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| 1 | Analysis of genetic diversity and population structure of Chinese yak breeds (Bos grunniens) using microsatellite markers显示文摘Nine Chinese yak breeds (Maiwa, Tianzhu White, Qinghai Plateau, Sibu, Zhongdian, Pali, Tibetan High Mountain, Jiulong, and Xin-jiang) and Gayal were analyzed by means of 16 microsatellite markers to determine the level of genetic variation within populations, genetic relationship between populations, and population structure for each breed. A total of 206 microsatellite alleles were observed. Mean F-statistics (0.056) for 9 yak breeds indicated that 94.4% of the genetic variation was observed within yak breeds and 5.6% of the genetic variation existed amongst breeds. The Neighbor-Joining phylogenetic tree was constructed based on Nei's standard genetic dis-tances and two clusters were obtained. The Gayal separated from the yaks far away and formed one cluster and 9 yak breeds were grouped together. The analysis of population structure for 9 yak breeds and the Gayal showed that they resulted in four clusters; one clus-ter includes yaks from Tibet Autonomous Region and Qinghai Province, one cluster combines Zhongdian, Maiwa, and Tianzhu White, and Jiulong and Xinjiang come into the third cluster. Pali was mainly in the first cluster (90%), Jiulong was mainly in the second cluster (87.1%), Zhongdian was primarily in the third cluster (83%), and the other yak breeds were distributed in two to three clusters. The Gayal was positively left in the fourth cluster (99.3%). | Guixiang Zhang Weisheng Chen Ming Xue Zhigang Wang Hong Chang Xu Han Xinjun Liao Donglei Wang | 2008 | Journal of Genetics and Genomics2008，35，4： | 8 |
| 2 | Last Deglaciation Climatic Fluctuation Record by the Palaeo-Daocheng Ice Cap, Southeastern Qinghai-Tibetan Plateau显示文摘The last deglaciation, a key period for understanding present and future climate changes, has long been the hot topic for palaeoclimatological study. The Qinghai-Tibetan Plateau(QTP) is often a target study area for understanding hemispheric, or even global environment changes. The glacial landforms on the QTP provide a unique perspective for its climate change. In order to investigate the onset of the last deglaciation at the QTP and its regional correlation, the terrestrial cosmogenic nuclides(TCN) 10 Be and 26 Al surface exposure dating was chosen to date the roche moutonnée, the polished surface and the moraine debris located at the palaeo-Daocheng Ice Cap(pDIC), southeastern QTP. Our results show that the onset of the last deglaciation is at about 19 ka, followed by another warming event occurring around 15 ka in the p-DIC area. These timings agree well with other records, e.g. equivalent with a rapid sea level rise at 19 ka and the onset of B?lling warming event at about 15 ka. Thus, our new data can provide good reveal constraint on the climate evolution at the QTP. | ZHANG Zhigang XU Xiaobin WANG Jian ZHAO Zhijun BAI Shibiao CHANG Zhi Yang | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 6 |
| 3 | Cosmogenic ^(10)Be and ^(26)Al Chronology of the Last Glaciation of the Palaeo-Daocheng Ice Cap,Southeastern Qinghai-Tibetan Plateau显示文摘The glacial landforms of the Qinghai-Tibetan Plateau(QTP) provide a unique opportunity to research hemispheric and global environmental changes. In this study,we focus on the glacial history of the palaeo-Daocheng Ice Cap(p-DIC) in the southeastern QTP during the last glacial cycle. Based on field investigations,morphostratigraphy,and surface exposure dating of roche moutonnée,polished surface and moraine debris through the terrestrial cosmogenic nuclides(TCN) 10 Be and 26 Al. We identify glacial deposits of the last deglaciation,with minimum ages of 14.9±1.3–18.7±1.7 ka,the Last Glacial Maximum(LGM) of 24.7±2.2 ka,and the early part of the last glacial period(marine oxygen isotope stage(MIS) 3) of 37.1±3.4–45.2±3.9 ka. Our results show that in this region,the extent of the glacial advance during MIS 3 was larger than that during the traditional LGM(MIS 2). These ages are consistent with prior chronologies,and the 10 Be age is consistent with the 26 Al age for the same sample. Thus,these data provide reliable constraints on climate change in the QTP,during the last glaciation. | ZHANG Zhigang WANG Jian XU Xiaobin BAI Shibiao CHANG ZhiYang | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 5 |
