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| 1 | Novel function of perforin in negatively regulating CD4^+ T cell activation by affecting calcium signaling显示文摘Perforin 是主要从事调停的形成毛孔的蛋白质目标 T 房间死亡并且被细胞毒素的 T 淋巴细胞(CTL ) 和自然漂亮房间采用。然而,它是否也在常规 CD4+ T 房间功能起一个作用,仍然保持不清楚。这里,我们报导那在 perforin 缺乏(PKO ) 老鼠, CD4+ T 房间是响应 T 的 hyperproliferative 房间受体(TCR ) 刺激。hyperproliferation 的这个特征被改进在房间分割并且在 IL-2 分泌物伴随。看起来, perforin 缺乏不在胸腺怒气和淋巴节点影响 T 房间开发。在 vivo, perforin 缺乏导致增加的抗原特定的 T 房间增长和抗体生产。而且, PKO 老鼠更产生试验性的自体免疫的眼色素层炎。探讨分子的机制,我们发现在 TCR 刺激以后,从 PKO 老鼠的 CD4+ T 房间显示增加的细胞内部的钙流动并且随后提高抄写因素 NFAT1 的激活。我们的结果显示 perforin 在由影响 TCR 依赖的 Ca2+ 发信号调整 CD4+ T 房间激活和有免疫力的反应起一个否定作用。 | Enguang Bi Chunjian Huang Yu Hu Xiaodong Wu Weiwen Deng Guomei Lin Zhiduo Liu Lin Tian Shuhui Sun Kairui Mao Jia Zou Yuhan Zheng Bing Sun | 2009 | Cell Research2009，19，7： | 2 |
| 2 | Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death显示文摘Immunogenic cell death(ICD) plays a major role in cancer immunotherapy by stimulating specific T cell responses and restoring the antitumor immune system.However,effective type Ⅱ ICD inducers without biotoxicity are still very limited.Herein,a tentative drug-or photo sensitizer-free strategy was developed by employing enzymatic self-assembly of the peptide F-pY-T to induce mitochondrial oxidative stress in cancer cells.Upon dephosphorylation catalyzed by alkaline phosphatase overexpressed on cancer cells,the peptide F-pY-T self-assembled to form nanoparticles,which were subsequently internalized.These affected the morphology of mitochondria and induced serious reactive oxygen species production,causing the ICD characterized by the release of danger-associated molecular patterns(DAMPs).DAMPs enhanced specific immune responses by promoting the maturation of DCs and the intratumoral infiltration of tumor-specific T cells to eradicate tumor cells.The dramatic immunotherapeutic capacity could be enhanced further by combination therapy of F-pY-T and anti-PD-L1 agents without visible biotoxicity in the main organs.Thus,our results revealed an alternative strategy to induce efficient ICD by physically promoting mitochondrial oxidative stress. | Debin Zheng Jingfei Liu Limin Xie Yuhan Wang Yinghao Ding Rong Peng Min Cui Ling Wang Yongjie Zhang Chunqiu Zhang Zhimou Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 3 | Mirror-enhanced scanning light-field microscopy for long-term high-speed 3D imaging with isotropic resolution显示文摘Various biological behaviors can only be observed in 3D at high speed over the long term with low phototoxicity.Light-field microscopy(LFM)provides an elegant compact solution to record 3D information in a tomographic manner simultaneously,which can facilitate high photon efficiency.However,LFM still suffers from the missing-cone problem,leading to degraded axial resolution and ringing effects after deconvolution.Here,we propose a mirrorenhanced scanning LFM(MiSLFM)to achieve long-term high-speed 3D imaging at super-resolved axial resolution with a single objective,by fully exploiting the extended depth of field of LFM with a tilted mirror placed below samples.To establish the unique capabilities of MiSLFM,we performed extensive experiments,we observed various organelle interactions and intercellular interactions in different types of photosensitive cells under extremely low light conditions.Moreover,we demonstrated that superior axial resolution facilitates more robust blood cell tracking in zebrafish larvae at high speed. | Bo Xiong Tianyi Zhu Yuhan Xiang Xiaopeng Li Jinqiang Yu Zheng Jiang Yihan Niu Dong Jiang Xu Zhang Lu Fang Jiamin Wu Qionghai Dai | 2021 | Light(Science & Applications)2021，10，12： | 1 |
| 4 | The conservation patterns of grassland ecosystem in response to the forage-livestock balance in North China显示文摘Being a key ecological security barrier and production base for grassland animal husbandry in China,the balance between grassland forage supply and livestock-carrying pressure in North China directly affects grassland degradation and restoration,thereby impacting grassland ecosystem services.This paper analyzes the spatiotemporal variation in grassland vegetation coverage,forage supply,and the balance between grassland forage supply and livestock-carrying pressure from 2000 to 2015 in North China.We then discuss the spatial pattern of grassland ecological conservation under