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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Characteristics of strong earthquake evolution around the eastern boundary faults of the Sichuan-Yunnan rhombic block显示文摘Based on the existing materials of fault segmentation,characteristic earthquakes,and their empirical relationships,we calculated the parameters of the fault segments,such as length,width,magnitudes of characteristic earthquakes,etc.Constrained by GPS velocity field,the slip rates of these fault segments in depth were inversed using the 3-D half-space elastic dislocation model.As not all of the recurrence periods and co-seismic displacements of characteristic earthquakes are known,we selected the fault segments with these two parameters known and calculated the accumulation rate of average co-seismic displacement,which shows the faults' slip rate in seismogenic layer.Then,the slip rate in depth was compared with that in seismogenic layer,the relationship between them was obtained,and this relationship was used to get the recurrence periods and co-seismic displacements of all fault segments.After the studies above,we calculated the co-seismic deformation field of all the earthquakes larger than M s 6.8 from AD 1700 one by one and inversed the potential displacement in the co-seismic deformation field.Then,we divided the potential displacement by the slip rate from GPS inversion to get the influences of these fault segments,added the influences into the elapsed time of the characteristic earthquakes,and obtained the earthquake hazard degree of all the segments we studied in the form of the ratio of elapsed time to recurrence period;so,we name the ratio as the Impending Earthquake Risk (IER).Historical earthquake cases show that the fault segment is in safety when the IER is less than 1 but in danger after the IER becomes larger than 1.In 2009,the IER is larger than 1 on the following segments,1.35 on the Tagong segment of Xianshuihe fault,1 on the Menggu-Dongchuan segment,1.04 on the Dongchuan-Xundian segment,and 1.09 on the Yiliang-Chengjiang segment of Xiaojiang fault. | CHENG Jia LIU Jie GAN WeiJun YU HuaiZhong LI Gang | 2011 | Science China Earth Sciences2011，54，11： | 15 |
| 3 | Site effects on earthquake ground motion based on microtremor measurements for metropolitan Beijing显示文摘A campaign of microtremor measurements was conducted in summer 2007 for assessing local site effects of seismic strong ground motion in metropolitan Beijing. Using the measurements from over 600 sites with approximately 1―2 km spacing covering the entire area inside Beijing’s 5th Beltway, we present the analysis results in the form of contours of the predominant resonant frequency, the thick- ness of the uppermost soft sediments, and the ground motion amplification factor. The microtremor- derived soft sediment thickness is generally in agreement with previous results based on much sparser borehole data, with the revealing of more short-wavelength undulations, which coincide with major geomorphological and neotectonic expressions in metropolitan Beijing. This study provides additional valuable information to the earthquake-resistant design of civil infrastructures and seismic hazard response in metropolitan Beijing. It also provides a feasible geophysical approaching to explore the 3-D structure beneath metropolitan cities. | CHEN QiFu LIU LanBo WANG WeiJun ROHRBACH Eric | 2009 | Chinese Science Bulletin2009，54，2： | 15 |
| 4 | Human mesenchymal stromal cells enhance the immunomodulatory function of CD8+CD28- regulatory T cells显示文摘 | Qiuli Liu Haiqing Zheng Xiaoyong Chen Yanwen Peng Weijun Huang Xiaobo Li Gang Li Wenjie Xia Qiquan Sun an Andy Peng Xiang | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 5 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 6 | NbN superconducting nanowire single photon detector with efficiency over 90% at 1550 nm wavelength operational at compact cryocooler temperature显示文摘The rapid development of superconducting nanowire single-photon detectors over the past decade has led to numerous advances in quantum information technology. The record for the best system detection efficiency at an incident photon wavelength of 1550 nm is 93%. This performance was attained from a superconducting nanowire single-photon detector made of amorphous WSi; such detectors are usually operated at sub-Kelvin temperatures. In this study, we first demonstrate superconducting nanowire single-photon detectors made of polycrystalline NbN with system detection efficiency of 90.2% for 1550-nm-wavelength photons at2.1 K, accessible with a compact cryocooler. The system detection efficiency saturated at 92.1% when the temperature was lowered to 1.8 K. We expect the results lighten the practical and high performance superconducting nanowire single-photon detectors to quantum information and other high-end applications. | WeiJun Zhang LiXing You Hao Li Jia Huang ChaoLin Lv Lu Zhang XiaoYu Liu JunJie Wu Zhen Wang XiaoMing Xie | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，12： | 9 |
