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| 1 | Effects of Temperature and Moisture on Soil Organic Matter Decomposition Along Elevation Gradients on the Changbai Mountains, Northeast China显示文摘Decomposition of soil organic matter(SOM) is of importance for CO_2 exchange between soil and atmosphere and soil temperature and moisture are considered as two important factors controlling SOM decomposition. In this study, soil samples were collected at 5 elevations ranging from 753 to 2 357 m on the Changbai Mountains in Northeast China, and incubated under different temperatures(5, 10, 15, 20, 25, and 30?C) and soil moisture levels(30%, 60%, and 90% of saturated soil moisture) to investigate the effects of both on SOM decomposition and its temperature sensitivity at different elevations. The results showed that incubation temperature(F = 1 425.10, P < 0.001), soil moisture(F = 1 327.65, P < 0.001), and elevation(F = 1 937.54, P < 0.001) all had significant influences on the decomposition rate of SOM. The significant effect of the interaction of incubation temperature and soil moisture on the SOM decomposition rate was observed at all the 5 sampling elevations(P < 0.001). A two-factor model that used temperature and moisture as variables fitted the SOM decomposition rate well(P < 0.001) and could explain 80%–93% of the variation of SOM decomposition rate at the 5 elevations. Temperature sensitivity of SOM decomposition, expressed as the change of SOM decomposition rate in response to a 10?C increase in temperature(Q_(10)), was significantly different among the different elevations(P < 0.01), but no apparent trend with elevation was discernible. In addition, soil moisture and incubation temperature both had great impacts on the Q_(10) value(P < 0.01), which increased significantly with increasing soil moisture or incubation temperature. Furthermore, the SOM decomposition rate was significantly related to soil total Gram-positive bacteria(R^2= 0.33, P < 0.01) and total Gram-negative bacteria(R^2= 0.58, P < 0.001). These findings highlight the importance of soil moisture to SOM decomposition and its Q_(10) value,which needs to be emphasized under warming climate scenarios. | WANG Dan HE Nianpeng WANG Qing LV Yuliang WANG Qiufeng XU Zhiwei ZHU Jianxing | 2016 | Pedosphere2016，26，3： | 12 |
| 2 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 3 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 4 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 5 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 6 | High loading carbon nanotubes deposited onto porous nickel yarns by solution imbibition as flexible wire-shaped supercapacitor electrodes显示文摘The deposition of active materials directly onto metal wires is a general strategy to prepare wire-shaped electrodes for flexible and wearable energy storage devices. However, it is still a critical challenge to coat active materials onto the aimed metal wires because of their smooth surface and small specific surface area. In this work, high porous nickel yarns(PNYs) was fabricated using commercial nylon yarns as templates through step-wise electroless plating, electroplating and calcination processes. The PNYs are composed of multiplied fibers with hollow tubular structure of 5–10 μm in diameter, allowing the imbibition of carbon nanotubes(CNTs) solution by a facile capillary action process. The prepared CNTs/PNY electrodes showed a typical electrochemical double layer capacitive performance and the constructed allsolid flexible wire-shaped symmetric supercapacitors provided a specific capacitance of 4.67 F/cm3 with good cycling stability at a current density of 0.6 A/cm3. | Chaoqun Kang Dashun Cao Yuejiao Liu Zhiwei Liu Ruiqing Liu Xiaomiao Feng Dan Wang Yanwen Ma | 2018 | Journal of Energy Chemistry2018，27，3： | 1 |
