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| 1 | Reversible hydrogels with tunable mechanical properties for optically controlling cell migration显示文摘 | Xin Wu Wenmao Huang Wen-Hao Wu Bin Xue Dongfang Xiang Ying Li Meng Qin Fei Sun Wei Wang Wen-Bin Zhang Yi Cao | 2018 | Nano Research2018，11，10： | 6 |
| 2 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 3 | Application of an analytic hierarchy process to hydrocarbon accumulation coefficient estimation显示文摘The hydrocarbon accumulation coefficient is a key parameter in resources evaluation by genetic techniques. Methods of obtaining its value scientifically have always been an important factor influencing evaluation credibility. In this paper, the hydrocarbon accumulation system is evaluated quantitatively by establishing a hierarchy structure model based on an analytical hierarchy process. The hydrocarbon accumulation system of a higher exploration degree is selected as a calibration area and its hydrocarbon accumulation coefficient can be calculated using methods of hydrocarbon generation potential and reservoir-scale sequence. The hydrocarbon accumulation coefficient of a petroleum accumulation system can be gained by analogy of reservoir forming comprehensive evaluation results with the calibration area. The hydrocarbon accumulation coefficient of each petroleum accumulation system in the upper reservoir-forming combination of the Liaohe Western Sag can be obtained with this method. Practice shows that using the analytical hierarchy process to quantitatively evaluate the hydrocarbon accumulation system and then quantitatively predict the hydrocarbon accumulation coefficient decreases the influence of human factors in resources evaluation, and makes the resources assessment more objective and closer to the actual geological condition. | Gao Yongjin Liu Lifeng Liu Huimin Zheng Feifei Wu Li Zhou Jingjing Qu Dongfang | 2010 | Petroleum Science2010，7，3： | 5 |
| 4 | Multiple sulfur and oxygen isotope compositions in Beijing aerosol显示文摘Multiple sulfur isotopes(32S, 33 S, 34 S, 36S) and oxygen isotopes(16O, 18O) in Beijing aerosols were measured with MAT-253 isotope mass spectrometer. The δ34S values of Beijing aerosol samples range from 1.68‰ to 12.57‰ with an average value of 5.86‰, indicating that the major sulfur source is from direct emission during coal combustion. The δ18O values vary from 5.29‰ to 9.02‰ with an average value of 5.17‰, revealing that the sulfate in Beijing aerosols is mainly composed of the secondary sulfate. The main heterogeneous oxidation of SO2 in atmosphere is related to H2O2 in July and August, whereas H2O2 oxidation and Fe3+ catalytic oxidation with SO2 exist simultaneously in September and October. Remarkable sulfur isotope mass-independent fractionation effect is found in Beijing aerosols, which is commonly attributed to the photochemical oxidation of SO2 in the stratosphere. In addition, thermochemical reactions of sulfur-bearing compounds might be also a source of sulfur isotope anomalies based on the correlation between ?33S and CAPE. | GUO ZhaoBing WU MengLong LIU FengLing WEI Ying LI DongFang | 2014 | Science China Earth Sciences2014，57，11： | 5 |
| 5 | A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication显示文摘Despite the recent advances in artificial tissue and organ engineering,how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine.Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues,yet it still faces difficulties to generate vasculatures and preserve cell functions in complex organ production.Here,we overcome the limitations of conventional bioprinting systems by converting a six degree-of-freedom robotic arm into a bioprinter,therefore enables cell printing on 3D complex-shaped vascular scaffolds from all directions.We also developed an oil bath-based cell printing method to better preserve cell natural functions after printing.Together with a self-designed bioreactor and a repeated print-and-culture strategy,our bioprinting system is capable to generate vascularized,contractible,and long-term survived cardiac tissues.Such bioprinting strategy mimics the in vivo organ development process and presents a promising solution for in vitro fabrication of complex organs. | Zeyu Zhang Chenming Wu Chengkai Dai Qingqing Shi Guoxin Fang Dongfang Xie Xiangjie Zhao Yong-Jin Liu Charlie CLWang Xiu-Jie Wang | 2022 | Bioactive Materials2022，7，12： | 4 |
| 6 | CILP-2 is a novel secreted protein and associated with insulin resistance显示文摘Genetic association studies have implicated that cartilage intermediate layer protein 2 (CILP-2) confers the risk susceptibility for type 2 diabetes (T2DM). However, it is still unknown whether CILP-2 is involved in the regulation of glucose homeostasis and insulin resistance (IR). In the current study, we initially observed that CILP-2 as a secreted protein was detected in both conditioned medium and lysates of cells transfected with an overexpressed vector. We then found that circulating CILP-2 levels had a progressive increase from normal to impaired glucose tolerance (a pre-diabetic status) and then to diabetes, which was correlated positively with waist-to-hip ratio, triglyceride, fasting blood glucose, 