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| 1 | Burden of Gastrointestinal Disease in the United States: 2012 Update显示文摘 | Anne F. Peery Evan S. Dellon Jennifer Lund Seth D. Crockett Christopher E. McGowan William J. Bulsiewicz Lisa M. Gangarosa Michelle T. Thiny Karyn Stizenberg Douglas R. Morgan Yehuda Ringel Hannah P. Kim Marco Dacosta DiBonaventura Charlotte F. Carroll Je | 2012 | Gastroenterology2012，，5： | 15 |
| 2 | Small RNA Profiling Reveals Phosphorus Deficiency as a Contributing Factor in Symptom Expression for Citrus Huanglongbing Disease显示文摘Huanglongbing (HLB ) 是与类 Candidatus Liberibacter 的细菌被联系的破坏柠檬疾病(Ca。L.) 。强大的诊断工具和管理策略被需要控制 HLB。小 RNA (sRNA ) 玩的主人在调整主人回答到病原体感染的一个重要角色并且为许多人的疾病被用作早诊断的标记,包括癌症。决定是否柠檬 sRNAs 调整主人回答到 HLB, sRNAs 从柠檬 sinensis 被介绍有 Ca 的 10 和 14 星期柱子 grafting。L。asiaticus (Las ) 积极或健康的织物。十新 microRNAs (miRNAs ) , 76 保存 miRNAs,和许多小介入 RNA (siRNAs ) 被发现。几 miRNAs 和 siRNAs 被 Las 感染高度导致,并且能潜在地被开发进 HLB 的早诊断标记。miR399,被磷饥饿在另外的植物种类导致,被与类似于 HLB 的症状引起柠檬 stubborna 疾病的 Las 然而并非 Spiroplasma citri 的感染明确地导致。我们与健康的树相比在 Las 积极的柠檬树上发现了磷的 35% 减小。HLB 积极的香甜的橘子树的适用的磷 oxyanion 答案减少了 HLB 症状严厉并且显著地在西南佛罗里达在 3 年的地试用期间改进了水果生产。我们的分子,生理,并且地数据建议那磷缺乏被连接到 HLB 疾病 symptomology。 | Hongwei Zhao Ruobai Sun Ute Albrecht Chellappan Padmanabhan Airong Wanga Michael D. Coffey Thomas Girke Zonghua Wang Timothy J. Close Mikeal Roose Raymond K. Yokomi Svetlana Folimonova Georgios Vidalakis Robert Rouse Kim D. Bowman Hailing Jin | 2013 | Molecular Plant2013，6，2： | 12 |
| 3 | 1999~2006年急性冠脉综合征患者死亡及心力衰竭发生率降低显示文摘背景:有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征(non—ST-segment elevation acute coronary syndrome,NSTE ACS)患者的作用,随机试验已经提供了足够的证据,但是是否已经转化为相应的临床变化还不清楚。
目的:确定ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。
设计、地点及患者:全球急性冠脉事件注册研究(Global Registry of Acute Coronary Events,GRACE)是一项多国家队列研究。自1999年7月1日至2006年12月31日,该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。
主要观测指标:当前循证药物和介入治疗应用的趋势及患者预后(死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死)。
结果:随着研究时间的进展,相关药物的应用增加(β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention,PCI]患者应用噻氯毗啶、糖蛋白Ⅱb/Ⅲa抑制剂和低分子肝素;P〈0.001)。STEMI患者药物再灌注治疗下降了22个百分点(95%可信区间[confidence interval,CI],-27~-17),而直接PCI增加了37个百分点(95%CI,33—41)。在NSTEMI患者中,PCI的比例显著升高了18个百分点(95%CI,15~20)。充血性心力衰竭和肺水肿在STEMI患者中降低了9个百分点(95%CI,-12~-6),在NSTEACS患者中降低了6.9个百分点(95%CI,-8.4~-4.7)。STEMI患者的院内死亡率降低了18个百分点(95%CI,-5.3~-1.9),心源性休克降低了24个百分点(95%CI,-4.3~-0.5)。校正了危险评分后,NSTEACS患者的院内死亡率降低了0.7个百分点(95%CI,-1.7~0.3);STEMI患者6个月随访时卒中发生率降低了0.8个百分点(95%CI,-1.7~0.1),心肌梗死发生率降低了2.8个百分点(95%CI,-6.4~0.9)。NSTEACS患者6个月死亡率降低了1.6个百分点(95%CI,-3.0~-0.1),卒中发生率降低了0.7个百分点(95%CI,-1.4~0.1)。
结论:在本项多国家观察性研究中,ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。 | Keith A. A. Fox Philippe Gabriel Steg Kim A. Eagle Shaun G. Goodman Frederick A. Anderson Christopher B. Granger Marcus D. Flather Andrzej Budaj Ann Quill Joel M. Gore 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 6 |