| 7 | Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial显示文摘An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to enrollment.The participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or BBIBP-CorV.The primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating strains.Between May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV group.Interim results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or 2.For immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by BBIBP-CorV.Our findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages. | Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 8 | Mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study显示文摘Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived COVID-19.Apart from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the world.The current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 survivors.Methods The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,2021.The demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the participants.Descriptive analyses,Pearson correlation analysis and Structural Equation Modeling were used to make data description and analysis.Results A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the analysis.Perceived stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,P<0.001),depression(r=0.325,P<0.001)and post-traumatic stress disorder(PTSD)(r=0.384,P<0.001).It has a direct effect on COVID-19 survivors’anxiety(β=0.326,P<0.001),depression(β=0.314,P<0.001),PTSD(β=0.385,P<0.001)and their resilience(β=−0.114,P<0.01).Resilience partially mediated the association between perceived stigma and anxiety(β=0.020,P<0.01),depression(β=0.020,P<0.01),and PTSD(β=0.014,P<0.01)among COVID-19 survivors.Conclusion Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 survivors.Based on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience. | Weijun Xiao Xiaoyang Liu Hao Wang Yiman Huang Zhenwei Dai Mingyu Si Jiaqi Fu Xu Chen Mengmeng Jia Zhiwei Leng Dan Cui Winnie W.S.Mak Liming Dong Xiaoyou Su | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
| 9 | Geological Guided Tomography Inversion Based on Fault Constraint and Its Application显示文摘Fault block reservoirs are one of the main types of hydrocarbon reservoirs found in offshore basins,and they are widely distributed within the Mesozoic and Cenozoic basins of the northern South China Sea.Conventional seismic profiles of complex fault areas often contain obvious fragmentation and distortion of seismic events that is corresponding to geological structure under the fault.This phenomenon is known as a fault shadow;it occurs in relation to rapid changes in velocity near the fault that deviate the ray path of waves,and it seriously affects the ability to determine the geological structure and subsequently evaluate the reserves of fault reservoirs.In the current conventional tomography inversion method,the velocity model is over-smoothed,which results in distortion of the reflection layer under the fault.Based on the velocity tomography inversion of imaging gathers method and the concept of regularization,this paper first introduces the anisotropy Gauss regularization operator.A high-resolution tomography inversion method is then developed,and the fault-controlled geological guidance is constrained.This technology is then applied to a complex fault block reservoir basin in the South China Sea,and the results show that it can significantly solve the problem of fault shadow imaging and determine the geological structures in the target area.The newly developed method thus has very good application prospects. | LI Sanfu ZHANG Xiaobo DAN Zhiwei SUN Bo SONG Peng SUN Leiming FANG Zhongyu LI Lie | 2021 | Journal of Ocean University of China2021，20，6： | 0 |
| 10 | An initial coprological survey of parasitic fauna in the wild Amur leopard(Panthera pardus orientalis)显示文摘The Amur leopard,one of nine recently recognized subspecies of leopard,is still the most threatened by a stochastic procession of extinction.Evaluation of the potential danger to the conservation of the Amur leopard originating from disease urgently needs to be studied.Unfortunately,research on the potential risk to Amur leopards caused by disease is rare.In terms of parasitic diseases that affect this species,even basic data for parasitic fauna are absent.The aim of this study is to acquire this knowledge to improve the general understanding of Amur leopard parasites.Seven parasite species,including 3 nematodes(Toxocara cati,a capillarid-type parasite,and a Metastrongyloideatype parasite),2 cestodes(Spirometra sp.and Taenia sp.),1 trematode(Paragonimus sp.),and 1 protozoan(Cystoisospora felis),were found in this research.Toxocara cati occurred most frequently,followed by Spirometra sp. | Zhijun HOU Zhiwei PENG Yao NING Dan LIU Hongliang CHAI Guangshun JIANG | 2020 | Integrative Zoology2020，15，5： | 0 |
