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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Effects of Cl- Ions on the Corrosion Behaviour of Low Alloy Steel in Deaerated Bicarbonate Solutions显示文摘The effect of Cl-ions on corrosion evolution of Ni Cu low alloy steel during immersion tests(up to 70days) in deaerated 0.05 mol/L bicarbonate solutions was investigated by in-situ electrochemical measurements combined with X-ray diffraction(XRD), scanning electron microscopy(SEM) and electron probe microanalysis(EPMA) characterisations. The results showed that due to the acceleration of substrate dissolution in the presence of Cl-, corrosion of Ni Cu low alloy steel underwent only two stages, i.e., a quick oxidation process followed by a final metastable passive state, without the initial slow anodic dissolution as observed in the Cl--free bicarbonate solution. The main components of the formed rust layer in the Cl--free bicarbonate solution were α-Fe OOH and Fe)_3O_4 , while apart from α-Fe OOH, (Fe)_6(OH)_(12)(CO)_3 was found evident instead of (Fe)_3O_4 in the Cl--containing solution. Metastable pits were only found in the Cl--containing solution where Cl-accumulated after the immersion test, confirming the attack of Cl-on the substrate after penetrating the formed corrosion product layer. | Yunfei Lu Junhua Dong Wei Ke | 2016 | Journal of Materials Science & Technology2016，32，4： | 11 |
| 3 | Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis显示文摘The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular functions.Here,a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living cells.Because of its nanoscale dimensions,mechanical flexibility,and minimal cytotoxicity to cells,the sensing module can be loaded in cells for long term in situ tracking with high sensitivity.A gradual increase in the nuclear refractive index during the apoptosis process is observed,revealing the increase in molecular density and the decrease in cell volume.The strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering. | Danran Li Nina Wang Tianyang Zhang Guangxing Wu Yifeng Xiong Qianqian Du Yunfei Tian Weiwei Zhao Jiandong Ye Shulin Gu Yanqing Lu Dechen Jiang Fei Xu | 2022 | Advanced Photonics2022，4，1： | 5 |
| 4 | A retrospective analysis of the safety and efficacy of apatinib in treating advanced metastatic colorectal cancer显示文摘Objective Colorectal cancer(CRC) is a heterogeneous disease in which both epigenetic alterations and gene mutations transform normal cells into cancer cells. Apart from a variety of standard treatments, there are few options available to improve a CRC patient's overall survival(OS) and quality of a life. The objective of the present retrospective study was to analyze the response and toxicity associated with apatinib in patients with metastatic CRC(m CRC).Method Data on the use of apatinib as salvage therapy were collected from patients diagnosed with m CRC, Eastern Cooperative Oncology Group(ECOG) performance status ≤ 3, from the Luhe Hospital. A total of 17 patients with stage IV unresectable m CRC, who received at least one cycle of apatinib, between October 2015 and February 2017, were involved in this study. Our primary endpoints were the overall response rate(ORR) and disease control rate(DCR), and the secondary objectives were progression-free survival(PFS), OS and safety.Result Seventeen patients with a median age of 62 years(34–83 years) were enrolled. Twelve patients were male, and the location of the primary tumor was in the colon and the rectum in 9 and 8 patients, respectively. Liver metastasis was observed in 9 patients and lung metastasis in 5. The ECOG performance status was 0 to 2 in 13 patients. The ORR at the first evaluation was 17.6 %(3/17). The DCR was 82.4%(14/17). The median PFS was 3.0 months(95% confidence interval(CI): 1.924–4.076 months) and the median OS was 5.4 months(95% CI: 3.383–7.417 months). Grade 1–2 adverse events included