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| 1 | The combined effects of the ENSO and the Arctic Oscillation on the winter climate anomalies in East Asia显示文摘With the warm/cold phases of the El Ni o and Southern Oscillation (ENSO) as a background, the impacts of monthly variation in the Arctic Oscillation (AO) on the winter climate anomalies in East Asia are studied with the NCEP/DOE Reanalysis 2 data and the Chinese station data regarding temperature and rainfall. The combined effects of ENSO and the AO indicate that the winter climate anomalies are mainly influenced by the AO in northern China and the ENSO in southern China, when an El Ni o couples with a negative AO month or a La Ni a couples with a positive AO month. These climate anomalies in China are consistent with the mechanisms proposed in previous studies. However, most of China presents a different pattern of climate anomalies if an El Ni o couples with a positive AO month or a La Ni a couples with a negative AO month, with the exception of the temperature anomalies in northern China, which are still affected dominantly by the AO. Further analysis suggests that the causes are attributed to the differences in both the stratosphere-troposphere interaction and the extratropics-tropics interaction. In the former cases, zonal symmetric circulation prevails in the winter and the extratropics-tropics interaction is weakened. Thus, the influences of the ENSO and the AO on the East Asian climate mainly present linear combination effects. On the contrary, an annular mode of atmospheric circulation is not favored in the latter cases and the extratropics-tropics interaction is strong. Hence, the combined effects of the ENSO and the AO on the winter climate in East Asia present nonlinear characteristics. | CHEN Wen LAN XiaoQing WANG Lin MA Yin | 2013 | Chinese Science Bulletin2013，58，12： | 30 |
| 2 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044sfppbnxnfb6096kfv.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 3 | Quasi-stationary planetary wave-mean flow interactions in the Northern Hemisphere stratosphere and their responses to ENSO events显示文摘Based on the ERA-40 reanalysis data from the European Centre for Medium-Range Weather Forecasts and the output of ECHAM5/MPI-OM, this study investigated the interactions between the quasi-stationary planetary wave (SPW) and mean flow, and their responses to El Ni o-Southern Oscillation (ENSO) events in the northern hemispheric stratosphere. Results show that the activity of SPW is the strongest in winter, when the SPW propagates along the polar waveguide into the stratosphere and along the low-latitude waveguide to the subtropical tropopause. The analysis of three dimensional SPW structure indicates that the main sources of SPW activity are located over the Eurasian continent and the North Pacific north of 45°N. On the one hand, the two waveguides of the SPW reflect the influence of mean flow on the propagation of the SPW. On the other hand, the upward propagating SPW can interact with the stratospheric mean flow, leading to deceleration of the zonal mean westerly. Furthermore, the SPW exhibits clear responses to ENSO events. During El Ni o winters, the SPW in the stratosphere tends to propagate more upward and poleward. Its interactions with mean flow can induce a dipole pattern in zonal mean zonal winds, with accelerated westerly winds at low-middle latitudes and decelerated westerly winds at high latitudes. The ECHAM5/MPI-OM model reproduces the climatology of the SPW well. Although the simulated SPW is slightly weaker than the observations in the stratosphere, the model's performance has significant improvements compared with other GCMs used in previous studies. However, there are still some problems in the responses of the SPW to ENSO in the model. Although the model reproduces the responses of both the amplitude and the SPW-mean flow interactions to ENSO well in the troposphere, the stratospheric responses are quite weak. Therefore, further studies are needed to improve the simulation of the stratospheric atmospheric circulation and related dynamical processes. | LAN XiaoQing CHEN Wen WANG Lin | 2012 | Science China Earth Sciences2012，55，3： | 6 |
| 4 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 5 | Long-Term Trend in Potential Vorticity Intrusion Events over the Pacific Ocean: Role of Global Mean Temperature Rise显示文摘In this study, we examine a long-term increasing trend in subtropical potential vorticity(PV) intrusion events over the Pacific Ocean in relation to the global mean temperature rise, based on multiple reanalysis datasets. The frequency of the PV intrusions is closely related to the upper-tropospheric equatorial westerly duct and the subtropical jet(STJ). An overall strengthening of the westerly duct and weakening of the STJ are found to be driven by the warming-induced strengthening of Walker circulation and regional changes in Hadley circulation on multi-decadal timescale, leading to an increase in the PV intrusion