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| 1 | Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability显示文摘Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the'life science'tool box and represent promising avenue for biomedical monitoring. | Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang Songlin Xie Chuanrui Chen Chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng | 2020 | Science China Chemistry2020，63，9： | 3 |
| 2 | CsPb(I_(x)Br_(1-x))_(3) solar cells显示文摘Owing to its nice performance, low cost, and simple solution-processing, organic-inorganic hybrid perovskite solar cell(PSC) becomes a promising candidate for next-generation high-efficiency solar cells.The power conversion efficiency(PCE) has boosted from 3.8% to 25.2% over the past ten years. Despite the rapid progress in PCE, the device stability is a key issue that impedes the commercialization of PSCs. Recently, all-inorganic cesium lead halide perovskites have attracted much attention due to their better stability compared with their organic-inorganic counterpart. In this progress report, we summarize the properties of CsPb(IxBr1-x)3 and their applications in solar cells. The current challenges and corresponding solutions are discussed. Finally, we share our perspectives on CsPb(IxBr1-x)3 solar cells and outline possible directions to further improve the device performance. | Xue Jia Chuantian Zuo Shuxia Tao Kuan Sun Yixin Zhao Shangfeng Yang Ming Cheng Mingkui Wang Yongbo Yuan Junliang Yang Feng Gao Guichuan Xing Zhanhua Wei Lijun Zhang Hin-Lap Yip Mingzhen Liu Qing Shen Longwei Yin Liyuan Han Shengzhong Liu Lianzhou Wang Jingshan Luo Hairen Tan Zhiwen Jin Liming Ding | 2019 | Science Bulletin2019，64，20： | 2 |
| 3 | Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis显示文摘 | Wei Li Baoyang Hu XuepengWang Tianda Li Tongtong Cui Dawei Yu Chao Liu Liyuan Jiang Guihai Feng Lei wang Rui Fu Xinxin Zhang Jie Hao Yukai Wang Liu Wang Qi Zhou | 2018 | Cell Research2018，28，1： | 2 |
| 4 | Cascading failure prevention of complex systems based on brittleness entropy game显示文摘A non-cooperative game model based on brittleness entropy is formulated for preventing cascading failure of complex systems.Subsystems of a complex system are mapped to the players of the game.The influence of collapsed subsystems to other subsystems is also taken into account in the definition of payoff function except for their own entropy increase.This influence is named brittleness entropy.Each player has two optional strategies;rational for negative entropy and irrational for negative entropy.The model is designed to identify the players who select an irrational strategy for negative entropy.The players who select the irrational strategy for negative entropy continue to compete for negative entropy after the recovery of ordered state and make other subsystems can' t get enough negative entropy to reduce entropy increase.It leads to cascading failure of the complex system in the end.Genetic algorithm is used to seek the solution of game model,and the simulation result verifies the effectiveness of the proposed model.The model provides a new way to prevent cascading failure of complex systems. | 曹然 Jin Hongzhang Feng Liyuan Xu Xu | 2013 | High Technology Letters2013，19，4： | 2 |
| 5 | EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy. | Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 6 | Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population显示文摘 | QingXu Lian‐yuanTao QiaoWu FeiGao Feng‐liangZhang LiYuan Xiao‐dongHe | 2012 | HPB2012，，6： | 2 |
| 7 | Recent progress in perovskite solar cells:from device to commercialization显示文摘Perovskite solar cells(PSCs) are undergoing rapid development and the power conversion efficiency reaches 25.7% which attracts increasing attention on their commercialization recently.In this review,we summarized the recent progress of PSCs based on device structures,perovskite-based tandem cells,large-area modules,stability,applications and industrialization.Last,the challenges and perspectives are discussed,aiming at providing a thrust for the commercialization of PSCs in the near future. | Xinhui Luo Xuesong Lin Feng Gao Yang Zhao Xiaodong Li Liqing Zhan Zexiong Qiu Jin Wang Cong Chen Lei Meng Xiaofeng Gao Yu Zhang Zijian Huang Rundong Fan Huifen Liu Yanrun Chen Xiaoxue Ren Jiahong Tang Chun-Hao Chen Dong Yang Yongguang Tu Xiao Liu Dongxue Liu Qing Zhao Jingbi You Junfeng Fang Yongzhen Wu Hongwei Han Xiaodan Zhang Dewei Zhao Fuzhi Huang Huanping Zhou Yongbo Yuan Qi Chen Zhaokui Wang Shengzhong(Frank)Liu Rui Zhu Jotaro Nakazaki Yongfang Li Liyuan Han | 2022 | Science China Chemistry2022，65，12： | 1 |
| 8 | Enhanced reversibility of red phosphorus/active carbon composite as anode for lithium ion batteries显示文摘 | Yonglong Wang Liyuan Tian Zhiheng Yao Feng Li Shu Li Shihai Ye | 2015 | Electrochimica Acta2015，，： | 1 |
