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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 3 | High- and Ultrahigh-pressure Metamorphism and Retrogressive Textures of Gneiss in the Donghai Area——Evidence from gneisses in drillhole ZK2304显示文摘In the gneisses from the drillhole ZK2304 of the Donghai area, there have been preserved high- and ultrahigh-pressure metamorphic mineral assemblages, a series of complicated retrogressive textures and relevant metamorphic reactions. In addition to garnet, jadeititic-clinopyroxene and rutile, other peak stage (M2) minerals in some gneisses include phengite, aragonite and coesite or quartz pseudomorphs after coesite. The typical peak-stage mineral assemblages in gneisses are characterized by garnet + jadeitic-clinopyroxene + rutile + coesite, garnet + jadeitic-clinopyroxene + phengite + rutile ± coesite and garnet + jadeitic-clinopyroxene + aragonite + rutile ± coesite. The grossular content (Gro) in garnet is high and may reach 50. 1 mol%. The SiO2 content of phengite ranges from 54.37% to 54.84% with 3.54-3.57 p.f.u. Quartz pseudomorphs after coesite occur as inclusions in garnet.The gneisses of the Donghai area have been subjected to multistage recrystallization and exhibit a closewise P-T | LIU Fulai, XU Zhiqin, XU Huifen and YANG Jingsui Institute of Geology, CAGS, 26 Baiwanzhuang Rd., Beijing 100037 Zhu Xiling | 1999 | Acta Geologica Sinica(English Edition)1999，73，3： | 12 |
| 4 | Plasma biomarker screening for liver fibrosis with the N-terminal isotope tagging strategy显示文摘A non-invasive diagnostic approach is crucial for the evaluation of severity of liver disease,treatment decisions,and assessing drug efficacy.This study evaluated plasma proteomic profiling via an N-terminal isotope tagging strategy coupled with liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry measurement to detect liver fibrosis staging.Pooled plasma from different liver fibrosis stages,which were assessed in advance by the current gold-standard of liver biopsy,was quantitatively analyzed.A total of 72 plasma proteins were found to be dysregulated during the fibrogenesis process,and this finding constituted a valuable candidate plasma biomarker bank for follow-up analysis.Validation results of fibronectin by Western blotting reconfirmed the mass-based data.Ingenuity Pathways Analysis showed four types of metabolic networks for the functional effect of liver fibrosis disease in chronic hepatitis B patients.Consequently,quantitative proteomics via the N-terminal acetyl isotope labeling technique provides an effective and useful tool for screening plasma candidate biomarkers for liver fibrosis.We quantitatively monitored the fibrogenesis process in CHB patients.We discovered many new valuable candidate biomarkers for the diagnosis of liver fibrosis and also partly identified the mechanism involved in liver fibrosis disease.These results provide a clearer understanding of liver fibrosis pathophysiology and will also hopefully lead to improvement of clinical diagnosis and treatment. | LI ShuLong LIU Xin WEI Lai WANG HuiFen ZHANG JiYang WEI HanDong QIAN XiaoHong JIANG Ying HE FuChu | 2011 | Science China(Life Sciences)2011，54，5： | 6 |
| 5 | Nutritional Quality of Mixed Silage of Lablab purpureus and Sweet Sorghum显示文摘[Objective] The paper was to evaluate the fermentation quality of mixed silage of Lablab purpureus and sweet sorghum,and to find out the appropriate mixing ratio.[Method]L.purpureus were mixed with sweet sorghum at different proportions,to identify the sensory character and quality of silage.[Result]The nutrient content of mixed silage of L.purpureus and sweet sorghum at different proportions decreased significantly at 30-60 d,while no significant changes were observed after 60 d.Mixed silage of L.purpureus and sweet sorghum had the best effort at the proportion of 3∶7; followed by the proportion of 5∶5.These two proportions significantly improved dry matter( DM) content and effectively alleviated the crude protein( CP) loss of raw materials; significantly improved the contents of crude fiber and crude ash; and significantly reduce ammonia nitrogen/total nitrogen( AT/TN).[Conclusion]From the perspective of silage quality,the appropriate mixing ratio of L.purpureus and sweet sorghum is 3∶7 or 5∶5. | Liu Hailin Deng Huifen Xu Huaqin Sun Ao | 2017 | Animal Husbandry and Feed Science2017，9，6： | 4 |
| 6 | The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis显示文摘Oscillations in cytosolic free calcium determine the polarity of tip-growing root hairs.The Ca2+channel cyclic nucleotide gated channel 14(CNGC14)contributes to the dynamic changes in Ca^2+concentration gradient at the root hair tip.However,the mechanisms that regulate CNGC14 are unknown.In this study,we detected a direct interaction between calmodulin 7(CaM7)and CNGC14 through yeast two-hybrid and bimolecular fluorescence complementation assays.We demonstrated that the third EF-hand domain of CaM7 specifically interacts with the cytosolic C-terminal domain of CNGC14.A two-electrode voltage clamp assay showed that CaM7 completely inhibitsCNGC14-mediated Ca2+influx,suggesting that CaM7 neg-atively regulates CNGC14-mediated calcium signaling.Fur-thermore,CaM7 overexpressing lines phenocopy the short root hair phenotype of a cngc14 mutant and this phenotype is insensitive to changes in external Ca^2+concentrations.We,thus,identified CaM7-CNGC14 as a novel interacting module that regulates polar growth in root hairs by con-trolling the tip-focused Ca2+signal. | Qudsia Zeb Xiaohan Wang Congcong Hou Xiwen Zhang Mengqi Dong Sisi Zhang Qian Zhang Zhijie Ren Wang Tian Huifen Zhu Legong Li Liangyu Liu | 2020 | Journal of Integrative Plant Biology2020，62，7： | 3 |
