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| 1 | Effect of SBS and crumb rubber on asphalt modification:A review of the properties and practical application显示文摘Owing to the environmental protection potential and the desirable high performance capabilities,asphalt rubber(AR)and styrene-butadiene-styrene(SBS)modified asphalt have been widely used.However,the poor construction workability and segregation issues of AR,along with the exorbitant cost of SBS modified asphalt,are of the serious problems that plague their application scope.Moreover,SBS/crumb rubber(CR)modified asphalt is gradually becoming widespread and it therefore becomes incumbent to find appropriate ways to mitigate the issues that may limit its use.As a consequence,it becomes crucial to analyze the interaction between CR and SBS modifiers in the composite mixture,as well as evaluate the influence of modifier dosage on the performance of the modified asphalt.This study presents a comprehensive review of the effects of SBS modifier,CR modifier and composite SBS/CR on the performance of modified asphalts.Macro analysis and micro analysis,including analysis on the conventional physical properties,are carried out.It can uncover the interaction between modifier and asphalt,which reveals how the modifiers influence the properties of modified asphalts.This study will serve as a source of invaluable information to researchers,engineers,and designers,informing them the development,potential and challenges of the CR,SBS and SBS/CR modified asphalts,the optimum contents to attain the best performance along with the mechanism involved. | Haibin Li Canyang Cui Ahmed Abdulakeem Temitope Zixuan Feng Guijuan Zhao Ping Guo | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，5： | 6 |
| 2 | Highlights and new Editorial Advisory Board members of the Journal of Environmental Sciences显示文摘The Journal of Environmental Sciences(JES)is honored to welcome Professors/Drs William A.Mitch,Jiuhui Qu,Susan D.Richardson,Jerald L.Schnoor,Hongxiao Tang,Shu Tao,and Hugh A.Tilson to serve on the Editorial Advisory Board(EAB).Their tremendous experience in scientific publications,leading expertise in topic areas pertinent to JES,diverse international networks/perspectives,and exemplary dedication to scientific excellence will guide and help the continuing healthy growth of JES. | Qingcai Feng Suqin Liu Zhengang Mao Jian Xu Zixuan Wang X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，9： | 4 |
| 3 | GENOME EDITING:A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021显示文摘‘Global Engineering Fronts’ is a report released by the Chinese Academy of Engineering(CAE) every year since 2017, which aims to assemble talents in the field of engineering science and technology to represent the global engineering research and development fronts by reviewing global papers, patents, and other data. The results are also expected to provide a reference for people on responding to global challenges and achieving sustainable development. | Jianxiang XU Yunzhou LI Yinkun YAO Jie ZHAO Jingyue TANG Zixuan FENG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，2： | 1 |
| 4 | Fabrication of paper-based devices for in vitro tissue modeling显示文摘Paper devices have recently attracted considerable attention as a class of cost-effective cell culture substrates for various biomedical applications.The paper biomaterial can be used to partially mimic the in vivo cell microenvironments mainly due to its natural three-dimensional characteristic.The paper-based devices provide precise control over their structures as well as cell distributions,allowing recapitulation of certain interactions between the cells and the extracellular matrix.These features have shown great potential for the development of normal and diseased human tissue models.In this review,we discuss the fabrication of paper-based devices for in vitro tissue modeling,as well as the applications of these devices toward drug screening and personalized medicine.It is believed that paper as a biomaterial will play an essential role in the field of tissue model engineering due to its unique performances,such as good biocompatibility,eco-friendliness,cost-effectiveness,and amenability to various biodesign and manufacturing needs. | Hongbin Li Feng Cheng Juan A.Robledo-Lara Junlong Liao Zixuan Wang Yu Shrike Zhang | 2020 | Bio-Design and Manufacturing2020，3，3： | 1 |
