chen | 2010 | Earthquake Science2010，23，1： | 10 |
| 3 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 4 | A Study of the Migration and Accumulation Efficiency and the Genesis of Hydrocarbon Natural Gas in the Xujiaweizi Fault Depression显示文摘摘要:为了在 Xujiaweizi 调查迁居和烃天然气的累积效率,并且为它的开始的分类提供新证据,指责消沉,在一个封闭系统的一个来源岩石热分解实验被设计并且执行了。基于这,为描述从有机物的产生和碳同位素分别在这期间处理的气体的运动模型被建立,校准然后外推到由联合 Xushen-1 的热历史数据很好的地质的条件。结果显示在 Xujiaweizi 差错消沉的煤措施是典型高效率的煤气的来源,从他们产生的天然气有高迁居和累积效率,并且因而,大规模天然气累积发生在区域。在 Xujiaweizi 差错消沉的高度 / 过去成熟的煤措施与高 13C1 价值产生 coaliferous 气体(>?20%) 在迟了的阶段,使碳成为器官的链烷气体的同位素作文反常地重。另外,通过天然气的 caprock 混合和驱散能导致否定的碳同位素顺序(13C1 > 13C2 > 13C3 > 13C4 ) 器官的链烷,气体,和驱散罐头也导致器官的链烷气体的反常地重的碳同位素作文。至于无机的 nonhydrocarbon 气体水库的发现,它能是仅仅服务一补助证据而非烃气体是无机的一条直接证据。作为结果,作为无机的气体在 Xujiaweizi 差错消沉分类烃天然气需要更充分的证据。 | LI Jijun LU Shuangfang XUE Haitao HUO Qiuli XU Qingxia | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 5 |
| 5 | The Impact of Aqueous Medium on Gas Yields and Kinetic Behaviors of Hydrogen Isotope Fractionation during Organic Matter Thermal Degradation显示文摘以便在有机物期间在煤气的收益和氢同位素分别的运动行为上认出水的媒介的影响热降级,金试管仪器被用来由与不同性质和比例的水混合 nC18 进行热模拟实验。天然气部件的收益,在每个部件和试验性的温度对加热的率的氢同位素作文之中的关系被获得了,并且结果显示在更高的温度条件下面,含水的实验在煤气的收益,更多什么时候流水上有明显的影响被增加,烃气体和 H2 的更高的数量被产出,并且水的存在显然与重烃气体的存在延长温度间隔。比由无水的实验产生了的,含水的实验产生的烃气体的氢同位素才显然轻,并且与增加的水的增加的数量,烃气体的 D 价值逐渐地减少。与煤气的收益相比, 5D 价值的变化对在热模拟实验的水的媒介更敏感。与增加的水的数量相比,然而,水的中等性质在煤气的收益上有更小的影响,它仍然在水的媒介的氢同位素作文上显示出 inherit 效果。通过模型模拟和同位素分别行为分析,氢同位素分别过程能被化学运动模型很好描述,这被验证。正常甲烷和包含 D 甲烷的反应部分的差别大,相应于一样的激活精力。正常甲烷的内容在有更低的激活精力的部分显然是更高的,当包含 D 甲烷的内容在有更高的激活精力的部分是更高的时。因此,它将导致更大的氢同位素分别振幅,和 D 价值将对成熟的变化更敏感。同时,从在含水的实验的 nC18 的甲烷产生的平均激活精力在无水的实验比那高,并且越增加的水的大数量,越 larger 甲烷产生反应的平均激活精力。这在形成历史和煤气来源的关联的煤气的水库的学习为它的探索申请打了基础,它在这取向显示研究和申请前景。 | LU Shuangfang WANG Min XUE Haitao LI Jijun CHEN Fangwen XU Qingxia | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 5 |
| 6 | Optical visualization and polarized light absorption of the single-wall carbon nanotube to verify intrinsic thermal applications显示文摘The predicted extraordinary properties of carbon nanotubes(CNTs)from theoretical calculations have great potential for many applications.However,reliable experimental determination of intrinsic properties at the single-tube level is currently a matter of concern,and many challenges remain because of the unhandled and nanoscale size of individual nanotubes.Here,we demonstrated a prototype to detect the intrinsic thermal conductivity of the single-wall carbon nanotube(SWCNT)and verify the significant non-resonant optical absorption behavior on tiny nanotubes by integrating the nanotube and ice into a new core-shell design.In particular,a reversible optical visualization method based on the individual suspended ultra-long SWCNT was first developed by wrapping a nanotube with ice in the cryogenic air environment.The light-induced thermal effect on the hybrid core-shell structure was used tomelt the ice shell,which subsequently acted as a temperature sensor to verify the intrinsic thermal conductivity of the core-like nanotube.More interestingly,we successfully determined for the first time the thermal response phenomenon of the tiny absorption cross section in SWCNT in the vertical-polarization configuration and the significant non-resonant absorption behavior in the parallel-polarization configuration.These investigations will provide a better understanding for the unique optical behaviors of CNT and enable the detection of intrinsic properties of various one-dimensional nanostructures such as nanotubes,nanowires,and nanoribbons. | Xiao Zhang Li Song Le Cai Xuezeng Tian Qiang Zhang Xiaoying Qi Wenbin Zhou Nan Zhang Feng Yang Qingxia Fan Yanchun Wang Huaping Liu Xuedong Bai Weiya Zhou Sishen Xie | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 7 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 8 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 9 | Multiple structure graphite stabilized stearic acid as composite phase change materials for thermal energy storage显示文摘This paper used 3 types of graphite with different physical structures as the porous matrix to prepare composite phase change materials(PCMs),and investigated their photo-thermal conversion performance and application in battery thermal management.Multiple structure graphite minerals,including microcrystalline graphite(MG),scale graphite(SG),and expanded graphite(EG)were used as porous matrix,while