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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | An Association Study on the Cognitive Function and the Cerebral Grey Matter Volume of Patients with First-Episode Schizophrenia显示文摘 | Xinyue ZHANG Jingjing YAO Yiding LV Xiaoxin ZHAO Yuan LI Yuxiu SUI Zhiping DAI | 2018 | 上海精神医学2018，30，3： | 4 |
| 3 | Rapid fabrication and characterization of micropores on pure nickel surface by high-current pulsed electron beams irradiation 显示文摘 | Lv Peng Hart ZhiYong Wang ZhiPing | 2012 | Advanced Materials Research2012，，560561： | 1 |
| 4 | 显示文摘 | Yang Zhiping Liu Pengfei Lv Liang | 2013 | Journal of Al- loys and Compounds2013，562，： | 1 |
| 5 | Wetting of graphene oxide: A molecular dynamics study显示文摘 | Wei Ning Lv Cunjing Xu Zhiping | 2014 | Langmuir2014，30，12： | 1 |
| 6 | Influences of vibration on surface formation in rotary ultrasonic machining of glass BK7显示文摘 | Dongxi Lv Hongxiang Wang Yongjian Tang Yanhua Huang Zhiping Li | 2013 | Precision Engineering2013，，： | 1 |
| 7 | The influence of modified zeolites as nucleating agents on crystallization behavior and mechanical properties of polypropylene 显示文摘 | Zhiping Lv Kunjun Wang Zhihua Qiao | 2010 | Materials & Design2010，31，8： | 1 |
| 8 | Design and properties of a novel nucleating agent for isotactic polypropylene显示文摘 | Lv Zhiping Yang Yunfei Wu Ran | 2012 | Materials & design2012，37，5： | 1 |
| 9 | Design and properties of a novel nucleating agent for isotactic polypropylene显示文摘 | Zhiping Lv Yunfei Yang Ran Wu Yuchao Tong | 2011 | Materials and Design2011，，： | 1 |
| 10 | A cell transcriptomic profile p ovides insights into adipocytes of porcine mammary gland across development显示文摘Background Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring adipocytes.Results Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from physiological mammary glands across five developmental stages(d 90 of gestation, G90;d 0 after lactation, L0;d 20 after lactation, L20;2 d post natural involution, PI2;7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation(G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation(L0 and L20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution(PI2 and PI7), epithelial cell populations dedifferentiate into mesenchymal stem cells to maintain the lactation potential of mammary glands for the next lactation cycle.Conclusion The molecular mechanisms of dedifferentiation, proliferation and redifferentiation of adipocytes and epithelial cells were revealed from late pregnancy to natural involution. This cell transcriptomic profile constitutes an essential reference for future studies in the development and remodeling of the mammary gland at different stages. | Yongliang Fan Long Jin Zhiping He Tiantian Wei Tingting Luo Jiaman Zhang Can Liu Changjiu Dai Chao A Yan Liang Xuan Tao Xuebin Lv Yiren Gu Mingzhou Li | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 11 | A direct probabilistic approach to solve state equations for nonlinear systems under random excitation显示文摘In this paper, a direct probabilistic approach(DPA) is presented to formulate and solve moment equations for nonlinear systems excited by environmental loads that can be either a stationary or nonstationary random process.The proposed method has the advantage of obtaining the response's moments directly from the initial conditions and statistical characteristics of the corresponding external excitations. First, the response's moment equations are directly derived based on a DPA, which is completely independent of the It?/filtering approach since no specific assumptions regarding the correlation structure of excitation are made.By solving them under Gaussian closure, the response's moments can be obtained. Subsequently, a multiscale algorithm for the numerical solution of moment equations is exploited to improve computational efficiency and avoid much wall-clock time. Finally, a comparison of the results with Monte Carlo(MC) simulation gives good agreement.Furthermore, the advantage of the multiscale algorithm in terms of efficiency is also demonstrated by an engineering example. | Zheng Lv Zhiping Qiu | 2016 | Acta Mechanica Sinica2016，32，5： | 0 |
| 12 | Iron-Catalyzed Oxidative Cyclization of 1,6-Enones with Alde- hydes: Synthesis of Functionalized 3,4-Dihydro-2H-pyrans显示文摘An iron-catalyzed cyclization of 1,6-enones with aldehydes was developed. With this method, a variety ofpoly-functionalized 3,4-dihydro-2H-pyrans were prepared efficiently and selectively. The 6-endo-trig radical cy-clization onto the keto oxygen is the key step of this transformation. | Leiyang Lv Zhiping Li | 2017 | Chinese Journal of Chemistry2017，35，3： | 0 |
| 13 | Concomitant functionalization of two different ketones by merging Brønsted acid catalysis and radical relay coupling显示文摘n the previous literature, incorporation of functional groups at the α-position of unactivated carbonylcompounds was mainly restricted to one kind of corresponding precursor. Herein, we report the concomitant functionalization of two distinct α-C–H bonds of carbonyls integrated with unactivated olefins andtert-butyl hydroperoxide selectively and efficiently in one pot by merging Brønsted acid catalysis andradical relay coupling, which delivers an array of structurally valuable unsymmetrical peroxy 1,9-diketonesin moderate to good yields under metal-free conditions. | Leilei Wang Leiyang Lv Zhiping Li | 2022 | Organic Chemistry Frontiers2022，9，6： | 0 |
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