| 11 | The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods显示文摘This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods.Porcine placenta was subjected to the analysis for its bioactive substances,and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract(PPE)and freeze-dried porcine placenta powder at high(PPH)and low(PPL)dosage.Results showed that porcine placenta contained placental peptides and 15 free amino acids,and the amounts of estrogen and progesterone in products developed from porcine placenta were within the limit of national standard.Mice model experiment revealed that compared with the control,the PPH treatment significantly improved the spleen index(P<0.05)by increasing the phagocytic rate of macrophages from 20%to 60%and the conversion rate of T lymphocytes from 8%to 60%.The q PCR analysis disclosed that the porcine placenta powder enhanced mice immunity via promoting the expression of Th1 cytokines of interleukin-2(IL-2)and IFN-γ,especially the former,by almost 8 times in the spleens of male mice,while inhibited Th2 cytokines of IL-4 and IL-10.This investigation has provided a reference for the development of porcine placenta as a raw material applied in functional foods to improve human immunity. | Zhiwei Zhou Dan Wang Wei Liu Lang He Pengkuan Liang Junli Hao Qun Sun | 2022 | Food Science and Human Wellness2022，11，6： | 0 |
| 12 | Disabled homolog 2 is required for migration and invasion of prostate cancer cells显示文摘残废相当或相同的事物(DAB2 ) 2 经常被删除或 epigenetically 在许多人的癌症房间的 silenced。因此, DAB2 总是被认为是肿瘤 suppressor 基因。然而,在肿瘤前进和转移的 DAB2 的角色仍然保持不清楚。在这研究, DAB2 表示是与人的前列腺癌症(PCa ) 一起的 upregulated 前进。在 LNCaP 和 PC3 房间线的 DAB2 overexpression 或击倒的效果被验证在 PCa 前进和转移探讨 DAB2 的生物功能。LNCaP 和 PC3 房间线分别地与低、高的变形潜力从人的 PCa 房间被产生。结果显示出那 DAB2 shRNA 击倒能禁止 PC3 房间,以及 tumorigenicity 的迁移、侵略的能力,而 DAB2 overexpression 提高了 LNCaP 房间移植和侵略。进一步的调查证明 DAB2 调整了房间迁居在 PC3 房间的联系基因,和微分 DAB2 在 LNCaP 和 PC3 房间之间的表示被 histone 部分调整 4 acetylation。因此, DAB2 可以在 PCa 前进和转移起一个重要作用。 | Yinyin Xie Yuanliang Zhang Lu Jiang Mengmeng Zhang Zhiwei Chen Dan Liu Qiuhua Huang | 2015 | Frontiers of Medicine2015，9，3： | 0 |
| 13 | Prediction method for energy con sumption per ton of fused magnesium furnaces using data driven and mechanism model显示文摘The electric energy consumed in every ton of acceptable product, namely energy consumption per ton (ECT), is an important overall index for the production process of a fused magnesium furnace. The furnace is the equipment for producing the fused magnesia. The ECT value depends on the current in the smelting process. The optimal operation for a fused magnesium furnace is supposed to have the ECT as low as possible, where the key is to predict ECT accurately. By introducing an unknown high-order non linear term, this paper builds a dynamic ECT model for differe nt production batches based on the static ECT model for one batch. The average current is taken as the input of the dynamic ECT model, which is composed of the unknown high-order nonlinear term and a nonlinear model with unknown parameters. The order of the nonlinear term is determined by the distance correlatio n and the nonlinear term is estimated by the stochastic con figuration n etwork, while the parameters of the non linear model is ide ntified by the least square method. The estimation of the nonli near term alter nates with the parameter identification. This paper proposes a prediction method for ECT, which is composed of the order identification of the non linear term, the alternating identification of the model and the ECT prediction model. The simulation experiments are conducted by the on-site data, and the results verify the effectiveness of the proposed prediction method. | Dan GUO Zhiwei WU Tianyou CHAI Jie YANG Jinliang DING | 2019 | Control Theory and Technology2019，17，1： | 0 |
| 14 | Internal Multiple Prediction Based on Imaging Profile Prediction and Kirchhoff Demigration显示文摘This paper introduces an internal multiple prediction method based on imaging profile prediction and Kirchhoff demigration.First,based on an inputted prestack time migration profile,the method predicts the prestack time migration profile that only includes internal multiples by inverse scattering series method.Second,the method uses velocity-weighted Kirchhoff demigration to create shot gathers that contains only internal multiples.Internal multiple prediction based on the prestack time migration profile effectively reduces the computational cost of multiple predictions,and the internal-multiple shot gathers created by Kirchhoff demigration remarkably reduces the complexity of the practical problem.Internal multiple elimination can be conducted through the combined adaptive multiple subtraction based on event tracing.Synthetic and field data tests show that the method effectively predicts internal multiples and possesses considerable potential in field data processing,particularly in areas where internal multiples develop seriously. | QIU Binhuang TAN Jun DAN Zhiwei YU Jiashun YAN Hongyan LIU Baohua YU Kaiben SONG Peng XIE Chuang | 2019 | Journal of Ocean University of China2019，18，6： | 0 |