stearic acid(SA)acts as the phase change material.The vacuum impregnation method was applied to prepare SA/MG,SA/SG,SA/EG,and SA/MG1,and SA/EG1was/were prepared by the ethyl alcohol method.Results show that the thermal conductivities of all composite phase change materials were 10.82 to 22.06 times higher than that of the pure SA.Thermogravimetric(TG)analysis showed that the loadages of SA were 43.61%,18.74%,and 92.66%for SA/MG,SA/SG,and SA/EG respectively.The load rates of SA were 18.98%and 18.88%for SA/MG1 and SA/EG1,respectively.For the 3 types of graphite materials of different dimensions,the BET(Brunauer,Emmett,and Teller)surface area determines the maximum load of SA.The Fourier-transform infrared(FTIR)and X-ray diffraction(XRD)results indicated that there was good compatibility between the SA and the supports.The SA/EG1 has better thermophysical properties in heat energy storage and release process.The thermal infrared images show that SA/EG1 has higher sensitivity to the temperature changes.SA/EG1 has better photo-heat conversion performance than SA/SG and SA/MG1 attributed to the multilayer structure of EG.SA/EG has better thermal management performance in the Li-ion batteries discharge process. | Xinbo Zhao Chuanchang Li Kaihao Bai Baoshan Xie Jian Chen Qingxia Liu | 2022 | International Journal of Mining Science and Technology2022，32，6： | 2 |
| 10 | Existence and stability for periodic boundary value problem of first order differential equations显示文摘 | Li Yanling Liu Anping Ma Qingxia | 2007 | Dynamics of Continuous Discrete and Impulsive Sysyems : A2007，14，： | 1 |
| 11 | A combinatorialmethod for antenna array design in minimum redun-dancy MIMO radars 显示文摘 | DONG Jian LI Qingxia GUO Wei | 2009 | IEEE Antennas and Wire-less Propagation Letters2009，8，： | 1 |
| 12 | Climatology and Trends of the Temporal and Spatial Distribution of Sandstorms in Inner Mongolia显示文摘 | Tao Gao Xiao Yu Qingxia Ma Haiying Li Xicang Li Yaobing Si | 2003 | Water Air and Soil Pollution: Focus2003，，2： | 1 |
| 13 | A method for seeking low redundancy large linear arrays in ap- erture synthesis microwave radiometers 显示文摘 | DONG Jian LI Qingxia JIN Rong | 2010 | IEEE Transaction on Antennas and Propagation2010，58，6： | 1 |
| 14 | Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling显示文摘 | Dechun Jiang Xiangrong Bai Qingxia Zhang Wei Lu Yuqin Wang Lin Li Markus Müller | 2009 | European Journal of Clinical Pharmacology2009，，12： | 1 |
| 15 | Simulating effect of anthropogenic activities and climate variation on Liulin Springs discharge depletion by using the ARIMAX model显示文摘 | Yonghong Hao Jing Wu Qingxia Sun Yuen Zhu Yan Liu Zhongtang Li Tian‐Chyi J. Yeh | 2013 | Hydrol Process2013，，18： | 1 |
| 16 | Ultrasound diagnosis of fetal limb wall syndrome显示文摘 | Li Fang Chert Bo Tang Qingxia | 2011 | Anhui medicine2011，15，02： | 1 |
| 17 | Water Role and Its Influence on Hydrogen Isotopic Composition of Natural Gas during Gas Generation显示文摘In order to discuss the role and influence of water during the generation of natural gas,the participation mechanism of water during the evolution of organic matter and its influences were summarized.In addition,we carried out an anhydrous cracking experiment of oil extracted from the Feixianguan Formation source rock in a closed system,which led to the establishment of the kinetic models for describing carbon and hydrogen isotopic fractionation during gas generation from organic matter.The models were c... | Jijun LI Shuangfang LU Wei WU Haitao XUE Qingxia XU Jie GENG Yinghua YU | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 1 |
| 18 | Existence and stability for periodic boundary value problem of first order differential equations显示文摘 | Li YanLing Liu Anping Ma Qingxia Wang Xiaomei | 2007 | Dynamics of Continuous Discrete and Impulsive Sysyems-Series A-Mathematical Analysis2007，14，： | 1 |
| 19 | A method for seeking low-redundancy large linear arrays for aperture synthesis microwave radiometers 显示文摘 | DONG Jian LI Qingxia JIN Rong | 2010 | IEEE Transac- tions on Antennas and Propagation2010，58，6： | 1 |
| 20 | The placement of antenna elements in aperture synthesis microwave radiometers for optimum radiometric sen- sitivity 显示文摘 | DONG Jian LI Qingxia SHI Ronghua | 2011 | IEEE Transactions on Antennas and Propagation2011，59，11： | 1 |
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