|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 2 | Prehistoric agriculture development in the Yunnan-Guizhou Plateau, southwest China: Archaeobotanical evidence显示文摘The origin, development and expansion of prehistoric agriculture in East Asia have been widely investigated over the past two decades using archaeobotanical analysis from excavated Neolithic and Bronze Age sites. Research on prehistoric agriculture has predominantly focused in the valleys of the Yellow River and the Yangtze River. Agricultural development during the Neolithic and Bronze Age periods in the Yunnan-Guizhou Plateau of southwest China, an important passageway for human migration into Southeast Asia, still remains unclear. In this paper, based on macrofossil and microfossil analysis and radiocarbon dating at the Shilinggang site, we investigate plant subsistence strategies in the Nujiang River valley during the Bronze Age period. Combined with previous archaeobotanical studies in the Yunnan-Guizhou Plateau, we explore agricultural development processes in this area during the Neolithic and Bronze Age. Our results indicate that rice and foxtail millet were cultivated in Shilinggang around 2500 cal a BP. Three phases of prehistoric agricultural development in the Yunnan-Guizhou Plateau can be identified: rice cultivation from 4800–3900 cal a BP, mixed rice and millet crop(foxtail millet and broomcorn millet) cultivation from 3900–3400 cal a BP, and mixed rice, millet crop and wheat cultivation from 3400–2300 cal a BP. The development of agriculture in the Yunnan-Guizhou Plateau during the Neolithic and Bronze Age periods was primarily promoted by prehistoric agriculture expansion across Eurasia, agricultural expansion which was also affected by the topographic and hydrological characteristics of the area. | LI HaiMing ZUO XinXin KANG LiHong REN LeLe LIU FengWen LIU HongGao ZHANG NaiMeng MIN Rui LIU Xu DONG GuangHui | 2016 | Science China Earth Sciences2016，59，8： | 6 |
| 3 | Population-level economic burden of lung cancer in China:Provisional prevalence-based estimations,2017-2030显示文摘Objective:Population-level economic burden is essential for prioritizing healthcare resources and healthcare budget making in the future.However,little is known about the economic burden of lung cancer in China.Methods:A prevalence-based approach was adopted to estimate the economic burden of lung cancer,including direct expenditure(medical and non-medical)and indirect cost(disability and premature death).Data on direct expenditure and work-loss days per patient in each year post-diagnosis were obtained from two primary surveys.Other parameters were obtained from literatures and official reports.Projections were conducted based on varying parameters.All expenditure data were reported in United States dollars(USD)using 2017 value(exchange rate:1 USD=6.760 CNY),with the discount rate of 3%.Results:The total economic burden of lung cancer was estimated to be 25,069 million USD in China in 2017(0.121%of gross domestic productivity,GDP).The estimated direct expenditure was 11,098 million USD,up to1.43%of total healthcare expenditure for China,covering 10,303 million USD and 795 million USD for medical and non-medical expenditure,respectively.The estimated indirect cost was 13,971 million,including 1,517 million USD due to disability and 12,454 million USD due to premature death.Under current assumptions,the projected total economic burden would increase to 30.1 billion USD,40.4 billion USD,and 53.4 billion USD in 2020,2025,and 2030,accounting for 0.121%,0.131%,and 0.146%of China's GDP,respectively.However,if China meets the United Nation sustainable development goal of reducing premature death from non-communicable diseases by one-third by 2030,the total economic burden in 2030 would be 31.9 billion USD,0.087%of China's GDP.Conclusions:The economic burden of lung cancer in China in 2017 is substantial and more likely to increase significantly in the future.Policy makers need to take urgent actions in budget making for health systems.The economic burden could be alleviated by reducing the disease burden of lung cancer via effective control and prevention actions. | Chengcheng Liu Jufang Shi Hong Wang Xinxin Yan Le Wang Jiansong Ren Mark Parascandola Wanqing Chen Alin Dai | 2021 | Chinese Journal of Cancer Research2021，33，1： | 6 |
| 4 | Mandible exosomal ssc-mir-133b regulates tooth development in miniature swine via endogenous apoptosis显示文摘Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs(miRNAs), from donors to receptors.MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b. Upregulation of ssc-mir-133b resulted in robust apoptosis in primary dental mesenchymal cells in the maxillofacial region. Cell leukemia myeloid 1(Mcl-1) was verified as the functional target, which triggered further downstream activation of endogenous mitochondria-related apoptotic processes during tooth development.More importantly, mandible exosomes were responsible for the initial apoptosis signal. An animal study demonstrated that ectopic expression of ssc-mir-133 b resulted in failed tooth formation after 12 weeks of subcutaneous transplantation in nude mice. The tooth germ developed abnormally without the indispensable exosomal signals from the mandible. | Ye Li Xinxin Wang Jiali Ren Xiaoshan Wu Guoqing Li Zhipeng Fan Chunmei Zhang Ang Li Songlin Wang | 2018 | Bone Research2018，6，4： | 5 |