| 7 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 8 | Almost simple groups with socle ^3D_4(q)act on finite linear spaces显示文摘After the classification of flag-transitive linear spaces,attention has now turned to line-transitive linear spaces.Such spaces are first divided into the point-imprimitive and the point-primitive,the first class is usually easy by the theorem of Delandtsheer and Doyen.The primitive ones are now subdivided,according to the O'Nan-Scotte theorem and some further work by Camina,into the socles which are an elementary abelian or non-abelian simple.In this paper,we consider the latter.Namely,T ≤ G ≤ Aut(T) and G acts line-transitively on finite linear spaces,where T is a non-abelian simple.We obtain some useful lemmas.In particular,we prove that when T is isomorphic to 3D4(q),then T is line-transitive,where q is a power of the prime p. | LIU Weijun, DAI Shaojun & GONG Luozhong School of Mathematics, Central South University, Changsha 410075, China Department of Mathematics, Hunan University of Science and Engineering, Yongzhou 425006, China | 2006 | Science China Mathematics2006，49，12： | 8 |
| 9 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 10 | Differentiation potential of bone marrow mesenchymal stem cells in duck显示文摘The bone marrow mesenchymal stem cells(MSCs) are multipotent stem cells which can differentiate into mesenchymal cells in vitro.In this study,MSCs in duck were isolated from bone marrow by density gradient centrifuge separation,purified and expanded in the me-dium.The primary MSCs were expanded for 11 passages.The different-passage MSCs were induced to differentiate into osteoblasts and neuron-like cells.Karyotype analysis indicated that MSCs kept diploid condition and the hereditary feature was stable.The different-passage MSCs expressed CD44,ICAM-1 and SSEA-4,but not CD34,CD45 and SSEA-1 when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 2,6 and 8(P > 0.05),but a significant difference existed among those of passages 2,6,8 and 11(P < 0.05).After the osteogenic inducement was added,the induced different-passage MSCs expressed high-level alkaline phosphatase(ALP),and are positive for tetracycline staining,Alizarin Red staining and Von Kossa staining.After the neural inducement was added,about 70% cells exhibited typical neuron-like phenotype,the induced different-passage MSCs expressed Nestin,neuron-specific enolase(NSE) and glial fibrillary acidic protein(GFAP) when detected by immunofluorescence staining.There was no significant difference among the positive rates of passages 3,4 and 6(P>0.05),but a significant difference existed among those of passages 3,4,6 and 8(P<0.05).These results suggest that MSCs in duck were capable of differentiating into osteoblasts and neuron-like cells in vitro. | Linfeng Li Xiujuan Bai Xuelian Gong Hongkun Liu Lina Chen Weijun Guan Yuehui Ma | 2009 | Journal of Genetics and Genomics2009，36，3： | 8 |
| 11 | Numerical Simulation of Multi-track and Multi-layer Temperature Field on Laser Direct Metal Shaping显示文摘To improve the mechanical properties of the parts fabricated by Laser Direct Metal Shaping(LDMS),it is of great significance to understand the distribution regularities of transient temperature field during LDMS process.Based on the“el- ement birth and death”technique of finite element method,a three-dimensional multi-track and multi-layer model for the transient temperature field analysis of LDMS is developed by ANSYS Parametric Design Language(APDL)for the first time.In the fab- ricated modal,X-direction parallel reciprocating scanning paths is introduced.Using the same process parameters,the simulation results show good agreement with the microstructure features of samples which fabricated by LDMS. | LONG Risheng~(1,2) LIU Weijun~1 (1.Advanced Manufacture Lab,Shenyang Institute of Automation,Shenyang 110016,China, 2.Graduate School,Chinese Academy of Sciences,Beijing 100039,China) | 2006 | 武汉理工大学学报2006，28，S3： | 8 |
| 12 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 13 | Effect of illumination intensity and light application time on secondary organic aerosol formation from the photooxidation of α-pinene显示文摘Secondary organic aerosol (SOA) formation from hydroxyl radical (OH.) initiated photooxidation of α-pinene was investigated in a home-made smog chamber. The size distribution of SOA particles was measured using aerodynamic particle sizer spectrometer. The effects of illumination intensity and light application time on SOA formation for α-pinene were evaluated. Experimental results show that the concentration of SOA particles increased significantly with an increasing of illumination intensity, and the light application time, the concentration, and the size of SOA particles were also increased. In addition, the factors influencing the formation of SOA were discussed. In addition, this article compared the effect of α-pinene with that of toluene, and discussed the contribution of α-pinene to SOA formation. | LIU Xianyun, ZHANG Weijun, HUANG Mingqiang, WANG Zhenya, HAO Liqing, ZHAO Wenwu Laboratory of Environment Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences,Hefei 230031, China. | 2009 | Journal of Environmental Sciences2009，21，4： | 7 |
