|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trends of incidence rate and age at diagnosis for cervical cancer in China,from 2000 to 2014显示文摘Objective: To analyze the trends of incidence rate and age at diagnosis for cervical cancer incidence in China using population-based cancer registration data from 2000 to 2014.Methods: Data were from National Central Cancer Registry of China.Crude incidence rates(CIRs),age-specific incidence rate,age-standardized incidence rates(ASIRs),age percentage distribution,standardized age percentage distribution,mean age at diagnosis and standardized mean age at diagnosis for cervical cancer in all areas of China,urban China and rural China were calculated separately.The world Segi's population was applied to remove the age structure influence.Joinpoint regression was performed to obtain average annual percent change(AAPC) and ageperiod-cohort analysis was used to examine the incidence trends.Results: CIRs and ASIRs for cervical cancer increased in China from 2000 to 2014.The AAPC of ASIRs in China was at 9.2% [95% confidence interval(95% CI): 7.0%–11.5%,P<0.05],and the AAPC in rural areas was relatively high.The age-specific incidence rate in groups aged 0–69 years have significantly increased over time.Groups aged 40–69 years showed the highest incidence risk,and the annual percent changes(APCs) of incidence rate in groups aged 40–59 years in urban China and groups aged 0–49 years in rural China were more than 10%.For each age group,the urban-to-rural incidence rate ratios(IRRs) got close to 1 over time.There were clear birth cohort effects in successive generations born from 1940 to 1970 in China.In rural China,the standardized mean age at diagnosis had significantly declined by 5.18 years.In China,the main peak and secondary peak of standardized age percentages appeared in the groups aged 45–49 and 40–44 years,respectively.In rural China,the main peak of standardized age percentage moved from the group aged 55–59 years to the group aged 45–49 years,and the standardized age percentages of groups aged 25–34 years also increased.In China,the standardized age percentages has significantly increased in groups aged 35–64 and 30–64 years over time,and accounted for about80% and 85% in 2014,respectively.Conclusions: The cervical cancer incidence increased in China and the gap of incidence between urban and rural China was narrowed.The trends of increasing cervical cancer incidence among younger women existed in China,especially in rural China.A more appropriate screening,vaccination and health education strategies should be established. | Xueting Li Rongshou Zheng Xuemei Li Haibin Shah Qi Wu Yan Wang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 64 |
| 2 | CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target显示文摘The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in TME.Over-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer patients.In TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and metastasis.The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME.Blocking the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression.CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the treatment.In this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME.The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed. | Wen Zhang Huishan Wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao | 2020 | Cancer Communications2020，40，2： | 19 |
| 3 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 4 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 5 | Environmental factors influencing snowfall and snowfall prediction in the Tianshan Mountains, Northwest China显示文摘Snowfall is one of the dominant water resources in the mountainous regions and is closely related to the development of the local ecosystem and economy. Snowfall predication plays a critical role in understanding hydrological processes and forecasting natural disasters in the Tianshan Mountains, where meteorological stations are limited. Based on climatic, geographical and topographic variables at 27 meteorological stations during the cold season(October to April) from 1980 to 2015 in the Tianshan Mountains located in Xinjiang of Northwest China, we explored the potential influence of these variables on snowfall and predicted snowfall using two methods: multiple linear regression(MLR) model(a conventional measuring method) and random forest(RF) model(a non-parametric and non-linear machine learning algorithm). We identified the primary influencing factors of snowfall by ranking the importance