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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | When water meets iron at Earth's core-mantle boundary显示文摘Hydrous minerals in subducted crust can transport large amounts of water into Earth's deep mantle. Our laboratory experiments revealed the surprising pressure-induced chemistry that, when water meets iron at the core-mantle boundary, they react to form an interlayer with an extremely oxygen-rich form of iron, iron dioxide, together with iron hydride. Hydrogen in the layer will escape upon further heating and rise to the crust, sustaining the water cycle. With water supplied by the subducting slabs meeting the nearly inexhaustible iron source in the core, an oxygen-rich layer would cumulate and thicken, leading to major global consequences in our planet. The seismic signature of the D″ layer may echo the chemical complexity of this layer. Over the course of geological time, the enormous oxygen reservoir accumulating between the mantle and core may have eventually reached a critical eruption point. Very large-scale oxygen eruptions could possibly cause major activities in the mantle convection and leave evidence such as the rifting of supercontinents and the Great Oxidation Event. | Ho-Kwang Mao Qingyang Hu Liuxiang Yang Jin Liu Duck Young Kim Yue Meng Li Zhang Vitali B.Prakapenka Wenge Yang Wendy L.Mao | 2017 | National Science Review2017，4，6： | 14 |
| 3 | MicroRNA expression profile and functional analysis reveal their roles in contact inhibition and its disruption switch of rat vascular smooth muscle cells显示文摘接触抑制和它脉管的光滑的肌肉房间(VSMC ) 的混乱是在脉管的疾病的重要细胞的事件。但是内在的分子的机制是不清楚的。在这研究,我们在接触抑制和它 VSMC 和包含的分子的机制的混乱调查了 microRNAs (miRNAs ) 的角色。老鼠 VSMC 在 30% 或 90% 融合被播种。在禁止接触的 conuent VSMC (90% 融合) 和 non-contact-inhibited 的 MiRNA 表示侧面低密度的 VSMC (30% 融合) 被决定。我们发现多重 miRNAs 是在二个组之间表示的差别。在他们之中, miR-145 显著地在禁止接触的 VSMC 被增加。浆液能破坏由 conuent VSMC 的得到的增长出现的接触抑制。伴有 miR-145 的一条下面规定的接触抑制混乱。VSMC 的导致浆液的接触抑制混乱被 miR-145 的 overexpression 堵住。而且, miR-145 的 downregulation 是足够的破坏 VSMC 的接触抑制。在导致浆液的接触抑制混乱的 miR-145 的 downregulation 与激活 PI3-kinase/Akt 小径有关,它被 PI3-kinase 禁止者 LY294002 堵住。KLF5, miR-145 的目标基因,被识别在 VSMC 接触抑制混乱上涉及 miR-145-mediated 效果,,它能被禁止由 KLF5 击倒。在摘要,我们的结果证明多重 miRNAs 是在禁止接触的 VSMC 并且在 non-contact-inhibited VSMC 表示的差别。在他们之中, miR-145 是在接触抑制和它 VSMC 的混乱的批评基因。PI3-kinase/Akt/miR-145/KLF5 是在导致浆液的接触抑制混乱的一条批评发信号小径。与 VSMC 的接触抑制有关的 miRNAs 指向可以为脉管的疾病代表一条新奇治疗学的途径。 | Ye-ying SUN Shan-shan QIN Yun-hui CHENG Chao-yun WANG Xiao-jun LIU Ying LIU Xiu-li ZHANG Wendy ZHANG Jia-xin ZHAN Shuai SHAO Wei-hua BIAN Bi-hui LUO Dong-feng LU Jian YANG Chun-hua WANG Chun-xiang ZHANG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 5 |
| 4 | Effectiveness of predicting tunneling-induced ground settlements using machine learning methods with small datasets显示文摘Prediction of tunneling-induced ground settlements is an essential task,particularly for tunneling in urban settings.Ground settlements should be limited within a tolerable threshold to avoid damages to aboveground structures.Machine learning(ML)methods are becoming popular in many fields,including tunneling and underground excavations,as a powerful learning and predicting technique.However,the available datasets collected from a tunneling project are usually small from the perspective of applying ML methods.Can ML algorithms effectively predict tunneling-induced ground settlements when the available datasets are small?In this study,seven ML methods are utilized to predict tunneling-induced ground settlement using 14 contributing factors measured before or during tunnel excavation.These methods include multiple linear regression(MLR),decision tree(DT),random forest(RF),gradient boosting(GB),support vector regression(SVR),back-propagation neural network(BPNN),and permutation importancebased BPNN(PI-BPNN)models.All methods except BPNN and PI-BPNN are shallow-structure ML methods.The effectiveness of these seven ML approaches on small datasets is evaluated using model accuracy and stability.The