the impacts of grassland degradation and restoration,and livestock-carrying pressure.Over the last 16 years,the total grassland area in North China decreased by about 16,000 km^(2),with vegetation coverage degraded by 6.7%of the grasslands but significantly restored by another 5.4%of grasslands.The provisioning of forage by natural grassland mainly increased over time,with an annual growth rate of approximately 0.3 kg/ha,but livestock-carrying pressure also increased continuously.The livestock-carrying pressure index without any supplementary feeding reached as high as 3.8.Apart from the potential livestock-carrying capacity in northeastern Inner Mongolia and the central Tibetan Plateau,most regions in North China are currently overloaded.Considering the actual supplementary feeding during the cold season,the livestock-carrying pressure index is about 3.1,with the livestock-carrying pressure mitigated in central and eastern Inner Mongolia.Assuming full supplementary feeding in the cold season,livestock-carrying pressure index will fall to 1.9,with the livestock-carrying pressure alleviated significantly in Inner Mongolia and on the Tibetan Plateau.Finally,we propose different conservation and development strategies to balance grassland ecological conservation and animal husbandry production in different regions of protected areas,pastoral areas,farming-pastoral ecotone,and farming areas,according to the grassland ecological protection patterns. | HUANG Lin NING Jia ZHU Ping ZHENG Yuhan ZHAI Jun | 2021 | Journal of Geographical Sciences2021，31，4： | 1 |
| 5 | Proteomics to reveal metabolic network shifts towardslipid accumulation following nitrogen deprivation in thediatom Phaeodactylum tricomutum 显示文摘 | Yang Zhikai Ma Yuhan Zheng Jianwei | 2014 | Journal ofApplied Phycology2014，26，1： | 1 |
| 6 | LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway显示文摘Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis.If the injury persists,liver injury can lead to cirrhosis and liver failure and ultimately results in the development of liver cancer.Emerging evidence has indicated that long noncoding RNAs(lncRNAs)play an important role in the development of liver injury.However,the role of antisense Igf2r RNA(Airn)in acute liver injury and its underlying mechanism remain largely unclear.In this study,we show that Airn is upregulated in liver tissue and primary hepatocytes from an acute liver injury mouse model.Consistently,Airn is also overexpressed in serum samples of patients with acute-on-chronic liver failure and is negatively correlated with the Model for End-Stage Liver Disease(MELD)score.Moreover,gene knockout and rescue assays reveal that Airn alleviates CCl_(4)-induced liver injury by inhibiting hepatocyte apoptosis and oxidative stress in vivo.Further investigation reveals that Airn decreases H_(2)O_(2)-induced hepatocyte apoptosis in vitro.Mechanistically,we reveal that Airn represses CCl_(4)-and H_(2)O_(2)-induced enhancement of phosphorylation of p65 and IκBα,suggesting that Airn inhibits hepatocyte apoptosis by inactivating the NF-κB pathway.In conclusion,our results demonstrate that Airn can alleviate acute liver injury by inhibiting hepatocyte apoptosis via inactivating the NF-κB signaling pathway,and Airn could be a potential biomarker for acute liver injury. | Shuai Shao Yu Zhang Feng Zhou Xiaoxiang Meng Zhenjun Yu Guantong Li Lina Zheng Kun Zhang Yuhan Li Beichen Guo Qi Liu Mengxia Zhang Xiaoxiao Du Wei Hong Tao Han | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 7 | Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors:mechanisms and strategies显示文摘Immunotherapies based on immune checkpoint blockade(ICB)have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade.To date,immune checkpoint inhibitors(ICIs)of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy.Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,however,a large subset of refractory patients presents poor responsiveness to ICB therapy;and the underlying mechanism remains elusive.Recently,numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment(TME)with various products of metabolism,and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy.Nevertheless,a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance.Here,we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints(CTLA-4,PD-1,and PD-L1)to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints. | Liming Liao Huilin Xu Yuhan Zhao Xiaofeng Zheng | 2023 | Frontiers of Medicine2023，17，5： | 1 |