frequency over the tropics. The results are robust in all datasets.The multi-decadal strengthening in the Pacific Walker circulation is consistent with the global mean temperature rise.In this way, the PV intrusions are correlated with the warming related global mean temperuate rise. When the interannual variability of ENSO is removed from the intrusion time series, the long-term trend in PV intrusions due to external forcing associated with anthropogenic warming(global mean temperature rise) becomes clearer. The link between the global mean temperature rise and intrusion frequency is further verified by performing a correlation analysis between the two. The significant(> 95%) correlation coefficient is 0.85, 0.94, 0.84, 0.83, and 0.84 for ERA-40,ERA-Interim, NCEP-NCAR, JRA-55, and JRA-25, respectively. This unequivocally indicates that the global mean temperature rise can explain around 69%–88% of the variance related to the long-term increase in PV intrusion frequency over the Pacific Ocean. | Debashis NATH Wen CHEN Xiaoqing LAN | 2017 | Journal of Meteorological Research2017，31，5： | 1 |
| 6 | Exopolysaccharides from lactic acid bacteria,as an alternative to antibiotics,on regulation of intestinal health and the immune system显示文摘Over-use or misuse of antibiotics in livestock and poultry production contributes to the rising threat of antibiotic resistance in animals and has negative ecological effects.Exopolysaccharides from lactic acid bacteria(LAB-EPS)are a class of biological macromolecules which are secreted by lactic acid bacteria to the outside of the cell wall during their growth and metabolism.Numerous studies demonstrated that LAB-EPS have anti-inflammatory and antimicrobial activities and are able to regulate intestinal health and the immune system in livestock.They are biodegradable,nontoxic and bio-compatible,which are considered as ideal alternatives to antibiotics.This review aims to discuss and summarize recent research findings of LAB-EPS on regulation of intestinal health and the immune system in animals,and thus provide scientific justification for commercial applications of LAB-EPS in livestock. | Shuo Yang Xiaoqing Xu Qing Peng Lan Ma Yu Qiao Bo Shi | 2023 | Animal Nutrition2023，，2： | 1 |
| 7 | Amygdalin attenuates PM2.5-induced human umbilical vein endothelial cell injury via the TLR4/NF-κB and Bcl-2/Bax signaling pathways显示文摘Mounting evidence supports that long-term exposure to fine particle pollutants(PM2.5)is closely implicated in cardiovascular diseases,especially atherosclerosis.Amygdalin is reported to attenuate external stimuli-induced cardiovascular diseases.However,the underlying mechanisms are still not understood.In this study,we aim to explore the protective effects of amygdalin on PM2.5-induced human umbilical vein endothelial cell(HUVEC)injury and unravel the specific mechanisms by MTT,DCFH-DA,biochemical,immunofluorescence,ELISA,RT-qPCR,flow cytometry,TUNEL and western blot analysis.The results reveal that amygdalin reverses PM2.5-induced cytotoxicity and attenuates intracellular ROS production.Moreover,amygdalin increases the levels of SOD and GSH and alleviates the MDA content.Additionally,amygdalin causes a decline of IL-6,IL-1β,TNF-αand COX-2 levels.Moreover,amygdalin inhibits NF-κB p50 and TLR4 protein expressions and NF-κB p65 nuclear translocation.Concomitantly,a decline of phospho-NF-κB p65/NF-κB p65 and phospho-IκB-α/IκB-αis detected.Meanwhile,amygdalin pretreatment reduces HUVEC apoptosis.In addition,amygdalin triggers an upregulation of Bcl-2 and a downregulation of Bax after stimulation with PM2.5.Collectively,these results suggest that amygdalin suppresses PM2.5-induced HUVEC injury by regulating the TLR4/NF-κB and Bcl-2/Bax signaling pathways,indicating that amygdalin may be a novel target for atherosclerosis treatments. | Bixu Wang Tong Sun Ling Sun Lan Li Haitong Wan Zhishan Ding Xiaoqing Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 1 |
| 8 | Effects of the Structure of Ce-Cu Catalysts on the Catalytic Combustion of Toluene in Air显示文摘 | Zhou Guilin Lan Han Yang Xiaoqing | 2013 | Ceram Int2013，39，4： | 1 |
| 9 | A Comparative Study on the Effects of Excess Iodine and Herbs with Excess Iodine on Thyroid Oxidative Stress in Iodine-Deficient Rats显示文摘 | Tianshu Gao Rui Shi Tengche Qi Huisi Yin Lan Mei Xiaoqing Han Peng Cui | 2014 | Biological Trace Element Research2014，，： | 1 |
| 10 | Agonist-induced Formation of Opioid Receptor-G Protein-coupled Receptor K inase (GRK)-Gβγ Complex onMembrane Is Required for GRK2 Function in Vivo显示文摘 | Jiali Li Bin Xiang Wenjuan Su Xiaoqing Zhang Yalin Huang Lan Ma | 2005 | 中国生物学文摘2005，19，8： | 0 |
