|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice显示文摘Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important hormones.Strigolactones(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental processes.Genetical and chemical modulation of the SL pathway is recognized as a promising approach to modify plant architecture.However,whether and how the genes involved in the SL pathway could be utilized in breeding still remain elusive.Here,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in rice.We found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the 1960s.Understanding how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield. | Yuexing Wang Lianguang Shang Hong Yu Longjun Zeng Jiang Hu Shen Ni Yuchun Rao Sanfeng Li Jinfang Chu Xiangbing Meng Lei Wang Ping Hu Jijun Yan Shujing Kang Minghao Qu Hai Lin Tao Wang Quan Wang Xingming Hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao Guo Dali Zeng Xudong Zhu Guosheng Xiong Jiayang Li Qian Qian | 2020 | Molecular Plant2020，13，6： | 23 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | A Comparative Study on the Performance of Typical Types of Bionic Groove Dry Gas Seal based on Bird Wing显示文摘 | Jinbo Jiang Xudong Peng Jiyun Li Yuan Chen | 2016 | Journal of Bionic Engineering2016，13，2： | 15 |
| 5 | Application of thyristor controlled phase shifting transformer excitation impedance switching control to suppress short-circuit fault current level显示文摘Short-circuit fault current suppression is a very important issue in modern large-interconnected power networks. Conventional short-circuit current limiters, such as superconducting fault current limiters, have to increase additional equipment investments. Fast power electronics controlled flexible AC transmission system(FACTS)devices have opened a new way for suppressing the fault current levels, while maintaining their normal functionalities for steady-state and transient power system operation and control. Thyristor controlled phase shifting transformer(TCPST) is a beneficial FACTS device in modern power systems, which is capable of regulating regional powerflow. The mathematical model for TCPST under different operation modes is firstly investigated in this study. Intuitively, the phase shifting angle control can adjust the equivalent impedance of TCPST, but the effect has been demonstrated to be weak. Therefore, a novel transformer excitation impedance switching(EIS) control method, is proposed for fault current suppressing, according to the impedance characteristics of TCPST. Simulation results on IEEE 14-bus system have shown considerable current limiting characteristic of the EIS control under various fault types. Also, analysis of the timing requirement during fault interruption, overvoltage phenomenon, and ancillary mechanical support issues during EIS control is discussed,so as to implement the proposed EIS control properly for fast fault current suppression. | Jun LIU Xudong HAO Xu WANG Yefu CHEN Wanliang FANG Shuanbao NIU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，4： | 14 |
| 6 | A review on carrier aircraft dispatch path planning and control on deck显示文摘As an important part in sortie/recovery process,the dispatch of carrier aircraft not only affects the sortie/recovery efficiency and safety,but also has severe influence on the carrier's combat efficiency and the comprehensive support capability.Path planning is the key to improve the efficiency and safety during the dispatch process.The main purpose of this paper is to propose a comprehensive investigation of techniques and research progress for the carrier aircraft's dispatch path planning on the deck.Three different dispatch modes of carrier aircraft and the corresponding modeling technologies are investigated,and the aircraft's dispatch path planning techniques and algorithms have been classified into different classes.Moreover,their assumptions and drawbacks have been discussed for single aircraft and multiple aircraft.To make the research work more comprehensive,the corresponding tracking control methodologies are also discussed.Finally,due to the similarity of path planning problem between the carrier aircraft's dispatch and those in other fields,this paper provides an exploratory prospect of the knowledge or method learned from other fields. | Xinwei WANG Jie LIU Xichao SU Haijun PENG Xudong ZHAO Chen LU | 2020 | Chinese Journal of Aeronautics2020，33，12： | 14 |