hypertension(52.9%), fatigue(64.7%), anorexia(29.4%), hoarseness(23.5%), proteinuria(23.5%), and development of rashes(17.6%). Grade 3 adverse events included thrombocytopenia(5.9%) and proteinuria(5.9%). There were no Grade 4 adverse events in our analysis.Conclusions Apatinib was found to be both safe and effective in the treatment of advanced m CRC, and its associated toxicities were acceptable and manageable. However, further studies are required to validate these findings. | Li Wang Juan Lu Yi Liu Yunfei Gao Man Kong Jiandong Yang Bin Kong Xuebing Li Xifen Huang Wenzhong Pei | 2017 | Oncology and Translational Medicine2017，3，5： | 4 |
| 5 | Novel biallelic TRNT1 mutations lead to atypical SIFD and multiple immune defects显示文摘Mutations in the gene encoding transfer RNA(tRNA)nucleotidyltransferase,CCAadding 1(TRNT1),an enzyme essential for the synthesis of the 30-terminal CCA sequence in tRNA molecules,are associated with a rare syndrome of congenital sideroblastic anemia,B cell immunodeficiency,periodic fevers,and developmental delay(SIFD).Clinical manifestations and immunological phenotypes were assessed in a Chinese patient with novel compound heterozygous mutations in TRNT1.The patient required multiple hospitalizations starting at the age of 2 years for recurrent fevers without an infective cause.During the febrile episode,the patient was found to have microcytic hypochromic anemia,B cell lymphopenia,and hypogammaglobulinemia.Targeted gene sequencing identified novel compound heterozygous mutations in the TRNT1 gene(c.525delT,p.Leu176X;c.938T>C,p.Leu313Ser).Immunophenotyping revealed increased CD8^+T cells,CD4^+ terminally differentiated effector memory helper T lymphocytes(CD4 TEMRA),and CD4^+ effector memory lymphocytes(CD4 EM).Analysis of CD4^+T subsets identified decreased T follicular helper cells(Tfh)with a biased phenotype to Th2-like cells.The patient also showed a lower percentage of switched memory B(smB)cells.Additionally,defects in the cytotoxicity of the patient’s NK andγτT cells were shown by CD107alpha expression.In conclusion,TRNT1 mutations may lead to multiple immune abnormality especially humoral and cytotoxicity defects,which indicate that SIFD is not only suffered‘Predominantly antibody deficiencies’in IUIS classification system,and further studies are needed to understand the pathogenesis of immunodeficiency in these patients. | Lu Yang Xiuhong Xue Ting Zeng Xuemei Chen Qin Zhao Xuemei Tang Jun Yang Yunfei An Xiaodong Zhao | 2020 | Genes & Diseases2020，7，1： | 3 |
| 6 | miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase显示文摘 | Yunfei Zhou Guohui Wan Riccardo Spizzo Cristina Ivan Rohit Mathur Xiaoxiao Hu Xiangcang Ye Jia Lu Fan Fan Ling Xia George A. Calin Lee M. Ellis Xiongbin Lu | 2014 | Molecular Oncology2014，，1： | 3 |
| 7 | Dynamic Tensile Property of Zr-based Metallic Glass/Porous W Phase Composite显示文摘The dynamic tensile deformation and fracture behavior of the Zr-based metallic glass/porous W phase composite were investigated at room temperature by means of the Split Hopkinson Tension Bar (SHTB).It was found that the composite exhibited no appreciable macroscopic plastic deformation prior to catastrophic fracture and the fracture surface was perpendicular to the axial direction.Substantive micro cracks were observed along the interface between W grains or the interface between the metallic glass phase and the W phase.Scanning electron microscopy (SEM) observations revealed that vein-like patterns,dimple-like patterns and substantive ridge-like structures were the typical fracture morphologies on the fracture surface for the metallic glass phase and the morphology of the W phase is a mixture of intergranular and transgranular fracture.Based on those results referred above,the dynamic tensile deformation and fracture mechanism of the Zr-based metallic glass/porous W phase composite were discussed in detail. | Yunfei Xue Lu Wang Huanwu Cheng Fuchi Wang Haifeng Zhang Aiming Wang | 2010 | Journal of Materials Science & Technology2010，26，10： | 2 |
