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| 1 | Exploring the molecular basis of heterosis for plant breeding显示文摘Since approximate a century ago, many hybrid crops have been continually developed by crossing two inbred varieties. Owing to heterosis(hybrid vigor) in plants, these hybrids often have superior agricultural performances in yield or disease resistance succeeding their inbred parental lines. Several classical hypotheses have been proposed to explain the genetic causes of heterosis. During recent years, many new genetics and genomics strategies have been developed and used for the identifications of heterotic genes in plants. Heterotic effects of the heterotic loci and molecular functions of the heterotic genes are being investigated in many plants such as rice, maize, sorghum, Arabidopsis and tomato.More and more data and knowledge coming from the molecular studies of heterotic loci and genes will serve as a valuable resource for hybrid breeding by molecular design in future. This review aims to address recent advances in our understanding of the genetic and molecular mechanisms of heterosis in plants. The remaining scientific questions on the molecular basis of heterosis and the potential applications in breeding are also proposed and discussed. | Jie Liu Mengjie Li Qi Zhang Xin Wei Xuehui Huang | 2020 | Journal of Integrative Plant Biology2020，62，3： | 13 |
| 2 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 3 | Petrogenesis and tectonic implications of early Paleozoic granitoids in East Kunlun belt: Evidences from geochronology, geochemistry and isotopes显示文摘The East Kunlun Orogenic Belt(EKOB) provides an important link to reconstruct the evolution of the Proto-Tethys and Paleo-Tethys realm. The EKOB is marked by widespread Early Paleozoic magmatism.Here we report the petrology, bulk geochemistry, zircon Ue Pb dating and, Lue Hf and SreN d isotopic data of the Early Paleozoic granitic rocks in Zhiyu area of the southern EKOB. Based on the zircon U-Pb dating, these granitoids, consisting of diorite, granodiorite and monzogranite, were formed during 450 -430 Ma the Late Ordovician to Middle Silurian. The diorite and granodiorite are high Sr/Y ratio as adakitic affinities, and the monzogranite belongs to highly fractionated I-type. Their(^(87)Sr/^(86)Sr)ivalues range from 0.7059 to 0.7085, εNd(t) values from -1.6 to -6.0 and the zircon εHf(t) values show large variations from +9.1 to -8.6 with Hf model ages(T_(DM2)) about 848 Ma and 1970 Ma. The large variations of whole-rock Nd and zircon Hf isotopes demonstrate strong isotopic heterogeneity of the source regions which probably resulted from multi-phase underplating of mantle-derived magmas. Geochemical and isotopic studies proved that the diorite and granodiorite had been derived from partial melting of heterogeneous crustal source with variable contributions from ancient continental crust and juvenile components, and the monzogranites were representing fractional crystallization and crustal contamination for arc magma. The Early Paleozoic adakitic rocks and high-K calc-alkaline granitoids in the southern EKOB were likely emplaced in a continental marginal arc setting possibly linked to the southwards subduction of the Paleo Kunlun Ocean and the magma generation is linked to partial melting of thickened continental crust induced by underplating of mantle-derived magmas. | Guochen Dong Mingfei Luo Xuanxue Mo Zhidan Zhao Liangqiong Dong Xuehui Yu Xin Wang Xiaowei Li Xiongfei Huang Yanbin Liu | 2018 | Geoscience Frontiers2018，9，5： | 10 |
| 4 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 5 | A high-quality genome sequence of alkaligrass provides insights into halophyte stress tolerance显示文摘Alkaligrass(Puccinellia tenuiflora) is a monocotyledonous halophytic forage grass widely distributed in Northern China. It belongs to the Gramineae family and shares a close phylogenetic relationship with the cereal crops, wheat and barley. Here, we present a high-quality chromosome-level genome sequence of alkaligrass assembled from Illumina, Pac Bio and 10× Genomics reads combined with genome-wide chromosome conformation capture(Hi-C) data. The ~1.50 Gb assembled alkaligrass genome encodes 38,387 protein-coding genes, and 54.9% of the assembly are transposable elements, with long terminal repeats being the most abundant. Comparative genomic analysis coupled with stress-treated transcriptome profiling uncovers a set of unique saline-and alkaline-responsive genes in alkaligrass. The high-quality genome assembly and the identified stress related genes in alkaligrass provide an important resource for evolutionary genomic studies in Gramineae and facilitate further understanding of molecular mechanisms underlying stress tolerance in monocotyledonous halophytes. The alkaligrass genome data is freely available at http://gffzz284c18d2de364501hx6pkuww5o5fn60on.ffgz.tsg.suse.edu.cn/data/alkaligrass.html. | Wenting Zhang Jie Liu Yongxue Zhang Jie Qiu Ying Li Baojiang Zheng Fenhong Hu Shaojun Dai Xuehui Huang | 2020 | Science China(Life Sciences)2020，63，9： | 8 |