2-h blood glucose after glucose overload, HbA1c, fasting insulin, 2-h plasma insulin after glucose overload, and homeostasis model assessment of insulin resistance but negatively with HDL-C. CILP-2 expression was increased in the liver and muscle but decreased in adipose tissues of obese mice or T2DM patients. Furthermore, we demonstrated that CILP-2 circulating levels were affected by OGTT and Exenatide. CILP-2 overexpression resulted in impaired glucose tolerance and hepatic IR in vivo and increased PEPCK expression whereas suppressed phosphorylation of insulin receptor and Akt kinase in vitro. Based on these findings, we have identified a direct interaction between CILP-2 and PEPCK and suggested that CILP-2 plays an important role in the regulation of hepatic glucose production. | Tong Wu Qin Zhang Shaobo Wu Wenjing Hu Tingting Zhou Ke Li Dongfang Liu Harvest FGu Hongting Zheng Zhiming Zhu Ling Li and Gangyi Yang | 2019 | Journal of Molecular Cell Biology2019，11，12： | 2 |
| 7 | Biomechanical research on operations of hangmann fracture with finite element method 显示文摘 | Yang Guo Biao Ding Zhu Quan Wu Kui Wang Dongfang | 2006 | Key Engineering Materials2006，，： | 1 |
| 8 | Optimal probability estimators for determining Weibull parameters显示文摘 | Song Lingyan Wu Dongfang Dan Yong | 2003 | Journal of Materials Science Letters2003，22，23： | 1 |
| 9 | Measurement and statistics of single pellet mechanical strength of different- ly shaped catalysts显示文摘 | Li Yongdan Wu Dongfang Zhang Jianpo | 2000 | Powder Technology2000，13，12： | 1 |
| 10 | Investigation of antimicrobial resistance in Escherichia coli and enterococci iso- lated from tibetan pigs显示文摘 | Li Peng Wu Dongfang Liu Kunyao | 2014 | PLoS One2014，9，4： | 1 |
| 11 | Modified Sagnac interferometer for distributed disturbance detection显示文摘 | Wu Dongfang Zhang Tianzhao Jia Bo | | 0，，06： | 1 |
| 12 | Association mapping of six yield-related traits in rapeseed ( Brassica napus L.)显示文摘 | Dongfang Cai Yingjie Xiao Wei Yang Wei Ye Bo Wang Muhammad Younas Jiangsheng Wu Kede Liu | 2014 | Theoretical and Applied Genetics2014，，1： | 1 |
| 13 | Earth Ecosystem Theory: Ⅱ Segm entation and Com-position Principles显示文摘We firstly put forward the definitions and principles of ecosystem segmentation and composition,and elaborate five kinds of characteristics of ecosystem segmentation and composition. Results show that ecosystem segmentation and composition are actually its space segmentation and composition,and time change decides change and succession of any ecosystems. Via temporal-spatial change of ecosystem and segmentation and composition,change and succession trend of ecosystem and future development are determined,which lays foundation for analyzing structure and composition of earth ecosystem. | Yang Dongfang Wang Fengyou He Huazhong Zhu Sixi Wu Yunjie | 2014 | Meteorological and Environmental Research2014，5，10： | 1 |
| 14 | Mesoporous zeolite-supported metal sulfide catalysts with high activities in the deep hydrogenation of phenanthrene显示文摘 | Wenqian Fu Lei Zhang Dongfang Wu Mei Xiang Qian Zhuo Kai Huang Zhongdong Tao Tiandi Tang | 2015 | Journal of Catalysis2015，，： | 1 |
| 15 | Earth Ecosystem Theory: Ⅲ Structure and Interface显示文摘By applying the segmentation and composition principles of ecosystem,the structure and interface of earth ecosystem are fully elaborated,and corresponding model diagrams are established to display its composition and interconversion. The research finds that earth ecosystem includes three sub-ecosystems: terrestrial ecosystem,marine ecosystem and atmospheric ecosystem. The impact sequence of sub-ecosystems on earth ecosystem is atmospheric ecosystem > marine ecosystem > terrestrial ecosystem. Based on the segmentation and composition principles of ecosystem and the application of earth ecosystem structure and interface,we give new explanations to Taoism and Taiji with the eight diagrams,which contributes to theoretical research of natural science. | Yang Dongfang Wang Fengyou Wu Youfu He Huazhong Zhu Sixi | 2014 | Meteorological and Environmental Research2014，5，11： | 0 |
| 16 | 腹腔镜肝肿瘤切除术15例报道(英文)显示文摘Objective:The aim of our study was to retrospectively analyze 15 patients' clinical materials with laparoscopic resection of liver neoplasms.Methods:From December 2007,a total of 15 patients with liver neoplasms were performed with laparoscopic hepatectomy,and their clinical materials,perioperative dates,postoperative complications,postoperative recovery and short-term curative effects were analyzed and summarized respectively.Results:Laparoscopic hepatectomy(LH) were performed in 15 patients,including 1 case underwent laparoscopic hepatic left lobectomy,1 case of left lateral hepatectomy,13 cases of partial liver resection.Fourteen cases of total laparoscopic liver resections for liver neoplasms,1 case of hand-assisted laparoscopic liver resection of the tumor,there was no conversion to open approach.Of the 15 patients with liver neoplasms,13 cases of hepatic neoplasms with the maximum diameter was 8 cm x 8 cm × 9 cm,9 cases of the borderline micro hepatocellular carcinoma(MHCC) with the diameter not more than 2 cm,3 cases of hepatic benign tumor.The mean operation time