| 5 | Effects of different processing methods on the lipid composition of hazelnut oil:a lipidomics analysis显示文摘Although hazelnut oil is rich in nutrients,its quality is greatly affected by how it is processed.However,no studies to date have comprehensively analyzed the lipid composition of hazelnut oil using different processing methods.Here,we conducted a lipidomics analysis using UPLC-QTOF-MS to characterize the lipid composition of cold-pressed hazelnut oil(CPO),ultrasonic-assisted hexane hazelnut oil(UHO)and enzyme-assisted aqueous hazelnut oil(EAO).A total of 10 subclasses of 98 lipids were identified,including35 glycerolipids(GLs),56 glycerophospholipids(GPs)and 7 sphingolipids(SPs).The total lipid and GL content were the highest in CPO,GP content was the highest in UHO and the ceramide content in SPs was most abundant in EAO.Multivariate statistical analysis showed that the lipid profiles of hazelnut oil prepared with different processing methods varied.Twelve significantly different lipids(TAG 54:3,TAG 52:2,TAG54:4,TAG 54:2,TAG 52:3,TAG 54:5,DAG 36:2,DAG 36:4,DAG 36:3,PC 36:2,PA 36:2 and PE 36:3)were identified,and these lipids could potentially be used as biomarkers to distinguish between hazelnut oil subjected to different processing methods.Our results provide useful information for hazelnut oil applications and new insight into the effects of edible oil processing. | Jiayang Sun Xiaonuo Feng Chunmao Lyu Shuang Zhou Zixuan Liu | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 6 | Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges显示文摘In recent years,significant breakthroughs have been made in the field of gene ther-apy.Adeno-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest.Among the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific tissues.Currently,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases. | Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang | 2024 | Genes & Diseases2024，11，1： | 1 |
| 7 | Structure,dielectric and relaxor properties of Sr_(0.7)Bi_(0.2)TiO_(3)—K_(0.5)Bi_(0.5)TiO_(3)lead-free ceramics for energy storage applications显示文摘Sr_(0.7)Bi_(0.2)TiO_(3)(SBT)by increasing the proportion and size of polar nano-region.Meanwhile,the BDS remains a high level with x<0.38 attributed to the addition of KBT with a large band gap.As a result,the 0.62SBT-0.38KBT exhibits a high energy storage density of 2.21 J/cm^(3)with high h of 91.4%at 220 kV/cm and superior temperature stability(-55~150℃),frequency stability(10~500 Hz)and fatigue resistance(105 cycles).Moreover,high pulsed discharge energy density(1.81 J/cm^(3)),high power density(49.5 MW/cm3)and great thermal stability(20~160℃)are achieved in 0.62SBT-0.38KBT.Based on these excellent properties,the 0.62SBT-0.38KBT are suitable for pulsed power systems.This work provides a novel strategy and systematic study for improving energy storage properties of SBT. | Peng Zhao Bin Tang Zixuan Fang Feng Si Chengtao Yang Gang Liu Shuren Zhang | 2021 | Journal of Materiomics2021，7，1： | 1 |
| 8 | Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression显示文摘 | Feng Huang Mei Wang Tingting Yang Jie Cai Qiang Zhang Zixuan Sun Xiaodan Wu Xu Zhang Wei Zhu Hui Qian Wenrong Xu | 2014 | Journal of Cancer Research and Clinical Oncology2014，，： | 1 |
| 9 | Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs显示文摘Fusobacterium nucleatum(F.nucleatum)is an early pathogenic colonizer in periodontitis,but the host response to infection with this pathogen remains unclear.In this study,we built an F.nucleatum infectious model with human periodontal ligament stem cells(PDLSCs)and showed that F.nucleatum could inhibit proliferation,and facilitate apoptosis,ferroptosis,and inflammatory cytokine production in a dose-dependent manner.The F.nucleatum adhesin Fad A acted as a proinflammatory virulence factor and increased the expression of interleukin(IL)-1β,IL-6 and IL-8.Further study showed that Fad A could bind with PEBP1 to activate the Raf1-MAPK and IKK-NF-κB signaling pathways.Time-course RNA-sequencing analyses showed the cascade of gene activation process in PDLSCs with increasing durations of F.nucleatum infection.NFκB1 and NFκB2 upregulated after 3 h of F.nucleatum-infection,and the inflammatory-related genes in the NF-κB signaling pathway were serially elevated with time.Using computational drug repositioning analysis,we predicted and validated that two potential drugs(piperlongumine and fisetin)could attenuate the negative effects of F.nucleatum-infection.Collectively,this study unveils the potential pathogenic mechanisms of F.nucleatum and the host inflammatory response at the early stage of F.nucleatum infection. | Yushang Wang Lihua Wang Tianyong Sun Song Shen Zixuan Li Xiaomei Ma Xiufeng Gu Xiumei Zhang Ai Peng Xin Xu Qiang Feng | 2023 | International Journal of Oral Science2023，15，1： | 1 |