| 6 | Effect of polycarboxylate-type superplasticizer on the paste fluidity based on the water film thickness of flocs显示文摘The excess water film theory and the properties of flocs are integrated to examine the effect of the polycarboxylate-type superplasticizer on the paste fluidity.The theory states that excess water can surround the flocs rather than the particles and that the cell consists of a floc and a superficial water film.Experiments on limestone powder pastes were conducted to verify the theory.The superplasticizer dosage(sp%)and the water–powder ratio by volume(Vw/Vp)were systematically varied.A sedimentation balance method was used to measure the size distribution of the flocs in the limestone powder pastes.The water film thickness(WFT)of flocs was then calculated and shown to determine the paste fluidity.Based on this WFT of flocs,the effect of the sp on the paste fluidity was determined and then compared with the effect of water. | WU Qiong AN XueHui LIU ChunNa | 2014 | Science China(Technological Sciences)2014，57，8： | 7 |
| 7 | Estimation of Storage and Density of Organic Carbon in Peatlands of China显示文摘Based on the results of the National Survey of Peat Resources(1983-1985) and the investigation results on the peatlands of China,the storage and density of the organic carbon in the peatlands of China were estimated.The total organic carbon storage(OCS) of the peatlands in China,including bare peatlands and buried peatlands,are 1.503 × 109 t,unevenly distributed over 30 provincial level administrative units and 16 climatic zones.Peatland organic carbon storage(POCS) in Sichuan(6.45 × 108 t) and Yunnan provinces(2.91 × 108 t) is the highest,accounting for 62.29% of the total POCS.Humid zone of plateau has the highest POCS of 7.14 × 108 t,especially in the Zoigê Plateau,where the POCS is 6.30 × 108 t,accounting for 41.92% of the total POCS of China.The organic carbon density(OCD) of the peatlands in China mostly ranges from 80 kg/m3 to 140 kg/m3,and the range of the maximum is 270-360 kg/m3,and the minimum is less than 80 kg/m3.Divided by the Yanshan Mountain,Taihang Mountains and Hengduan Mountains,the peatland oganic carbon density(POCD) is lower on the northwestern side than that on the southeastern side.Jiangxi Province has the highest POCD due to the ancient buried peatlands.The OCD of the bare peatlands is mostly in the range of 60-150 kg/m3,and that of the buried peatlands is more than 100 kg/m3.In the bare peatlands,the OCD generally increases from the surface layer to the below surface layer,and then decreases with the depth.Although the peatlands area in China is small,the OCS per unit area is far higher than the other soil types,so peatlands protection can effectively mitigate climate change. | LIU Zigang WANG Ming MA Xuehui | 2012 | Chinese Geographical Science2012，22，6： | 7 |
| 8 | Roles of fishing and climate change in long-term fish species succession and population dynamics in the outer Beibu Gulf,South China Sea显示文摘A prevailing,controversial hypothesis is that fishing pressure has played a greater role than climatic and environmental drivers,in changing fish species succession and biomass fluctuation in the South China Sea(SCS).Based on otter trawl survey data from 1959 to 2010 in the outer Beibu Gulf(OBG),northern SCS,large seasonal and interannual variation is reported for fish species composition,the proportional abundances of dominant taxa,and fish biomass.Generalized additive models are developed to quantify relationships between fish biomass and the external factors of fishing pressure and climate change.Fishing pressure proved to be the main driver of sharp declines in demersal fish stocks,with high-value species being replaced by low-value ones over time.Abrupt decreases in fish biomass during the years of 1993 and 1998 correspond to El Nino events,with climate change possibly the main driver of proportional representation of pelagic species in fisheries trawl catch.The need to differentiate impacts of fishing and environmental drivers on fish species with different life history strategies is stressed to better understand fish community dynamics. | Xuehui Wang Yongsong Qiu Feiyan Du Weida Liu Dianrong Sun Xiao Chen Weiwen Yuan Yong Chen | 2019 | Acta Oceanologica Sinica2019，38，10： | 6 |
