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| 1 | Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention显示文摘 | Li-Ye Wei Xiang-Hua Fu Wei Li Xi-Le Bi Shi-Ru Bai Kun Xing Yan-Bo Wang | 2015 | Chinese Medical Journal2015，，9： | 27 |
| 2 | Yield-related QTLs and Their Applications in Rice Genetic Improvement显示文摘Grain yield is one of the most important indexes in rice breeding,which is governed by quantitative trait loci (QTLs).Different map-ping populations have been used to explore the QTLs controlling yield related traits.Primary populations such as F 2 and recombi-nant inbred line populations have been widely used to discover QTLs in rice genome-wide,with hundreds of yield-related QTLs detected.Advanced populations such as near isogenic lines (NILs) are efficient to further fine-map and clone target QTLs.NILs for primarily identified QTLs have been proposed and confirmed to be the ideal population for map-based cloning.To date,20 QTLs directly affecting rice grain yield and its components have been cloned with NIL-F 2 populations,and 14 new grain yield QTLs have been validated in the NILs.The molecular mechanisms of a continuously increasing number of genes are being unveiled,which aids in the understanding of the formation of grain yield.Favorable alleles for rice breeding have been 'mined' from natural cultivars and wild rice by association analysis of known functional genes with target trait performance.Reasonable combination of favorable alleles has the potential to increase grain yield via use of functional marker assisted selection. | Xufeng Bai | 2012 | Journal of Integrative Plant Biology2012，54，5： | 22 |
| 3 | Relative apparent diffusion coefficient: a promising tool to differentiate metastatic from benign lymph nodes in animal models显示文摘背景散开加权的成像广泛地被用来区分 lymphadenopathy 的特性。但是优先的研究之间有重要差别。学习的目的是在二个观察员独立地测量了的兔子 model.Methods 在变形、良性的淋巴节点的区别比较明显的散开系数(模数转换器) 和 rADC 的利益在有兴趣(ROI ) 的区域的不同尺寸的散开加权的图象上的每只兔子的四头肌的模数转换器。为 rADC 的适当 ROI 用 interobserver 系数被决定。rADC 被 ADClesion/ADCreference 地点计算。接收装置操作特征(巨鸟) 分析被执行在区分比较 ADC 值的诊断的值和 rADC 值从良性的淋巴 nodes.Results 变形当 ROI 包括了五个象素时, ICC 是 0.816,显示一个好 interobserver 协议。在变形、良性的淋巴节点之间的模数转换器和 rADC 价值的差别两个都是统计上重要的。在 ROC 曲线下面的区域比为 ADC 为 rADC 是更大的。与 0.640 的 rADC 标准,为区分的敏感和特性从良性的淋巴节点变形是 93 和 90,是的 respectively.Conclusion 一个参考地点,肌肉用小 ROI 揭示好重覆性, rADC 可以为在动物模型检测变形节点改进诊断精确性。 | XING Wei SHENG Jing CHEN Jie TIAN Jian-ming BI Heng-liang | 2011 | Chinese Medical Journal2011，，18： | 11 |
| 4 | Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats显示文摘Objective This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats. Methods Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid(TUDCA), and all of them were treated with 5-20 μmol/kg cadmium(Cd) for 48 h. The oxidative stress levels were analyzed using kits. The mRNA and protein expression levels of endoplasmic reticulum stress-related factors and Nrf2 signaling pathway-related factors were determined using RT-PCR and western blot. Results Cd exposure resulted in oxidative stress in the kidneys of rats and upregulated the expression of endoplasmic reticulum stress(ERS)-related factors and Nrf2 signaling pathway-related factors, especially at doses of 10 and 20 μmol/kg Cd, and the expression changes were particularly obvious. Moreover, after pretreatment with bacitracin, Cd upregulated the expression of ERS-related factors to a certain extent and, at higher doses, increased the mRNA expression of Nrf2. After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the transcriptional expression of phase II detoxification enzymes under these experimental conditions. ERS has a positive regulation effect on Nrf2 signaling pathway but has little effect on the negative regulation of Nrf2 signaling pathway in cadmium toxicity. | CHEN Zhi Jian CHEN Jia Xing WU Li Kang LI Bi Yun TIAN Ya Feng XIAN Min HUANG Zi Pei YU Ri An | 2019 | Biomedical and Environmental Sciences2019，32，1： | 6 |
| 5 | Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015显示文摘A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015.Based on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin.The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of Africa.The affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean flyways.These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans. | Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao | 2016 | Virologica Sinica2016，31，4： | 5 |