| 9 | The Research and Realization of UDDI in Service-Oriented Architecture显示文摘It is a trend that SOA is becoming the future enterprise software architecture world widely.The key point is howto describe and discover services,thus these mainly rely on UDDI.Firstly,the current situation of SOA and UDDI are introduced,and then UDDI V3and related technical specifications are analyzed.Secondly,UDDI models,working principle,the mapping of WSDL and UDDI,and its implementation technologies are delved into.On this basis,the overall framework of UDDI is built and the service publishing and inquiring process are analyzed.Finally,a registry based on the latest standard of UDDI is achieved. | ZANG Tianxiang TIAN Minghao ZHANG Liyuan FENG Yongxin | 2014 | 沈阳理工大学学报2014，33，6： | 1 |
| 10 | Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges显示文摘In recent years,significant breakthroughs have been made in the field of gene ther-apy.Adeno-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest.Among the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific tissues.Currently,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases. | Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun Gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang | 2024 | Genes & Diseases2024，11，1： | 1 |
| 11 | Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1显示文摘Endometrial dysfunction is an important factor for implantation failure.The function of the endometrium is regulated by multiple factors like sex hormones and circadian rhythms.Endometrial stromal cells(ESCs)are a major cellular component in the endometrium,which is essential for proper physiological activities of the endometrium and the establishment of pregnancy.Melatonin,as a circadian-controlled hormone,plays beneficial roles in the regulation of reproductive processes.MT1,a melatonin receptor,can regulate cell proliferation and apoptosis.Whether melatonin-MT1 signal affects biological function of ESCs remains unknown.Here,we showed that MT1 was expressed in human ESCs(hESCs),which could be regulated by estrogen and progesterone.MT1 knockdown inhibited proliferative activity and promoted apoptosis of hESCs by activating caspase-3 and upregulating the Bax/Bcl2 ratio.Melatonin could reverse the effect of MT1 knockdown on proliferative activity and apoptosis of hESCs.Melatonin could promote proliferative activity of hESCs via the JNK/P38 signal pathway and repress the apoptosis of hESCs via the JNK signal pathway.Moreover,in vivo experiments showed that MT1 expression was decreased in endometrial cells from mice with disrupted circadian rhythm,accompanied by increased apoptosis and suppressed proliferative activity,which could be alleviated by administration of melatonin.These results showed the regulatory effect of melatonin-MT1 signal on biological behaviors of ESCs,which might provide a novel therapeutic strategy for endometrial dysfunction induced by disrupted circadian rhythm. | Liyuan Cui Feng Xu Zhuxuan Jiang Songcun Wang Xinyi Li Yan Ding Ying Zhang Meirong Du | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 1 |
| 12 | Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction:regrulatory effects of hydroxytyrosol显示文摘 | FENG Zhihui BAI Liyuan YAN Jiong | | 0，，10： | 1 |
| 13 | Key Issues Study on the Operation Management of Medical Waste Incineration Disposal Facilities显示文摘 | Yang Chen Liyuan Liu Qinzhong Feng Gang Chen | 2012 | Procedia Environmental Sciences2012，，： | 1 |
| 14 | Determination of volatile nitrosamines in latex products by HS-SPME-GC-MS 显示文摘 | Feng Di Liu Luo Zhao Liyuan | 2011 | Chromatographia2011，74，： | 1 |
| 15 | Rapid determination of single-stalk and population lodging resistance strengths and an assessment of the stem lodging wind speeds for winter wheatand an assessment of the stem lodging wind speeds for winter wheat显示文摘 | Niu Liyuan Feng Suwei Ru Zhengang | 2012 | Field Crops Research2012，139，： | 1 |
| 16 | Research on Characteristic Parameters of Coal-dust Explosion显示文摘 | Weiguo Cao Liyuan Huang Jianxin Zhang Sen Xu Shanshan Qiu Feng Pan | 2012 | Procedia Engineering2012，，： | 1 |
| 17 | Novel electrochemical redoxactive species: one-step synthesis of polyaniline defivative-AtdPd and its application for multiplexed irmnunoassay显示文摘 | Wang Liyuan Feng Feng Ma Zhanfang | 2015 | SciRep2015，5，16： | 1 |
| 18 | Breast Cancer Awareness and Association with Frequency of Screening Among Women—China,2020显示文摘Summary What is already known about this topic?Breast cancer awareness plays a crucial role in promoting screening attendance,enabling early detection,and improving survival rates associated with breast cancer.Nevertheless,a persistent issue is the low public awareness of breast cancer warning signs and risk factors. | Heling Bao Liyuan Liu Shu Cong Fei Wang Lixiang Yu Liwen Fang Xuening Duan Feng Tan Zhigang Yu Linhong Wang | 2023 | China CDC weekly2023，5，15： | 0 |
| 19 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 20 | CMOS image sensors in ISSCC 2023显示文摘In IEEE International Solid-State Circuits Conference(ISSCC)2023,CMOS process is still the dominating fabrication technology for image sensors,and three-dimensional(3D)wafer-stacked process with Cu–Cu pixel-level connection has been adopted to achieve small pixel size and high integration level.The development of CMOS image sensors(CIS)is still focusing on the trends of high performance and more functionalities,such as hybrid event-based vision sensor(EVS)and terahertz(THz)/X-ray image sensor. | Peng Feng Nanjian Wu Jian Liu Liyuan Liu | 2023 | Journal of Semiconductors2023，44，4： | 0 |
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