| 10 | Recent Progress in Flax Fiber‑Based Functional Composites显示文摘In recent years,fax fber as a green and renewable resources have attracted considerable attention to be used as reinforcement in composites,using various technology.This review presents a summary of recent developments of fax fber-based functional composites toward energy,biomedical,and environment.Firstly,we analyze the design and fabrication strategies,which are used for preparation of fax-based functional composites.The most promising applications of fax fber-based composites are discussed subsequently.It is believed that fax fber as a functional composites will play a crucial role in the feld of energy,biomedical,and environment mainly attributed to its unique properties,such as specifc mechanical properties,good biocompatibility,eco-friendliness,cost-efectiveness,and amenability to various functional design and manufacturing needs. | Hongbin Li Rongrong Tang Jiliang Dai Zixuan Wang Shiqi Meng Xiang Zhang Feng Cheng | 2022 | Advanced Fiber Materials2022，4，2： | 1 |
| 11 | Conductive proteins-based extracellular electron transfer of electroactive microorganisms显示文摘Electroactive microorganisms(EAMs)could utilize extracellular electron transfer(EET)pathways to exchange electrons and energy with their external surroundings.Conductive cytochrome proteins and nanowires play crucial roles in controlling electron transfer rate from cytosol to extracellular electrode.Many previous studies elucidated how the c-type cytochrome proteins and conductive nanowires are synthesized,assembled,and engineered to manipulate the EET rate,and quantified the kinetic processes of electron generation and EET.Here,we firstly overview the electron transfer pathways of EAMs and quantify the kinetic parameters that dictating intracellular electron production and EET.Secondly,we systematically review the structure,conductivity mechanisms,and engineering strategies to manipulate conductive cytochromes and nanowire in EAMs.Lastly,we outlook potential directions for future research in cytochromes and conductive nanowires for enhanced electron transfer.This article reviews the quantitative kinetics of intracellular electron production and EET,and the contribution of engineered c-type cytochromes and conductive nanowire in enhancing the EET rate,which lay the foundation for enhancing electron transfer capacity of EAMs. | Junqi Zhang Zixuan You Dingyuan Liu Rui Tang Chao Zhao Yingxiu Cao Feng Li Hao Song | 2023 | Quantitative Biology2023，11，4： | 0 |
| 12 | Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering显示文摘Indole alkaloids have attracted considerable attention from synthetic chemists and biochemists for their structural diversity and important biological activities.Compared with traditional organic synthesis methods,the strategy of using cytochrome P450s'extraordinary abilities to selectively activate carbon-hydrogen bonds to assist in the synthesis of various indole alkaloids has the characteristics of short synthetic route,mild conditions and high atomic economy.Here,we utilized P450 monooxygenases HinD and TleB to synthesize a novel 6/5/8 tricyclic product from(S)-N-((S)-1-(4-fluoro-1H-indol-3-yl)-3-hydroxypropan-2-yl)-2-mercapto-3-methylbutanamide through the substrate structure-directed strategy.TleB was more effective in catalyzing C–S coupling,and was used to synthesize a series of 6/5/8 tricyclic indololactam derivatives to provide drug candidates.Interestingly,the S–S coupling product was observed in HinD catalysis,which was a minor product in the wild-type TleB catalysis.With the help of protein engineering,we accurately regulated the catalytic flow and reversed the selectivity of TleB to obtain the S–S coupling product.At the same time,the reaction mechanism was reasonably speculated by means of site blocking and protein-substrate complex analysis. | Xinying Ge Yan Long Jun Wang Bo Gu Zixuan Yang Yinyin Feng Shuo Zheng Yingying Li Wupeng Yan Heng Song | 2023 | Science China Chemistry2023，66，11： | 0 |
| 13 | Digital light processing (DLP)-based (bio)printing strategies for tissue modeling and regeneration显示文摘Digital light processing(DLP)-based bioprinting technology has recently aroused considerable concerns as a strategy to deliver biomedical materials and/or specific cells to create sophisticated structures for various tissue modeling and regeneration.In this review,we display a concise introduction of DLP bioprinting,and a further discussion on the design and manufacture of DLP(bio)printer with varied bioinks and their biomedical applications toward drug screening,disease modeling,tissue repair,and regenerative medicine.Finally,the advantages,challenges,and perspectives of the DLP printing platforms are detailed.It is believed that DLP bioprinting will play a decisive role in the field of tissue model and regenerative medicine,mainly due to its time-efficient,higher resolution,and amenability to automation for various tissue needs. | Hongbin Li Jiliang Dai Zixuan Wang Heshan Zheng Wanlu Li Mian Wang Feng Cheng | 2023 | Aggregate2023，4，2： | 0 |