| 7 | Toward a stepwise Kwangsian Orogeny显示文摘The Kwangsian Orogeny originated along the southeast coast of China and stepwise developed in a northwest direction.It includes two stages,a long locally varying uplift from the Late Ordovician to the early Silurian and a finally tectonic movement near the Silurian and Devonian transition.The Kwangsian uplift event shows a stepwise delay northwestwards from the southeastern coast area in Nemagraptus gracilis Biozone(Sa1)to the south side of the Xuefeng Mountains in or later than Cystograptus vesiculosus Biozone(R3)to Coronograptus cyphus Biozone(R4).In the southern of Yangtze Platform,the Yichang Uplift was droved by the Kwangsian Orogeny forming a diachronous stratigraphical break through Rhuddanian and Aeronian.The distribution of the early Telychian lower marine red beds indicates a northwestward increase of the Cathaysian Oldland.Stratigraphical evidence may explain why the Kwangsian movement was marked by an angular disconformity during the Pridoli to earliest Devonian interval. | CHEN Xu FAN JunXuan CHEN Qing TANG Lan HOU XuDong | 2014 | Science China Earth Sciences2014，57，3： | 13 |
| 8 | Laser performance of the SG-Ⅲ laser facility显示文摘SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Jingqin Su Kuixing Zheng Xiaodong Yuan Hai Zhou Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Xuewei Deng | 2016 | High Power Laser Science and Engineering2016，4，3： | 13 |
| 9 | Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility显示文摘The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng | 2017 | Matter and Radiation at Extremes2017，2，5： | 13 |
| 10 | First observations of low latitude whistlers using WHU ELF/VLF receiver system显示文摘The recently developed high-quality WHU ELF/VLF receiver system has been deployed in Suizhou, China(geomagnetic latitude 21.81°N, longitude 174.44°E, L=1.16) to detect low latitude extremely-low-frequency(ELF: 0.3-3 k Hz) and very-low-frequency(VLF: 3-30 k Hz) emissions originating from either natural or artificial sources since February 2016. During the first-month operation of the receiver system, a total of 3039 clear whistlers have been recorded at this low latitude station with the majority(97.0%) occurring on 28 February and 1 March 2016. Observed whistlers manifest various types including single one-hop, echo train, multi-flash, and multi-path. They tend to intensify after local midnight, reach the peak around 04-05 LT, and then weaken quickly. Both features of lower cutoff frequencies of most whistlers below ~1.6 k Hz and almost uniform dispersion for many successive multi-flash whistlers suggest that these whistlers propagate along the geomagnetic field lines in the duct mode. The computed dispersion varies between ~15 s^(1/2) and 23 s^(1/2) for observed one-hop whistlers and is greater than 50 s^(1/2) for three-hop echo train whistlers, indicating that the whistlers observed at the Suizhou station are low latitude whistlers. | CHEN YanPing NI BinBin GU XuDong ZHAO ZhengYu YANG GuoBin ZHOU Chen ZHANG YuanNong | 2017 | Science China(Technological Sciences)2017，60，1： | 12 |
| 11 | Gas Film Disturbance Characteristics Analysis of High-Speed and High-Pressure Dry Gas Seal显示文摘The dry gas seal(DGS) has been widely used in high parameters centrifugal compressor, but the intense vibrations of shafting,especially in high-speed condition, usually result in DGS's failure. So the DGS's ability of resisting outside interference has become a determining factor of the further development of centrifugal compressor. However, the systematic researches of which about gas film disturbance characteristics of high parameters DGS are very little. In order to study gas film disturbance characteristics of high-speed and high-pressure spiral groove dry gas seal(S-DGS) with a flexibly mounted stator, rotor axial runout and misalignment are taken into consideration, and the finite difference method and analytical method are used to analyze the influence of gas film thickness disturbance on sealing performance parameters, what's more, the effects of many key factors on gas film thickness disturbance are systematically investigated. The results show that, when sealed pressure is 10.1MPa and seal face average linear velocity is 107.3 m/s, gas film thickness disturbance has a significant effect on leakage rate, but has relatively litter effect on open force; Excessively large excitation amplitude or excessively high excitation frequency can lead to severe gas film thickness disturbance; And it is beneficial to assure a smaller gas film thickness disturbance when the stator material density is between 3.1 g/cm^3 to 8.4 g/cm^3; Ensuring sealing performance while minimizing support axial stiffness and support axial damping can help to improve dynamic tracking property of dry gas seal. The proposed research provides the instruction to optimize dynamic tracking property of the DGS. | CHEN Yuan JIANG Jinbo PENG Xudong | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 11 |