| 4 | Mass Spectrometric Analyses Reveal a Central Role for Ubiquitylation in Remodeling the Arabidopsis Proteome during Photomorphogenesis显示文摘 | Victor Aguilar-Hernandez Do-Young Kim Robert J. Stankey Mark Scalf Lloyd M. Smith Richard D. Vierstra | 2017 | Molecular Plant2017，10，6： | 6 |
| 5 | Endocrine Regulation of Energy Metabolism by the Skeleton显示文摘 | Na Kyung Lee Hideaki Sowa Eiichi Hinoi Mathieu Ferron Jong Deok Ahn Cyrille Confavreux Romain Dacquin Patrick J. Mee Marc D. McKee Dae Young Jung Zhiyou Zhang Jason K. Kim Franck Mauvais-Jarvis Patricia Ducy Gerard Karsenty | 2007 | Cell2007，，3： | 5 |
| 6 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 7 | High-performance oxygen reduction and evolution carbon catalysis: From mechanistic studies to device integration显示文摘能容易集成于存在的高效、便宜的氧减小和进化催化剂的发展设备为利用 O 2-H2 O 化学,例如再生燃料房间和金属空气电池。此处,我们报导 NH 3-activated 做 N 的层次碳(NHC ) 催化剂经由一条可伸缩的线路综合了,并且表明它的设备集成。NHC 催化剂为氧减小反应(ORR ) 和氧进化反应(OER ) 展出了好性能,当综合时,借助于电气化学的研究和评估示威了进一个再生燃料房间的氧电极。为 ORR 和 OER 观察的活动比得上最先进的磅和红外催化剂在碱的环境完成的那些。我们进一步通过密度为电气化学的活动作为活跃地点识别了碳缺点的关键角色功能的理论计算和高分辨率的 TEM 可视化。这个工作加亮 NHC 的潜力在再生燃料房间并且可能代替商业宝贵金属为断断续续的可更新的精力的划算的存储的金属空气电池。 | John W. F. To Jia Wei Desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao | 2017 | Nano Research2017，10，4： | 4 |
| 8 | Synergistic Effects of A1896, T1653 and T1762/A1764 Mutations in Genotype C2 Hepatitis B Virus on Development of Hepatocellular Carcinoma显示文摘 | H. Lyu D. Lee Y.‐H. Chung J. A. Kim J.‐H. Lee Y.‐J. Jin W. Park P. Mathews E. Jaffee L. Zheng E. Yu Y. J. Lee | 2012 | J Viral Hepat2012，，3： | 3 |
| 9 | Prediction of response to entecavir therapy in patients with HBeAg‐positive chronic hepatitis B based on on‐treatment HBsAg, HBeAg and HBV DNA levels显示文摘 | J. W. Shin S. W. Jung B. R. Park C. J. Kim J. B. Eum B. G. Kim I. D. Jeong S.‐J. Bang S.‐H. Lee S. R. Kim N. H. Park | 2012 | Journal of Viral Hepatitis2012，，10： | 3 |
| 10 | Enhanced reversible capacity of Li-S battery cathode based on graphene oxide显示文摘Lithium sulfur battery (LSB) offers several advantages such as very high energy density, low-cost, and environmental-friendliness. However, it suffers from serious degradation of its reversible capacity because of the dissolution of reaction intermediates, lithium polysulfides, into the electrolyte. To solve this limitation, there are many studies using graphene-based materials due to their excellent mechanical strength and high conductivity. Compared with graphene, graphene oxide (GO) contains various oxygen functional groups, which enhance the reaction with lithium polysulfides. Here, we investigated the positive