was(120 ± 30) min,and the intraoperative average hemorrhage was 100 mL,beginning to eat and get out of bed following 1-2 days of operation.The average postoperative hospitalization was 8 days,WBC,ALT,AST,albumin,bilirubin returned to normal after one week of operation.There were no postoperative complications such as hemorrhage,bile leakage or air embolism etc.Twelve patients with HCC were confirmed by postoperative pathology,1 case of liver smooth muscle lipoma,2 case of hepatic hemangioma.By one year of followed-up in 12 cases of HCC,the longest survival was 38 months,and no recurrence or death,1 year survival rate was 100%.Conclusion:Among the choice of cases,the advantages of LH for liver neoplasms compared with open surgery were less trauma,faster recovery and less blood loss.it is safe and effective for choosing a reasonable surgical indication,especially for peripheral micro hepatocellular carcinoma. | Dongfang Huang Jinsheng Wu Jianhuai Zhang Shaochuang Wang Lei Liu Fuzhen Qi Dianhua Gu Yebo Wang Ling Liu Guofeng Chen Ping Wang Gang Xu Yong Sun Yong Cai | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，5： | 0 |
| 17 | Study of pollutant transport in depth-averaged flows using random walk method显示文摘The random walk particle tracking(RWPT)method is compared with the Eulerian methods in investigating pollutant transport in depth-averaged flows.As a typical representative of the Eulerian model with high performance,the MacCormack scheme with Total Variation Diminishing modification(TVD-Mac)is selected for comparison.Solute concentration is simulated in four case studies.First,both numerical models have been tested in two idealized cases and compared against analytical solutions.Numerical dissipation is observed for TVD-Mac model where the concentration changes abruptly,especially under the circumstances of low resolution and misalignment between the flow direction and grid orientation.On the contrary,simulations by the random walk model achieve higher accuracy in both cases and are free of fictitious oscillations in the vicinity of sharp concentration gradients.Then,the solute oscillation along a one-dimensional hypothetical tidal estuary is simulated,with the RWPT accurately con serving mass and suffering less rm merical diffusion compared with the Eulerian method.Finally,the process of pollutant transport in a Yangzte River reach is predicted by the RWPT.The longitudinal dispersion coefficient DL is calculated accordingly.It is compared favorably with the theoretical/empirical formulae,indicating the validity of the RWPT in solving complex natural problems. | Xue-fei Wu Dongfang Liang | 2019 | Journal of Hydrodynamics2019，31，2： | 0 |
| 18 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 19 | Jiaozhou Bay and Surrounding Waters not Polluted by Cr显示文摘Based on the investigation data of water area in Jiaozhou Bay in April and August of 1981,Cr content and its surface horizontal distribution in water area of Jiaozhou Bay were studied. Research results showed that Cr content in the water body of Jiaozhou Bay was between 0. 18 and 32.32μg/L,corresponding with national class-one seawater quality standard( 50. 00μg/L). The water area of Jiaozhou Bay was not polluted by any Cr. In April,Cr content was higher in northeast water area of Jiaozhou Bay and lower in southern coastal waters. In August,Cr content was lower in whole Jiaozhou Bay. Cr in water area of Jiaozhou Bay was mainly from river,which was between 1. 85 and 32. 32 μg/L. It showed that Cr content of river transportation was lower,and river was not polluted by Cr,and water quality was all very clean from river to all marine coastal waters and gulf waters. | Yang Dongfang Wang Fengyou Zhu Sixi He Huazhong Wu Youfu | 2017 | Meteorological and Environmental Research2017，8，4： | 0 |
| 20 | As Sources in Jiaozhou Bay Waters显示文摘Based on data from the investigation in Jiaozhou Bay waters in 1982,the distribution,transfer and seasonal variation of As in Jiaozhou Bay were analyzed. Research results showed that in Jiaozhou Bay,As content was 0. 22-2. 80 μg /L at surface layer in one year and 0. 84-4. 48 μg /L at bottom layer. In one year,there was no As pollution in the whole waters of Jiaozhou Bay,and only low-content As was input into Jiaozhou Bay. By the horizontal distribution in the waters,it was able to determine if the mater was transported from the land into the waters and what the way of the transportation was. In April and October,there was no As source in the bay; the As content came from the river transportation in June and from the surface runoff transportation in July. In the land transfer process,the As content change in waters of Jiaozhou Bay was determined by the rainy season. There was no pollution of As in the soils and waters around the bay,so the As content was very low in the rivers around the bay.In the waters transfer process,in July and October,if there was the As source in the waters of Jiaozhou Bay or not,the bottom area with the highcontent As was formed in the bay center. | Yang Dongfang Zhu Sixi Wang Fengyou He Huazhong Wu Qingjie | 2014 | Meteorological and Environmental Research2014，5，5： | 0 |
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