| 4 | Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing显示文摘The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss,which are difficult to regenerate.Furthermore,severe burns often accompanied with large amount of wound exudates making the wound moist,easily infected,and difficult to heal.Therefore,it is of great clinical significance to develop wound dressings to remove wound exudates and promote hair follicle regeneration.In this study,a sandwich-structured wound dressing(SWD)with Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics(Hardystonite,ZnCS)and hydrophobic polylactic acid(PLA).This unique organic/inorganic Janus membrane structure revealed excellent exudate absorption property and effectively created a dry wound environment.Meanwhile,the incorporation of ZnCS bioceramic particles endowed the dressing with the bioactivity to promote hair follicle regeneration and wound healing through the release of Zn^(2+)and SiO^(2-)_(3)��ions,and this bioactivity of the wound dressing is mainly attributed to the synergistic effect of Zn^(2+)and SiO^(2-)_(3)��to promote the recruitment,viability,and differentiation of hair follicle cells.Our study demonstrates that the utilization of the Janus membrane and synergistic effect of different type bioactive ions are effective approaches for the design of wound dressings for burn wound healing. | Zhaowenbin Zhang Wenbo Li Ying Liu Zhigang Yang Lingling Ma Hui Zhuang Endian Wang Chengtie Wu Zhiguang Huan Feng Guo Jiang Chang | 2021 | Bioactive Materials2021，6，7： | 3 |
| 5 | Influence of HEPES buffer on the local pH and formation of surface layer during in vitro degradation tests of magnesium in DMEM显示文摘The human body is a buffered environment where p H is effectively maintained. HEPES is a biological buffer often used to mimic the buffering activity of the body in in vitro studies on the degradation behavior of magnesium. However, the influence of HEPES on the degradation behavior of magnesium in the DMEM pseudo-physiological solution has not yet been determined. The research aimed at elucidating the degradation mechanisms of magnesium in DMEM with and without HEPES. The morphologies and compositions of surface layers formed during in vitro degradation tests for 15–3600 s were characterized. The effect of HEPES on the electrochemical behavior and corrosion tendency was determined by performing electrochemical tests. HEPES indeed retained the local p H, leading to intense intergranular/interparticle corrosion of magnesium made from powder and an increased degradation rate. This was attributed to an interconnected network of cracks formed at the original powder particle boundaries and grain boundaries in the surface layer, which provided pathways for the corrosive medium to interact continuously with the internal surfaces and promoted further dissolution. Surface analysis revealed significantly reduced amounts of precipitated calcium phosphates due to the buffering activity of HEPES so that magnesium became less well protected in the buffered environment. | S.Naddaf Dezfuli Zhigang Huan J.M.C.Mol M.A.Leeflang Jiang Chang Jie Zhou | 2014 | Progress in Natural Science:Materials International2014，24，5： | 3 |
| 6 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 7 | An Offloading Scheme Leveraging on Neighboring Node Resources for Edge Computing over Fiber-Wireless (FiWi) Access Networks显示文摘The computation resources at a single node in Edge Computing(EC)are commonly limited,which cannot execute large scale computation tasks.To face the challenge,an Offloading scheme leveraging on NEighboring node Resources(ONER)for EC over Fiber-Wireless(FiWi)access networks is proposed in this paper.In the ONER scheme,the FiWi network connects edge computing nodes with fiber and converges wireless and fiber connections seamlessly,so that it can support the offloading transmission with low delay and wide bandwidth.Based on the ONER scheme supported by FiWi networks,computation tasks can be offloaded to edge computing nodes in a wider range of area without increasing wireless hops(e.g.,just one wireless hop),which achieves low delay.Additionally,an efficient Computation Resource Scheduling(CRS)algorithm based on the ONER scheme is also proposed to make offloading decision.The results show that more offloading requests can be satisfied and the average completion time of computation tasks decreases significantly with the ONER scheme and the CRS algorithm.Therefore,the ONER scheme and the CRS algorithm can schedule computation resources at neighboring edge computing nodes for offloading to meet the challenge of large scale computation tasks. | Wei Chang Yihong Hu Guochu Shou Yaqiong Liu Zhigang Guo | 2019 | China Communications2019，16，11： | 3 |