| 14 | Multi-Agent Consensus Control Scheme for the Load Control Problem显示文摘With the help of smart grid technologies,a lot of electrical loads can provide demand response to support the active power balance of the grid.Compared with centralized control methods,decentralized methods reduce the computational burden of the control center and enhance the reliability of the communication.In this paper,a novel second-order multi-agent consensus control method is proposed for load control problem.By introducing the velocity state into the model,the proposed method achieves better performance than traditional ones.Simulation results verify the effectiveness of the proposed method. | Te Xu Zhixian Lin Xinwei Lin Changsheng Lin Feng Gao Zixuan Li Peiwen Liu | 2022 | Energy Engineering2022，119，4： | 0 |
| 15 | Investigation on the short-term outcome and prognostic impact of predisposition,and precipitants in inpatients with chronic liver disease from Chinese AcuTe on CHronic LIver FailurE(CATCH-LIFE)cohorts显示文摘Aim:The study aimed to investigate the short-term outcomes of hospitalized patients with chronic liver disease(CLDs)and assess the prognostic impact of predisposition and precipitants,which currently remains unclear.Methods:The study included 3970 hospitalized patients with CLDs from two prospective longitudinal multicenter studies(NCT02457637 and NCT03641872)conducted in highly endemic hepatitis B virus(HBV)areas.Competing risk analysis was used to evaluate the effect of predispositions,including the etiology and severity of CLDs and precipitants;on sequential 28,90,and 365-day liver transplantation(LT)-free mortality.Results:Among all enrolled patients,76.8%of adverse outcomes(including death and LT)within one year occurred within 90 days.Compared with alcoholic etiology,the association of HBV etiology with poorer outcomes was remarkably on the 28th day(hazard ratio[HR],1.81;95%confidence interval[CI],1.07-3.06;p=0.026);however,and dimin-ished or became insignificant at 90 days and 365 days.Cirrhosis increased the adjusted risk for 365-day(HR,1.50;CI,1.13-1.99;p=0.004)LT-free mortality when compared with noncirrhosis.In patients with cirrhosis,prior decompensation(PD)independently increased the adjusted risk of 365-day LT-free mortality by 1.25-fold(p=0.021);however,it did not increase the risk for 90-day mortality.Neither the category nor the number of precipitants influenced the adjusted risk of 28 or 90-day LT-free mortality.Conclusions:The 90-day outcome should be considered a significant endpoint for evaluating the short-term prognosis of hospitalized patients with CLD.Predisposing factors,other than etiology,mainly affected the delayed(365-day)outcome.Timely effective therapy for CLD etiology,especially antiviral treatments for HBV,and post-discharge long-term surveillance monitoring in cirrhotic patients undergoing PD are suggested to enhance disease management and reduce mortality. | Yan Zhang Wenting Tan Xiaobo Wang Xin Zheng Yan Huang Beiling Li Zhongji Meng Yanhang Gao Zhiping Qian Feng Liu Xiaobo Lu Jia Shang Yubao Zheng Weituo Zhang Shan Yin Wenyi Gu Tongyu Wang Jianyi Wei Zixuan Shen Guohong Deng Yi Zhou Yixin Hou Qun Zhang Shue Xiong Jing Liu Liyuan Long Ruochan Chen Jinjun Chen Xiuhua Jiang Sen Luo Yuanyuan Chen Chang Jiang Jinming Zhao Liujuan Ji Xue Mei Jing Li Tao Li Rongjiong Zheng Xinyi Zhou Haotang Ren Yu Shi Hai Li for the CATCH‐LIFE Study Investigators of Chinese(Acute‐on)Chronic Liver Failure(CLIF)Consortium(Ch‐CLIFC) | 2023 | Portal Hypertension & Cirrhosis2023，2，3： | 0 |
| 16 | Cover features and new Associate Editors of the Journal of Environmental Sciences显示文摘We are very pleased to announce that five Associate Editors have joined the editorial team of the Journal of Environmental Sciences(JES).Professors/Drs.Yong Cai,Paul Lam,Jonathan Martin,Michael Plewa,and Po Keung Wong bring a wealth of expertise in environmental sciences.As preeminent scientists in their chosen areas of research,they have made outstanding contributions to the discipline of | Qingcai Feng Suqin Liu Zhengang Mao Jian Xu Zixuan Wang X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，10： | 0 |
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