of eight selected predictor variables based on the relative contribution of each variable in the two models. Model simulations were compared using different performance indices and the results showed that the RF model performed better than the MLR model, with a much higher R^2 value(R^2=0.74; R^2, coefficient of determination) and a lower bias error(RSR=0.51; RSR, the ratio of root mean square error to standard deviation of observed dataset). This indicates that the non-linear trend is more applicable for explaining the relationship between the selected predictor variables and snowfall. Relative humidity, temperature and longitude were identified as three of the most important variables influencing snowfall and snowfall prediction in both models, while elevation, aspect and latitude were of secondary importance, followed by slope and wind speed. These results will be beneficial to understand hydrological modeling and improve management and prediction of water resources in the Tianshan Mountains. | ZHANG Xueting LI Xuemei LI Lanhai ZHANG Shan QIN Qirui | 2019 | Journal of Arid Land2019，11，1： | 8 |
| 6 | Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes显示文摘As an excitatory transmitter system,the glutamatergic transmitter system controls excitability and conductivity of neurons.Since both cardiomyocytes and neurons are excitable cells,we hypothesized that cardiomyocytes may also be regulated by a similar system. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qiang Ji Qicheng Zou Lingling Wang Yi Liu Dandan Liang Jinfeng Xue Luxin Wang Xueting Gao Xingdong Gu Hongyu Liu r Xiaoyu He Li Li Jian Yang Youming Lu Luying Peng Yi-Han Chen | 2021 | Cell Research2021，31，9： | 5 |
| 7 | Expression Analysis of Genes Related to Auxin Metabolism at Different Growth Stages of Pak Choi显示文摘Pak choi is a low-temperature vernalized plant that readily undergoes premature bolting during spring, but little is known about the governing molecular regulation of vernalization. In order to enhance our understanding of mechanism about premature bolting, we discussed the relationship between auxin(indole-3-acetic acid, IAA) and flowering of pak choi. During vernalization, hormone metabolism is an important regulatory pathway, and IAA plays a specific role. IAA metabolism has been studied in Arabidopsis thaliana and other plants, but not in pak choi. In this paper, the IAA content in pak choi shoot apices during vernalization and different growth stages was compared. The IAA content decreased significantly after low-temperature treatment(4 °C) and then increased rapidly during vegetative growth. During floral bud initiation,the IAA content decreased rapidly and was the lowest. Expressions of genes encoding key IAA metabolic enzymes were analyzed, and a major synthetase-encoding gene was downregulated, while a key degrading enzyme-encoding gene was upregulated during each comparison period,resulting in decreased IAA content. Expressions of four genes(Bra034975, Bra030246, Bra012239 and Bra040296) were consistent with changes in the IAA content. The functions of differentially expressed genes(DEGs) were analyzed, and 15 DEGs were found to be related to IAA metabolism.The findings illuminated the molecular mechanism regulating IAA content during vernalization in pak choi. | Yuxiang Hou Xueting Wang Zhujun Zhu Mengxia Sun Meilan Li Leiping Hou | 2020 | Horticultural Plant Journal2020，6，1： | 4 |
| 8 | Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression,evoking oxidative stress,and activating inflammation and apoptosis显示文摘Background:The immune system is one aspect of health that is affected by dietary selenium(Se)levels and selenoprotein expression.Spleen is an important immune organ of the body,which is directly involved in cellular immunity.However,there are limited reports on Se levels and spleen health.Therefore,this study established a Se-deficient pig model to investigate the mechanism of Se deficiency-induced splenic pathogenesis.Methods:Twenty-four pure line castrated male Yorkshire pigs(45 days old,12.50±1.32 kg,12 full-sibling pairs)were divided into two equal groups and fed Se-deficient diet(0.007 mg Se/kg)or Se-adequate diet(0.3 mg Se/kg)for 16 weeks.At the end of the trial,blood and spleen were collected to assay for erythroid parameters,the osmotic fragility of erythrocytes,the spleen index,histology,terminal deoxynucleotidyl transferase nick-end labeling(TUNEL)staining,Se concentrations,the selenogenome,redox status,and signaling related inflammation and apoptosis.Results:Dietary Se deficiency decreased the erythroid