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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 3 | Synthesis of Mg-Al-carbonate layered double hydroxide by an atom-economic reaction显示文摘A clean method for preparing layered double hydroxides (LDHs) has been developed, featured by using the hydroxides of two different metals as starting materials by atom-economic reactions. The reactions were carried out under hydrothermal conditions in either a high pressure autoclave or a microwave digester. The compositions, structural parameters and thermal behavior of the resulting LDHs are very similar to those of materials produced by using the separate nucleation and aging steps (SNAS) method. The major advantage of the new method is that no by-product is produced, so that filtration and washing processes are unnecessary. The consequent reduction in water consumption is beneficial to the environment. | Xiangyu Xu Dianqing Li Jiaqing Song Yanjun Lin Zhi Lv Min Wei Xue Duan | 2010 | Particuology2010，8，3： | 4 |
| 4 | One-Dimensional Magnetic FeCoNi Alloy Toward Low-Frequency Electromagnetic Wave Absorption显示文摘Rational designing of one-dimensional(1D)magnetic alloy to facilitate electromagnetic(EM)wave attenuation capability in low-frequency(2-6 GHz)microwave absorption field is highly desired but remains a significant challenge.In this study,a composite EM wave absorber made of a FeCoNi medium-entropy alloy embedded in a 1D carbon matrix framework is rationally designed through an improved electrospinning method.The 1D-shaped FeCoNi alloy embedded composite demonstrates the high-density and continuous magnetic network using off-axis electronic holography technique,indicating the excellent magnetic loss ability under an external EM field.Then,the in-depth analysis shows that many factors,including 1D anisotropy and intrinsic physical features of the magnetic medium-entropy alloy,primarily contribute to the enhanced EM wave absorption performance.Therefore,the fabricated EM wave absorber shows an increasing effective absorption band of 1.3 GHz in the low-frequency electromagnetic field at an ultrathin thickness of 2 mm.Thus,this study opens up a new method for the design and preparation of high-performance 1D magnetic EM absorbers. | Bintong Yang Jiefeng Fang Chunyang Xu Hui Cao Ruixuan Zhang Biao Zhao Mengqiu Huang Xiangyu Wang Hualiang Lv Renchao Che | 2022 | Nano-Micro Letters2022，14，10： | 4 |
| 5 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 6 | Adaptive Attitude Control for a Coaxial Tilt-Rotor UAV via Immersion and Invariance Methodology显示文摘Dear Editor,This letter is concerned with the attitude control for a novel tiltrotor unmanned aerial vehicle with two pairs of tiltable coaxial rotors and one rear rotor.An immersion and invariance-based adaptive attitude controller for the tilt-rotor unmanned aerial vehicle is proposed.In the proposed control strategy,an adaptive update law is specially designed to compensate for the uncertainties of damping coefficients.The stability of the resulting closed-loop coaxial tiltrotor unmanned aerial vehicle(CTRUAV)system is proved by the Lyapunov methodology and LaSalle’s invariance theory.Finally。 | Longlong Chen Zongyang Lv Xiangyu Shen Yuhu Wu Xi-Ming Sun | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，9： | 2 |
| 7 | Preparation of Eu^(2+),Dy^(3+),Zr^(4+)ions co-doped strontium aluminate/molybdate multi-optical functional hybrid pigments for anti-counterfeiting显示文摘Eu^(2+),Dy^(3+)and Zr_(4+)ions co-doped strontium aluminate(i.e.,SrAl_(2)O_(4):Eu^(2+),Dy^(3+),Zr_(4+))/molybdate(i.e.,Ho2MoO6or Nd2MoO6)with photo-/mechano-luminescence and allochroic effect as multi-optical functional hybrid pigments were prepared via solid state reactions and subsequent mixing.The phosphor and hybrid pigments were characterized by X-ray diffraction,scanning electron microscopy with energy dispersive X-ray spectroscopy,ultraviolet-visible spectroscopy,L*a*b*color scale analysis,spectrophotometry and mechanoluminescent measurement.The results show that the optimum luminescent emission intensity of SrAl_(2)O_(4):Eu^(2+),Dy^(3+),Zr_(4+)phosphor can be obtained when 5 mol%Zr_(4+)ions is doped into the lattice.Under the excitation of 365 nm wavelength,the hybrid pigments prepared with the phosphor and molybdate at a mass ratio of 1:1 present a green broad band emission located at 460-650 nm due to 4f65d1→4f7transitions of Eu^(2+)ions.The hybrid pigments have the superior mechanoluminescent property and emit light after being exerted by mechanical stresses.Besides,the hybrid pigments also exhibit an allochroic effect under different illuminants.In addition,the anti-counterfeiting of the hybrid pigments as a promising application was also presented. | Haitao Lv Yanmin Wang Zhidong Pan Xiangyu Li Yehong Zhang | 2023 | Journal of Rare Earths2023，41，5： | 1 |
