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| 1 | Soft-sediment Deformation Structures Related to Earthquake from the Devonian of the Eastern North Qilian Mts.and Its Tectonic Significance显示文摘摘要:在北方 Qilian orogenic 带和 Hexi 走廊的泥盆纪开发了在北方中国板和 Qaidam microplate 之间的碰撞引起的低岬盆的以后的舞台的陆上的 molasse。低岬盆触发了强烈地震,并且形成了 seismites 和地震相关的软沉积的变丑。在东方北方 Qilian 山的泥盆纪的软沉积的变丑结构由 seismo 裂缝组成,沙岩女同性恋, syn-depositional 差错, microfolds (微弄皱迭合) ,使流体化的静脉,负担演员组,火焰结构,枕头结构和 brecciation。seismo 裂缝, syn-depositional 差错和 microfolds 是地震的摆动直接形成的裂缝,差错和褶层。地震女同性恋由沉积灌输进地震裂缝形成了。使流体化的静脉被灌输进使流体化的沙的 seismo 裂缝做。负担演员组,火焰结构和枕头结构被下沉并且灌输形成沿着在沙、泥泞的床之间的脸从地震的摆动引起了。brecciation 源于地震的摆动并且沉积的层裂开。在泥盆纪的 seismites 和软沉积的变丑在造山运动期间触发了与构造活动有关的地震并且北方 Qilian 山高举。 | DU Yuansheng XU Yajun YANG Jianghai | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 13 |
| 2 | Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B/pyrin domain-containing protein 3 pathway显示文摘OBJECTIVE: To evaluate the effectiveness of Sini powder for the treatment of non-alcoholic fatty liver disease(NAFLD) in rats and the molecular mechanisms involved.METHODS: A rat model of stress-induced NAFLD was established by a combination of long-term tethering and feeding of a high-fat, high-calorie diet. These rats were then intragastrically administered with either simvastatin, Sini powder, or vehicle for 1 week. The body mass and field test scores for each group were recorded weekly. Serum aspartate aminotransferase and alanine aminotransferase activities, and triglyceride, total cholesterol,and free fatty acid concentrations were measured.Liver tissue histopathology was examined on hematoxylin and eosin-stained paraffin sections and oil red O-stained frozen sections. The hepatic m RNA expression of nuclear factor kappa-B(NF-κB),NOD-, LRR-, and pyrin domain-containing protein 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC), and caspase-1 were measured by reverse transcription-polymerase chain reaction(RT-PCR). The hepatic protein concentrations of NF-κB and NLRP3, ASC, caspase-1, interleukin-1β(IL-1β), interleukin-6(IL-6), and the serum concentrations of IL-1β and IL-6 were measured by enzyme-linked immunosorbent assay.RESULTS: Compared with the Blank group, rats in the Compound model group showed significant pathologic manifestations of NAFLD, and the expression of NF-κB, NLRP3, ASC, caspase-1, IL-1βand IL-6 were significantly higher(all P < 0.01). Both simvastatin and Sini powder significantly ameliorated the NAFLD pathology and the abnormal expression of NF-κB, NLRP3, ASC, caspase-1, IL-1β, and IL-6(all P < 0.01).CONCLUSION: Sini powder inhibits the inflamma-tory response in rats with NAFLD, which is mediated by NF-κB/NLRP3, IL-1β, and IL-6, reduces the effects of psychological stress, and improves lipid metabolism. Therefore, Sini powder may be effective for the treatment of stress-related NAFLD through multiple mechanisms. | Mu Jie Cheng Fafeng Wang Qingguo Wang Xueqian Zhu Wenxiang Ma Chongyang Yin Xiangjun Ren Beida Lian Yajun Du Xin Zhang Haixia Liu Shuling Zhang Shuang | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 3 | Sedimentary geochemistry and provenance of the Lower and Middle Devonian Laojunshan Formation,the North Qilian Orogenic Belt显示文摘The Laojunshan Formation is a suite of molasse formed during the rapid uplift of the North Qilian Orogenic Belt (NQOB). Forty-one samples of sandstone have been collected from the Sunan and Minle sections in the western sector and the Gulang and Jingyuan sections in the eastern sector of the NQOB belt. Geochemical analyses of those samples indicated: 1) The MgO+Fe2O3T and Al2O3/SiO2 values are higher, and K2O/Na2O ratios are lower in the western sector than those in the eastern sector. 2) All of them are depleted in Nb and Ta elements. The samples from the western sector are depleted in Rb element and enriched with Sc, Co, Ni, V, and Cr elements in the Upper Crust-normalized patterns. However, those from the eastern sector are depleted in Sr without enrichments of Sc, Co, Ni, V, and Cr. 3) All of the samples display a right-inclined REE pattern af- ter Chondrite-normalized REE pattern. But LaN/YbN and Eu/Eu* ratios of the samples from the western sector are lower than those of the samples from the eastern sector. These geochemical characteristics suggest the prominent input of mafic clast with minor granitic rocks into the Sunan area, felsic clast into