| 14 | Ambient noise as the new source for urban engineering seismology and earthquake engineering: a case study from Beijing metropolitan area显示文摘In highly populated urban centers, traditional seismic survey sources can no longer be properly applied due to restrictions in modern civilian life styles. The ambient vibration noise, including both microseisms and microtremor, though are generally weak but available anywhere and anytime, can be an ideal supplementary source for conducting seismic surveys for engineering seismology and earthquake engineering. This is fundamentally supported by advanced digital signal processing techniques for effectively extracting the useful information out from the noise. Thus, it can be essentially regarded as a passive seismic method. In this paper we first make a brief survey of the ambient vibration noise, followed by a quick summary of digital signal processing for passive seismic surveys. Then the applications of ambient noise in engineering seismology and earthquake engineering for urban settings are illustrated with examples from Beijing metropolitan area. For engineering seismology the example is the assessment of site effect in a large area via microtremor observations. For earthquake engineering the example is for structural characterization of a typical reinforced concrete high-rise building using background vibration noise.By showing these examples we argue that the ambient noise can be treated as a new source that is economical, practical, and particularly valuable to engineering seismology and earthquake engineering projects for seismic hazard mitigation in urban areas. | Lanbo Liu Qi-fu Chen Weijun Wang Eric Rohrbach | 2014 | Earthquake Science2014，27，1： | 7 |
| 15 | The Distribution of Different Clades of Seneca Valley Viruses in Guangdong Province,China显示文摘Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in significant economic losses to the swine industry. The first identification of SVV in China was reported in Guangdong Province, a major swine producing province. The cases of SVV were continuously reported in Guangdong in 2015 and 2016. However, the spread of SVV in Guangdong in 2017 remains unknown.In this study, we determined two new SVV strains, CH-GD-2017-1 and CH-GD-2017-2, from Guangdong. The genetic analysis suggested that the two Guangdong strains showed different characteristics to previous Guangdong strains. They showed lower nucleotide similarity with strains isolated in 2015 and 2016, and were more similar to the US strains.Phylogenetic analyses indicated that the new strains were clustered in a different clade with previous Guangdong strains.We found 28 mutated amino acids in the new strains, compared with the first Guangdong strain, SVV CH-01-2015. In the geographic analysis, we found that the US and China reported more SVV cases than other countries, and most of the SVV cases were reported in east and central China—of which, Guangdong Province is one of the major epidemic regions. In conclusion, our findings indicate that SVV continued to spread in Guangdong Province in 2017, and two different clades of SVVs have emerged in this region. | Pan Chen Fan Yang Weijun Cao Huanan Liu Keshan Zhang Xiangtao Liu Zhiwen Xu Zixiang Zhu Haixue Zheng | 2018 | Virologica Sinica2018，33，5： | 7 |
| 16 | Morphology,composition,and sources of individual aerosol particles at a regional background site of the YRD,China显示文摘Aerosol samples were collected at Lin'an, a background site of Yangtze River Delta(YRD).Morphology, size, composition, and mixing state of individual aerosol particles were characterized by transmission electron microscopy(TEM) coupled with energy dispersive X-ray spectroscopy(EDS), and the soluble ions of PM_(1.0) were studied by aerosol mass spectrometer(AMS). The daily average AMS mass concentrations of sulfate, nitrate, and ammonium were about 5.8, 8.6, and 5.6 μg/m^3, respectively. Individual aerosol particles were classified into seven types: S-rich, K-rich, organic matter(OM), soot, fly ash, metal, and mineral. S-rich particles were dominant in all size bins, and 51%(by number) of S-rich particles were internally mixed with other particles. The fraction of organic coating particles was 13.7% in morning, 25.2% in afternoon, and 11% in evening, suggesting that the strong photochemical process during afternoon produced more secondary organic aerosols(SOA) on the surface of inorganic particles. Fly ash and metal particles were abundant during the day, suggesting the influence of emissions from coal-fired power plants and steel plants. The results indicate that the intense industrial emissions in the YRD significantly transported to the background areas. PM_(2.5) concentration may be lower in background air than in urban air but complex mixing state of aerosol particles indicates that the long-range transported particles substantially influenced the background air quality. | Liang Xu A.P.Lingaswamy Yinxiao Zhang Lei Liu Yuanyuan Wang Jian Zhang Qianli Ma Weijun Li | 2019 | Journal of Environmental Sciences2019，31，3： | 6 |