| 8 | First detection of cutavirus DNA in stools of patients with rheumatic diseases in Guangzhou,China显示文摘Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descriptive study was conducted among hospitalized patients with rheumatic diseases and individuals undergoing medical health check-ups between June 2019 and June 2022 in Guangzhou,China.Stool samples of subjects were tested for CuV DNA.Demographic and fecal examination data of patients were obtained from electronic medical records.A total of 505 patients with rheumatic diseases and 244 individuals who underwent medical health check-ups were included in the study.Of the patients with rheumatic disease,5.74%[95%confidence interval(CI):4.03%–8.12%]were positive for CuV DNA,while no individual in the medical health check-up group was positive,indicating a close correlation between CuV and rheumatic disease.Men and patients with rheumatoid arthritis or ankylosing spondylitis,according to the disease classification,were more susceptible to being infected with CuV(P<0.01).After adjustments,being male remained the only significant factor,with an adjusted odd ratio(OR)of 4.4(95%CI:1.7–11.4,P?0.002).Phylogenetic analysis of the CuV VP2 sequences showed three diverse clades,one of which was segregated to be a single branching independent of previously known sequences,which is possible a new genotype. | Yongzhi Li Liting Zheng Huan He Husheng Xiong Jiaqi Chen Hengbiao Sun Caiyun Chen Qiushuang Li Jiaqi Fu Fei Wu Yuhan Gao Juxian Xian Minyi Liang Gang Xiao Qing Chen | 2023 | Virologica Sinica2023，38，6： | 0 |
| 9 | Beautiful,charming Hubei显示文摘Let the world meet Hubei,and let Hubei go global!A place of remarkable beauty and amazing scenery,Hubei is the host of this year's culture and tourism expo.The province is ready to receive visitors from all over the world and invite them to enjoy its scenic mountains and waters and share in the vibrant lifestyle of its local people.Let Hubei and the world build a better future together! | Zheng Yuhan(Photo) | 2021 | Changjiang Weekly2021，，46： | 0 |
| 10 | Conformal Human–Machine Integration Using Highly Bending‑Insensitive,Unpixelated,and Waterproof Epidermal Electronics Toward Metaverse显示文摘Efficient and flexible interactions require precisely converting human intentions into computer-recognizable signals,which is critical to the breakthrough development of metaverse.Interactive electronics face common dilemmas,which realize highprecision and stable touch detection but are rigid,bulky,and thick or achieve high flexibility to wear but lose precision.Here,we construct highly bending-insensitive,unpixelated,and waterproof epidermal interfaces(BUW epidermal interfaces)and demonstrate their interactive applications of conformal human–machine integration.The BUW epidermal interface based on the addressable electrical contact structure exhibits high-precision and stable touch detection,high flexibility,rapid response time,excellent stability,and versatile“cut-and-paste”character.Regardless of whether being flat or bent,the BUW epidermal interface can be conformally attached to the human skin for real-time,comfortable,and unrestrained interactions.This research provides promising insight into the functional composite and structural design strategies for developing epidermal electronics,which offers a new technology route and may further broaden human–machine interactions toward metaverse. | Chao Wei Wansheng Lin Liang Wang Zhicheng Cao Zijian Huang Qingliang Liao Ziquan Guo Yuhan Su Yuanjin Zheng Xinqin Liao Zhong Chen | 2023 | Nano-Micro Letters2023，15，11： | 0 |