| 9 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 10 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 11 | Zn–Ca–Al mixed oxide as efficient catalyst for synthesis of propylene carbonate from urea and 1,2-propylene glycol显示文摘A series of Zn–Ca–Al oxides with different CaO and ZnO contents have been prepared and evaluated in the synthesis of propylene carbonate(PC) from 1,2-propylene glycol(PG) and urea in a batch reactor. The effect of catalyst composition, basicity and reaction process parameters such as temperature, catalyst dose, molar ratio of PG to urea, purge gas flow and reaction time has been studied to find suitable reaction conditions for the PC synthesis. The PC selectivity and yield under the desired conditions could reach 98.4% and 90.8%, respectively. The best performing catalyst also exhibited a good reusability without appreciable loss in the PC selectivity and yield after five consecutive reaction runs. In addition, a stepwise reaction pathway involving a 2-hydroxypropyl carbamate intermediate was proposed for the urea alcoholysis to PC in the presence of Zn–Ca–Al catalysts, according to the time dependences of reaction intermediates and products. | Sen Liu Suhong Sun Xuehui Tian Peiyong Sun Shenghong Zhang Zhilong Yao | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 4 |
| 12 | Genome-wide identification of agronomically important genes in outcrossing crops using OutcrossSeq显示文摘Many important crops(e.g.,tuber,root,and tree crops)are cross-pollinating.For these crops,no inbred lines are available for genetic study and breeding because they are self-incompatible,clonally propagated,or have a long generation time,making the identification of agronomically important genes difficult,particularly in crops with a complex autopolyploid genome.In this study,we developed a method,OutcrossSeq,for mapping agronomically important loci in outcrossing crops based on whole-genome low-coverage resequencing of a large genetic population,and designed three computation algorithms in OutcrossSeq for different types of outcrossing populations.We applied OutcrossSeq to a tuberous root crop(sweet potato,autopolyploid),a tree crop(walnut tree,highly heterozygous diploid),and hybrid crops(double-cross populations)to generate high-density genotype maps for the outcrossing populations,which enable precise identification of genomic loci underlying important agronomic traits.Candidate causative genes at these loci were detected based on functional clues.Taken together,our results indicate that OutcrossSeq is a robust and powerful method for identifying agronomically important genes in heterozygous species,including polyploids,in a cost-efficient way.The OutcrossSeq software and its instruction manual are available for downloading at www.xhhuanglab.cn/tool/OutcrossSeq.html. | Mengjiao Chen Weijuan Fan Feiyang Ji Hua Hua Jie Liu Mengxiao Yan Qingguo Ma Jiongjiong Fan Qin Wang Shufeng Zhang Guiling Liu Zhe Sun Changgeng Tian Fengling Zhao Jianli Zheng Qi Zhang Jiaxin Chen Jie Qiu Xin Wei Ziru Chen Peng Zhang Dong Pei Jun Yang Xuehui Huang | 2021 | Molecular Plant2021，14，4： | 4 |
| 13 | Enhancing rice grain production by manipulating the naturally evolved cis-regulatory element-containing inverted repeat sequence of OsREM20显示文摘Grain number per panicle(GNP)is an important agronomic trait that contributes to rice grain yield.Despite its importance in rice breeding,the molecular mechanism underlying GNP regulation remains largely unknown.In this study,we identified a previously unrecognized regulatory gene that controls GNP in rice,Oryza sativa REPRODUCTIVE MERISTEM 20(OsREM20),which encodes a B3 domain transcription factor.Through genetic analysis and transgenic validation we found that genetic variation in the CArG box-containing inverted repeat(IR)sequence of the OsREM20 promoter alters its expression level and contributes to GNP variation among rice varieties.Furthermore,we revealed that the IR sequence regulates OsREM20 expression by affecting the direct binding of OsMADS34 to the CArG box within the IR sequence.Interestingly,the divergent pOsREM20IR and pOsREM20ΔIR alleles were found to originate from different Oryza rufipogon accessions,and were independently inherited into the japonica and indica subspecies,respectively,during domestication.Importantly,we demonstrated that IR sequence variations in the OsREM20 promoter can be utilized for germplasm improvement through either genome editing or traditional breeding.Taken together,our study characterizes novel genetic variations responsible for GNP diversity in rice,reveals the underlying molecular mechanism in the regulation of agronomically important gene expression,and provides a promising strategy for improving rice production by manipulating the cis-regulatory element-containing IR sequence. | Xiaowei Wu Yan Liang Hengbin Gao Jiyao Wang Yan Zhao Lekai Hua Yundong Yuan Ahong Wang Xiaohui Zhang Jiafan Liu Jie Zhou Xiangbing Meng Dahan Zhang Shaoyang Lin Xuehui Huang Bin Han Jiayang Li Yonghong Wang | 2021 | Molecular Plant2021，14，6： | 3 |
