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| 1 | Plate tectonic control on the formation and tectonic migration of Cenozoic basins in northern margin of the South China Sea显示文摘The tectonic evolution history of the South China Sea(SCS) is important for understanding the interaction between the Pacific Tectonic Domain and the Tethyan Tectonic Domain,as well as the regional tectonics and geodynamics during the multi-plate convergence in the Cenozoic.Several Cenozoic basins formed in the northern margin of the SCS,which preserve the sedimentary tectonic records of the opening of the SCS.Due to the spatial non-uniformity among different basins,a systematic study on the various basins in the northern margin of the SCS constituting the Northern Cenozoic Basin Group(NCBG) is essential.Here we present results from a detailed evaluation of the spatial-temporal migration of the boundary faults and primary unconformities to unravel the mechanism of formation of the NCBG.The NCBG is composed of the Beibu Gulf Basin(BBGB),Qiongdongnan Basin(QDNB),Pearl River Mouth Basin(PRMB) and Taixinan Basin(TXNB).Based on seismic profiles and gravity-magnetic anomalies,we confirm that the NE-striking onshore boundary faults propagated into the northern margin of the SCS.Combining the fault slip rate,fault combination and a comparison of the unconformities in different basins,we identify NE-striking rift composed of two-stage rifting events in the NCBG:an early-stage rifting(from the Paleocene to the Early Oligocene) and a late-stage rifting(from the Late Eocene to the beginning of the Miocene).Spatially only the late-stage faults occurs in the western part of the NCBG(the BBGB,the QDNB and the western PRMB),but the early-stage rifting is distributed in the whole NCBG.Temporally,the early-stage rifting can be subdivided into three phases which show an eastward migration,resulting in the same trend of the primary unconformities and peak faulting within the NCBG.The late-stage rifting is subdivided into two phases,which took place simultaneously in different basins.The first and second phase of the early-stage rifting is related to back-arc extension of the Pacific subduction retreat system.The third phase of the earlystage rifting resulted from the joint effect of slab-pull force due to southward subduction of the proto-SCS and the back-arc extension of the Pacific subduction retreat system.In addition,the first phase of the late-stage faulting corresponds with the combined effect of the post-collision extension along the Red River Fault and slab-pull force of the proto-SCS subduction.The second phase of the late-stage faulting fits well with the sinistral faulting of the Red River Fault in response to the Indochina Block escape tectonics and the slab-pull force of the proto-SCS. | Pengcheng Wang Sanzhong Li Yanhui Suo Lingli Guo Guangzeng Wang Gege Hui M.Santosh Ian D.Somerville Xianzhi Cao Yang Li | 2020 | Geoscience Frontiers2020，11，4： | 10 |
| 2 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 3 | Traffic Clustering Algorithm of Urban Data Brain Based on a Hybrid-Augmented Architecture of Quantum Annealing and Brain-Inspired Cognitive Computing显示文摘In recent years,the urbanization process has brought modernity while also causing key issues,such as traffic congestion and parking conflicts.Therefore,cities need a more intelligent'brain'to form more intelligent and efficient transportation systems.At present,as a type of machine learning,the traditional clustering algorithm still has limitations.K-means algorithm is widely used to solve traffic clustering problems,but it has limitations,such as sensitivity to initial points and poor robustness.Therefore,based on the hybrid architecture of Quantum Annealing(QA)and brain-inspired cognitive computing,this study proposes QA and Brain-Inspired Clustering Algorithm(QABICA)to solve the problem of urban taxi-stand locations.Based on the traffic trajectory data of Xi’an and Chengdu provided by Didi Chuxing,the clustering results of our algorithm and K-means algorithm are compared.We find that the average taxi-stand location bias of the final result based on QABICA is smaller than that based on K-means,and the bias of our algorithm can effectively reduce the tradition K-means bias by approximately 42%,up to approximately 83%,with higher robustness.QA algorithm is able to jump out of the local suboptimal solutions and approach the global optimum,and brain-inspired cognitive computing provides search feedback and direction.Thus,we will further consider applying our algorithm to analyze urban traffic flow,and solve traffic congestion and other key problems in intelligent transportation. | Ning Wang Gege Guo Baonan Wang Chao Wang | 2020 | Tsinghua Science and Technology2020，25，6： | 3 |
| 4 | The Least Eigenvalue of Unicyclic Graphs with Application to Spectral Spread显示文摘Let U^(g)_(n)be the set of connected unicyclic graphs of order n and girth g.Let C(T_(1),T_(2),…,T_(g))∈U^(g)_(n)be obtained from a cycle v_(1)v_(2)…v_(g)v_(1)(in an anticlockwise direction)by identifying v_(i)with the root of a rooted tree T_(i)of order n_(i)for each i=1,2,…,g,where n_(i)≥1 and∑^(g)_(i=1)n_(i)=n.In this note,the graph with the minimal least eigenvalue(and the graph with maximal spread)in C(T_(1),T_(2),…,T_(g))is determined. | Jiming Guo Gege Zhang Zhiwen Wang Panpan Tong | 2022 | Algebra Colloquium2022，29，2： | 1 |