model accuracy is measured by the coefficient of determination(R2)of training and testing datasets,and the stability of a learning algorithm indicates robust predictive performance.Also,the quantile error(QE)criterion is introduced to assess model predictive performance considering underpredictions and overpredictions.Our study reveals that the RF algorithm outperforms all the other models with the highest model prediction accuracy(0.9)and stability(3.0210^(-27)).Deep-structure ML models do not perform well for small datasets with relatively low model accuracy(0.59)and stability(5.76).The PI-BPNN architecture is proposed and designed for small datasets,showing better performance than typical BPNN.Six important contributing factors of ground settlements are identified,including tunnel depth,the distance between tunnel face and surface monitoring points(DTM),weighted average soil compressibility modulus(ACM),grouting pressure,penetrating rate and thrust force. | Linan Liu Wendy Zhou Marte Gutierrez | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 5 |
| 5 | Multi-dimensional, light-controlled switch of fluorescence resonance energy transfer based on orderly assembly of 0D dye@micro-micelles and 2D ultrathin-layered nanosheets显示文摘荧光回声精力转移(烦恼) 系统在视觉察觉,聪明的材料,和生物成像有宽广应用,所有哪个帮助通过多重尺寸并且在多样的方向的光的传播。此处,我们示威了多维(0D 和 2D ) 由采用 layer-by-layer (LBL ) 在一部多层的 ultrathin 电影(UTF ) 以内烦恼集会技术。(tert 丁基 acrylate-co-ethyl acrylate-co-methacrylic 酸)(PTBEM ) anionic 块共聚物 micelle poly 为二度(8-hydroxyquinolate ) 的加入被选择为一个分子的搬运人锌(Znq 2) 和开戒指的 merocyanine (MC )( 是表示了(Znq 2/MC)@PTBEM) 。或者,静电的汇编与 cationic 被执行分层的双氢氧化物(LDH ) nanosheets (是表示了[(Znq 2/MC)@PTBEM/LDH] n ) 。这[(Znq 2/MC)@PTBEM/LDH] n 系统提供多维的繁殖媒介并且保证 FRET 施主和领受人位于他们的 F 以内 ? 在每个方向的 rster 半径。系统表明能经由轮流出现被交换的 FRET 进程紫外 / 可见(UV/vis ) 照耀与悦耳的 blue-green/red 荧光,象 81.7% 一样高导致 FRET 效率。这被期望这个汇编方法,它在 2D 上使用 0D 微粒分层的材料,能为进一步的开发被扩大到另外的系统多维烦恼。 | Zhixiong Li Ruizheng Liang Simin Xu Wendi Liu Dongpeng Yan Min Wei David G. Evans Xue Duan | 2016 | Nano Research2016，9，12： | 4 |
| 6 | New language outcome measures for Mandarin speaking children with hearing loss显示文摘Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM)was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM.A pilot study reported here shows that DREAM provided detailed information about hearing impaired children's language abilities and can be used to aid intervention planning to maximize progress.Conclusion:DREAM represents an example of translational science,transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention.Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills,are normed on Mandarin speaking children in China's Mainland,and are designed to capture features central to Mandarin language acquisition. | Xueman Liu Jill de Villiers Wendy Lee Chunyan Ning Eric Rolfhus Teresa Hutchings Fan Jiang Yiwen Zhang | 2016 | Journal of Otology2016，11，1： | 4 |
| 7 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 8 | Long-term Results of Ligation of Intersphincteric Fistula Tract (LIFT) for Fistula-in-Ano显示文摘 | Wendy Y. Liu Armen Aboulian Amy H. Kaji Ravin R. Kumar | 2013 | Diseases of the Colon & Rectum2013，，3： | 2 |
| 9 | E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells显示文摘Upon recognition of dsRNA,toll-like receptor 3(TLR3)recruits the adaptor protein TRIF to activate IRF3 and NF-κB signaling,initiating innate immune responses.The ubiquitination of TLR3 downstream signaling molecules and their roles in the innate response have been discovered;however,whether TLR3 itself is ubiquitinated and then functionally involved remains to be elucidated.By immunoprecipitating TLR3-binding proteins in macrophages,we identified ring finger protein 170(RNF170)as a TLR3-binding E3 ligase.RNF170 mediated the K48-linked polyubiquitination of K766 in the TIR domain of TLR3 and promoted the degradation of TLR3 through the proteasome pathway.The genetic ablation of RNF170 selectively augmented TLR3-triggered innate immune responses both in vitro and in vivo.Our results reveal a novel role for RNF170 in selectively inhibiting TLR3-triggered innate immune responses by promoting TLR3 degradation. | Xiaoqi Song Shuo Liu Wendie Wang Zhongfei Ma Xuetao Cao Minghong Jiang | 2020 | Cellular & Molecular Immunology2020，17，8： | 2 |