| 14 | Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets显示文摘The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques. Tacrolimus solid dispersion was prepared using glycerylbehenate(Compritol~?ATO888) and Pluronic F127 as the carrier materials with hot-melt method, which was then blended with hydrogel matrix materials, such as HPMC and lactose, the powders were directly compressed into tablets. In vitro drug release tests were carried out to evaluate the performance of the solid dispersions and the tablets. The dissolution rate of tacrolimus was significantly improved by the lipid-based solid dispersion, and the incorporation of HPC into the solid dispersion obviously improved its stability after storage. Extended release tablets loaded with tacrolimus solid dispersion showed prolonged drug release patterns over 24 h, the release patterns of the tablets can be tailored by the compositions of the matrix materials, including the types and content of HPMCs. A modified processing method that directly mixed the melted solid dispersion with HPMC powders improved the uniformity of the solid dispersion inside the tablet matrix and release profile. The release data of the extended release tablet fitted well to the Korsmeyer–Peppas model with n value of 0.85, which suggested diffusion-and erosion-controlled release mechanism. The combination of lipid-based solid dispersion and HPMC hydrogel matrix may find wide applications in the extended release dosage forms of high potent, water-insoluble drugs. | Hui Xu Li Liu Xuehui Li Junyuan Ma Rui Liu Shaoning Wang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 15 | A Preliminary Investigation on Phenotypic Characteristics of Phytophthora infestans from Guizhou Province显示文摘[Objective] This study aimed to investigate the phenotypic characteristics of Phytophthora infestans from Guizhou Province.[Method] The metalaxyl resistance,mating type and isozyme genotype of 292 P. infestans strains isolated from Guizhou Province were analyzed.[Result] Metalaxyl-resistant P. infestans strains were found in different areas of Guizhou Province. Resistant,moderately resistant and susceptible strains accounted for 35. 62%,33. 90% and 30. 48%,respectively. Both mating types A1 and A2 were found,which accounted for 65. 38% and 34. 62%,respectively. P. infestans strains isolated from Guizhou Province mainly belonged to Gpi genotypes 100 /100 and 100 /100 /111,accounting for 50. 68% and 43. 84%,respectively.[Conclusion]This study provides the theoretical basis for the prevention and control of potato late blight in Guizhou Province. | Lu HUANG Xiaojun CHEN Haiyong HE Xuehui LIU Shiping WU | 2016 | Agricultural Biotechnology2016，5，3： | 2 |
| 16 | Life Prediction Model of Machine Tool based on Deep Learning显示文摘In view of the shortage of traditional life prediction methods for machine tools,such as low accuracy of life prediction and few samples basis attributes,a life prediction model of machine tools combined with machine tool attributes is proposed.The life prediction model of machine tool adopts KL dispersion distribution theory,uses modal superposition method to carry out machine tool life analysis,calculates the theoretical life of machine tool,and then carries on the simulation,obtains the machine tool life prediction value.Compared with the traditional method of machine tool life prediction,the model is based on the application life fatigue damage model,which superimposes the service times and maintenance cycle of the machine tool,derives the influence factor of machine tool life,and obtains the linear relationship between the influence factor of machine tool life and the life of machine tool.The influence factor of machine tool life is introduced as the life prediction parameter of machine tool.The data transformation relationship of HT300 parts is constructed.The original part data is enhanced.The effective training set is obtained.The life prediction model of machine tool based on deep learning is completed.The quantitative analysis of machine tool life is carried out.The experiment of machine tool life prediction using training data set proves the validity of the model.Regression test was carried out on the training data set to reflect the robustness of the model.The prediction accuracy of the model is further verified by Weibull test. | HE Jiawei ZHAO Chendi GAO Ruiyu LIU Xuehui WANG Xue | 2021 | International Journal of Plant Engineering and Management2021，26，1： | 2 |
