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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | X protein mutations in hepatitis B virus DNA predict postoperative survival in hepatocellular carcinoma显示文摘 | Ying Xie Shufeng Liu Yue Zhao Zhanjun Guo Jinsheng Xu | 2014 | Tumor Biology2014，，10： | 3 |
| 3 | Scale-location specific relations between soil nutrients and topographic factors in the Fen River Basin, Chinese Loess Plateau显示文摘 | Hongfen ZHU Rutian BI Yonghong DUAN Zhanjun XU | 2017 | Frontiers of Earth Science2017，11，2： | 2 |
| 4 | Bird nest-like zinc oxide nanostructures for sensitive electrochemical glucose biosensor显示文摘In this research,a novel bird nest-like zinc oxide(BN-ZnO)nanostructures were prepared by a simple solvothermal method.A sensitive electrochemical glucose biosensor was for the first time developed based on the immobilization of glucose oxidase(GOx)on nanostructured BN-ZnO modified electrode.The BN-ZnO nanostructure and the resultant biosensor were characterized by scanning electron microscope,X-ray diffraction spectroscopy,Fourier transform infrared spectroscopy,and electrochemical impedance spectroscopy.BN-ZnO nanostructures have large specific surface area and can load large amounts of GOx molecules.Meanwhile,BN-ZnO provides an excellent microenvironment to retain the native bioactivity of enzymes and to promote direct electron transfer between GOx and electrode surface.The proposed biosensor shows a wide linear range of 0.005–1.6 mmol/L,high sensitivity of15.6 mA L mol^(-1)cm^(-2)with a low detection limit of 0.004 mmol/L.The resulting biosensor also shows excellent selectivity,acceptable stability and reproducibility,and can be successfully applied in the detection of glucose in human serum samples at-0.37 V. | Feng Shi Jinming Xu Zhongfang Hu Chuanli Ren Yadong Xue Yongcai Zhang Juan Li Chengyin Wang Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 5 | Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA and age-at-onset of patients with chronic kidney disease显示文摘 | Bai Yaling Guo Zhanjun Xu Jinsheng Zhang Junxia Cui Liwen Zhang Huiran Zhang Shenglei Ai Xiaolu | 2014 | Chinese Medical Journal2014，，17： | 1 |
| 6 | Monitoring of Real-Time Complex Deformed Shapes of Thin-Walled Channel Beam Structures Subject to the Coupling Between Bi-Axial Bending and Warping Torsion显示文摘Structural health monitoring(SHM)is a research focus involving a large category of techniques performing in-situ identification of structural damage,stress,external loads,vibration signatures,etc.Among various SHM techniques,those able to monitoring structural deformed shapes are considered as an important category.A novel method of deformed shape reconstruction for thinwalled beam structures was recently proposed by Xu et al.[1],which is capable of decoupling complex beam deformations subject to the combination of different loading cases,including tension/compression,bending and warping torsion,and also able to reconstruct the full-field displacement distributions.However,this method was demonstrated only under a relatively simple loading coupling cases,involving uni-axial bending and warping torsion.The effectiveness of the method under more complex loading cases needs to be thoroughly investigated.In this study,more complex deformations under the coupling between bi-axial bending and warping torsion was decoupled using the method.The set of equations for deformation decoupling was established,and the reconstruction algorithm for bending and torsion deformation were utilized.The effectiveness and accuracy of the method was examined using a thin-walled channel beam,relying on analysis results of finite element analysis(FEA).In the analysis,the influence of the positions of the measurement of surface strain distributions on the reconstruction accuracy was discussed.Moreover,different levels of measurement noise were added to the axial strain values based on numerical method,and the noise resistance ability of the deformation reconstruction method was investigated systematically.According to the FEA results,the effectiveness and precision of the method in complex deformation decoupling and reconstruction were demonstrated.Moreover,the immunity of the method to measurement noise was proven to be considerably strong. | Rui Lu Zhanjun Wu Qi Zhou Hao Xu | 2019 | Structural Durability & Health Monitoring2019，13，3： | 1 |