| 12 | Microprofiles of activated sludge aggregates using microelectrodes in completely autotrophic nitrogen removal over nitrite (CANON) reactor显示文摘在 situ 杂交(鱼) 的 Microsensor 大小和荧光分析被联合在在亚硝酸根(教规) 上为完全自造营养物质的氮移动定序批反应堆(SBR ) 的实验室规模调查微生物引起的人口和活动。在氨用合成废水富人喂了, SBR 移开 82.5 桴獯 ?湩琠敨映物瑳猠獵数獮潩 | Yongtao LV Xuan CHEN Lei WANG Kai JU Xiaoqiang CHEN Rui MIAO Xudong WANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 11 |
| 13 | Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo显示文摘 | Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen | 2018 | Protein & Cell2018，9，10： | 11 |
| 14 | Matrix Power Control Algorithm for Multi-input Multi-output Random Vibration Test显示文摘汽车力量光谱和跨力量的光谱需要在多输入多产量(MIMO ) 被控制随机的颤动测试。在有差别控制算法(DCA ) 的控制进程期间,一个更低的三角形的矩阵从一个引用光谱矩阵的 Cholesky 分解被导出。更低的三角形的矩阵(DELTM ) 的斜元素可以变得否定。这些否定价值没在物理意义和汽车力量光谱控制的罐头原因分叉有意思。一个比例的根平均数平方控制算法(PRMSCA ) 提供另一个方法避免 DELTM,而是 PRMSCA 的否定的值引起的分叉不能控制跨力量的光谱。一个新控制算法把矩阵力量控制称为算法(MPCA ) 在纸被建议。MPCA 能保证 DELTM 在汽车力量光谱控制总是是积极的。MPCA 能也控制跨力量的光谱。在这三个控制算法被分析以后,三输入的三产量的随机的颤动控制测试在三轴的颤动 shaker 上被实现。结果显示出建议 MPCA 的有效性。 | CUI Xuli CHEN Huaihai HE Xudong JIANG Shuangyan | 2011 | Chinese Journal of Aeronautics2011，24，6： | 11 |
| 15 | Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats显示文摘Glycine is a well-documented cytoprotective agent.However,whether it has a protective effect against myocar-dial ischemia-reperfusion injury in vivo is still unknown.By using an open-chest anesthetized rat model,we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats.The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%,respectively,in glycine-treated rats.The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment.Importantly,administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium,which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase,as well as the Fas ligand.These results suggest that gly-cine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis. | Xiaozheng Zhong Xiaoyu Li Lingling Qiana Yiming Xu Yan Lu Jing Zhang Nan Li Xudong Zhu Jingjing Ben Qing Yang Qi Chen | 2012 | The Journal of Biomedical Research2012，26，5： | 10 |
| 16 | A study on the Dushiling tungsten-copper deposit in the Miao'ershan-Yuechengling area, Northern Guangxi, China:Implications for variations in the mineralization of multi-aged composite granite plutons显示文摘The polymetallic Dushiling W-Cu deposit is a large, altered, skarn-type deposit, located in the northeastern part of the Miao'ershan-Yuechengling pluton, China. Two types of granite have been identified in the deposit: a medium-grained porphyritic biotite granite, and a medium- to fine-grained biotite granite. Both are spatially and temporally related to ore bodies, suggesting they may be the source of mineralization in the deposit. A medium- to fine-grained porphyritic biotite granite is exposed at the surface in the region of mineralization. U-Pb dating of zircons yielded magmatic ages of 423 Ma for the medium-grained porphyritic biotite granite and 421 Ma for the medium- to fine-grained porphyritic biotite granite, while a younger age(217 Ma) obtained for surface samples indicates later diagenesis. Thus, magmatism occurred during the Caledonian and Indosinian, respectively. The petrological and geochemical characteristics of the two Caledonian granites show that both are calc-alkaline and peraluminous.They are moderately enriched in Cs, Rb, U, and REE, and strongly depleted in Sr,Ba,P,and Ti; they show similar REE behavior,including negative Eu anomalies. These geochemical similarities suggest that the two granites were derived from the same source,although they were emplaced during different stages of the evolution of the magma. Furthermore, the granites are associated with mineralization, suggesting they were the source of mineralization in the Dushiling W-Cu deposit. Sm-Nd ages of scheelite from the Dushiling W-Cu deposit indicate that metallogenesis occurred at 417±35 Ma, while the two types of titanite, intergrown with scheelite, yield U-Pb ages of 423–425 Ma(in altered granite sample) and 218 Ma(in skarn sample). These ages place the main mineralization event in the late Caledonian, and later magmatic-hydrothermal activity occurred in the Indosinian. The ages obtained for the Dushiling W-Cu deposit in the western Nanling Range, northern Yuechengling, together with the occurrence and ages of the Niutangjie W deposit in southern Yuechengling, provide insight into the process of ore concentration during the Caledonian and Indosinian. | CHEN WenDi ZHANG WenLan WANG RuCheng CHU ZhuYin XIAO Rong ZHANG Di CHE XuDong | 2016 | Science China Earth Sciences2016，59，11： | 10 |