| 15 | Long-term outcomes in COVID-19 patients who recovered from the first wave of the pandemic显示文摘This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019(COVID-19)in Jianghan District(Wuhan,China).The results showed that 61.4%of COVID-19 patients reported at least one symptom and 8.8%had depressive symptoms at the 17-month follow-up.The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19hospitals was 31.6%and 41.1%,respectively,and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8%and 60.9%,respectively.Female sex(odds ratio[OR]=1.48,95%confidence interval[CI]:1.16–1.88),severe disease(OR=1.46,95%CI:1.01–2.10)and a higher number of initial symptoms(OR=1.31,95%CI:1.23–1.40)were associated with the development of sequelae symptoms at 17 months.This study involving community-dwelling COVID-19adults may help determine the long-term effects of COVID-19 during the first pandemic wave.Nonetheless,larger follow-up studies are needed to characterize the post-COVID-19 condition. | Dan Cui Simiao Chen Luzhao Feng Mengmeng Jia Yeming Wang Weijun Xiao Yanxia Sun Qiangru Huang Libing Ma Zhiwei Leng Hao Wang Bin Cao Weizhong Yang Juntao Yang Chen Wang | 2022 | National Science Review2022，9，11： | 0 |
| 16 | Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis显示文摘Indoor microorganisms impact asthma and allergic rhinitis(AR),but the associated microbial taxa often vary extensively due to climate and geographical variations.To provide more consistent environmental assessments,new perspectives on microbial exposure for asthma and AR are needed.Home dust from 97 cases(32 asthma alone,37 AR alone,28 comorbidity)and 52 age-and gender-matched controls in Shanghai,China,were analyzed using high-throughput shotgun metagenomic sequencing and liquid chromatography-mass spectrometry.Homes of healthy children were enriched with environmental microbes,including Paracoccus,Pseudomonas,and Psychrobacter,and metabolites like keto acids,indoles,pyridines,and flavonoids(astragalin,hesperidin)(False Discovery Rate<0.05).A neural network co-occurrence probability analysis revealed that environmental microorganisms were involved in producing these keto acids,indoles,and pyridines.Conversely,homes of diseased children were enriched with mycotoxins and synthetic chemicals,including herbicides,insecticides,and food/cosmetic additives.Using a random forest model,characteristic metabolites and microorganisms in Shanghai homes were used to classify high and low prevalence of asthma/AR in an independent dataset in Malaysian schools(N=1290).Indoor metabolites achieved an average accuracy of 74.9%and 77.1%in differentiating schools with high and low prevalence of asthma and AR,respectively,whereas indoor microorganisms only achieved 51.0%and 59.5%,respectively.These results suggest that indoor metabolites and chemicals rather than indoor microbiome are potentially superior environmental indicators for childhood asthma and AR.This study extends the traditional risk assessment focusing on allergens or air pollutants in childhood asthma and AR,thereby revealing potential novel intervention strategies for these diseases. | Yu Sun Hao Tang Shuang Du Yang Chen Zheyuan Ou Mei Zhang Zhuoru Chen Zhiwei Tang Dongjun Zhang Tianyi Chen Yanyi Xu Jiufeng Li Dan Norback Jamal Hisham Hashim Zailina Hashim Jie Shao Xi Fu Zhuohui Zhao | 2023 | Eco-Environment & Health2023，2，4： | 0 |
| 17 | Accurate Determination of Water Permeabilities of Sub-anochannels.显示文摘Water permeability of membranes has been the focus of fundamental researches and technical applications.However,water permeability in sub-100 nm regime is not yet well understood as evidenced by the previously published data which are divergent from theory. | Xu Fangfang Liu Zhiwei Huang Ran Zhang Jiaming Liu Jie Hu Zhenguo Ma Jie Yao Huijun Sun Youmei Chen Yonghui Zhang Shengxia Mo Dan Duan Jinglai | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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