| 7 | Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS:a multicenter randomized controlled trial显示文摘We examined the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)infusion for immune nonresponder(INR)patients with chronic HIV-1 infection,who represent an unmet medical need even in the era of efficient antiretroviral therapy(ART).Seventy-two INR patients with HIV were enrolled in this phase II randomized,double-blinded,multicenter,placebo-controlled,dose-determination trial(NCT01213186)from May 2013 to March 2016.They were assigned to receive high-dose(1.5 x 106/kg body weight)or low-dose(0.5 x 106/kg body weight)hUC-MSC,or placebo.Their clinical and immunological parameters were monitored during the 96-week follow-up study.We found that hUC-MSC treatment was safe and well-tolerated.Compared with baseline,there was a statistical increase in CD4+T counts in the high-dose(P<0.001)and low-dose(P<0.001)groups after 48-week treatment,but no change was observed in the control group.Kaplan-Meier analysis revealed a higher cumulative probability of achieving an immunological response in the low-dose group compared with the control group(95.8%vs.70.8%,P=0.00A).However,no significant changes in CD4/CD84-T counts and CD4/CD8 ratios were observed among the three groups.In summary,hUC-MSC treatment is safe.However,the therapeutic efficacy of hUC-MSC treatment to improve the immune reconstitution in INR patients still needs to be further investigated in a large cohort study. | Lifeng Wang Zheng Zhang Ruonan Xu Xicheng Wang Zhanjun Shu Xiejie Chen Siyu Wang Jiaye Liu Yuanyuan Li Li Wang Mi Zhang Wei Yang Ying Wang Huihuang Huang Bo Tu Zhiwei Liang Linghua Li Jingxin Li Yuying Hou Ming Shi Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 8 | Sodium dodecyl sulfate sensitized electrochemical method for subnanomole level determination of ortho-phenylphenol at a novel disposable electrode显示文摘The electrochemical behavior of ortho-phenylphenol(OPP) at a disposable electrode(an improved wax-impregnated graphite electrode) in the presence of sodium dodecyl sulfate(SDS) was studied for the first time.The results demonstrated that the electrocatalytic oxidation process of OPP was accompanied with two-charge-two-proton transference.The electronic transmission coefficient(α) and diffusion coefficient(DR) for OPP were calculated to be 0.8126 and 3.61 × 10-2 cm2/s,respectively.The electrochemical signal was apparently improved by SDS at the disposable electrode and the oxidative peaks current was proportional to the concentration of OPP over the range from 1.0 × 10-9 to 4.0 × 10-6 mol/L with the detection limit of 8.7 × 10-10 mol/L.This novel and highly sensitive method can be successfully applied to detect OPP in the orange rind sample. | LI HongBo LI Jing MENG DongMei PENG JinYun QIAO QiuJu YANG ZhanJun XU Qin HU XiaoYa | 2011 | Science China Chemistry2011，54，7： | 0 |
| 9 | Use of 1.32-μm and 1.06-μm wavelength lasers for vascular cutting in a porcine model of liver and stomach bleeding显示文摘Objective The aim of this study was to analyze and evaluate 1.32-μm and 1.06-μm neodymium-doped yttrium aluminum garnet(Nd:YAG) lasers for use in liver and gastroepiploic vessel vaporization and coagulation. Methods The effects of 1.32-μm and 1.06-μm Nd:YAG lasers were compared for gastroepiploic vessel hemostasis in porcine liver.Results The results were observed and measured under the same parameters and dose conditions. The 1.32-μm laser showed greater vaporization width and depth than the 1.06-μm laser. Both lasers controlled active bleeding. The coagulation band with the 1.32-μm laser was thinner than with the 1.06-μm laser, at nearly 3 mm. After cutting of 1-and 2-mm porcine vessels, no grossly visible bleeding was apparent. Intravascular thrombus was visible under the microscope. The length of vessel thrombosis in the experimental group was 2 mm and the diameter was 2 mm; the control group exhibited thrombi as 2.3–4.9 mm in length. Thrombosis completely blocked the blood vessels.Conclusion The 1.32-μm laser had greater vaporization capability than the 1.06-μm laser and achieved hemostasis requirements for vessels less than 2 mm in diameter. | Lu Han Wenyuan Gao Yangyang Shen Kai Pang Zhanjun Jiang Yonghui Gao Peng Xu Sheng Li | 2017 | Oncology and Translational Medicine2017，3，4： | 0 |
| 10 | Sodium dodecyl sulfate sensitized electrochemical method for sub-picomole level determination of topotecan hydrochloride at a novel disposable electrode显示文摘A sub-picomole level topotecan hydrochloride determination method was first proposed using sodium dodecyl sulfate (SDS) as a sensitized reagent at a novel disposable electrode (an improved wax-impregnated graphite electrode).The effects of different kinds of surfactants on the electrochemical response to topotecan hydrochloride were examined.The results indicate the electrochemical signal was apparently improved by SDS.At optimal conditions,the oxidative peak current increased linearly with the logarithm of concentrations for topotecan hydrochloride in the ranges of 2.0 × 10-12 to 1.0 × 10-11 mol/L and 8.0 × 10-11 to 8.0 × 10-10 mol/L with a detection limit of 6.4 × 10-13 mol/L.The proposed method could be applied in determining topotecan hydrochloride in urine. | LI HongBo LI Jing YANG ZhanJun XU Qin HU XiaoYa | 2011 | Science China Chemistry2011，54，1： | 0 |