| 17 | Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophage显示文摘Macrophage death in advanced atherosclerosis promotes plaque necrosis and destabilization.Involvement of autophagy in bulk degradation of cellular components has been recognized recently as an important mechanism for cell survival under endoplasmic reticulum(ER) stress.We previously found that the engagement of class A scavenger receptor(SR-A) triggered JNK-dependent apoptosis in ER-stressed macrophages.However,pro-apoptotic mechanisms mediated by SR-A are not fully understood.Therefore,we sought to see if SR-A mediated apoptosis was associated with autophagy in macrophages.Here,we showed that fucoidan inhibited microtubule-associated protein light chain 3-phospholipid conjugates(LC3-Ⅱ) formation as well as the number of autophagosomes under ER stress.The inhibition of LC3-Ⅱ formation was paralleled by the activation of the mTOR pathway,and the inhibition of mTOR allowed LC3-Ⅱ induction in macrophages treated with thapsigargin plus fucoidan.Furthermore,apoptosis induced by fucoidan was prevented under ER stress by the mTOR inhibitor.We propose that fucoidan,a SR-A agonist,may contribute to macrophage apoptosis during ER stress by inhibiting autophagy. | Hanpeng Huang Xiaoyu Li Yan Zhuang Nan Li Xudong Zhu Jin Hu Jingjing Ben Qing Yang Hui Bai Qi Chen | 2014 | The Journal of Biomedical Research2014，28，3： | 9 |
| 18 | Prognostic Factors Predicting the Postoperative Survival Period Following Treatment for Primary Retroperitoneal Liposarcoma显示文摘 | Xudong Zhao Peiyu Li Xiaohui Huang Lin Chen Na Liu Yaoguang She | 2015 | Chinese Medical Journal2015，，1： | 9 |
| 19 | microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming显示文摘成纤维细胞能由 Yamanaka 因素(OSKM ) 的申请是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed,但是位于这 reprogramming 下面的机制仍然保持糟糕理解。这里,我们报导 Sox2 直接调整内长的 microRNA-29b (miR-29b ) 表示为调停 OSKM 、调停 OSK 的 reprogramming 在 iPSC 产生和那 miR-29b 表情期间被要求。Dnmt3a 和 Dnmt3b 在 miR-29b 和那 Dnmt3a 和 Dnmt3b 表示的 vivo 目标的机械学的研究表演相反地在 reprogramming 期间与 miR-29b 表示被相关。而且, reprogramming 上的 miR-29b 的效果能被 Dnmt3a 或 Dnmt3b overexpression 堵住。进一步的实验显示发信号的 miR-29b-DNMT 显著地涉及 DNA methylation 相关的 reprogramming 事件的规定,例如 mesenchymal-to-epithelial 转变(相遇) 并且 Dlk1-Dio3 区域抄写。因此,我们的研究不仅表明 miR-29b 是 reprogramming 因素 Sox2 的一个新奇调停人而且为 Sox2 在驾驶表明调整 DNA 的轴的 miR-29b-DNMT 的 multistep 机制提供证据 methylation 相关的事件在 reprogramming 期间。 | Xudong Guo Qidong Liu Guiying Wang Songcheng Zhu Longfei Gao Wujun Hong Yafang Chen Minjuan Wu Houqi Liu Cizhong Jiang Jiuhong Kang | 2013 | Cell Research2013，23，1： | 9 |
| 20 | An organic junction between the vein and membrane of the dragonfly wing显示文摘A dragonfly wing consists of membranes and both longitudinal and cross veins.We observed the microstructure cross-section at several locations in the dragonfly wing using environmental scanning electron microscopy(ESEM).The organic nature of the junction between the vein and the membrane was clearly identifiable.The membrane was divided into two layers,the upper epidermis and the lower epidermis.These layers extend around the sandwich structure vein,and combine with the adjacent membrane at a symmetrical location along the vein.Thus,we defined this as an organic junction between the vein and the membranes. The organic junction is able to form a tight corrugation angle,which dramatically increases both the warping rigidity and the strength of the wing,but not the torsional rigidity.The torsional deformation is primarily controlled by the microstructure of the longitudinal veins,and is based on the relative rotation angle between the epidermal layer and the inner layer of the vein that forms the zigzag section. | CHEN YingLong WANG XiShu REN HuaiHui LI XuDong | 2011 | Chinese Science Bulletin2011，56，16： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员