| 8 | RFHUI:an RFID based human-unmanned aerial vehicle interaction system in an indoor environment显示文摘In this paper,we present an RFID based human and Unmanned Aerial Vehicle(UAV)Interaction system,termed RFHUI,to provide an intuitive and easy-to-operate method to navigate a UAV in an indoor environment.It relies on the passive Radio-Frequency IDentification(RFID)technology to precisely track the pose of a handheld controller,and then transfer the pose information to navigate the UAV.A prototype of the handheld controller is created by attaching three or more Ultra High Frequency(UHF)RFID tags to a board.A Commercial Off-The-Shelf(COTS)RFID reader with multiple antennas is deployed to collect the observations of the tags.First,the precise positions of all the tags can be obtained by our proposed method,which leverages a Bayesian filter and Channel State Information(CSI)phase measurements collected from the RFID reader.Second,we introduce a Singular Value Decomposition(SVD)based approach to obtain a 6-DoF(Degrees of Freedom)pose of the controller from estimated positions of the tags.Furthermore,the pose of the controller can be precisely tracked in a real-time manner,while the user moves the controller.Finally,control commands will be generated from the controller's pose and sent to the UAV for navigation.The performance of the RFHUI is evaluated by several experiments.The results show that it provides precise poses with 0.045m mean error in position and 2.5∘mean error in orientation for the controller,and enables the controller to precisely and intuitively navigate the UAV in an indoor environment. | Jian Zhang Zhitao Yu Xiangyu Wang Yibo Lv Shiwen Mao Senthilkumar CG.Periaswamy Justin Patton Xuyu Wang | 2020 | Digital Communications and Networks2020，6，1： | 1 |
| 9 | Thermal and morphological study of Al2O3 nanofibers derived from boehm- ite precursor显示文摘 | PENG Lingli XU Xiangyu LV Zhi | 2012 | Journal of Thermal Analysis and Calorimetry2012，110，2： | 1 |
| 10 | SiO 2 /graphene composite for highly selective adsorption of Pb(II) ion显示文摘 | Liying Hao Hongjie Song Lichun Zhang Xiangyu Wan Yurong Tang Yi Lv | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 11 | A novel method for solving shortest tool length based on compressing 3D check surfaces relative to tool postures显示文摘Solving the shortest tool length quickly under a known tool trajectory in multi-axis machining of complex channel parts is an urgent problem in industrial production. To solve this problem, a novel and efficient method is proposed which is featured by extracting only a few necessary curves from the check surface instead of sampling the entire surface. By rotating and compressing the 3 D check surface relative to all tool postures, the boundaries of the area occupied by the 2 D compressed surfaces are the essential elements for determining the shortest tool length. A tracking-based numerical algorithm is introduced to efficiently solve the silhouette curves which are formed in compressing. To define the multi-taper shaped tool holding system(THS) which is commonly used in production, a characterization model for THS profile is established. A model for solving the shortest tool length is finally constructed based on the critical interference relationship between the THS profile and all compressed boundary curves. For acceleration, the boundary splines are segmented according to their knot vectors. Then a new concept called the axis-aligned tool length box(AATB) is introduced,which can provide a conservative range of tool length for a spline segment. By scanning the AATBs of all spline segments, the very few effective spline segments that may ultimately determine the shortest tool length are filtered out. This acceleration method makes the solution for the shortest tool length more focused and efficient. The results of experimental examples are also reported to validate the efficiency and accuracy of the proposed algorithm. | Xiangyu LI Junxue REN Ximing LV Yuke ZHOU Congle LIU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 1 |