| 11 | Spatial prediction of soil organic carbon in coal mining subsidence areas based on RBF neural network显示文摘A quantitative research on the effect of coal mining on the soil organic carbon(SOC)pool at regional scale is beneficial to the scientific management of SOC pools in coal mining areas and the realization of coal low-carbon mining.Moreover,the spatial prediction model of SOC content suitable for coal mining subsidence area is a scientific problem that must be solved.Tak-ing the Changhe River Basin of Jincheng City,Shanxi Province,China,as the study area,this paper proposed a radial basis function neural network model combined with the ordinary kriging method.The model includes topography and vegetation factors,which have large influence on soil properties in mining areas,as input parameters to predict the spatial distribution of SOC in the 0-20 and 2040 cm soil layers of the study area.And comparing the prediction effect with the direct kriging method,the results show that the mean error,the mean absolute error and the root mean square error between the predicted and measured values of SOC content predicted by the radial basis function neural network are lower than those obtained by the direct kriging method.Based on the fitting effect of the predicted and measured values,the R^(2) obtained by the radial basis artificial neural network are 0.81,0.70,respectively,higher than the value of 0.44 and 0.36 obtained by the direct kriging method.Therefore,the model combining the artificial neural network and kriging,and considering environmental factors can improve the prediction accuracy of the SOC content in mining areas. | Qiangqiang Qi Xin Yue Xin Duo Zhanjun Xu Zhe Li | 2023 | International Journal of Coal Science & Technology2023，10，2： | 0 |
| 12 | Recent research progress of laser plasma interactions in Shenguang laser facilities显示文摘Wereport experimental research on laser plasma interaction(LPI)conducted in Shenguang laser facilities during the past ten years.The research generally consists of three phases:(1)developing platforms for LPI research in mm-scale plasma with limited drive energy,where both gasbag and gas-filled hohlraum targets are tested;(2)studying the effects of beam-smoothing techniques,such as continuous phase plate and polarization smoothing,on the suppression of LPI;and(3)exploring the factors affecting LPI in integrated implosion experiments,which include the laser intensity,gas-fill pressure,size of the laser-entrance hole,and interplay between different beam cones.Results obtained in each phase will be presented and discussed in detail. | Tao Gong Liang Hao Zhichao Li Dong Yang Sanwei Li Xin Li Liang Guo Shiyang Zou Yaoyuan Liu Xiaohua Jiang Xiaoshi Peng Tao Xu Xiangming Liu Yulong Li Chunyang Zheng Hongbo Cai Zhanjun Liu Jian Zheng Zhebin Wang Qi Li Ping Li Rui Zhang Ying Zhang Fang Wang Deen Wang Feng Wang Shenye Liu Jiamin Yang Shaoen Jiang Baohan Zhang Yongkun Ding | 2019 | Matter and Radiation at Extremes2019，4，5： | 0 |
| 13 | A generalized tripartite scheme for splitting an arbitrary 2-qubit state with three 2-qubit partially entangled states and the Kraus measurement显示文摘We put forward a generalized tripartite scheme for splitting an arbitrary 2-qubit pure state with three 2-qubit non-maximally en-tangled states as quantum channels.The scheme for the first time incorporates the Kraus measurement into quantum information splitting scheme.In contrast to the similar scheme using the same quantum channels and the ancilla-entangled measurement,our scheme is superior in terms of operation and complexity,success probability,resource consumption and effciency. | XU ChunJie LIU YiMin ZHANG Wen ZHANG ZhanJun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 0 |
| 14 | A Modified Principal Component Analysis Method for Honeycomb Sandwich Panel Debonding Recognition Based on Distributed Optical Fiber Sensing Signals显示文摘The safety and integrity requirements of aerospace composite structures necessitate real-time health monitoring throughout their service life.To this end,distributed optical fiber sensors utilizing back Rayleigh scattering have been extensively deployed in structural health monitoring due to their advantages,such as lightweight and ease of embedding.However,identifying the precise location of damage from the optical fiber signals remains a critical challenge.In this paper,a novel approach which namely Modified Sliding Window Principal Component Analysis(MSWPCA)was proposed to facilitate automatic damage identification and localization via distributed optical fiber sensors.The proposed method is able to extract signal characteristics interfered by measurement noise to improve the accuracy of damage detection.Specifically,we applied the MSWPCA method to monitor and analyze the debonding propagation process in honeycomb sandwich panel structures.Our findings demonstrate that the training model exhibits high precision in detecting the location and size of honeycomb debonding,thereby facilitating reliable and efficient online assessment of the structural health state. | Shuai Chen Yinwei Ma Zhongshu Wang Zongmei Xu Song Zhang Jianle Li Hao Xu Zhanjun Wu | 2024 | Structural Durability & Health Monitoring2024，18，2： | 0 |
