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| 1 | Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury显示文摘Bone marrow mesenchymal stem cells were isolated, purified and cultured in vitro by Percoll density gradient centrifugation combined with the cell adherence method. Passages 3-5 bone marrow mesenchymal stem cells were transplanted into rats with traumatic spinal cord injury via the caudal vein. Basso-Beattie-Bresnahan scores indicate that neurological function of experimental rats was significantly improved over transplantation time (1-5 weeks). Expressions of choline acetyltransferase, glutamic acid decarboxylase and synapsins in the damaged spinal cord of rats was significantly increased after transplantation, determined by immunofluorescence staining and laser confocal scanning microscopy. Bone marrow mesenchymal stem cells that had migrated into the damaged area of rats in the experimental group began to express choline acetyltransferase, glutamic acid decarboxylase and synapsins, 3 weeks after transplantation. The Basso-Beattie- Bresnahan scores positively correlated with expression of choline acetyltransferase and synapsins. Experimental findings indicate that intravenously transplanted bone marrow mesenchymal stem cells traverse into the damaged spinal cord of rats, promote expression of choline acetyltransferase, glutamic acid decarboxylase and synapsins, and improve nerve function in rats with spinal cord injury. | Shaoqiang Chen Bilian Wu Jianhua Lin | 2012 | Neural Regeneration Research2012，7，19： | 5 |
| 2 | Crashworthiness Design and Multi-Objective Optimization for Bio-Inspired Hierarchical Thin-Walled Structures显示文摘Thin-walled structures have been used in many fields due to their superior mechanical properties.In this paper,two types of hierarchical multi-cell tubes,inspired by the self-similarity of Pinus sylvestris,are proposed to enhance structural energy absorption performance.The finite element models of the hierarchical structures are established to validate the crashworthiness performance under axial dynamic load.The theoreticalmodel of themean crushing force is also derived based on the simplified super folded element theory.The finite element results demonstrate that the energy absorption characteristics and deformation mode of the bionic hierarchical thin-walled tubes are further improved with the increase of hierarchical sub-structures.It can be also obtained that the energy absorption performance of corner self-similar tubes is better than edge self-similar tubes.Furthermore,multiobjective optimization of the hierarchical tubes is constructed by employing the response surface method and genetic algorithm,and the corresponding Pareto front diagram is obtained.This research provides a new idea for the crashworthiness design of thin-walled structures. | Shaoqiang Xu Weiwei Li Lin Li Tao Li Chicheng Ma | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 1 |
| 3 | Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice显示文摘 | Zhuofeng Lin Fan Wu Shaoqiang Lin Xuebo Pan Leigang Jin Tingting Lu Lihua Shi Yu Wang Aimin Xu Xiaokun Li | 2014 | Journal of Hepatology2014，，： | 1 |
| 4 | DeepBSA: A deep-learning algorithm improves bulked segregant analysis for dissecting complex traits显示文摘Bulked segregant analysis(BSA)is a rapid,cost-effective method for mapping mutations and quantitative trait loci(QTLs)in animals and plants based on high-throughput sequencing.However,the algorithms currently used for BSA have not been systematically evaluated and are complex and fallible to operate.We developed a BSA method driven by deep learning,DeepBSA,for QTL mapping and functional gene cloning.DeepBSA is compatible with a variable number of bulked pools and performed well with various simulated and real datasets in both animals and plants.DeepBSA outperformed all other algorithms when comparing absolute bias and signal-to-noise ratio.Moreover,we applied DeepBSA to an F2 segregating maize population of 7160 individuals and uncovered five candidate QTLs,including three well-known plant-height genes.Finally,we developed a user-friendly graphical user interface for DeepBSA,by integrating five widely used BSA algorithms and our two newly developed algorithms,that is easy to operate and can quickly map QTLs and functional genes.The DeepBSA software is freely available to noncommercial users at http://gffzzd7ca967c75304241hvuvbf00pc0n66fkk.ffgz.tsg.suse.edu.cn/tools.html and http://gffzz188fe103f8f1460asvuvbf00pc0n66fkk.ffgz.tsg.suse.edu.cn/lizhao007/DeepBSA. | Zhao Li Xiaoxuan Chen Shaoqiang Shi Hongwei Zhang Xi Wang Hong Chen Weifu Li Lin Li | 2022 | Molecular Plant2022，15，9： | 1 |