| 8 | Meta-Analysis of Enteral Nutrition versus Total Parenteral Nutrition in Patients with Severe Acute Pancreatitis显示文摘 | Cao Yunfei Xu Yinglong Lu Tingna Gao Feng Mo Zengnan | 2009 | Annals of Nutrition & Metabolism (-)2009，，3： | 2 |
| 9 | The effect of pore size and porosity of Ti6Al4V scaffolds on MC3T3-E1 cells and tissue in rabbits显示文摘Electron beam melting(EBM) allows the fabrication of specific porous titanium implants, whereas their in vitro and in vivo biological performance should be further investigated. In this study, we examined the porous Ti6 Al4 V scaffolds(low, 334.1 μm pore size with 55.4% porosity;middle, 383.2 μm pore size with 65.2% porosity;and high, 401.6 μm pore size with 78.1%porosity) fabricated through EBM. The structural characterization and mechanical properties of porous Ti6 Al4 V scaffolds were measured through micro-computed tomography(micro-CT), scanning electron microscopy, and a material testing system.MC3 T3-E1 cells were used to assess the proliferation and differentiation of the cells on different scaffolds at day 7 and day 14 based on the expression levels of genes, including alkaline phosphatase, bone morphogenetic protein-2, osteopontin and runtrelated transcription factor-2. Rabbits with distal femoral defects were utilized to evaluate bone ingrowth in the porous titanium.All of the samples were subjected to micro-CT and histological analysis after 12 weeks. Results showed that compressive Young’s modulus of 0.3–1.1 GPa was similar to the trabecular bone. The three types of porous Ti6 Al4 V scaffolds were inclined to promote cell proliferation, whereas cell differentiation and bone ingrowth into the porous scaffolds were biased to the porous titanium with relatively large pores and porosity(middle and high). This study implied that the present porous implant design,which had the combined advantages of different pore sizes and porosity, might be meaningful and promising for trabecular bone defect restoration. | LUAN HuiQin WANG LiTing REN WeiYan CHU Zhao Wei HUANG YunFei LU ChengLin FAN YuBo | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 10 | Study on dispersion, adsorption and flow retaining behaviors of cement mortars with TPEG-type polyether kind polycarboxylate superplasticizers显示文摘 | Yinwen Li Chaolong Yang Yunfei Zhang Jian Zheng Huilong Guo Mangeng Lu | 2014 | Construction and Building Materials2014，，： | 2 |
| 11 | Interface Reversible Electric Field Regulated by Amphoteric Charged Protein-Based Coating Toward High-Rate and Robust Zn Anode显示文摘Metallic interface engineering is a promising strategy to stabilize Zn anode via promoting Zn^(2+) uniform deposition.However,strong interactions between the coating and Zn^(2+) and sluggish transport of Zn^(2+) lead to high anodic polarization.Here,we present a bio-inspired silk fibroin(SF)coating with amphoteric charges to construct an interface reversible electric field,which manipulates the transfer kinetics of Zn^(2+) and reduces anodic polarization.The alternating positively and negatively charged surface as a build-in driving force can expedite and homogenize Zn^(2+) flux via the inter-play between the charged coating and adsorbed ions,endowing the Zn-SF anode with low polarization voltage and stable plating/stripping.Experimental analyses with theo-retical calculations suggest that SF can facilitate the desolvation of[Zn(H_(2)O)_(6)]^(2+) and provide nucleation sites for uniform deposition.Consequently,the Zn-SF anode delivers a high-rate performance with low voltage polarization(83 mV at 20 mA cm^(−2)) and excellent stability(1500 h at 1 mA cm^(−2);500 h at 10 mA cm^(−2)),realizing exceptional cumulative capacity of 2.5 Ah cm^(−2).The full cell coupled with Zn_(x)V_(2)O_(5)·nH_(2)O(ZnVO)cathode achieves specific energy of~270.5/150.6 Wh kg^(−1)(at 0.5/10 A g^(−1))with-99.8% Coulombic