| 15 | Shape Sensing of Thin Shell Structure Based on Inverse Finite Element Method显示文摘Shape sensing as a crucial component of structural health monitoring plays a vital role in real-time actuation and control of smart structures,and monitoring of structural integrity.As a model-based method,the inverse finite element method(iFEM)has been proved to be a valuable shape sensing tool that is suitable for complex structures.In this paper,we propose a novel approach for the shape sensing of thin shell structures with iFEM.Considering the structural form and stress characteristics of thin-walled structure,the error function consists of membrane and bending section strains only which is consistent with the Kirchhoff–Love shell theory.For numerical implementation,a new four-node quadrilateral inverse-shell element,iDKQ4,is developed by utilizing the kinematics of the classical shell theory.This new element includes hierarchical drilling rotation degrees-of-freedom(DOF)which enhance applicability to complex structures.Firstly,the reconstruction performance is examined numerically using a cantilever plate model.Following the validation cases,the applicability of the iDKQ4 element to more complex structures is demonstrated by the analysis of a thin wallpanel.Finally,the deformation of a typical aerospace thin-wall structure(the composite tank)is reconstructed with sparse strain data with the help of iDKQ4 element. | Zhanjun Wu Tengteng Li Jiachen Zhang Yifan Wu Jianle Li Lei Yang Hao Xu | 2022 | Structural Durability & Health Monitoring2022，16，1： | 0 |
| 16 | Bottlebrush prodrug provides a novel strategy for nanomedicine-mediated combination therapy of multiple myeloma显示文摘A method to enhance the limitation of synergistic chemodrugs based on nanomedicine delivering to tumors was proposed in a recent paper published in Nature Nanotechnology[1].This research not only improves current front-line combination therapies for multiple myeloma(MM),but also offers a novel design idea for nanomedicine of other diseases. | Haozhi Xu Shuang Zhu Zhanjun Gu | 2023 | Science China Materials2023，66，7： | 0 |
| 17 | Spatio-temporal variation prediction on Cd content in the rice grains from Northern Zhejiang Plain during 2014–2019 based on high-precision soil geochemical data显示文摘In recent years,Cadmium(Cd)pollution has been found in many soil geochemical surveys in Northern Zhejiang Plain,a crucial rice production area in East China,located in the lower Yangtze River.To more scientifically predict the effect of soil Cd on rice safety,data including 348 local rhizosphere soil-rice samples obtained in 2014 were used in this study.Meanwhile,we extracted 90% of random samples as variables based on soil Cd content(Cd_(soil)),soil organic matter(SOM),pH,and other indicators.In addition,a multivariate linear model for rice Cd content(Cd_(rice))prediction based on the indicators including the soil Cd content(Cd_(soil)),the soil organic matter(SOM),and the pH value.The remaining 10%of random samples were used for the significance test.Based on the 2014 soil Cd content(Cd_(soil14))and the 2019 soil Cd content(Cd_(soil19)),this study predicted Cd content in 2019 rice grains(Cd_(p-rice19)).The spatio-temporal variation of Cdrice was contrasted in the five years from 2014 to 2019,and the risk areas of rice safety production were analyzed using the Geographical Information System(GIS).The results indicated that compared with the actual Cd content in 2014 rice grains(Cdrice14),the proportion of Cd_(p-rice19),which exceeded the standard food level in China(GB2762-2017),increased dramatically.Moreover,the high-value areas of Cdrice distributed greatly coincidentally in these two years.By contrast,both Cdrice and Cdsoil show very different spatial scales.The dominant reason is the distribution of the local canal systems,indicating that economic activities and agricultural irrigation may aggravate the risk of soil Cd pollution,thus threatening safe rice production. | YIN Hanqin LU Xinzhe SUN Rui HUANG Chunlei KANG Zhanjun XU Mingxing WEI Yingchun CAI ZiHua | 2023 | Journal of Geographical Sciences2023，33，2： | 0 |
