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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice显示文摘Acinetobacter baumannii (一。Baumannii ) 是为获得医院的感染负责的新兴的机会主义的病原体,并且它现在组成足够地严肃的威胁到公共健康要求一支有效疫苗的发展。在这研究, recombinant 熔化了蛋白质命名 OmpK/Omp22 和二单个蛋白质 OmpK 和 Omp22 用 recombinant 被获得表示和 Ni 亲密关系纯化。一些 BALB/c 老鼠与这些蛋白质被使免疫并且与 A 的临床上孤立的紧张质问了。baumannii。在血,在肺织物的病理学的变化和在挑战以后的幸存率的细菌的负担被评估。与 OmpK/Omp22 使免疫的老鼠熔化了蛋白质对 A 的提供的显著地更大的保护。baumannii 挑战个别地二蛋白质与也比那些使免疫。结果对 A 为疫苗的未来设计提供新奇线索。baumannii。 | GUO San Jun REN Shan XIE Yong En | 2018 | Biomedical and Environmental Sciences2018，31，2： | 5 |
| 3 | Effects of yttrium and phosphorus on growth and physiological characteristics of Microcystis aeruginosa显示文摘Yttrium is a main kind of rare earth elements(REEs) with wide applications in modern industry and farming. Phosphorus, an essential element of algae, is used as the nutrients and also one of the main factors of eutrophication. To investigate the effects of yttrium and phosphorus on Microcystis aeruginosa(M. aeruginosa), the growth and physiological changes were studied by lab cultured experiments. In the experiment, exogenous yttrium was tested by a concentration gradient(0.0, 0.1, 0.3, 0.5, 1.0 mg/L),meanwhile, phosphorus was tested by three concentrations(0.0, 0.02, 0.2 mg/L). The results show that the contents of chlorophyll a(chl-a) and soluble protein increase compared with the control and they have certain correlation with algal cells density. The growth status of algae is stimulated by initial yttrium concentration <0.3 and 0.2 mg/L phosphorus, while it is inhabited by 0.5 and 1.0 mg/L yttrium. Besides,the activity of superoxide dismutase(SOD) of algae increases with addition of yttrium dose(0-0.3 mg/L)when phosphorus dose is 0.2 mg/L. Furthermore, when yttrium dose is 0.5 and 1.0 mg/L, the vitality of SOD presents a sharp decline. The malondialdehyde(MDA) contents increase with time and addition of yttrium dose, 0.2 mg/L phosphorus weakens the accumulation of MDA. | Yingjun Wang Yuanwei Li Xiaoyu Luo Yin'an Ren En'guang Gao Haojie Gao | 2018 | Journal of Rare Earths2018，36，7： | 4 |
| 4 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 5 | On the wear behavior of surface clad layers under high temperature 显示文摘 | Aoh Jon Ving Jeng Yau Ren Chu En Lo | 1999 | Wear1999，，： | 1 |
| 6 | Determining the level of extra-pair paternity in yellow-bellied prinias,a socially monogamous passerine显示文摘DEAR EDITOR,Previous work based on molecular evidence has shown that most socially monogamous birds follow a genetic polyandrous mating system.However,our knowledge about avian mating systems is heavily biased toward the north temperate zone,with data on tropical birds remaining relatively scarce.This uneven distribution of both phylogenetic and spatial sampling has hampered our understanding and interpretation of results.In this study,we investigated the frequency of extra-pair paternity(EPP)in a tropical population of yellow-bellied prinias(Prinia flaviventris)in Guangxi,southern China.A total of 129 individuals belonging to 24 nests were sampled,among which 12 out of 83 chicks(14.46%)in seven nests were found to be EPP offspring.In nests in which all nestlings were sampled,only five out of 56 chicks were EPP offspring,accounting for an unbiased EPP rate of 8.93%.This rate is below the average rate of EPP in the family Sylviidae.The possible causes of EPP in prinias and the occurrence of EPP in birds with high resource investment and intensive parental care are discussed.This study highlights the value of genome-wide markers in determining relatedness in a wild bird species without a reference genome. | Zhi-Feng Ding Chun-Lan Zhang Wen-Sui Zhang Qian-Min Yuan Long-Wu Wang Gang Ren En Li Hui-Jian Hu Wei Liang | 2021 | Zoological Research2021，42，1： | 1 |
| 7 | On the wear behavior of surface clad layers under high temperature显示文摘 | Jong Ning Aoh Yau Ren Jeng En Lo Chu | 1999 | Wear1999，，： | 1 |
| 8 | Mineral iron based self-assembling: bridging the small molecular drugs and transformative application显示文摘The nanoparticle-based treatment and diagnosis of cancer remain challenging in clinical translation, mainly due to the hurdles that can be associated with the development of targeted delivery, biological side effects, poor drug loading efficiency (DLE), and instability and so on [1,2]. | En Ren Chengchao Chu Xin Pang Peng Lv Zhao Lei Gang Liu | 2019 | Science Bulletin2019，64，4： | 1 |