effect of using GO mixed with carbon black on the performance of cathode in LSB. We have observed a smaller drop of capacity in GO mixed sulfur cathode. We further demonstrate that the mechanistic origin of reversibility improvement, as confirmed through CV and Raman spectra, can be explained by the stabilization of sulfur in lithium polysulfide intermediates by oxygen functional groups of GO to prevent dissolution. Our findings suggest that the use of graphene oxide-based cathode is a promising route to significantly improve the reversibility of current LSB. | Jin Won Kim Joey D. Ocon Dong-Won Park Jaeyoung Lee | 2013 | Journal of Energy Chemistry2013，22，2： | 3 |
| 11 | Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review显示文摘 | Sameer D. Saini Hyungjin Myra Kim Philip Schoenfeld | 2006 | Gastrointestinal Endoscopy2006，，4： | 3 |
| 12 | Endoscopic ultrasound-guided versus conventional transmural drainage for pancreatic pseudocysts: a prospective randomized trial显示文摘 | D. Park S. Lee S.-H. Moon S. Choi S. Jung D. Seo S. Lee M.-H. Kim | 2009 | Endoscopy2009，，10： | 3 |
| 13 | The feasibility of endoscopic submucosal dissection for rectal carcinoid tumors: comparison with endoscopic mucosal resection显示文摘 | D. Lee S. Jeon S. Park M. Jung C. Cho W. Tak Y. Kweon S. Kim | 2010 | Endoscopy2010，，08： | 3 |
| 14 | Antiviral treatment for hepatitis B virus recurrence following liver transplantation显示文摘 | Sanghoon Lee Choon Hyuck D. Kwon Hyung Hwan Moon Tae‐Seok Kim Youngnam Roh Sanghyun Song Milljae Shin Jong Man Kim Jae Berm Park Sung Joo Kim Jae‐Won Joh Suk‐Koo Lee | 2013 | Clin Transplant2013，，5： | 3 |
| 15 | Acute encephalitis associated with measles: MRI features显示文摘 | K. Y. Lee W. H. Cho S. H. Kim H. D. Kim I. O. Kim | 2003 | Neuroradiology2003，，2： | 2 |
| 16 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 17 | Effect of melt processing conditions on the extent of exfoliation in organoclay-based nanocomposites显示文摘 | H.R. Dennis D.L. Hunter D. Chang S. Kim J.L. White J.W. Cho D.R. Paul | 2001 | Polymer2001，，23： | 2 |
| 18 | Genome-Wide Identification and Validation of a Novel Methylation Biomarker, SDC2 , for Blood-Based Detection of Colorectal Cancer显示文摘 | TaeJeong Oh Nayoung Kim Youngho Moon Myung Soon Kim Benjamin D. Hoehn Chan Hee Park Tae Soo Kim Nam Kyu Kim Hyun Cheol Chung Sungwhan An | 2013 | The Journal of Molecular Diagnostics2013，，4： | 2 |
| 19 | A cost-effective and fast synthesis of nanoporous SiO 2 aerogel powders using water-glass via ambient pressure drying route显示文摘 | Sharad D. Bhagat Yong-Ha Kim Myung-Jun Moon Young-Soo Ahn Jeong-Gu Yeo | 2007 | Solid State Sciences2007，，7： | 2 |
| 20 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
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