parameters and increased the number of osmotically fragile erythrocytes(P<0.05).The spleen index did not change,but hematoxylin and eosin and TUNEL staining indicated that the white pulp decreased,the red pulp increased,and splenocyte apoptosis occurred in the Se deficient group.Se deficiency decreased the Se concentration and selenoprotein expression in the spleen(P<0.05),blocked the glutathione and thioredoxin antioxidant systems,and led to redox imbalance.Se deficiency activated the NF-κB and HIF-1αtranscription factors,thus increasing pro-inflammatory cytokines(IL-1β,IL-6,IL-8,IL-17,and TNF-α),decreasing anti-inflammatory cytokines(IL-10,IL-13,and TGF-β)and increasing expression of the downstream genes COX-2 and iNOS(P<0.05),which in turn induced inflammation.In addition,Se-deficiency induced apoptosis through the mitochondrial pathway,upregulated apoptotic genes(Caspase3,Caspase8,and Bak),and downregulated antiapoptotic genes(Bcl-2)(P<0.05)at the mRNA level,thus verifying the results of TUNEL staining.Conclusions:These results indicated that Se deficiency induces spleen injury through the regulation of selenoproteins,oxidative stress,inflammation and apoptosis. | Shuang Li Wenjuan Sun Kai Zhang Jiawei Zhu Xueting Jia Xiaoqing Guo Qingyu Zhao Chaohua Tang Jingdong Yin Junmin Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 4 |
| 9 | Honokiol: an effective inhibitor of tumor necrosis factor-α-induced up-regulation of inflammatory cytokine and chemokine production in human synovial fibroblasts显示文摘在这研究,我们调查了在肿瘤坏死因素(TNF ) 位于 honokiol 的反煽动性的效果下面的机制 -- 刺激风湿性关节炎 synovial 成纤维细胞(RASF ) 。RASF 与 honokiol (020 M ) 预先对待与 TNF-(20 ng/ml ) 被刺激。前列腺素 E2 ( PGE2 )的层次,氮的氧化物(没有),可溶的细胞间的粘附 molecule-1 ( sICAM-1 ),转变生长 factor-1 ( TGF-1 ),单核白血球趋化性的 protein-1 ( MCP-1 ),并且巨噬细胞在上层清液的煽动性的 protein-1 ( MIP-1 )被连接酶的 immunosorbent 试金( ELISA )和 Griess 试金决定。另外, cyclooxygenase-2 (COX-2 ) 的蛋白质表示层次,可诱导的氮的氧化物 synthase (iNOS ) ,和 phosphorylated Akt,原子因素 kappa B (NFB ) ,和细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 1/2 被西方的污点决定。NFBp65 的表示被 immunocytochemical 分析估计。TNF- 处理显著地起来调整 PGE2 的层次,不在 RASF 的上层清液的 sICAM-1, TGF-1, MCP-1,和 MIP-1,在 RASF 增加了 Akt, IB- , NFB,和 ERK1/2 的 COX-2, iNOS,和导致的 phosphorylation 的蛋白质表示。TNF -- 这些分子的导致的表示被预告的处理与 honokiol 以一种剂量依赖者方式禁止。在 NFBp65 活动的 honokiol 的禁止的效果被 immunocytochemical 分析也证实。在结论, honokiol 是 TNF 的一个潜在的禁止者 -- 在 RASF 导致了煽动性的因素的表示,抓住作为潜在的反煽动性的药答应它。 | Jie Li Xueting Shao Lijuan Wu Tingting Feng Changzhong Jin Meixin Fang Nanping Wu Hangping Yao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 4 |
| 10 | Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling显示文摘Testosterone deficiency is common in male patients with chronic obstructive pulmonary disease (COPD) and may correlate with the deterioration of COPD. Clinical research suggests that testosterone replacement therapy may slow the COPD progression, but the specific biological pathway remains unclear. In this study, we explored the effect of testosterone on pulmonary inflammation in male COPD rats. The animals were co-treated with lipopolysaccharide (LPS) and cigarette to induce COPD. In COPD rats, nuclear respiratory factor 1 (NRF1) and NF-κB p65 were upregulated. In cigarette smoke extract (CSE)-, LPS-, or the combination of CSE and LPS-treated L132 cells, NRF1 and p65 were also upregulated. Silencing NRF1 resulted in the downregulation of p65. ChIP‒seq, ChIP‒qPCR, and luciferase results showed that NRF1 transcriptionally regulated p65. Both male and female COPD rats showed an upregulated NRF1 level and similar pulmonary morphology. But NRF1 was further upregulated in male castrated rats. Further supplementing testosterone in castrated male rats significantly reduced NRF1, pulmonary lesions, and inflammation. Supplementation of testosterone also reduced the phosphorylation of p65 and IKKβ induced by LPS or CSE in L132 cells. Our results suggest that testosterone plays a protective role in pulmonary epithelial inflammation of COPD through inhibition of NRF1-derived NF-κB signaling and the phosphorylation of p65. | Xueting Wang Linlin Huang Shan Jiang Kang Cheng Dan Wang Qianqian Luo Xiaomei Wu Li Zhu | 2021 | Journal of Molecular Cell Biology2021，13，2： | 4 |