| 10 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 11 | Evidence for oxygenation of Fe-Mg oxides at mid-mantle conditions and the rise of deep oxygen显示文摘As the reaction product of subducted water and the iron core,FeO2 with more oxygen than hematite(Fe_(2)O_(3))has been recently recognized as an important component in the D'layer just above the Earth’s core-mantle boundary.Here,we report a new oxygen-excess phase(Mg,Fe)_(2)O_(3)+δ(0<δ<1,denoted as‘OE-phase’).It forms at pressures greater than 40 gigapascal when(Mg,Fe)-bearing hydrous materials are heated over 1500 kelvin.The OE-phase is fully recoverable to ambient conditions for ex situ investigation using transmission electron microscopy,which indicates that the OE-phase contains ferric iron(Fe^(3+))as in Fe_(2)O_(3) but holds excess oxygen through interactions between oxygen atoms.The new OE-phase provides strong evidence that H_(2)O has extraordinary oxidation power at high pressure.Unlike the formation of pyrite-type FeO_(2)H_(x) which usually requires saturated water,the OE-phase can be formed with under-saturated water at mid-mantle conditions,and is expected to be more ubiquitous at depths greater than 1000 km in the Earth’s mantle.The emergence of oxygen-excess reservoirs out of primordial or subducted(Mg,Fe)-bearing hydrous materials may revise our view on the deep-mantle redox chemistry. | Jin Liu Chenxu Wang Chaojia Lv Xiaowan Su Yijin Liu Ruilian Tang Jiuhua Chen Qingyang Hu Ho-Kwang Mao Wendy L.Mao | 2021 | National Science Review2021，8，4： | 2 |
| 12 | Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-α in adult rat liver 显示文摘 | Liu ML Wendy M Zarnegar R | 1994 | Hepatology1994，19，6： | 1 |
| 13 | Modulation of macrophage phenotype by cell shape显示文摘 | Frances Y. McWhorter Tingting Wang Phoebe Nguyen Thanh Chung Wendy F. Liu | 2013 | Proceedings of the National Academy of Sciences2013，，43： | 1 |
| 14 | US Renal Data System 2011 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Blanche Chavers David Gilbertson Charles Herzog Kirsten Johansen Bertram Kasiske Nancy Kutner Jiannong Liu Wendy St. Peter Haifeng Guo Sally Gustafson Brooke Heubner Kenneth Lamb Shuling Li Suying Li Yi Peng Yang Qiu Trici | 2011 | American Journal of Kidney Diseases2011，，1： | 1 |
| 15 | Identification and Cloning of an Orphan G Protein-Coupled Receptor of the Glycoprotein Hormone Receptor Subfamily显示文摘 | Terry McDonald Ruiping Wang Wendy Bailey Guochun Xie Fang Chen C.Thomas Caskey Qingyun Liu | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 1 |
| 16 | US Renal Data System 2010 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Charles Herzog Blanche Chavers David Gilbertson Areef Ishani Bertram Kasiske Jiannong Liu Lih-Wen Mau Marshall McBean Anne Murray Wendy St. Peter Haifeng Guo Sally Gustafson Qi Li ShuLing Li Suying Li Yi Peng Yang Qiu Tric | 2010 | American Journal of Kidney Diseases2010，，1： | 1 |
| 17 | US Renal Data System 2010 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Charles Herzog Blanche Chavers David Gilbertson Areef Ishani Bertram Kasiske Jiannong Liu Lih-Wen Mau Marshall McBean Anne Murray Wendy St. Peter Haifeng Guo Sally Gustafson Qi Li ShuLing Li Suying Li Yi Peng Yang Qiu Tric | 2010 | American Journal of Kidney Diseases2010，，1： | 1 |
| 18 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
| 19 | The assessment of anti-cancer activities and saponin profiles of Gynostemma pentaphyllum saponins obtained from different regions of China显示文摘 | PUI KEI WU XIN LIU WENDY WEN-LUAN HSIAO | 2008 | Journal of Biotechnology2008，136，1： | 1 |
| 20 | Flow control for VATT by fixed and oscillating flap显示文摘 | Xiao Qing Liu Wendi Incecik A | 2013 | Renewable Energy2013，51，2： | 1 |
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