| 11 | Self-powered Internet of Things sensing node based on triboelectric nanogenerator for sustainable environmental monitoring显示文摘The myriad sensing nodes in the Internet of Things(IoT)are mainly powered by battery,which has limited the lifespan and increased the maintenance costs.Herein,a self-powered IoT sensing node based on triboelectric nanogenerator(TENG)is proposed for the sustainable environmental monitoring.The wind powered TENG(W-TENG)is adopted in freestanding mode with the rabbit hair and six pairs of finger electrodes.With the energy management module,the weak electrical energy from WTENG can be converted into a stable direct current(DC)2.5 V voltage for the operation of the IoT sensing node.When the storage energy exceeds 4.4 V,the node can be activated,then the microprogrammed control unit(MCU)transmits the monitoring data.Thereafter,the monitoring data will be identified and relayed to the IoT cloud platform by narrowband IoT(NBIoT)module.At a wind speed of 8.4 m/s,the node can realize the wireless monitoring and data transmission for temperature and atmosphere pressure every 30 s.This work has provided a universal strategy for sustainable IoT sensing nodes powered by environmental micro-nano mechanical energy and exhibited potential applications in IoT,big data,and environmental monitoring. | Yuhan Qin Xianpeng Fu Yuan Lin Zheng Wang Jie Cao Chi Zhang | 2023 | Nano Research2023，16，9： | 0 |
| 12 | Optimization of Extraction Process of Polyphenols from Chrysanthemum morifolium and the Development of Chrysanthemum Rice Wine显示文摘[Objectives]This study was conducted to provide a theoretical basis for the extraction and comprehensive utilization of functional active components of Chrysanthemum morifolium polyphenols.[Methods]With C.morifolium as a raw material,polyphenols were extracted by water extraction.The extraction process of polyphenols were optimized by single factor tests on solid-liquid ratio,extracting time and times.Old rice wine selected as the base wine was added with C.morifolium polyphenol extract,honey,citric acid and other auxiliary materials to prepare a kind of chrysanthemum old rice wine.Through sensory analysis combined with fuzzy mathematics comprehensive evaluation method,the optimal formula of chrysanthemum old rice wine was determined,and the corresponding physicochemical indicators of the obtained chrysanthemum old rice wine were tested.[Results]The optimal soaking process for C.morifolium was as follows:extraction time of 20 min,a solid-liquid ratio of C.morifolium to warm water at 1:40,extraction times of 3 times.The physical and chemical indicators of the chrysanthemum wine obtained from the above optimal formula were as follows:sugar content 5%,ethanol content 11%,and pH value 4.04.The chrysanthemum old rice wine obtained was clear and transparent,and the fragrance of chrysanthemum was coordinated with the mellow aroma of rice wine.The taste was refreshing and suitable for the vast majority of people to drink.[Conclusions]The new type of chrysanthemum old rice wine combines the polyphenolic active substances in C.morifolium with the low ethanol content of old rice wine,which not only improves the utilization rate of C.morifolium,but also strengthens the health function of old rice wine products,improves the quality of old rice wine,and promotes the healthy and rapid development of the old rice wine industry. | Weiyi CHEN Yufeng ZHANG Zoukai HUANG Ruyi ZHENG Caiyun HUANG Xunjian CHEN Yuhan FU Weixin WANG | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 13 | Identifying human-induced influence on microbial community:A comparative study in the effluent-receiving areas in Hangzhou Bay显示文摘Microbial community structure is afiected by both natural processes and human activities.In coastal area,anthropegenetic activity can usually lead to the discharge of the effluent from wastewater treatment plant(WWTP)to sea,and thus the water quality chronically turns worse and marine ecosystem becomes unhealthy.Microorganisms play key roles in pollutants degradation and ecological restoration;however,there are few studies about how the WWTP effluent disposal influences coastal microbial communities.In this study,sediment samples were collected from two WWTP effluentreceiving areas(abbreviated as JX and SY)in Hangzhou Bay.First,based on the high-throughput sequencing of 16S rRNA gene,microbial community structure was analyzed.Secondly,several statistical analyses were conducted to reveal the microbial community characteristics in response to the effluent disposal.Using PCoA,the significant difference of in microbial community structure was determined between JX and SY;using RDA,water COD and temperature,and sediment available phosphate and ammonia nitrogen were identified as the key environmental factors for the community difference;using LDA effect size analysis,the most distinctive microbes were found and their correlations with environmental factors were investigated;and according to detrended beta-nearesttaxon-index,the sediment microbial communities were found to follow'niche theory'.An interesting and important finding was that in SY that received more and toxic COD,many distinctive microbes were related to the groups that were capable of degrading toxic organic pollutants.This study provides a clear illustration of eco-environmental deterioration under the long-term human pressure from the view of microbial ecology. | Yuhan Zheng Zhiguo Su Tianjiao Dai Feifei Li Bei Huang Qinglin Mu Chuanping Feng Donghui Wen | 2019 | Frontiers of Environmental Science & Engineering2019，13，6： | 0 |