| 12 | Determination of bemegride and its Salts in Cosmetics by HPLC and Their Verification by HPLC-MS/MS显示文摘A high-performance liquid chromatography (HPLC) method has been developed for the determination of bemegride and its salts in cosmetics. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was used for the verification of the analytical results. Cosmetic samples were ultrasonically extracted with methanol, centrifuged and filtered by microporous membrane filter prior to instrumental analysis. The chromatographic separation of the analytes was performed using a Symmetry C18 (4.6 mm × 250 mm, 5 μm) column. The quantitation was carried out by external standard method. The experimental results indicated that the limit of quantitation (LOQ) for bemegride and its salts was 0.5 mg/kg. The mean recoveries at three spiked levels ranged from 85.1% to 107.4% with the relative standard deviations (RSDs) between 3.7% and 9.3%. The suspected positive samples were subjected to further verification by HPLC-MS/ MS. The method is accurate, rapid, sensitive and can be used for the inspection of cosmetics. | Guo Xiangyu Meng Xianshuang Bai Hua Ma Qiang Lv Yueguang Chen Meng Wang Chun | 2019 | China Detergent & Cosmetics2019，4，1： | 0 |
| 13 | Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory显示文摘With advancements in mobile communication technologies,there have been multiple user device(UD)connections to cellular networks.Because of changes in the spatial distribution of UDs and application requirements,the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs).Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks,the traditional offloading mechanism will result in high energy consumption,and UD’s offloading decision must be dynamically adjusted.The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution.This information includes details regarding the spatial distribution of UDs,application requirements,and the offloading period of computing tasks.Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’computing tasks by reasonably planning the offloading BSs of the UDs in the networks.The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09%when compared to the traditional offloading mechanism,and the traffic managed by each BS is balanced. | Xiangyu LV Xiaohu GE Yi ZHONG Qiang LI Yong XIAO | 2024 | Science China(Information Sciences)2024，67，2： | 0 |
| 14 | Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability显示文摘Metastasis is crucial for the mortality of non-small cell lung carcinoma(NSCLC) patients.The epithelial-mesenchymal transition(EMT) plays a critical role in regulating tumor metastasis.Glioma-associated oncogene 1(Gli1) is aberrantly active in a series of tumor tissues. However, the molecular regulatory relationships between Gli1 and NSCLC metastasis have not yet been identified. Herein,we reported Gli1 promoted NSCLC metastasis. High Gli1 expression was associated with poor survival of NSCLC patients. Ectopic expression of Gli1 in low metastatic A549 and NCI-H460 cells enhanced their migration, invasion abilities and facilitated EMT process, whereas knock-down of Gli1 in high metastatic NCI-H1299 and NCI-H1703 cells showed an opposite effect. Notably, Gli1 overexpression accelerated the lung and liver metastasis of NSCLC in the intravenously injected metastasis model. Further research showed that Gli1 positively regulated Snail expression by binding to its promoter and enhancing its protein stability, thereby facilitating the migration, invasion and EMT of NSCLC. In addition, administration of GANT-61, a Gli1 inhibitor, obviously suppressed the metastasis of NSCLC. Collectively, our study reveals that Gli1 is a critical regulator for NSCLC metastasis and suggests that targeting Gli1 is a prospective therapy strategy for metastatic NSCLC. | Xueping Lei Zhan Li Yihang Zhong Songpei Li Jiacong Chen Yuanyu Ke Sha Lv Lijuan Huang Qianrong Pan Lixin Zhao Xiangyu Yang Zisheng Chen Qiudi Deng Xiyong Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 0 |