| 8 | Effects on antioxidant enzyme activities and osmolytes in Halocnemum strobilaceum under salt stress显示文摘The seedlings of Halocnermum strobilaceum were cultivated in 0.5%hoagland nutrient solution containing 0.0%,0.9%,2.7%and 5.4%of NaCl as well as composite salt(Na^+,Ca^(2+),K^+,Si^(4+)) for 20 days;all the contents are in weight ratio.Succulent level,inorganic ions(Na^+,K^+),organics such as betaine,proline,malondialdehyde,and antioxidant enzyme activities including superoxide dismutase(SOD),catalase(CAT),peroxidase(POD),betaine aldehyde dehydrogenase(BADH) were measured to reveal its salt tolerance mechanism.When the composite salt concentration reaches 5.4%,SOD activity level,and MDA content is five times the control group;when it reaches 2.7%,the succulent level of seedlings,and the content of K^+ in roots is nearly two times the NaCl treatment;the dry weight is more than three times the control group;with the NaCl treatment,MDA is three times the contrast;when the salt concentration is 2.7%,POD reaches the maximum.Results indicate that Si^(4+),K^+,and Ca^(2+) from composite salt in the roots of H.strobilaceum improved the water-holding capacity.The activities of antioxidant enzyme were raised by the accumulation of proline and betaine,which increased the salt tolerance.The absorption of K^+ promoted the high ratio of K^+/Na^+ and alleviated the damage of cell membranes of H.strobilaceum,which is associated with osmotic contents such as betaine and proline. | TianPeng Gao Rui Guo XiangWen Fang ZhiGang Zhao GuoHua Chang YinQuan Chen Qing Zhang | 2016 | Research in Cold and Arid Regions2016，8，1： | 2 |
| 9 | Elevation dependency of recent and future minimum surface air temperature trends in the Tibetan Plateau and its surroundings 显示文摘 | Liu Xiaodong Chang Zhigang Yah Libin | 2009 | Global and Planetary Change2009，68，3： | 1 |
| 10 | Performance and reliability of electrical power grids under cascading failures显示文摘 | Liang Chang Zhigang Wu | 2011 | International Journal of Electrical Power and Energy Systems2011，，8： | 1 |
| 11 | Construction of [Cu_nI_n]-based coordination polymers via flexible benzimidazolyl-based ligands显示文摘Four new [CunIn]-based coordination polymers, [{Cu4(μ3-I)4(mbbm)2}·2DMF]n (1), [(CuI)2(mbbm)2]n (2), [{Cu2(μ-I)2-(ebbm)2}·2MeCN]n (3), and [Cu2(μ-I)2(prbbm)2]n (4), were prepared from solvothermal reactions of CuI with three flexible ligands [(bzim)(CH2)n(bzim)] (bzim = benzimidazole; n = 1, mbbm; n = 2, ebbm; n = 3, prbbm). These compounds were characterized by elemental analysis, IR and X-ray crystallography. 1 consists of cubanelike [Cu4(μ3-I)4] fragments that link the neighboring ones via mbbm bridges to form a 1D ladder-type chain. 2 contains mononuclear [CuI] fragments that are bridged by mbbm ligands to yield a 1D zigzag chain. 3 or 4 contains a [Cu2(μ-I)2] dimeric fragment, which works as a four-connecting node to link its four equivalent ones to form a 2D (4,4) network (3) or acts as a two-connecting node to connect its two equivalent ones via two pairs of prbbm bridges to form a 1D double chain (4). The photoluminescent properties of 1-4 in the solid state at ambient temperature were investigated. | LI LingLing, REN ZhiGang, Lü Xue, WANG HeMing, CHANG YuJie, LI HongXi, WU Bing & LANG JianPing College of Chemistry, Chemical Engineering and Materials Science, Suzhou University, Suzhou 215123, China | 2010 | Science China Chemistry2010，53，10： | 1 |
| 12 | Rock magnetic studies on the hominoid-bearing sediments at Zhupeng, Yuanmou Basin, southwestern China and its paleoclimatic significance显示文摘It has been proposed that paleoclimatic changes and tectonic events strongly affect hominoid evolution. The Zhupeng section at Yuanmou Basin, southwestern China, with the hominoid-bearing fluvial-lacustrine sediments, is an ideal natural laboratory to test this hypothesis. This study provided an integrated magnetic study, including low-fre- quency susceptibility, the anisotropy of magnetic susceptibil-ity, temperature-dependent susceptibility, hysteresis loops, isothermal remanent magnetization, and anhysteretic rema-nent magnetization, on samples from the Baozidongqing section at Zhupeng. Results show