| 5 | Accelerationof diabetic wound healing with chitosan-crosslinked collagen-sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabeticrats显示文摘 | Wang Wei Lin Shaoqiang Xiao Yechen | 2008 | Life Sci2008，，： | 1 |
| 6 | Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabetic rats显示文摘 | Wei Wang Shaoqiang Lin Yechen Xiao Yadong Huang Yi Tan Lu Cai Xiaokun Li | 2007 | Life Sciences2007，，3： | 1 |
| 7 | Solvable Lie Algebras with Quasifiliform Nilradicals显示文摘 | WANG Yan LIN Jie DENG Shaoqiang | 2008 | Communications in Algebra2008，36，： | 1 |
| 8 | Accelerationof dia- betic wound healing with chitosan -crosslinked collagensponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ diabeticrats显示文摘 | Wang Wei Lin Shaoqiang Xiao Yechen | 2008 | Life Sci2008，82，： | 1 |
| 9 | Prevalence and Countermeasures of Porcine Circovirus 3显示文摘The development history, etiology, epidemiology, clinical symptoms, pathological changes and diagnosis technology of porcine circovirus3 were summarized, and countermeasures for prevention and control of the disease were put forward based on the prevalence status in China. | Feng Chunyan Wang Caixia Liu Dandan Zhang Yongning Du Fangyuan Lin Xiangmei Wu Shaoqiang | 2018 | Animal Husbandry and Feed Science2018，10，3： | 0 |
| 10 | A brief review of novel nucleic acid test biosensors and their application prospects for salmonids viral diseases detection显示文摘Viral diseases represent one of the major threats for salmonids aquaculture.Early detection and identification of viral pathogens is the main prerequisite prior to undertaking effective prevention and control measures.Rapid,sensitive,efficient and portable detection method is highly essential for fish viral diseases detection.Biosensor strategies are highly prevalent and fulfill the expanding demands of on-site detection with fast response,cost-effectiveness,high sensitivity,and selectivity.With the development of material science,the nucleic acid biosensors fabricated by semiconductor have shown great potential in rapid and early detection or screening for diseases at salmonids fisheries.This paper reviews the current detection development of salmonids viral diseases.The present limitations and challenges of salmonids virus diseases surveillance and early detection are presented.Novel nucleic acid semiconductor biosensors are briefly reviewed.The perspective and potential application of biosensors in the on-site detection of salmonids diseases are discussed. | Xiaofei Liu Songyin Qiu Haiping Fang Lin Mei Hongli Jing Chunyan Feng Shaoqiang Wu Xiangmei Lin | 2023 | Journal of Semiconductors2023，44，2： | 0 |
| 11 | 保护电子传递链完整性的小分子可以阻断线粒体凋亡途径显示文摘细胞凋亡的刺激会使得哺乳动物细胞中的线粒体释放细胞色素c和其他凋亡蛋白,导致胱天蛋白酶的激活和细胞死亡。Bcl-2蛋白家族的促凋亡成员如Bim和Bax可促进这一过程,Bim和Bax分别从线粒体启动和执行细胞色素c释放。 | Xian Jiang Li Li Zhengxin Ying Chenjie Pan Shaoqiang Huang Lin Li Miaomiao Dai Bo Yan Ming Li Hui Jiang She Chen Zhiyuan Zhang 王晓东 | 2017 | 科学新闻2017，19，4： | 0 |
| 12 | Molecular Identification of Hyalomma anatolicum,Hyalomma asiaticum and Hyalomma detritum显示文摘Hyalomma anatolicum,Hyalomma asiaticum and Hyalomma detritum are wide-spread tick vectors in China. They could transmit a great variety of serious animal and human pathogens,which are great threats to the health of human beings and the safety of stockbreeding. Most of them are distributed in Xinjiang and Inner Mongolia,and they share similar morphologies. This study is to establish a method for identifying H. anatolicum,H. asiaticum and H. detritum with molecular markers and to revealing the phylogenetic relationship of these ticks. Ticks were collected from domestic animals in Xinjiang and Inner Mongolia autonomous regions and classified by morphological characters. 