efficiency and retains~80.3%(at 5.0 A g^(−1))after 3000 cycles. | Meihua Zhu Qing Ran Houhou Huang Yunfei Xie Mengxiao Zhong Geyu Lu Fu-Quan Bai Xing-You Lang Xiaoteng Jia Danming Chao | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 12 | Corrigendum to “Novel biallelic TRNT1 mutations lead to atypical SIFD and multiple immune defects” [Genes Dis 7 (1) (2020) 128-137]显示文摘We regret that an error was made in“Novel biallelic TRNT1 mutations lead to atypical SIFD and multiple immune defects”(Volume 7,Issue 1,March 2020,Pages 128e137).In the original manuscript,the grant number of the Natural Science Foundation of China was incorrectly written with the project number.The correct grant number is 81601753.We apologize for the error and for any inconvenience that may cause to the readers and the editors of this journal. | Lu Yang Xiuhong Xue Ting Zeng Xuemei Chen Qin Zhao Xuemei Tang Jun Yang Yunfei An Xiaodong Zhao | 2020 | Genes & Diseases2020，7，3： | 1 |
| 13 | Thermal Residual Stresses in W Fibers/Zr-based Metallic Glass Composites by High-energy Synchrotron X-ray Diffraction显示文摘Thermal residual stresses in W fibers/Zr-based metallic glass composites were measured by in situ high energy synchrotron X-ray diffraction(HEXRD). The W fibers for the composites were 300,500,and 700 m m in diameter,respectively. Coaxial cylinder model(CCM) and finite element model(FEM) were employed to simulate the distribution of thermal residual stress,respectively. HEXRD results showed that the selected diameters of W fiber had little influence on the value of thermal residual stresses in the present composites. Thermal residual stresses simulated by CCM and FEM were in good agreement with HEXRD measured results. In addition,FEM results exhibited that thermal residual stress concentrated on interface between the two phases and area where the two W fibers were the closest ones to each other. | Xinqiang Zhang Yunfei Xue Haifeng Zhang Huameng Fu Zhengbin Wang Zhihua Nie Lu Wang | 2015 | Journal of Materials Science & Technology2015，31，2： | 1 |
| 14 | Interaction of U(VI) with Na-attapulgite in the presence and absence of humic acid as a function of pH, ionic strength and temperature显示文摘 | Xiaoping Song Yajie Wang Jingjing Cai Songsheng Lu Yunfei Chen | 2013 | Journal of Radioanalytical and Nuclear Chemistry2013，1，295： | 1 |
| 15 | Design and properties of a novel nucleating agent for isotactic polypropylene显示文摘 | Lu Zhiping Yang Yunfei Wu Ran | 2012 | Materials & Design2012，37，5： | 1 |
| 16 | Bioactive glass promotes the barrier functional behaviors of keratinocytes and improves the Re-epithelialization in wound healing in diabetic rats显示文摘Upon skin injury,re-epithelialization must be triggered promptly to restore the integrity and barrier function of the epidermis.However,this process is often delayed or interrupted in chronic wounds like diabetic foot ulcers.Considering that BG particles can activate multiple genes in various cells,herein,we hypothesized that bioactive glass(BG)might be able to modulate the barrier functional behaviors of keratinocytes.By measuring the transepithelial electrical resistance(TEER)and the paracellular tracer flux,we found the 58S-BG extracts substantially enhanced the barrier function of keratinocyte monolayers.The BG extracts might exert such effects by promoting the keratinocyte differentiation and the formation of tight junctions,as evidenced by the increased expression of critical differentiation markers(K10 and involucrin)and TJ protein claudin-1,as well as the altered subcellular location of four major TJ proteins(claudin-1,occludin,JAM-A,and ZO-1).Besides,the cell scratch assay showed that BG extracts induced the collective migration of keratinocytes,though they did not accelerate the migration rate compared to the control.The in vivo study using a diabetic rat wound model demonstrated that the BG extracts accelerated the process of re-epithelialization,stimulated keratinocyte differentiation,and promoted the formation of tight junctions in the newly regenerated epidermis.Our findings revealed the crucial effects of BGs on keratinocytes and highlighted its potential application for chronic wound healing by restoring the barrier function of the wounded skin effectively. | Fengling Tang Junliang Li Weihan Xie Yunfei Mo Lu Ouyang Fujian Zhao Xiaoling Fu Xiaofeng Chen | 2021 | Bioactive Materials2021，6，10： | 1 |