| 9 | In hibitory effects of praeruptorin-c on cattle aortic smooth mus ele cell proliferation 显示文摘 | WEI EN HUI RAO MAN REN CHEN XIN YING | 2002 | Aeta Pharmacol Sin2002，23，2： | 1 |
| 10 | Indocyanine green-based nanodrugs: A portfolio strategy for precision medicine显示文摘As the sole cyanine dye approved by the Food and Drug Administration(FDA), indocyanine green(ICG) has been widely applied in solid tumor and metastases surgical navigation as well as malignant tissue destruction. The great performance of ICG benefits from excellent fluorescent properties in the near infrared region(NIR) and reactive oxygen species(ROS) or hyperthermia effects under irradiation. Nevertheless, some intrinsic limitations, such as unstable optical properties, concentration-dependent aggregation, proneness to photo-bleaching, and poor aqueous stability in vivo, severely restrict its further applications. To overcome these challenges, ICG-based nanodrugs(nanoICG), as one kind of portfolio strategy, could bridge the efficient cargo-carriers and ICG molecules to artificially improve their existing performance. In this mini-review, we will focus on the developed engineering strategies for nano-ICG formulation synthesis and their desired performance in tumor tracing and eradication. A critical analysis of assembly mechanisms, excellent performance, and further improvement tactics will be examined. | Qixuan Dai En Ren Dazhuang Xu Yun Zeng Chuan Chen Gang Liu | 2020 | Progress in Natural Science:Materials International2020，30，5： | 1 |
| 11 | On the wear behavior of surface clad layers under high temperature 显示文摘 | Aoh Jon Ning Jeng Yau Ren Chu En Eo at el | 1999 | Wear1999，，： | 1 |
| 12 | On the wear behavior of surface clad layers under high temperature显示文摘 | Jon - Ning Aoh Yau - Ren Jeng En - Lo Chu etc | 1999 | Wear1999，，： | 1 |
| 13 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 14 | Instability of microsatellites linked to targeted genes inCRISPR/Cas9-edited and traditional gene knockout mouse strains显示文摘The classic method for gene knockout (KO) is based on homolo-gous recombination (HR) and embryonic stem cell technique(Gerlai, 1996). Actually, the procedure of homologous replacementis complicated and time consuming, although it has been popularduring the past decades. | Xueyun Huo Xiulin Zhang Yihan Liu Yizhu Sun Yu Ren Changlong Li Xiaoyan Du Zhenw en Chen | 2018 | Journal of Genetics and Genomics2018，45，10： | 0 |
| 15 | Cell-surface cascaded landing location for nanotheranostics显示文摘Theranostics is an appealing approach in precision medicine and it is still a critical challenge to design smart strategies which can precisely accumulate the functional probes/drugs into targeted disease areas.Cell-surface cascaded landing location is an effective strategy to develop functional drug-loading platforms to explore basic physiological processes at the cellular level and to facilitate the development of nanotheranostics for disease treatment. | En Ren Junqing Wang Gang Liu | 2017 | Chinese Chemical Letters2017，28，9： | 0 |
| 16 | CRINISINE,A NEW ALKALOID FROM CRINUM ASIATICUM L.VAR.SINICUM (ROXB.EX HERB)BAKER显示文摘CRINISINE,ANEWALKALOIDFROMCRINUMASIATICUML.VAR.SINICUM(ROXB.EXHERB)BAKER￥RenJiuTANG;NingjiBI(GuangxiInstituteofTraditionalMed... | Ren Jiu TANG Ningji BI (Guangxi Institute of Traditional Medical and Pharmaceutical Science,Nanning, 530022)Guang En MA (The National Institute of Pharmaceutical Research &. Development,Beijing, 102206) | 1994 | Chinese Chemical Letters1994，5，10： | 0 |
| 17 | Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy显示文摘Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process,the bioorthogonal reaction that commonly contains the“bond formation”and“bond cleavage”system has been widely used in targeted therapy for a variety of tumors.Herein,several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy,and the innovative tactics for reducing the metal ions’toxic and side effects with microneedle patches will be highlighted.Based on these applications,the complexities,potential pitfalls,and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated. | Lan Lin Lai Jiang En Ren Gang Liu | 2023 | Frontiers of Chemical Science and Engineering2023，17，4： | 0 |
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