16 S rRNA and mitochondrial cytochrome oxidase subunit I gene( COI) of ticks were amplified by PCR and subsequently sequenced. Phylogenetic trees were constructed by MEGA 5. 0 and Mrbayes 3. 2. On the 16 S rRNA-based phylogenetic tree,H. anatolicum and H. aisaticum were clustered together with their respective classes. H. detritum was clustered with their respective class and the H. anatolicum,H. asiaticum formed distinct branches on the phylogenetic trees based on the COI. The method based on morphology that combined with molecular 16 S rRNA and COI seemed a simple and accurate method for species identification of H. anatolicum,H. asiaticum and H. detritum. | Lv Jizhou Wu Shaoqiang Zhang Yongning Wang Zhenbao Feng Chunyan Wang Caixia Deng Junhua Yuan Xiangfen Lin Xiangmei | 2014 | Animal Husbandry and Feed Science2014，6，3： | 0 |
| 13 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 14 | Efficacy and safety of the combination of Liushen capsules and Arbidol in the treatment of COVID-19:protocol for a randomized,multi-center pilot study显示文摘Background:From early experience,some Traditional Chinese Medicine and Arbidol had effects of against COVID-19,infer that the combination of Liushen capsules and Arbidol may further increase the therapeutic.Methods/Design:We conducted a randomized,blank parallel-controlled,open-label,multi-center,basal therapy-loaded design clinical trial.A total of 40 patients are going to be recruited after satisfying the criteria.Participants will be allocated randomly into the treatment group with the combination of Arbidol and Liushen capsules and the control group with the basic therapy.Each group will receive treatment at least 7-days or until the virus becomes negative,and visits after drug administration at day 3(visit 1),the day when the virus becomes negative(visit 2),day 7(visit 3),the day before discharge(visit 4)and day 28(visit 5),to collect their survival status and disease prognosis so that the efficacy and safety of a combination of Arbidol and Liushen capsule will be evaluated.Discussion:We described the protocol of the first clinical trial for treatment COVID-19 by using a combination of Arbidol and Liushen capsules.The results of this study will provide a basis for the design and sample size estimate of subsequent large-scale clinical trials.Trial registration:This study has been registered at Chinese clinical trial Registry(chictr.org.cn):ChiCTR2000029993. | Yangqing Zhan Zhengtu Li Jiayang He Shaoqiang Li Ye Lin Jingyi Liang Jie Zhou Yanmei Wu Xuandan Su Feng Ye Zifeng Yang | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
| 15 | Identification of tick-borne pathogens using metagenomic analyses in H.longicornis feeding on humans in downtown Beijing显示文摘On August 14th,2018,a Beijing resident living in Xicheng District found a female H.longicornis tick attached to the skin at the front of his upper shin.On examination,the patient was afebrile and appeared well.The species of the tick was identified through morphological characteristics and phylogenetic analysis based on cytochrome C oxidase subunit I.This H.longicornis tick was screened for tick-borne pathogens such as viruses,bacteria and parasites.RNA pathogens were screened by PCR and sequencing,while DNA pathogens were screened by metagenomic analyses.It was found that the tick was positive for the DNA sequences of zoonotic and animal pathogens such as A phagocytophilum,Ehrlichia minasensis and C.burnetii.Considering the good health condition of the patient,we hypothesized that the pathogens originated from the tick specimen itself rather than host blood meal.For the first time,our study reveals the possible risk of transmission of tick-borne pathogens to human beings through tick bit in downtown Beijing.Further research is needed to screen for tick-borne pathogens among unfed ticks collected from central Beijing. | Jizhou Lv Huiyu Wang Xueqing Han Lin Mei Xiangfen Yuan Yufang Kong Junhua Deng Zhen F.Fu Shaoqiang Wu Xiangmei Lin | 2021 | Animal Diseases2021，1，3： | 0 |
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