| 5 | A review on the electric vehicle routing problems: Variants and algorithms显示文摘Over the past decade,electric vehicles(EVs)have been considered in a growing number of models and methods for vehicle routing problems(VRPs).This study presents a comprehensive survey of EV routing problems and their many variants.We only consider the problems in which each vehicle may visit multiple vertices and be recharged during the trip.The related literature can be roughly divided into nine classes:Electric traveling salesman problem,green VRP,electric VRP,mixed electric VRP,electric location routing problem,hybrid electric VRP,electric dial-a-ride problem,electric two-echelon VRP,and electric pickup and delivery problem.For each of these nine classes,we focus on reviewing the settings of problem variants and the algorithms used to obtain their solutions. | Hu QIN Xinxin SU Teng REN Zhixing LUO | 2021 | Frontiers of Engineering Management2021，8，3： | 3 |
| 6 | Numerical analysis of enhanced mixing in a Gallay tote blender显示文摘 | Xinxin Ren Guangzheng Zhou Ji xu Lijie Cui Wei Ge | 2016 | Particuology2016，14，6： | 3 |
| 7 | Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells显示文摘Cytochrome P450(CYP)enzymes metabolize numerous endogenous substrates,such as retinoids,androgens,estrogens and vitamin D,that can modulate important cellular processes,including proliferation,differentiation and apoptosis.The aim of this study is to characterize the expression of CYP genes in CD34+human cord blood hematopoietic stem and early progenitor cells(CBHSPCs)as a first step toward assessment of the potential biological functions of CYP enzymes in regulating the expansion or differentiation of these cells.CD34+CBHSPCs were purified from umbilical cord blood via antibody affinity chromatography.Purity of CD34+CBHSPCs was assessed using fluorescence-activated cell sorting.RNA was isolated from purified CD34+CBHSPCs and total mononuclear cells(MNCs)for RNA-PCR analysis of CYP expression.Fourteen human CYPs were detected in the initial screening with qualitative RT-PCR in CD34+CBHSPCs.Further quantitative RNA-PCR analysis of the detected CYP transcripts yielded evidence for preferential expression of CYP2R1 in CD34+CBHSPCs relative to MNCs;and for greater expression of CYP1B1 in MNCs relative to CD34+CBHSPCs.These findings provide the basis for further studies on possible functions of CYP2R1 and CYP1B1 in CBHSPCs'proliferation and/or differentiation and their potential utility as targets for drugs designed to modulate CD34+CBHSPC expansion or differentiation. | Shuoqi Xu Zhihua Ren Yanan Wang Xinxin Ding Yongping Jiang | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 2 |
| 8 | Recent Advances of Transition Metal Basic Salts for Electrocatalytic Oxygen Evolution Reaction and Overall Water Electrolysis显示文摘Electrocatalytic oxygen evolution reaction(OER)has been recognized as the bottleneck of overall water splitting,which is a promising approach for sustainable production of H_(2).Transition metal(TM)hydroxides are the most conventional and classical non-noble metal-based electrocatalysts for OER,while TM basic salts[M^(2+)(OH)_(2-x)(A_(m^(-))_(x/m),A=CO_(3)^(2−),NO_(3)^(−),F^(−),Cl^(−)]consisting of OH−and another anion have drawn extensive research interest due to its higher catalytic activity in the past decade.In this review,we summarize the recent advances of TM basic salts and their application in OER and further overall water splitting.We categorize TM basic salt-based OER pre-catalysts into four types(CO_(3)^(2−),NO_(3)^(−),F^(−),Cl^(−)according to the anion,which is a key factor for their outstanding performance towards OER.We highlight experimental and theoretical methods for understanding the structure evolution during OER and the effect of anion on catalytic performance.To develop bifunctional TM basic salts as catalyst for the practical electrolysis application,we also review the present strategies for enhancing its hydrogen evolution reaction activity and thereby improving its overall water splitting performance.Finally,we conclude this review with a summary and perspective about the remaining challenges and future opportunities of TM basic salts as catalysts for water electrolysis. | Bingrong Guo Yani Ding Haohao Huo Xinxin Wen Xiaoqian Ren Ping Xu Siwei Li | 2023 | Nano-Micro Letters2023，15，4： | 2 |