that the dominant mag-netic carrier is hematite, with minor amount of magnetite. Both the composition and concentration of magnetic miner-als strongly correlate with the lithostratigraphy. At least eight short-term events defined by higher concentrations of magnetite were identified. These short events reflect that the subtropical dry-hot climate is similar to today’s climate. Basing on the lithostratigraphic and rock magnetic results, we suggest that Yuanmou Basin was in a steady deposition environment from about 11 to 7 Ma, which is characterized by alternating of long-term torrid-humid climate and short-term dry-hot climate. Our study provides invaluable environment information for understanding the climate shift and the relationship between paleoenvironment and homi-noid evolution in southwestern China during late Miocene. | YAO Haitao LIU Qingsong Lü Lianqing CHANG Zhigang ZHU Rixiang | 2005 | Chinese Science Bulletin2005，50，15： | 1 |
| 13 | LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques显示文摘Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular diseases.Despite the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and undesirable.Herein,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting delivery.DS,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)effect.In addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging capabilities.The engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment period.This specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns. | Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu Man Ye Yixin Zhong Shuling Liu Junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing Guo | 2022 | Bioactive Materials2022，7，10： | 1 |
| 14 | Partitioning of the grain-size components of Dali Lake core sediments: evidence for lake-level changes during the Holocene显示文摘 | Jule Xiao Zhigang Chang Bin Si Xiaoguang Qin Shigeru Itoh Zaur Lomtatidze | 2009 | Journal of Paleolimnology2009，，2： | 1 |
| 15 | Holocene climate changes in the mid-high-latitude-monsoon margin reflected by the pollen record from Hulun Lake, northeastern Inner Mongolia 显示文摘 | Wen Ruilin Xiao Jule Chang Zhigang | 2010 | Quaternary Research2010，73，： | 1 |
| 16 | PCPD:Plant cytochrome P450 database and web-based tools for structural construction and ligand docking显示文摘Plant cytochrome P450s play key roles in the diversification and functional modification of plant natural products.Although over 200,000 plant P450 gene sequences have been recorded,only seven crystalized P450 genes severely hampered the functional characterization,gene mining and engineering of important P450s.Here,we combined Rosetta homologous modeling and MD-based refinement to construct a high-resolution P450 structure prediction process(PCPCM),which was applied to 181 plant P450s with identified functions.Furthermore,we constructed a ligand docking process(PCPLD)that can be applied for plant P450s virtual screening.10 examples of virtual screening indicated the process can reduce about 80%screening space for next experimental verification.Finally,we constructed a plant P450 database(PCPD:http://gffzz90f9b80da1174166h505wcbxqvoup69pu.ffgz.tsg.suse.edu.cn/),which includes the sequences,structures and functions of the 181 plant P450s,and a web service based on PCPCM and PCPLD.Our study not only developed methods for the P450-specific structure analysis,but also introduced a universal approach that can assist the mining and functional analysis of P450 enzymes. | Hui Wang Qian Wang Yuqian Liu Xiaoping Liao Huanyu Chu Hong Chang Yang Cao Zhigang Li Tongcun Zhang Jian Cheng Huifeng Jiang | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 1 |
| 17 | Effects of cerium on nitrogen metabolism of peach plantlet in vitro显示文摘 | Song Weiping Hong Fashui Wan Zhigang Zhou Yuzhen Gu Fugen Xu Hongoing Yu Mingliang Chang Youhong Zhao Mizhen Su Jiale | 2003 | Biological Trace Element Research2003，，3： | 1 |
| 18 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 19 | Four Ln III-Mg II metal organic frameworks containing fan-like helices and independent2+units显示文摘 | CHANG Limei ZHAO Xia GU Zhigang | 2012 | Z Anorg Allg Chem2012，638，： | 1 |
| 20 | Holocene weak monsoon intervals indicated by low lake levels at Hulun Lake in the monsoonal margin region of northeastern Inner Mongolia, China显示文摘 | Xiao Jule Chang Zhigang Wen Ruilin | 2009 | Holocene2009，19，6： | 1 |
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