| 11 | Assembling Superfine Bi_(3)TaO_(7) Particles into 2D Fe_(2)O_(3) Nanosheets for Enhanced Usability to Aqueous Tetracycline Residues显示文摘Composites of 2D/0D Fe_(2)O_(3)-Bi_(3)TaO_(7)(FO-BTO)prepared by a hydrothermal method in which superfine Bi_(3)TaO_(7) particles were mounted onto lamellae of Fe_(2)O_(3) sheets could efficiently remove aqueous tetracycline(TC)residues.The optimal composite FO-3BTO had a TC removal rate of 95%in 120 min under solar light,and its overall properties were better than those of reported photocatalysts.According to XRD,HRTEM,XPS,SEM,PL,EIS,and photocurrent tests,Fe_(2)O_(3) and Bi_(3)TaO_(7) composites formed on effective S-scheme heterojunctions,and the tight contact structure contributed to the increase in efficiency of aqueous TC residue removal. | Liu Xiaoqing Cheng Hongjun Wang Zisha Zhang Jian Lan Yanhua Wang Xiaojing | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 12 | Graphene oxide and mineralized collagen-functionalized dental implant abutment with effective soft tissue seal and romotely repeatable photodisinfection显示文摘Grasping the boundary of antibacterial function may be better for the sealing of soft tissue around dental implant abutment.Inspired by‘overdone is worse than undone’,we prepared a sandwich-structured dental implant coating on the percutaneous part using graphene oxide(GO)wrapped under mineralized collagen.Our unique coating structure ensured the high photothermal conversion capability and good photothermal stability of GO.The prepared coating not only achieved suitable inhibition on colonizing bacteria growth of Streptococcus sanguinis,Fusobacterium nucleatum and Porphyromonas gingivalis but also disrupted the wall/membrane permeability of free bacteria.Further enhancements on the antibacterial property were generally observed through the additional incorporation of dimethylaminododecyl methacrylate.Additionally,the coating with sandwich structure significantly enhanced the adhesion,cytoskeleton organization and proliferation of human gingival fibroblasts,which was effective to improve soft tissue sealing.Furthermore,cell viability was preserved when cells and bacteria were cultivated in the same environment by a coculture assay.This was attributed to the sandwich structure and mineralized collagen as the outmost layer,which would protect tissue cells from photothermal therapy and GO,as well as accelerate the recovery of cell activity.Overall,the coating design would provide a useful alternative method for dental implant abutment surface modification and functionalization. | Yichun Gao Ke Kang Bin Luo Xiaoqing Sun Fang Lan Jing He Yao Wu | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 13 | Pyrolysis Mechanism of a Cyclotriphosphazene-Based Flame-Retardant Epoxy Resin by ReaxFF Molecular Dynamics显示文摘Cyclotriphosphazene derivatives can effectively improve the flame retardancy and fire safety of epoxy resins(EPs)via their influence on the pyrolysis process.In this work,the effects of hexa(5-methyl-2-pyridinoxyl)cyclotriphosphazene(HMPOP)incorporation on the initial pyrolysis of an EP at 500–3500 K were studied using the ReaxFF method.The pyrolysis fragments,initial reaction pathways,and main products were identified for the EP and EP/HMPOP composites.The activation energies were derived by fitting the weight percentage curves for solid species during the pyrolysis reactions and the obtained values were in good agreement with experimental data.The initial EP pyrolysis reactions included four major decomposition modes,which primarily involved the cleavage of C–O and C–N bonds.The main pyrolysis products were H_(2)O,CO,C_(2)H_(4),and CH_(2)O.HMPOP bonded with the oxygen-containing fragments to form larger molecular fragments and reduced the amounts of C_(0)–C_(4) products,especially that of the harmful gas CH_(2)O.Thus,HMPOP promoted the formation of carbon clusters and reduced the generation of combustible gases,ultimately decreasing the capacity for fire propagation. | Jiang Shuaijun Meng Weifeng Wan Yongqing Qin Weihua Liu Xiaoqing Lan Yanhua | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，3： | 0 |
| 14 | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine显示文摘Persistent asymptomatic(PA)SARS-CoV-2 infections have been identified.The immune responses in these patients are unclear,and the development of effective treatments for these patients is needed.Here,we report a cohort of 23 PA cases carrying viral RNA for up to 191 days.PA cases displayed low levels of inflammatory and interferon response,weak antibody response,diminished circulating follicular helper T cells(cTfh),and inadequate specific CD4+and CD8+T-cell responses during infection,which is distinct from symptomatic infections and resembling impaired immune activation.Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses,resulting in successful viral clearance.Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months,indicating long-term protection.Therefore,our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections. | Shaofu Qiu Zhao Chen Airu Zhu Qiuhui Zeng Hongbo Liu Xiaoqing Liu Feng Ye Yingkang Jin Jie Wu Chaojie Yang Qi Wang Fangli Chen Lan Chen Sai Tian Xinying Du Qingtao Hu Jinling Cheng Canjie Chen Fang Li Jing Sun Yanqun Wang Jingxian Zhao Jincun Zhao Hongbin Song | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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