| 18 | The effects of incident light wavelength difference on the collective stimulated Brillouin scattering in plasmas显示文摘The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility.Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering(SBS),collective behaviors are excited to enhance the octad SBS.In particular,when two-color/cone lasers with wavelength separation 0.3 nm are used,the backward SBS reflectivities show novel behavior in which beams of longer wavelength achieve higher SBS gain.This property of SBS can be attributed to the rotation of the wave vectors of common ion acoustic waves due to the competition of detunings between geometrical angle and wavelength separation.This mechanism is confirmed using massively parallel supercomputer simulations with the three-dimensional laser–plasma interaction code LAP3D. | Qiang Wang Zhichao Li Zhanjun Liu Tao Gong Wenshuai Zhang Tao Xu Bin Li Ping Li Xin Li Chunyang Zheng Lihua Cao Xincheng Liu Kaiqiang Pan Hang Zhao Yonggang Liu Bo Deng Lifei Hou Yingjie Li Xiangming Liu Yulong Li Xiaoshi Peng Zanyang Guan Qiangqiang Wang Xingsen Che Sanwei Li Qiang Yin Wei Zhang Liqiong Xia Peng Wang Xiaohua Jiang Liang Guo Qi Li Minqing He Liang Hao Hongbo Cai Wudi Zheng Shiyang Zou Dong Yang Feng Wang Jiamin Yang Baohan Zhang Yongkun Ding Xiantu He | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
| 19 | Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury显示文摘Over the years,electroconductive hydrogels(ECHs)have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral nerve injury(PNI)with diabetes,given their favorable mechanical and electrical properties identical to endogenous nerve tissue.Nevertheless,PNI causes the loss of locomotor function and inflammatory pain,especially in diabetic patients.It has been established that bone marrow stem cells-derived exosomes(BMSCs-Exos)have analgesic,anti-inflammatory and tissue regeneration properties.Herein,we designed an ECH loaded with BMSCs-Exos(ECH-Exos)electroconductive nerve dressing to treat diabetic PNI to achieve functional recovery and pain relief.Given its potent adhesive and self-healing properties,this laminar dressing is convenient for the treatment of damaged nerve fibers by automatically wrapping around them to form a size-matched tube-like structure,avoiding the cumbersome implantation process.Our in vitro studies showed that ECH-Exos could facilitate the attachment and migration of Schwann cells.Meanwhile,Exos in this system could modulate M2 macrophage polarization via the NF-κB pathway,thereby attenuating inflammatory pain in diabetic PNI.Additionally,ECH-Exos enhanced myelinated axonal regeneration via the MEK/ERK pathway in vitro and in vivo,consequently ameliorating muscle denervation atrophy and further promoting functional restoration.Our findings suggest that the ECH-Exos system has huge prospects for nerve regeneration,functional restoration and pain relief in patients with diabetic PNI. | Qinfeng Yang Shenghui Su Shencai Liu Sheng Yang Jing Xu Yixiu Zhong Yusheng Yang Liangjie Tian Zilin Tan Jian Wang Zhiqiang Yu Zhanjun Shi Fangguo Liang | 2023 | Bioactive Materials2023，，8： | 0 |
| 20 | Toxicity of silicon dioxide nanoparticles with varying sizes on the cornea and protein corona as a strategy for therapy显示文摘The human cornea is exposed directly to particulate matter(PM) in polluted air. This exposure can cause eye discomfort and corneal injury. Ultrafine PM(diameter <100 nm) is thought to be particularly harmful to health, but there is limited research investigating its toxicity to the eye. In this study, we evaluated toxicity differences among 30-, 40-, 100-and 150-nm silicon dioxide nanoparticles(SiO_2 NPs) on the cornea. A 24-hour in vitro exposure of primary human corneal epithelial cells(hCECs) to ultrafine(30 and 40 nm) SiO_2 NPs produced toxicity, as evidenced by cell membrane damage, reduced cell viability,increased cell death and mitochondrial dysfunction. In vivo exposure to the same nanoparticles produced observable corneal injury. These effects were more severe with ultrafine than with fine(100 and 150 nm)SiO_2 NPs. Common antioxidant compounds, e.g., glutathione, did not protect the cornea from SiO_2 NP-induced damage. However, foetal bovine serum(FBS) did significantly reduce toxicity, likely by forming a protective protein corona around the nanoparticles. This finding suggests that FBS(or its derivatives) may be a useful clinical therapy for corneal toxicity caused by ultrafine particulates. | Dayu Sun Linji Gong Jing xie Xianliang Gu Yijian Li Qinglin Cao Qiyou Li Luodan A. Zhanjun Gu Haiwei Xu | 2018 | Science Bulletin2018，63，14： | 0 |
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