| 7 | Micro-area Chemical Composition and Preserved P-T Evolution Trace of Phengite in Albite Gneiss from the Donghai Ultrahigh-Pressure Metamorphic Area,East China显示文摘Study of micro-area chemical compositions indicates that phengite in albite gneiss from hole ZK2304 of the Donghai region has evident compositional zoning. SiO2 and tetrahedrally coordinated Si contents decrease, and Al2O3, AlIV and AlVI contents increase gradually from core to rim. However, K2O, MgO and FeO contents basically remain unchanged from core to rim. According to P-T estimates obtained from geothermometers and barometers, combined with previous experimental data, the core belt (micro-area I) of phengite was formed at T=637-672℃ and P=1.55-1.73 GPa, and the transitional belt (micro-area II) of the phengite were formed at r=594-654℃ and P=1.35-1.45 GPa. Towards the rim belt (micro-area III), the temperature decreased slightly, but the pressure decreased rapidly with r=542-630℃ and P=1.12-1.19 GPa. The P-T evolution path recorded by the compositional zoning of phengite is characterized by significant near-isothermal decompression, revealing that the gneiss has. undergone | LIU Fulai ZHANG Zeming XU Zhiqin YANG Jingsui XU Huifen | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 2 |
| 8 | MOFs for water purification显示文摘Metal-organic frameworks (MOFs),as emerging porous crystalline materials,were constructed from metal ions or clusters as nodes and organic ligands as linkers.Due to the superior features like diverse structure,abundant functional groups,tunable pore channels,large specific surface area and so on,MOFs have received increasing attentions in various fields like gas separation&storage,catalysis/photocatalysis,adsorption,sensor,electrochemistry as well as biochemistry. | Huifen Fu Chong-Chen Wang Wen Liu | 2022 | Chinese Chemical Letters2022，33，4： | 2 |
| 9 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 10 | Simultaneous qualitative assessment and quantitative analysis of flavonoids in various tissues of lotus ( Nelumbo nucifera ) using high performance liquid chromatography coupled with triple quad mass spectrometry显示文摘 | Sha Chen Linchuan Fang Huifen Xi Le Guan Jinbao Fang Yanling Liu Benhong Wu Shaohua Li | 2012 | Analytica Chimica Acta2012，，： | 1 |
| 11 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 12 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 13 | A New Normalized-cut Image Segmentation Algorithm Based on Watershed Transform显示文摘 | Liu Haitao Wang Yinlong Yao Huifen | 2012 | Applied Mechanics and Materials2012，235，1： | 1 |
| 14 | Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity显示文摘 | Xiaopan Wu Zhenhui Xin Wei Zhang Jia Wu Kangmei Chen Huifen Wang Xilin Zhu Liping Pan Zhuo Li Hui Li Ying Liu | 2013 | Int J Cancer2013，，5： | 1 |
| 15 | Effect of Soil Organic Matter on Adsorption and Insecticidal Activity of Toxins from Bacillus thuringiensis显示文摘With the large-scale cultivation of transgenic crops expressing Bacillus thuringiensis (Bt) insecticidal toxin in the world, the problem of environmental safety caused by these Bt crops has received extensive attention. The effects of soil organic matter (SOM) on the adsorption and insecticidal activity of Bt toxin in variable- and constant-charge soils (red and brown soils, respectively) were studied. Organic carbon in the soils was removed using hydrogen peroxide (H_2O_2). After H_2O_2 treatment, the SOM in the red and brown soils decreased by 71.26% and 82.82%, respectively. Mineral composition of the H_2O_2-treated soils showed no significant changes,but soil texture showed a slight change. After SOM removal, the cation exchange capacity (CEC) and pH decreased, while the specific surface area (SSA), point of zero charge (PZC), and zeta potential increased. The adsorption isotherm experiment showed that the Bt toxin adsorption on the natural and H_2O_2-treated soils fitted both the Langmuir model (R^2≥ 0.985 7) and the Freundlich model (R^2≥ 0.984 1), and the amount of toxin adsorbed on the H_2O_2-treated soils was higher than that on the natural soils. There was a high correlation between the maximum adsorption of Bt toxin and the PZC of soils (R^2= 0.935 7); thus, Bt toxin adsorption was not only influenced by SOM content, but also by soil texture, as well as the SSA, CEC, PZC, and zeta potential. The LC_(50) (lethal concentration required to kill 50% of the larvae) values for Bt toxin in the H_2O_2-treated soils were slightly lower than those in the natural soils, suggesting that the environmental risk from Bt toxin may increase if SOM decreases. As the measurement of insecticidal activity using insects is expensive and time consuming, a rapid and convenient in vitro method of enzyme-linked immunosorbent assays is recommended for evaluating Bt toxin degradation in soils in future studies. | ZHOU Xueyong YANG Zhe LIU Huifen LU Xianzhi HAO Jianchao | 2018 | Pedosphere2018，28，2： | 1 |
| 16 | Electroacupuncture attenuates morphine withdrawal signs and c -Fos expression in the central nucleus of the amygdala in freely moving rats显示文摘 | Liu Shen Zhou Wenhua Liu Huifen | 2005 | Brain Res2005，1044，2： | 1 |
| 17 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 18 | Increased c-Fos expression in the medial part of the lateral habenula during cue-evoked heroin-seeking in rats显示文摘 | Zhang Fuqiang Zhou Wenhua Liu Huifen | 2005 | Neuroscience Letters2005，，： | 1 |
| 19 | Increased c - Fos expression in the medial part of the lateral habenula during cue - evoked heroin - seeking in rats 显示文摘 | Zhang Fu-qing Zhou Wen-hua Liu Huifen | 2005 | Neurosci Lett2005，386，2： | 1 |
| 20 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
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