| 11 | Boundary-aware texture region segmentation from manga显示文摘Due to the lack of color in manga(Japanese comics), black-and-white textures are often used to enrich visual experience. With the rising need to digitize manga, segmenting texture regions from manga has become an indispensable basis for almost all manga processing, from vectorization to colorization. Unfortunately, such texture segmentation is not easy since textures in manga are composed of lines and exhibit similar features to structural lines(contour lines). So currently, texture segmentation is still manually performed, which is labor-intensive and time-consuming. To extract a texture region, various texture features have been proposed for measuring texture similarity, but precise boundaries cannot be achieved since boundary pixels exhibit different features from inner pixels. In this paper, we propose a novel method which also adopts texture features to estimate texture regions. Unlike existing methods, the estimated texture region is only regarded an initial, imprecise texture region. We expand the initial texture region to the precise boundary based on local smoothness via a graph-cut formulation. This allows our method to extract texture regions with precise boundaries. We have applied our method to various manga images and satisfactory results were achieved in all cases. | Xueting Liu Chengze Li Tien-Tsin Wong | 2017 | Computational Visual Media2017，3，1： | 2 |
| 12 | Performance and uncertainty analysis of a short-term climate reconstruction based on multi-source data in the Tianshan Mountains region,China显示文摘Short-term climate reconstruction,i.e.,the reproduction of short-term(several decades)historical climatic time series based on the relationship between observed data and available longer-term reference data in a certain area,can extend the length of climatic time series and offset the shortage of observations.This can be used to assess regional climate change over a much longer time scale.Based on monthly grid climate data from a Coupled Model Inter-comparison Project phase 5(CMIP5)dataset for the period of 1850–2000,the Climatic Research Unit(CRU)dataset for the period of 1901–2000 and the observed data from 53 meteorological stations located in the Tianshan Mountains region(TMR)of China during the period of 1961–2011,we calibrated and validated monthly average temperature(MAT)and monthly accumulated precipitation(MAP)in the TMR using the delta,physical scaling(SP)and artificial neural network(ANN)methods.Performance and uncertainty during the calibration(1971–1999)and verification(1961–1970)periods were assessed and compared using traditional performance indices and a revised set pair analysis(RSPA)method.The calibration and verification processes were subjected to various sources of uncertainty due to the influence of different reconstructed variables,different data sources,and/or different methods used.According to traditional performance indices,both the CRU and CMIP5 datasets resulted in satisfactory calibrated and verified MAT time series at 53 meteorological stations and MAP time series at 20 meteorological stations using the delta and SP methods for the period of 1961–1999.However,the results differed from those obtained by the RSPA method.This showed that the CRU dataset produced a low degree of uncertainty(positive connection degree)during the calibration and verification of MAT using the delta and SP methods compared to the CMIP5 dataset.Overall,the calibrated and verified MAP had a high degree of uncertainty(negative connection degree)regardless of the dataset or reconstruction method used.Therefore,the reconstructed time series of MAT for the period of 1850(or 1901)–1960 based on the CRU and CMIP5 datasets using the delta and SP methods could be used for further study.The results of this study will be useful for short-term(several decades)regional climate reconstruction and longer-term(100 a or more)assessments of regional climate change. | LI Xuemei Slobodan P SIMONOVIC LI Lanhai ZHANG Xueting QIN Qirui | 2020 | Journal of Arid Land2020，12，3： | 2 |
| 13 | SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction显示文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. | HAN NIU XIN CHEN XUEQI FU JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG | 2021 | BIOCELL2021，45，4： | 2 |
| 14 | Research on Data Fusion of Adaptive Weighted Multi-Source Sensor显示文摘Data fusion can effectively process multi-sensor information to obtain more accurate and reliable results than a single sensor.The data of water quality in the environment comes from different sensors,thus the data must be fused.In our research,self-adaptive weighted data fusion method is used to respectively integrate the data from the PH value,temperature,oxygen dissolved and NH3 concentration of water quality environment.Based on the fusion,the Grubbs method is used to detect the abnormal data so as to provide data support for estimation,prediction and early warning of the water quality. | Donghui Li Cong Shen Xiaopeng Dai Xinghui Zhu Jian Luo Xueting Li Haiwen Chen Zhiyao Liang | 2019 | Computers, Materials & Continua2019，，9： | 2 |