| 6 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 7 | Surface charge accumulation and preflashover characteristics induced by metal particles on the insulator surfaces of 1100 kV GILs under AC voltage显示文摘With the increase in the voltage and capacitance of gas-insulated transmission lines(GILs),the insulation failure of GIL has attracted more and more attention.Further understanding of the partial discharge(PD)and flashover characteristics of metal particles on the insulator surface,as well as the flashover mechanism,is necessary to reduce the failure rate and improve the reliability of the equipment.In this study,an ultra-high voltage(UHV)AC insulator PD test and measurement system based on the cross-reference pulse current(PC)and ultra-high frequency(UHF)methods were established.The PD development and flashover characteristics of 5 mm-long metal particles at different positions on the surface of a UHV AC insulator,as well as the surface charge accumulation,were studied.The results show that the discharge of millimetre-scale metal particles on the insulator surface under PD test conditions is relatively low(generally lower than 2PC),and it is difficult to be detected by the conventional PC and UHF methods due to their insufficient sensitivity.Moreover,it is found that the weak PDs of the millimetrescale metal particles will result in a charge accumulation on the insulator surface under AC voltage,which eventually will lead to the insulator flashover.The PDs of the UHV AC insulator before flashover are generally small,which will make it difficult for online monitoring systems to give an effective alarm before flashover. | Li Xing Liu Weidong Xu Yuan Chen Weijiang Bi Jiangang | 2020 | High Voltage2020，5，2： | 4 |
| 8 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 9 | Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and activating KATP channels显示文摘 | Hong-yan LING Guang WANG Wei ZHANG Xing LI Shou-hong ZHOU Bi HU | 2012 | Acta Pharmacologica Sinica2012，33，8： | 4 |
| 10 | Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied. | XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 11 | Fluorescence polarization assay improves the rapid detection of human brucellosis in China显示文摘Background:Brucellosis is an infectious-allergic zoonotic disease caused by bacteria of the genus Brucella.Early diagnosis is the key to preventing,treating,and controlling brucellosis.Fluorescence polarization immunoassay(FPA)is a new immunoassay for relatively rapid and accurate detection of antibodies or antigens based on antigen-antibody interaction.However,there is no report on FPA-based detection of human brucellosis in China.Therefore,this study is to evaluate the value of FPA for the diagnosis of human brucellosis in China. | Shuai-Bing Dong Di Xiao Jing-Yao Liu Hui-Mei Bi Zun-Rong Zheng Li-Da Wang Xiao-Wen Yang Guo-Zhong Tian Hong-Yan Zhao Dong-Ri Piao Zhi-Feng Xing Hai Jiang | 2021 | Infectious Diseases of Poverty2021，10，2： | 3 |
| 12 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 13 | Rapid detection of intestinal pathogens in fecal samples by an improved reverse dot blot method显示文摘AIM:To develop a new, rapid and accurate reverse dot blot(RDB) method for the detection of intestinal pathogens in fecal samples.METHODS:The 12 intestinal pathogens tested were Salmonella spp., Brucella spp., Escherichia coli O157:H7, Clostridium botulinum , Bacillus cereus , Clostridium perfringens , Vibrio parahaemolyticus , Shigella spp., Yersinia enterocolitica, Vibrio cholerae, Listeria monocytogenes and Staphylococcus aureus.The two universal primers were designed to amplify two variable regions of bacterial 16S and 23S rDNA genes from all of the 12 bacterial species tested.Five hundred and forty fecal samples from the diarrhea patients were detected using the improved RDB assay.RESULTS:The methods could identify the 12 intestinal pathogens specifi cally, and the detection limit was as low as 103 CFUs.The consistent detection rate of the improved RDB assay compared with the traditional culture method was up to 88.75%.CONCLUSION:The hybridization results indicated that the improved RDB assay developed was a reliable method for the detection of intestinal pathogen in fecal samples. | Jian-Ming Xing Su Zhang Ying Du Dan Bi Li-Hui Yao | 2009 | World Journal of Gastroenterology2009，15，20： | 3 |