| 17 | The mass-balance characteristics and sensitivities to climate variables of Laohugou Glacier No.12,western Qilian Mountains,China显示文摘Due to global warming, glaciers on the Tibetan Plateau(TP) are experiencing widespread shrinkage; however, the mechanisms controlling glacier variations across the TP are still rather unclear, especially on the northeastern TP. In this study, a physically based, distributed surface-energy and mass-balance model was used to simulate glacier mass balance forced by meteorological data. The model was applied to Laohugou No. 12 Glacier, western Qilian Mountains, China, during2010~2012. The simulated albedo and mass balance were validated and calibrated by in situ measurements. The simulated annual glacier-wide mass balances were-385 mm water equivalent(w.e.) in 2010/2011 and-232 mm w.e. in 2011/2012,respectively. The mean equilibrium-line altitude(ELA) was 5,015 m a.s.l., during 2010~2012, which ascended by 215 m compared to that in the 1970 s. The mean accumulation area ratio(AAR) was 39% during the two years. Climatic-sensitivity experiments indicated that the change of glacier mass balance resulting from a 1.5 °C increase in air temperature could be offset by a 30% increase in annual precipitation. The glacier mass balance varied linearly with precipitation, at a rate of130 mm w.e. per 10% change in total precipitation. | JiZu Chen ShiChang Kang Xiang Qin WenTao Du WeiJun Sun YuShuo Liu | 2017 | Research in Cold and Arid Regions2017，9，6： | 6 |
| 18 | Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures显示文摘Vascular endothelial growth factor A(Vegfa) signaling regulates vascular development during embryogenesis and organ formation.However,the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely understood.In this study,we utilized transcription activator-like effector nuclease(TALEN) to generate zebrafish vegfaa mutants.vegfaa^(-/-) embryos are embryonic lethal,and display a complete loss of the dorsal aorta(DA) and expansion of the cardinal vein.Activation of Vegfa signaling expands the arterial cell population at the expense of venous cells during vasculogenesis of the axial vessels in the trunk.Vegfa signaling regulates endothelial cell(EC) proliferation after arterial-venous specification.Vegfa deficiency and overexpression inhibit the formation of tip cell filopodia and interfere with the pathfinding of intersegmental vessels(ISVs).In the head vasculature,vegfaa^(-/-) causes loss of a pair of mesencephalic veins(MsVs) and central arteries(CtAs),both of which usually dvelop via sprouting angiogenesis.Our results indicate that Vegfa signaling induces the formation of the DA at the expense of the cardinal vein during the trunk vasculogenesis,and that Vegfa is required for the angiogenic formation of MsVs and CtAs in the brain.These findings suggest that Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures. | Daqing Jin Diqi Zhu Yabo Fang Yiwei Chen Gaihong Yu Weijun Pan Dong Liu Fen Li Tao P.Zhong | 2017 | Journal of Genetics and Genomics2017，44，10： | 6 |
| 19 | Experimental study of photooxidation products of ethylbenzene显示文摘Smog chamber experiments were performed to investigate the composition of products formed from photooxidation of aromatic hydrocarbon ethylbenzene.Vacuum ultraviolet photoionization mass spectrometer and aerosol time-of-flight mass spectrometer were used to measure the products in the gas and particle phases in real-time.Experimental results demonstrated that ethylphenol,methylglyoxal,phenol,benzaldehyde,and 2-ethylfurane were the predominant photooxidation products in both the gas and particle phases.However,there were some dierences between detected gas phase products and those of particle phase,for example,2-ethylfurane,ethylglyoxylic acid,nitroethylbenzene,3,4-dioxopentanal and ethyl-nitrophenol were only existing in the particle-phase. The possible reaction mechanisms leading to these products were also discussed and proposed. | Mingqiang Huang Weijun Zhang Liqing Hao Zhenya Wang Li Fang Ruihong Kong Xiaobin Shan Fuyi Liu Liusi Sheng | 2010 | Journal of Environmental Sciences2010，22，10： | 5 |
| 20 | Ultrahigh sensitive near-infrared photodetectors based on MoTe2/germanium heterostructure显示文摘The efficient near-infrared light detection of the MoTe2/germanium(Ge)heterojunction has been demonstrated.The fabricated MoTe2/Ge van der Waals heterojunction shows excellent photoresponse performances under the illumination of a 915 nm laser.The photoresponsivity and specific detectivity can reach to 12,460 A/W and 3.3×10^12 Jones,respectively.And the photoresponse time is 5 ms.However,the MoTe2/Ge heterojunction suffers from a large reverse current at dark due to the low barrier between MoTe2 and Ge.Therefore,to reduce the reverse current,an ultrathin GeO2 layer deposited by ozone oxidation has been introduced to the MoTe2/Ge heterojunction.The reverse current of the MoTe2/GeO2/Ge heterojunction at dark was suppressed from 0.44µA/µm^2 to 0.03 nA/µm^2,being reduced by more than four orders of magnitude.The MoTe2/Ge heterojunction with the GeO2 layer also exhibits good photoresponse performances,with a high responsivity of 15.6 A/W,short response time of 5 ms,and good specific detectivity of 4.86×10^11 Jones.These properties suggest that MoTe2/Ge heterostructure is one of the promising structures for the development of high performance near-infrared photodetectors. | Wenjie Chen Renrong Liang Shuqin Zhang Yu Liu Weijun Cheng Chuanchuan Sun Jun Xu | 2020 | Nano Research2020，13，1： | 5 |
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