| 15 | Removal of sulfamethoxazole and trimethoprim from reclaimed water and the biodegradation mechanism显示文摘Sulfamethoxazole (SMX)and trimethoprim (TMP)are two critical sulfonamide antibiotics with enhanced persistency that are commonly found in wastewater treatment plants.Recently,more scholars have showed interests in how SMX and TMP antibiotics are biodegraded,which is seldom reported previously.Novel artificial composite soil treatment systems were designed to allow biodegradafion to effectively remove adsorbed SMX and TMP from the surface of clay ceramsites.A synergy between sorption and biodegradation improves the removal of SMX and TMP.One highly efficient SMX and TMP degrading bacteria strain,Bacillus subtilis,was isolated from column reactors.In the removal process,this bacteria decade SMX and TMP to NH4^+,and then further convert NH4^+to NO3^- in a continuous process.Microbial adaptation time was longer for SMX degradation than for TMP,and SMX was also able to be degraded in aerobic conditions.Importantly,the artificial composite soil treatment system is suitable for application in practical engineering. | Qinqin Liu Miao Li Xiang Liu Quan Zhang Rui Liu Zhenglu Wang Xueting Shi Jin Quan Xuhui Shen Fawang Zhang | 2018 | Frontiers of Environmental Science & Engineering2018，12，6： | 2 |
| 16 | Bulk growth and separation of single-walled carbon nanotubes from rhenium catalyst显示文摘Bulk synthesis of single-walled carbon nanotubes(SWNTs)using solid catalyst has been challenging,despite of recent breakthrough in the chirality-specific growth on the flat substrate surface.In this work,we propose a porous magnesia support rhenium catalyst for bulk synthesis of SWNTs.It is found that the well-dispersed catalyst with a high melting point and the optimal chemical vapor deposition reaction conditions account for the growth of SWNTs.Detailed characterizations reveal the produced SWNTs are dominant in(n,n−1)and(n,n−2)species.Furthermore,by using a multicolumn chromatography post-growth separation method,SWNTs with three defined diameter ranges were obtained.This work guides the design of porous oxide supported catalyst for bulk synthesis and diameter-dependent sorting of SWNTs,which will ultimately help harness the extraordinary properties of SWNTs. | Chen Ma Yumin Liu Lili Zhang Liu Qian Yiming Zhao Ying Tian Qianru Wu Dong Li Nan Zhao Xueting Zhang Liantao Xin Huaping Liu Pengxiang Hou Chang Liu Maoshuai He Jin Zhang | 2022 | Nano Research2022，15，7： | 2 |
| 17 | Progress and challenges of prelithiation technology for lithium-ion battery显示文摘Prelithiation technology is widely considered a feasible route to raise the energy density and elongate the cycle life of lithium-ion batteries.The principle of prelithiation is to introduce extra active Li ions in the battery so that the lithium loss during the first charge and long-term cycling can be compensated.Such an effect does not need to change the major electrode material or battery structure and is compatible with the majority of current lithium-ion battery production lines.At this stage,various prelithiation methods have been reported,some of which are already in the pilot-scale production stage.But there is still no definitive development roadmap for prelithiation.In this review,we first introduce the influence of prelithiation on electrochemical performance from a theoretical point of view and then compare the pros and cons of different prelithiation methods in different battery manufacturing stages.Finally,we discuss the challenges and future development trends of prelithiation.We aim to build up a bridge between academic research and industrial application.Some engineering problems in the promotion of prelithiation technique are extensively discussed,including not only the implementation of prelithiation but also some collateral issues on battery designing and management. | Zhenyu Huang Zhe Deng Yun Zhong Mingkang Xu Sida Li Xueting Liu Yu Zhou Kai Huang Yue Shen Yunhui Huang | 2022 | Carbon Energy2022，4，6： | 1 |