| 14 | Research on the Therapeutic Effect of Sandplay Intervention on Emotional and Behavioral Problems of a Primary School Student显示文摘With the aim to explore the therapeutic effect of sandplay therapy on children with emotional and behavioral problems,in this study,a primary school student with emotional and behavioral problems was selected as the research object undergoing 12 times sandplay intervention,combining the methods of observation,interview,and questionnaire.It turns out that:(1)The traumatic theme indicates an overall downward trend in the process of intervention,while the cure theme indicates an overall upward trend.(2)The results of“strengths and difficulties questionnaire”were found to be consistent with the results of descriptive evaluation before and after sandplay intervention.(3)Based on the interview,sandplay,and questionnaire analysis,it is found that sandplay therapy shows a better therapeutic effect on children with emotional and behavioral problems. | Rongshuang Zheng Yuhan Zhou | 2023 | Journal of Contemporary Educational Research2023，7，10： | 0 |
| 15 | LEAF项目建设状态报告显示文摘LEAF or the Low Energy heavy ion Accelerator Facility is a multidiscipline heavy ion research platform under construction at IMP.It is a 5 year National Major Instruments Research Program supported by National Science Foundation of China(NSFC)started in 2015.Oriented to the frontier research in Material Sciences,Astrophysics,Atomic Physics and Highly Charged Ion Physics,LEAF has been designed and constructed with the state of the art technologies for low energy heavy ion acceleration.This facility features a 45 GHz ECR ion source FECR,a heavy ion CW 4-vane radio frequency quadruple accelerator LRFQ,300 kV HV platform,LEBT,MEBT and several dedicated experimental terminals. | Sun Liangting Yang Yao Lu Liang Guo Yuhui Liu Xiaojun Jing Long Li Libin Sun Liepeng Gao Zheng Ma Hongyi Jin Xiaofeng Zhai Yuhan Xu Xianbo Shi Longbo Xing Chaochao Liu Yuting Zhu Tieming Hu Qiang Zhang Peng Zhang Xuezhen Fang Xing Jia Huan Zhang Bin Liu Chaodong Ma Yingming Zhao Bo Wu Beimin Zhu Li Li Jiaqing Lu Wang Guo Junwei Li Chenxing Wang Zhijun Dou Weiping Wu Junxia Zhang Zimin Yao Qinggao Wu Wei Zhou Zhongzu Zhang Junhui Ma Lizhen He Yuan Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 16 | 神经胶质细胞与神经突触的相互作用——从星形胶质细胞到小胶质细胞和少突胶质细胞谱系细胞显示文摘哺乳动物的大脑是一个由神经元、神经胶质细胞和超过1×1014个突触组成的复杂的器官。神经元是一组异质的电活性细胞,形成大脑复杂电回路的框架。然而,神经胶质细胞约占哺乳动物中枢神经系统(CNS)所有神经细胞的一半,主要分为星形胶质细胞、小胶质细胞、少突胶质细胞(OL)和少突胶质细胞前体细胞(OPC);神经胶质细胞主要为大脑中的神经元提供营养支持。近二十年来,“三联突触”的概念引起了广泛关注,该概念强调星形胶质细胞是突触的组成部分,并在接受神经元信号后以反馈方式调节神经元活动。自此,神经胶质细胞的突触调节得到了广泛的研究和实质性的修改。本综述总结了关于神经胶质细胞(特别是小胶质细胞和OL谱系细胞)如何影响和重塑大脑突触结构和功能的最新重要发现。我们的综述强调了神经元-神经胶质细胞串扰的细胞和分子方面,并提供了有关神经元和神经胶质细胞之间的异常突触通讯如何导致神经病理学的额外信息。 | Yao Liu Xi Shen Yuhan Zhang Xiaoli Zheng Carlos Cepeda YaoWang Shumin Duan Xiaoping Tong 杜一星(编译) | 2023 | 神经损伤与功能重建2023，18，9： | 0 |
| 17 | Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway显示文摘This study aimed to investigate the effect and mechanisms of Ephedra Herb(EH)extract on adriamycin-induced nephrotic syndrome(NS),providing an experimental basis for the clinical treatment of NS.Hematoxylin and eosin staining,creatinine,urea nitrogen,and kidn injury molecule-1 were used to evaluate the activities of EH extract on renal function.The levels of inflammatory factors and oxidative stress were detected by kits.The levels of reactive oxygen species,immune cells,and apoptosis were measured by flow cytometry.A network pharmacological approach was used to predict the potential targets and mechanisms of EH extract in the treatment of NS.The protein levels of apoptosis-related proteins and CAMKK2,p-CAMKK2,AMPK,p-AMPK,mTOR and p-mTOR in the kidneys were detected by Western