| 9 | Applying artificial intelligence for cancer immunotherapy显示文摘Artificial intelligence(AI)is a general term that refers to the use of a machine to imitate intelligent behavior for performing complex tasks with minimal human intervention,such as machine learning;this technology is revolutionizing and reshaping medicine.AI has considerable potential to perfect health-care systems in areas such as diagnostics,risk analysis,health information administration,lifestyle supervision,and virtual health assistance.In terms of immunotherapy,AI has been applied to the prediction of immunotherapy responses based on immune signatures,medical imaging and histological analysis.These features could also be highly useful in the management of cancer immunotherapy given their ever-increasing performance in improving diagnostic accuracy,optimizing treatment planning,predicting outcomes of care and reducing human resource costs.In this review,we present the details of AI and the current progression and state of the art in employing AI for cancer immunotherapy.Furthermore,we discuss the challenges,opportunities and corresponding strategies in applying the technology for widespread clinical deployment.Finally,we summarize the impact of AI on cancer immunotherapy and provide our perspectives about underlying applications of AI in the future. | Zhijie Xu Xiang Wang Shuangshuang Zeng Xinxin Ren Yuanliang Yan Zhicheng Gong | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 2 |
| 10 | Effects of sulfide on microbial fuel cells with platinum and nitrogen-doped carbon powder cathodes显示文摘 | Yujie Feng Xinxin Shi Xin Wang He Lee Jia Liu Youpeng Qu Weihua He S.M. Senthil Kumar Byung Hong Kim Nanqi Ren | 2011 | Biosensors and Bioelectronics2011，，1： | 1 |
| 11 | Application of nitrogen-doped carbon powders as low-cost and durable cathodic catalyst to air–cathode microbial fuel cells显示文摘 | Xinxin Shi Yujie Feng Xin Wang He Lee Jia Liu Youpeng Qu Weihua He S.M. Senthil Kumar Nanqi Ren | 2011 | Bioresource Technology2011，，： | 1 |
| 12 | The effect of water proofing on the performance of nickel foam cathode in microbial fuel cells显示文摘 | Jia Liu Yujie Feng Xin Wang Qiao Yang Xinxin Shi Youpeng Qu Nanqi Ren | 2011 | Journal of Power Sources2011，，： | 1 |
| 13 | Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa显示文摘 | Ying Chen Yi-Qing Liu Ting Su Xiang Ren Li Shi Dazi Liu Jun Gu Qing-Yu Zhang Xinxin Ding | 2003 | Biochemical Pharmacology2003，，7： | 1 |
| 14 | Power generation using adjustable Nafion/PTFE mixed binders in air-cathode microbial fuel cells显示文摘 | Xin Wang Yujie Feng Jia Liu Xinxin Shi He Lee Nan Li Nanqi Ren | 2010 | Biosensors and Bioelectronics2010，，2： | 1 |
| 15 | Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamouscell carcinoma显示文摘 | Pengfei Ren Hua Ye Liping Dai Mei Liu Xinxin Liu Yurong Chai Qing Shao Yang Li Ningjing Lei Bo Peng Wu Yao Jianying Zhang | 2013 | Oncology Reports2013，，5： | 1 |
| 16 | An Analysis of the Patents concerning Hevea brasiliensis显示文摘This paper mainly analyzes the application data of patents concerning Hevea brasiliensis in the world and China from the perspectives of time,research field,and the geographical distribution of applicants. It also interprets the patents for invention in China from time,research field,and types of applicants. Based on the study,it shows that although the patent applications fluctuate,the general trend is rising. And the patents are mostly concentrated in plant protection,and agricultural biotechnology. The Chinese applicants of patents for invention largely work in the research institutes,and most of these patents focus on the field of plant protection,agricultural biotechnology,and agro-processing.However,the foreign applicants mainly work in companies,and most of these patents only focus on plant protection. These findings will provide a reference for formulating development policies about natural rubber industry in China. | Xijuan LI Qing CHEN Bingjiang XU Xinxin REN Huasun HUANG Qiong LI | 2015 | Asian Agricultural Research2015，7，9： | 0 |
| 17 | Coordinated transcriptional and post-transcriptional epigenetic regulation during skeletal muscle development and growth in pigs显示文摘Background:N6-methyladenosine(m^(6)A)and DNA 5-methylcytosine(5mC)methylation plays crucial roles in diverse biological processes,including skeletal muscle development and growth.Recent studies unveiled a potential link between these two systems,implicating the potential mechanism of coordinated transcriptional and post-transcrip-tional regulation in porcine prenatal myogenesis and postnatal skeletal muscle growth.Methods:Immunofluorescence and co-IP assays were carried out between the 5mC writers and m^(6)A writers to investigate the molecular basis underneath.Large-scale in-house transcriptomic data were compiled for applying weighted correlation network analysis(WGCNA)to identify the co-expression patterns of m^(6)A and 5mC regulators