| 18 | GSH-induced chemotaxis nanomotors for cancer treatment by ferroptosis strategy显示文摘Overexpression of glutathione(GSH) in tumor cells greatly inhibits the therapy effect of traditional ferroptosis inducers;thus,control of the GSH level is an important way to improve the efficacy of ferroptosis.Herein,a kind of nanomotor based on metal organic framework material NH_(2)-MIL-101 is constructed,in which polyethylene glycol(PEG) and glutathione hydrolase γ-glutamyltransferase(GGT) are asymmetrically modified to obtain mPEG@MIL-101@GGT nanomotors(PMG NMs).The nanomotor proposed in this article can be induced by overexpressing GSH in tumors to form chemotactic effects through the specific affinity between enzymes and substrates.Results indicate that the tail structure provided by PEG and the affinity between GGT and GSH can enable the stable chemotaxis behavior of nanomotors in a complex environment,thus enriching and penetrating deeply at the tumor site.In addition,after loading the ferroptosis inducer Erastin,the system shows a highly effective induction effect of tumor ferroptosis.Erastin in the system can effectively inhibit the synthesis of GSH,and PMG NMS can react with GSH through Fe^(3+)and GGT to promote GSH depletion.The produced Fe^(2+)can generate excessive reactive oxygen species through Fenton reaction,which further promotes the death of tumor cells.Meantime,the chemotaxis behavior of the nanomotors based on the endogenous biochemical reaction of GGT-catalyzed GSH hydrolysis can endow nanomotors with the enhanced delivery and penetration ability in tumors,thus collaboratively enhancing the ferroptosis effect.This strategy designed according to the physiological characteristics of tumors has good biosafety and treatment effect,providing new perspectives for micro/nanomotor and tumor treatment. | Zhiyong Liu Ting Li Nan Li Yujing Wang Lin Chen Xueting Tang Mimi Wan Chun Mao | 2022 | Science China Chemistry2022，65，5： | 1 |
| 19 | Brocaeloid D,a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049显示文摘Microbes serve as the most important resource for drug discovery.During our screening for bioactive compounds from our natural products library,a pathogenic fungus,Microdochium majus strain 99049,from wheat was selected for further investigation.A new alkaloid named brocaeloid D(1),together with six previously characterized compounds(2–7)were identified.Compound 1 belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide substructure.All the structures of these newly isolated compounds were determined by different means in spectroscopic experiments.The absolute configurations of 1 was further deduced from comparison of its CD spectrum with that of known compound 2.The bioactivities of these identified compounds were evaluated against several pathogenic microorganisms and cancer cell lines.Compounds 1–5 showed activity against HUH-7 human hepatoma cells with IC50 values of 80μg/mL.Compound 6 showed mild activity against HeLa cells(IC50=51.9μg/mL),weak anti-MTB activity(MIC=80μg/mL),and moderate anti-MRSA activity(MIC=25μg/mL),and compound 7 showed weak anti-MRSA activity(MIC=100μg/mL). | Jingyu Zhang Zhenzhen Wang Zhijun Song Loganathan Karthik Chengjian Hou Guoliang Zhu Lan Jiang Jianying Han Rong Ma Li Li Lixin Zhang Xueting Liu Tom Hsiang | 2019 | Synthetic and Systems Biotechnology2019，4，4： | 1 |
| 20 | Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing显示文摘The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy.Moreover,after more than 2 years,many populations are still under pressure of infection.Thus,a broader perspective in developing antiviral strategies is still of great importance.Inspired by the observed multiple benefits of heparin in the treatment of thrombosis,the potential of low molecular weight heparin(LMWH)for the treatment of COVID-19 have been explored.Clinical applications found that LMWH decreased the level of inflammatory cytokines in COVID-19 patients,accordingly reducing lethality.Furthermore,several in vitro studies have demonstrated the important roles of heparan sulfate in SARS-CoV-2 infection and the inhibitory effects of heparin and heparin mimetics in viral infection.These clinical observations and designed studies argue for the potential to develop heparin mimetics as anti-SARS-CoV-2 drug candidates.In this review,we summarize the properties of heparin as an anticoagulant and the pharmaceutical possibilities for the treatment of virus infection,focusing on the perspectives of developing heparin mimetics via chemical synthesis,chemoenzymatic synthesis,and bioengineered production by microbial cell factories.The ultimate goal is to pave the eminent need for exploring novel compounds to treat coronavirus infection-caused diseases. | Lan Jiang Tianji Zhang Hongzhong Lu Saijuan Li Kangjie Lv Alex Tuffour Lixin Zhang Kan Ding Jin-Ping Li Hongmei Li Xueting Liu | 2023 | Synthetic and Systems Biotechnology2023，8，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员