blot.The effective material basis of EH extract was screened by MTT assay.The AMPK pathway inhibitor(compound C,CC)was added to investigate the effect of the potent material basis on adriamycin-induced cell injury.EH extract significantly improved renal injury and relieve inflammation,oxidative stress,and apoptosis in rats.Network pharmacology and Western blot results showed that the effect of EH extract on NS may be associated with the CAMKK2/AMPK/mTOR signaling pathway.Moreover,methylephedrine significantly ameliorated adriamycin-induced NRK-52e cell injury.Methylephedrine also significantly improved the phosphorylation of AMPK and mTOR,which were blocked by CC.In sum,EH extract may ameliorate renal injury via the CAMKK2/AMPK/mTOR signaling pathway.Moreover,methylephedrine may be one of the material bases of EH extract. | ZHANG Yuhan ZENG Mengnan LI Benke ZHANG Beibei CAO Bing WU Yuanyuan YE Shan XU Ruiqi ZHENG Xiaoke FENG Weisheng | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 0 |
| 18 | Wind Turbine Spindle Operating State Recognition and Early Warning Driven by SCADA Data显示文摘An operating condition recognition approach of wind turbine spindle is proposed based on supervisory control and data acquisition(SCADA)normal data drive.Firstly,the SCADA raw data of wind turbine under full working conditions are cleaned and feature extracted.Then the spindle speed is employed as the output parameter,and the single and combined normal behavior model of the wind turbine spindle is constructed sequentially with the preprocessed data,with the evaluation indexes selected as the optimal model.Finally,calculating the spindle operation status index according to the slidingwindowprinciple,ascertaining the threshold value for identifying the abnormal spindle operation status by the hypothesis of small probability event,analyzing the 2.5 MW wind turbine SCADA data froma domestic wind field as a sample,The results show that the fault warning time of the early warningmodel is 5.7 h ahead of the actual fault occurrence time,as well as the identification and early warning of abnormal wind turbine spindle operationwithout abnormal data or a priori knowledge of related faults. | Yuhan Liu Yuqiao Zheng Zhuang Ma Cang Wu | 2023 | Energy Engineering2023，120，5： | 0 |
| 19 | Beam Commissioning and Operation of LEAF in 2019显示文摘Beam commissioning with several ion species,such as H2^(+),He^(+),N^(2+).Kr^(13+).Xe^(20+) and so on,was implemented in 2019.The layout of LEAF is shown in Fig.1.The transmission efficiency of the RFQ is higher than 97%with beam intensity at the level of one-hundred microampere. | Yang Yao Zhai Yuhan Guo Yuhui Jing Long Lu Wang Ma Hongyi Zhang Wenhui Sun Liepeng Xu Xianbo Shi Longbo Xing Chaochao Yang Lei He Tao Fang Xing Gao Zheng Chang Jianjun Liu Xiaojun Jin Xiaofeng Sun Liangting He Yuan Zhao Hongwei | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 20 | Research on the Four Collaborative Innovation Mechanisms of Industry-education Integration Based on the Concept of Community显示文摘The concept of community is of great significance in guiding the innovation of the mechanism of industry-education integration,which can promote the integration of industry-education integration from'integration'to real'integration'.We summarize the current situation of the development of industry-teaching integration mode through research,point out the'four deviations'in the development of industry-teaching integration,analyze the causes of deviations,and put forward the research strategy of'four synergistic'innovation mechanism for industry-teaching integration based on the concept of community,i.e.,synergistic development of community planning It proposes the research strategy of'four synergies'innovation mechanism based on the concept of community,namely the synergy of community planning and development,the synergy of community governance concept,the synergy of community multi-party educating mechanism,and the synergy of community fusion effect system,so as to establish collaborative ties,build a new form of cooperation concepts,safeguard the docking of talent supply and demand,and enhance the effect of integration of industry and education. | Yanwei Wang Yuhan Jiang Shuxue Tian Yu Zheng Shihang Zhou Huilin Huang | 2023 | 教育技术与创新2023，5，4： | 0 |
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