| 17 | How to Increase Farmers' Income in the Poor Mountainous Areas ?显示文摘Using the gray system theory and gray relational analysis method,the relationship between added value of hybrid corn,hogs,Juglans sigillata,Pisum Sativum L.,safflower and that of farmers' net income in Bailongjing Village,Wafang Township,Longyang District,Baoshan City,Yunnan Province was analyzed,and the ways to increase farmers' per capita net income were studied. The results showed that economic income of farmers by structure adjustment of agriculture is Juglans sigillata > Pisum Sativum L. > safflower > hogs > hybrid corn. The study can provide scientific basis for optimizing agricultural industrial structure in Baoshan City,and promoting the rapid growth of farmers' economic income. | Yunfei SONG Yan LIU Lin ZENG Shunsheng LU Guotian YANG Yan SHAN Guixian WU Lamei YANG | 2015 | Asian Agricultural Research2015，7，4： | 1 |
| 18 | Application of Grey Correlation Degree Analysis in Broad Bean Strain Screening显示文摘[Objectives] The aim was to clarify the target and approach to purifying and selecting Baoshan Touxinlv broad bean. [Methods] In 2012,5 homozygous strains were selected successfully as the material,and completely randomized block arrangement was adopted with 3 repeated trials to analyze the effects of plant height,effective length of podding branches,branch number per plant,pod number per plant,grain number per pod and 100-grain weight on the yield of each plant in the system. [Results] The results showed that the effects of the various factors on the yield of Baoshan broad beans were in the order of grain number per pod > effective length of podding branches > 100-grain weight > pod number per plant > branch number per plant > plant height. [Conclusions]In breeding new strains of Baoshan broad beans,under the premise of ensuring the seed nature and quality of the original variety,priority should be given to the gain number per pod and the increment of effective length of podding branches,followed by the pod number per plant,branch number per plant,plant height,which is the best way to breed new strains of Baoshan Touxinlv broad beans. | Lin ZENG Chunqin WU Guotian YANG Chaozhong ZHANG Shunsheng LU Yunfei SONG Yan LIU Lamei YANG Guixian WU | 2018 | Agricultural Biotechnology2018，7，3： | 1 |
| 19 | Failure Mechanism of Electromigration in Solder Joint显示文摘 | Lu Yudong He Xiaoqi En Yunfei | 2008 | Adv Mater Res2008，4446，8： | 1 |
| 20 | Corrosion Evolution of Low Alloy Steel in Deaerated Bicarbonate Solutions显示文摘Corrosion evolution during immersion tests(up to 43 days) of Ni Cu steel in deaerated 0.1 mol/L bicarbonate solutions was investigated by electrochemical measurements, scanning electron microscopy(SEM) and X-ray diffraction(XRD). Results show that Ni Cu steel transformed from the anodic dissolution in the early stage of immersion to a metastable passive state in the final stage as the open-circuit potential value shifted positively, which was aroused by the precipitation of corrosion products. This process was mainly promoted by the trace amount of oxygen. Simultaneously, dominant cathodic reaction transformed from the hydrogen evolution in early stage to reduction processes of corrosion products in later stages. Possible corrosion processes were discussed with the assistance of a corresponding Pourbaix diagram. | Yunfei Lu Junhua Dong Wei Ke | 2015 | Journal of Materials Science & Technology2015，31，10： | 1 |
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