| 17 | Hot-Water Deposition of Pyritic Stromatolite and Its Relation to Biomineralization显示文摘Pyritic stromatolite, a rich pyrite ore, is scattered as reef masses in sedex deposits of the Proterozoic Yanshan rift trough. The pyritic stromatolite consists of a core and alternating concentric rims of light colloidal pyrite and dark organic materials. The concentric rims are cemented together by trichomes highly similar to the trichomic microorganisms inhabiting substantively around the black chimneys on the current sea beds while the core is composed chiefly of groups of thermophilous sulphur bacteria. Biomarkers for the molecules of pyritic stromatolite include pristane, phytane, regular isoprenoids paraffin, methyl-heptadecyl, and so on. This study reveals the existence of methane-yielding bacteria in the pyritic stromatolite and reflects the evolution of thermophilous thallophyta.Long pulsation of mineralizing thermal solutions venting up along contemporaneous faults in rift troughs contributed greatly not just to the reproduction of thermophilous organisms living around the vents, but to | XIA Xuehui LIU Changtao LI Zhongmo | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 2 |
| 18 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 19 | Coherence-enhancing line drawing for color images显示文摘Line drawing plays an important role in many image-based non-photorealistic applications.However,most existing approaches use a grayscale edge detector for line extraction,so that only luminance diferences between nearby image pixels is taken into account,but the chrominance diferences is ignored.This leads to the undesirable consequence that visually signifcant edges in adjacent regions with diferent colors of similar luminance cannot be detected.To address this limitation,we present a novel enhanced line drawing method based on a flow-based diference-of-Gaussians(FDoG)flter.Because of an inherent property of the thresholded DoG edge model,captured lines may appear dislodged from the true edges in the image.To this end,we provide a gradient-guided warping technique so that smooth and coherent lines can be extracted in the correct location.The GPU implementation of the proposed algorithms allows real-time performance,and experimental examples with various color images demonstrate the method’s superior qualitative performance over previous approaches. | WANG ShanDong MA ZiYang LIU XueHui CHEN YanYun WU EnHua | 2013 | Science China(Information Sciences)2013，56，11： | 2 |
| 20 | Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P显示文摘Pyroptosis is a type of regulated cell death executed by gasdermin family members.However,how gasdermin-mediated pyroptosis is negatively regulated remains unclear.Here,we demonstrate that mannose,a hexose,inhibits GSDME-mediated pyroptosis by activating AMP-activated protein kinase(AMPK).Mechanistically,mannose metabolism in the hexosamine biosynthetic pathway increases levels of the metabolite N-acetylglucosamine-6-phosphate(GlcNAc-6P),which binds AMPK to facilitate AMPK phosphorylation by LKB1.Activated AMPK then phosphorylates GSDME at Thr6,which leads to blockade of caspase-3-induced GSDME cleavage,thereby repressing pyroptosis.The regulatory role of AMPK-mediated GSDME phosphorylation was further confirmed in AMPK knockout and GSDME^(T6E) or GSDME^(T6A) knock-in mice.In mouse primary cancer models,mannose administration suppressed pyroptosis in small intestine and kidney to alleviate cisplatin-or oxaliplatin-induced tissue toxicity without impairing antitumor effects.The protective effect of mannose was also verified in a small group of patients with gastrointestinal cancer who received normal chemotherapy.Our study reveals a novel mechanism whereby mannose antagonizes GSDME-mediated pyroptosis through GlcNAc-6P-mediated activation of AMPK,and suggests the utility of mannose supplementation in alleviating chemotherapy-induced side effects in clinic applications. | Yuan-li Ai Wei-jia Wang Fan-jian Liu Wei Fang Hang-zi Chen Liu-zheng Wu Xuehui Hong Yuekun Zhu Ci-xiong Zhang Long-yu Liu Wen-bin Hong Bo Zhou Qi-tao Chen Qiao Wu | 2023 | Cell Research2023，33，12： | 2 |
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