| 14 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 15 | Mesomorphous structure change by tail chain number in ionic liquid crystalline complexes of linear polymer and amphiphiles显示文摘Three polymer-amphiphile complexes were prepared by combining poly(allylamine hydrochloride)(PAH) with the potassium salt of mono-,di-,and trisubstituted benzoic acid dendrons(4-octyloxybenzoic acid,3,5-dioctyloxybenzoic acid,and 3,4,5- trioctyloxybenzoic acid).The solid structure and properties were monitored with FT-IR,XRD,TG,DSC,and polarized optical microscope(POM).Difference in the tail chain number of the dendritic amphiphile induced two different mesomorphous structures: lamella for the mono-,disubstituted dendron containing complexes and hexagonal column for the trisubstituted dendron containing complexes.These corresponded to the ionic thermotropic liquid crystal SmA andΦ_h phases,respectively.This finding is significant for design of functional nanostructures based on the ionic complexation of polymers and amphiphiles. | Zhi Yu Cheng Bi Ye Ren Shu Ying He Xin Xing Liu Zhen Tong | 2011 | Chinese Chemical Letters2011，22，11： | 2 |
| 16 | Clinical comparison of patients with benign urachal masses versus urachal carcinomas显示文摘The clinical features of 17 patients with benign urachal masses and 30 patients with urachal carcinoma treated at Sun Yat-sen University Cancer Center were analyzed retrospectively. Univariate analysis indicated that seven parameters difered signiicantly between the two groups. Binary logistic regression analyses showed that the rate of gross hematuria was signiicantly higher(P = 0.042, Exp[B] = 7.889) and the rate of fatty iniltration of the Retzius space was signiicantly lower(P = 0.006, Exp[B] = 0.028) in patients with urachal carcinoma than in those with benign urachal masses. Gross hematuria and fatty iniltration of the Retzius space may be indications of malignant and benign urachal masses, respectively. | Xing Bi Zhiming Wu Hui Han Fangjian Zhou | 2017 | Chinese Journal of Cancer2017，36，1： | 2 |
| 17 | Generation of Nb-enriched mafic rocks and associated adakitic rocks from the southeastern Central Asian Orogenic Belt:Evidence of crust-mantle interaction显示文摘Melting of subducting oceanic lithosphere and associated melt-mantle interactions in convergent plate margins require specific geodynamic environment that allows the oceanic slab to be abnormally heated.Here we focus on the Early Mesozoic mafic rocks and granite porphyry,which provide insights into slab melting processes associated with final closure of the Paleo-Asian Ocean.The granite porphyry samples are calc-alkaline and distinguished by high Sr contents,strong depletion of heavy rare earth elements,resulting in high(La/Yb);and Sr/Y ratios,and negligible Eu anomalies.Based on their high Na_(2)O and Mg O,low K_(2)O contents,positiveε_(Hf)(t)andε_(Nd)(t)and low(^(87)Sr/^(86)Sr)ivalues,we propose that the granite porphyry was likely derived from partial melting of subducting Paleo-Asian oceanic crust.The Nb-enriched mafic rocks are enriched in Rb,Th,U,Pb and K,and depleted in Nb,Ta,Ba,P and Ti,corroborating a subduction-related origin.Their heterogeneous Sr-Nd-Hf-O isotopic compositions and other geochemical features suggest that they were likely derived from partial melting of peridotitic mantle wedge interacted with oceanic slab-derived adakitic melts.Trace element and isotope modeling results and elevated zirconδ^(18)O values suggest variable subducting sediments input into the mantle wedge,dominated by terrigenous sediments.Synthesizing the widely-developed bimodal rock associations,conjugated dikes,thermal metamorphism,tectonic characteristics,paleomagnetic constraints,and paleogeographical evidence along the Solonke-Changchun suture zone,we identify a slab window triggered by slab break-off,which accounts for slab melting and formation of the Nb-enriched mafic rocks and associated adakitic granite porphyry in southeastern Central Asian Orogenic Belt. | Yan Jing Wenchun Ge M.Santosh Yu Dong Hao Yang Zheng Ji Junhui Bi Hongying Zhou Dehe Xing | 2022 | Geoscience Frontiers2022，13，2： | 2 |
| 18 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 19 | Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore显示文摘 | Tian Tian Xiaorun Li Yingying Liu Chengliang Wang Xing Liu Guoqiang Bi Xuan Zhang Xuebiao Yao Z Hong Zhou Jianye Zang | 2018 | Cell Research2018，28，3： | 2 |
| 20 | Felodipine Reduces Cardiac Expression of IL-18 and Perivascular Fibrosis in Fructose-Fed Rats显示文摘 | Shan-Shan XING Hong-Wei TAN Xiu-Ping BI | 2008 | Mol Med2008，14，78： | 1 |
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