the Gulang and Jingyuan area, and both mafic and felsic clast into the Minle area. The angular shapes of gravels imply that these ill-sorted sediments were deposited near their sources without recy- cling. Geochemical features above also demonstrated that no major chemical weathering occurred for the western provenance, but deposits in the eastern sector resulted from low or middle degree chemical weathering. Evidences combining tectonic discriminations and comparisons with potential provenances revealed that sediments in the Sunan area were derived mainly from the North Qilian Continental arc, whereas sediments in the Minle, Gulang, and Jingyuan areas were derived not only from the North Qilian Continental arc but also from the basement of the Middle Qilian block. Integrated with the characteristics of development of Silurian and Devonian, these imply that the orogeny of NQOB is diachronous in the trending direction due to the oblique collision. | XU YaJun DU YuanSheng YANG JiangHai HUANG Hu | 2010 | Science China Earth Sciences2010，53，3： | 7 |
| 4 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 5 | Structural basis of immunosuppression by the therapeutic antibody daclizumab显示文摘发信号的 Interleukin-2 (IL )-2 在小径被显示出为在有机关移植的病人的免疫力的抑制有效减轻 / 消除 allograft 拒绝的堵住这的有免疫力的回答,和药的激活起一个枢轴的作用。首先人性化的 monoclonal 抗体(mAb ) daclizumab 掉进这个范畴并且对 IL-2 受体建筑群的一个关键部件显示出高特性和亲密关系,也就是 IL-2R 伪。揭示由 daclizumab 表明小径的 IL-2 的抑制的分子的机制,我们在 2.6 和 2.8 点与 IL-2R 伪 ectodomain 在免费形式并且在建筑群决定了 daclizumab Fab 的水晶结构?分辨率分别地。daclizumab Fab 当面采用类似的符合构造或 IL-2R 伪 ectodomain 的缺席。daclizumab 的抗原绑定地点主要由决定形成大断然控告的表面消沉和通常是恐水病的二个 flanking 补丁的区域(CDR ) 的五补充组成。 conformational epitope 由 IL-2R 伪 ectodomain 的几个不连续的片断组成,哪个与与 IL-2 交往的区域重叠的大部分,建议到 IL-2R 伪 的 daclizumab 的绑定将阻止 IL-2 绑定到 IL-2R 伪 和 IL-2/IL-2R 伪尾纬c 建筑群的随后的形成,因此堵住表明小径的 IL-2 。这些结果也为指向 IL-2R 伪的改进 mAb 药的设计和发展有含意。 | Hui Yang Jianchuan Wang Jiamu Du Chen Zhong Dapeng Zhang Huaizu Guo Yajun Guo Jianping Ding | 2010 | Cell Research2010，20，12： | 5 |
| 6 | Molecular mechanism of non-alcoholic fatty liver disease induced and aggravated by chronic stress through HSL/ATGL-FFA which promotes fat mobilization显示文摘Objective:To study the effects of social stress(CS)and social stress combined with high-fat diet on fat mobilization as a candidate mechanism for the induction or aggravation of non-alcoholic fatty liver disease(NAFLD).Methods:Thirty-two male Wistar rats(250±10 g)were randomly allocated to a blank control group(BC),a high-fat diet group(HFD),a CS group,and a combined CS and high-fat diet group(CS t HFD).Rats were sacrificed and tissues were collected after 8 weeks.Liver and body mass were measured and used to calculate the liver index.Serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),and free fatty acids(FFAs)were measured.Liver sections were examined microscopically after oil red O and hematoxylin and eosin staining.The relative mRNA expression of acetyl-CoA carboxylase(ACCase),hydroxymethylglutaryl coenzyme A(HMG-CoA)reductase in liver,and hormone-sensitive lipase(HSL),and adipose triglyceride lipase(ATGL)in subcutaneous adipose tissue,were measured by real-time PCR.The liver concentrations of triglyceride,reactive oxygen species,and ACCase were measured by ELISA and HSL activity was determined using turbidimetry.Results:NAFLD developed in the CS,HFD,and CS t HFD groups,with the most severe NAFLD being in the CS t HFD group.Serum AST,ALT,and FFA,liver index,and hepatic triglyceride,FFA,and tumor necrosis factor-a were significantly higher in both the CS and CS t HFD groups.However,food intake and ACCase mRNA expression were lower.The mRNA expression of HSL and ATGL in adipose tissue was much higher,and HSL activity was higher in the CS group than in the BC group,and in the CS t HFD group than in the HFD group.Conclusion:We have successfully established two models of stress-induced NAFLD,suggesting stress can induce and aggravate NAFLD by promoting fat mobilization through upregulation of HSL and ATGL. | Jie Mu Xueqian Wang Qingguo Wang Fafeng Cheng Wenxiang Zhu Changxiang Li Chongyang Ma Changming Zhai Yajun Lian Xin Du | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 2 |