and their potential role in pig myogenesis.Whole-genome bisulfite sequencing(WGBS)and methylated RNA immu-noprecipitation sequencing(MeRIP-seq)were performed on the skeletal muscle samples from Landrace pigs at four postnatal growth stages(days 30,60,120 and 180).Results:Significantly correlated expression between 5mC writers and m^(6)A writers and co-occurrence of 5mC and m^(6)A modification were revealed from public datasets of C2C12 myoblasts.The protein-protein interactions between the DNA methylase and the m^(6)A methylase were observed in mouse myoblast cells.Further,by analyzing tran-scriptome data comprising 81 pig skeletal muscle samples across 27 developmental stages,we identified a 5mC/m^(6)A epigenetic module eigengene and decoded its potential functions in pre-or post-transcriptional regulation in postnatal skeletal muscle development and growth of pigs.Following integrative multi-omics analyses on the WGBS methylome data and MeRIP-seq data for both m^(6)A and gene expression profiles revealed a genome/transcriptome-wide correlated dynamics and co-occurrence of 5mC and m^(6)A modifications as a consequence of 5mC/m^(6)A crosstalk in the postnatal myogenesis progress of pigs.Last,we identified a group of myogenesis-related genes collaboratively regulated by both 5mC and m^(6)A modifications in postnatal skeletal muscle growth in pigs.Conclusions:Our study discloses a potential epigenetic mechanism in skeletal muscle development and provides a novel direction for animal breeding and drug development of related human muscle-related diseases. | Du Zhang Shumei Wu Xinxin Zhang Shuqiang Ren Zhonglin Tang Fei Gao | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 0 |
| 18 | Structural basis of INTAC-regulated transcription显示文摘DearEditor,Eukaryotic transcription by RNA polymerase I(Pol I)is a strictly regulated process that involves the interplay of numerous factors.Promoter-proximal pausing is a regulatory mechanism that connects transcription initiation and productive elongation in metazoans(Core and Adelman,2019).Pol II forms a paused elongation complex(PEC)through binding of two transcriptional regulation factors DSIF and NELF(Vos et al.,2018).Following the duration of pausing,Pol II either proceeds into productive elongation or undergoes promoter-proximal premature transcription termination(PTT)(Kamieniarz-Gdula and Proudfoot,2019),which plays a decisive role in determining transcriptional outputs. | Hai Zheng Qianwei Jin Xinxin Wang Yilun Qi Weida Liu Yulei Ren Dan Zhao Fei Xavier Chen Jingdong Cheng Xizi Chen Yanhui Xu | 2023 | Protein & Cell2023，14，9： | 0 |
| 19 | Metformin and Lactic Acidosis in Diabetic Patients显示文摘Metfommin is the basic drug in the clinical treatment of Diabetes,often used in the treatment of Type 2 Diabetes Mellitus(T2DM).Its effect has been fully verificd in the clinical treatment of T2DM.However,in the treatment of T2DM with metformin,there is still a certain probability of related lactic acidosis,and the fatality rate is high.Therefore,is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients?This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis,so as to further explore the relationship between metformin and lactic acidosis in diabetic patients,and provide help and reference for metformin drugs in the clinical treatment ofT2DM. | Baiyan Zhao Zhilu Li Zhangyi He Xinxin Zhou Yiying Yu Kerong Ren Pingping Yan | 2021 | Journal of Endocrinology Research2021，3，1： | 0 |
| 20 | Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response显示文摘Several types of modifications have been proven to participate in the metabolism and processing of different RNA types,including non-coding RNAs(ncRNAs).N-6-methyladenosine(m6A)is a dynamic and reversible RNA modification that is closely involved in the ncRNA homeostasis,and serves as a crucial regulator for multiple cancer-associated signaling pathways.The ncRNAs usually regulate the epigenetic modification,mRNA transcription and other biological processes,displaying enormous roles in human cancers.In this review,we summarized the significant implications of m6A-ncRNA interaction in various types of cancers.In particular,the interplay between m6A and ncRNAs in cancer pathogenesis and therapeutic resistance are being widely recognized.We also discussed the relevance of m6A-ncRNA interaction in immune regulation,followed by the interference on cancer immunotherapeutic procedures.In addition,we briefly highlighted the computation tools that could identify the accurate features of m6A methylome among ncRNAs.In summary,this review would pave the way for a better understanding of the biological functions of m6A-ncRNA crosstalk in cancer research and treatment. | Yuanliang Yan Jinwu Peng Qiuju Liang Xinxin Ren Yuan Cai Bi Peng Xi Chen Xiang Wang Qiaoli Yi Zhijie Xu | 2023 | Genes & Diseases2023，10，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员