| 15 | E3 ligase MG53 suppresses tumor growth by degrading cyclin D1显示文摘Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.In particular,the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only the pathogenesis of malignancies but also the refractory to cancer treatment regiments with CDK4/6 inhibitors.Here we show that in colorectal and gastric cancer patients,MG53 is downregulated in more than 80%of tumors compared to the normal gastrointestinal tissues from the same patient,and the reduced MG53 expression is correlated with increased cyclin D1 abundance and inferior survival.Mechanistically,MG53 catalyzes the K48-linked ubiquitination and subsequent degradation of cyclin D1.Thus,increased expression of MG53 leads to cell cycle arrest at G1,and thereby markedly suppresses cancer cell proliferation in vitro as well as tumor growth in mice with xenograft tumors or AOM/DSS induced-colorectal cancer.Consistently,MG53 deficiency results in accumulation of cyclin D1 protein and accelerates cancer cell growth both in culture and in animal models.These findings define MG53 as a tumor suppressor via facilitating cyclin D1 degradation,highlighting the therapeutic potential of targeting MG53 in treating cancers with dysregulated cyclin D1 turnover. | Meng Fang Hong-Kun Wu Yumeng Pei Yan Zhang Xiangyu Gao Yanyun He Gengjia Chen Fengxiang Lv Peng Jiang Yumei Li Wenwen Li Peng Jiang Lin Wang Jiafu Ji Xinli Hu Rui-Ping Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 16 | Photochemical graft of γ-cyclodextrin's interior leading to in-situ charge-transfer complexes with unusual regioselectivity and its application in 3D photo-printing显示文摘Photoirradiation of anthraquinone(AQ)derivatives withγ-cyclodextrin(γ-CD)in aqueous solution led to aγ-CD derivative with a 9,10-dihydroxylanthracene grafting unprecedentedly at the 5′-position of one glucoside ofγ-CD in high efficiency.Meanwhile,another AQ enters into the remaining space of the 9,10-dihydroxylanthracene-occupiedγ-CD cavity to in-situ form a selfincluded quinhydrone charge transfer(CT)complex.The structure of the supramolecular CT complex was unambiguously demonstrated by 1 D and 2 D NMR(^(1)H NMR,^(13)C NMR,DEPT,^(1)H-^(1)H COSY,HSQC,HMBC,TOCSY,and ROESY)spectroscopies,which revealed a highly stereoselective stacking of the quinhydrone pairs in theγ-CD cavity.The supramolecular CT complex showed an unusually high binding affinity and improved oxidation resistance.Polyacrylamides bearingγ-CD or anthraquinone were respectively synthesized by co-polymerization of acrylamide with the corresponding monomer.Photoirradiation of aqueous mixtures containing these two types of polymers led to gelation,which was applied to 3 D photo-printing of soft materials. | Dongjing Zhang Wenting Liang Jigao Yi Jinlei Chen Yongjun Lv Ting Zhao Chao Xiao Xiangyu Xie Wanhua Wu Cheng Yang | 2022 | Science China Chemistry2022，65，6： | 0 |
| 17 | Ancestral function but divergent epigenetic regulation of HAIKU2 reveals routes of seed developmental evolution显示文摘Evolution is driven by various mechanisms.A directional increase in the embryo to endosperm ratio is an evolutionary trend within the angiosperms.The endosperm constitutes a major portion of the seed volume in Poales and some dicots.However,in other dicots such as Arabidopsis and soybean,the endosperm proliferates early,followed by embryo growth to replace the endosperm.The Arabidopsis leucine-rich repeat receptor protein kinase AtHAIKU2(AtIKU2)is a key regulator of early endosperm proliferation.In this study,we found that IKU2s from Brachypodium,rice,and soybean can complement the abnormal seed developmental phenotype of Atiku2,while AtIKU2 also rescues the defective endosperm proliferation in the Brachypodium BdIKU2 knockout mutant seeds.AtIKU2 and soybean GmIKU2 are actively expressed a few days after fertilization.Thereafter,expression of AtIKU2 is suppressed by the FIS-PRC2 complex-mediated H3K27me3.The soybean GmIKU2 locus is also enriched with H3K27me3 marks.The histone methyltransferase AtMEA is unique to Brassicaceae,but one GmSWN in soybean plays a similar role in seed development as AtMEA.By contrast,the BdIKU2 and rice OsIKU2 loci are continuously expressed and are devoid of H3K27me3 marks.Taken together,these results suggest that IKU2 genes retain an ancestral function,but the duration of their expression that is controlled by PRC2-mediated epigenetic silencing contributes to silenced or persistent endosperm proliferation in different species.Our study reveals an epigenetic mechanism that drives the development of vastly different seed ontogenies. | Di Wu Yiming Wei Xiangyu Zhao Boka Li Huankai Zhang Gang Xu Juntong Lv Dajian Zhang Xiansheng Zhang Min Ni | 2022 | Molecular Plant2022，15，10： | 0 |
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