| 7 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 8 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 9 | Detrital zircon of 4.1 Ga in South China显示文摘One hadean zircon from the Cambrian sandstone in the southern part of South China has a U-Pb age of 4107±29 Ma with ε Hf(t) value similar to that of the homochronous depleted mantle and Hf model age of 4102±21 Ma.This demonstrates the existence of hadean crustal remnant in South China.A close match between the U-Pb age and Hf model age with the highly position ε Hf(t) value indicates the growth and immediate reworking of juvenile crust from the depleted mantle at ca 4.1 Ga.The prominent 'Pan-African' and Grenville zircons derived from the exotic sources were also found in the sample,which indicates a linking between South China and Gondwana in the Cambrian period.The southern part of South China has complex histories of crustal growth and tectonic evolution. | XU YaJun DU YuanSheng HUANG HongWei HUANG ZhiQiang HU LiSha ZHU YanHui YU WenChao | 2012 | Chinese Science Bulletin2012，57，33： | 2 |
| 10 | Intelligent Spider's Algorithm of Search Engine Based on Keyword显示文摘 | YaJun Du HaiMing Li Zheng Pei | 2005 | Transactions on Computer and Information technology2005，1，1： | 1 |
| 11 | Detrital zircon record of continental collision: Assembly of the Qilian Orogen, China显示文摘 | Xu Yajun Du Yuansheng Cawood P A | 2010 | Sedimentary Geology2010，230，： | 1 |
| 12 | New Fast Algorithm for Constructing Concept attice显示文摘 | Yajun Du Zheng Pei Haiming Li | 2007 | ICCSA2007，10，2： | 1 |
| 13 | Provenance record of a foreland basin: Detrital zircon U- Pb ages from Devonian strata in the North Qilian Orogenic Belt, China显示文摘 | Xu Yajun Du Yuansheng Cawood P A | 2010 | Tectonophysics2010，495，34： | 1 |
| 14 | Strategy for mining association rules for web pages based on formal concept analysis 显示文摘 | Du Yajun Li Haiming | 2010 | Appl Soft Comput2010，10，3： | 1 |
| 15 | An optimized relevancy Context Graph based on social network显示文摘 | Hu Qiang Du Yajun Yang Jiaying | 2014 | Journal of Information and Computational Science2014，11，6： | 1 |
| 16 | New Zircon U-Pb Age of Late Devonian Tuff in Guangxi, South China and the Significance for the Paleo-Tethys Branch Ocean显示文摘Objective The eastern extending range of the Paleo-Tethys Ocean in southwest China has always been focused and controversial.At the beginning of this century some scholars proposed that the Paleo-Tethys Branch Ocean may extend to the Babu–Pingxiang and Cengxi areas along the stouthwestern margin of the South China Block(Cai and Zhang,2009).However,the pivotal proof of | HU Lisha DU Yuansheng XU Yajun WANG Zhiwen WANG Chenghao | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 17 | Observation of cavitation and water-refilling processes in plants with X-ray phase contrast microscopy显示文摘With the spatial coherence of X-rays and high flux and brightness of the 3rd generation synchrotron radiation facility,X-ray phase contrast microscopy(XPCM)at Shanghai Synchrotron Radiation Facility(SSRF)can provide high resolution dynamic imaging of low electron density materials in principle.In this paper,we investigated the cavitation and water-refilling processes in rice and bamboo leaves utilizing XPCM at SSRF.The occurrence of xylem cavitation was recorded in vivo.The study also revealed that under different dehydration conditions,cavitation occurs in different degrees,and therefore,the refilling process is different.The results demonstrate that SSRF can provide high enough fluxes to study dynamic processes in plants in real-time,and XPCM is expected to be a promising method to reveal the mechanisms of cavitation and its repair in plants nondestructively. | XUE Yanling XIAO Tiqiao DU Guoha TONG Yajun LIU Huiqiang DENG Biao XIE Honglan XU Hongjie | 2013 | Nuclear Science and Techniques2013，24，6： | 1 |
| 18 | Magnetic nanohydroxyapatite/PVA composite hydrogels for promoted osteoblast adhesion and proliferation显示文摘 | Ruixia Hou Guohua Zhang Gaolai Du Danxia Zhan Yang Cong Yajun Cheng Jun Fu | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 19 | Y ersinia protein kinase A phosphorylates vasodilator‐stimulated phosphoprotein to modify the host cytoskeleton显示文摘 | Yuehua Ke Yafang Tan Na Wei Fen Yang Huiying Yang Shiyang Cao Xiaohui Wang Jian Wang Yanping Han Yujing Bi Yujun Cui Yanfeng Yan Yajun Song Xiaoming Yang Zongmin Du Ruifu Yang | 2015 | Cell Microbiol2015，，： | 1 |
| 20 | Semantic ranking of web pages based on formal concept analysis显示文摘 | Du Yajun Hai Yufeng | 2013 | Journal of Systems and Software2013，86，1： | 1 |
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