| 5 | Linkage between reactivation of the sinistral strike-slip faults and 28 September 2018 Mw7.5 Palu earthquake, Indonesia显示文摘On September 28, 2018, a Mw7.5 earthquake occurred near Sulawesi, Indonesia as a result of strike-slip faulting at shallow depth within the interior of the Molucca Sea Microplate that forms a part of the broader Sunda Plate. Focal mechanism solutions and distribution for the earthquakes indicate rupture occurred on a left-lateral NNW-SSE-to N-S-striking fault. This region has been characterized by complex tectonics in which motions of numerous small microplates are accommodating large-scale convergence between the Australia, Sunda, Pacific and Philippine Sea plates. In this paper, the Coulomb stress calculation verified the WNW-, nearly E-W-trending sinistral strike slip receiver fault in Sulawesi, which is consistent with the giant sinisterly strike-slip fault system across New Guinea, Pacific Tectonic System and the Tethys Tectonic System caused by the oblique convergence. The result has been reconciled within the modern GPS velocity field. | Gege Hui Sanzhong Li Pengcheng Wang Yanhui Suo Qian Wang Ian D.Somerville | 2018 | Science Bulletin2018，63，24： | 1 |
| 6 | Distributed implantation of a flexible microelectrode array for neural recording显示文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions. | Chunrong Wei Yang Wang Weihua Pei Xinyong Han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 7 | An M-ALO-SVR Model to Predict Output of Industry-University-Research Collaboration Network in China显示文摘The output prediction of industry-university-research cooperation network is a prerequisite for optimization of network resource allocation and improvement of network innovation performance.Accurate prediction of network output can provide data for feedback systems,offermethods and reference to government macro-level control,and avoid resource wastes caused by improper input of capital and humans.In this paper,a prediction model based on Ant Lion Optimizer and Support Vector Regression is proposed.First,the M-ALO-SVR model was built.Then,Pareto function and regulatory factors were applied to accelerate the convergence of ALO-SVR optimization,improving the global search ability of the algorithm.Finally,the empirical research of the industry-university-research cooperation network was implemented,and simulation experiments were conducted with samples of China Statistical Yearbooks.The results show that the M-ALO-SVR model performs well in the innovation network output prediction.The predictive goodness of fit of the model reaches 99.7%,improved by 0.02%and 3.3%respectively compared with that of ALO-SVR model and SVM.The running time of the model is two seconds fewer than that of the ALO-SVR model.In addition,the optimizing function of the model converges at higher speed and its MSE is optimal. | Ruiqiong Zhong Ben Wang Gege Feng | 2021 | 国际计算机前沿大会会议论文集2021，，2： | 0 |
| 8 | Influence of nano-mechanical evolution of Ti_(3)AlC_(2) ceramic on the arc erosion resistance of Ag-based composite electrical contact material显示文摘Al-containing MAX phase ceramic has demonstrated great potential in the field of high-performance low-voltage electrical contact material.Elucidating the anti-arc erosion mechanism of the MAX phase is crucial for further improving performance,but it is not well-understood.In this study,Ag/Ti_(3)AlC_(2) electrical contact material was synthesized by powder metallurgy and examined by nanoindentation techniques such as constant loading rate indentation,creep testing,and continuous stiffness measurements.Our results indicated a gradual degradation in the nano-mechanical properties of the Ti_(3)AlC_(2) reinforcing phase with increasing arc erosion times,although the rate of this degradation appeared to decelerate over arc erosion times.Specifically,continuous stiffness measurements highlighted the uneven mechanical properties within Ti_(3)AlC_(2),attributing this heterogeneity to the phase’s decomposition.During the early(1-100 times)and intermediate(100-1000 times)stages of arc erosion,the decline in the nano-mechanical properties of Ti_(3)AlC_(2) was primarily ascribed to the decomposition of Ti_(3)AlC_(2) and limited surface oxidation.During the later stage of arc erosion(1000-6200 times),the inner region of Ti_(3)AlC_(2) also sustained arc damage,but a thick oxide layer formed on its surface,enhancing the mechanical properties and overall arc erosion resistance of the Ag/Ti_(3)AlC_(2). | Xuelian Wu Chengzhe Wu Xinpeng Wei Wanjie Sun Chengjian Ma Yundeng Zhang Gege Li Liming Chen Dandan Wang Peigen Zhang Zhengming Sun Jianxiang Ding | 2024 | Journal of Advanced Ceramics2024，13，2： | 0 |
| 9 | Determination of Triazine Herbicides in Environmental Water Samples by Acetonitrile Inorganic Salt Aqueous Two-Phase Microextraction System显示文摘Acetonitrile inorganic salt aqueous two-phase extraction method was established for the determination of triazine herbicides(simeton,cyanazine,desmetryn,terbumeton,terbuthylazine and dimethametryn)in environmental water samples by high-performance liquid chromatography(HPLC).The extraction solvents types and volume of acetonitrile,the inorganic salt types and amount of(NH_(4))_(2)SO_(4),extraction time and pH of sample solution were optimized by single-factor experiment and central composite design.Under the optimum extraction conditions,all linear ranges were obtained with coefficients of determination(r)≥0.9993.The limits of detection for this proposed method were in the range of 0.16-0.28μg/L for six triazine herbicides.The developed method has been successfully applied to the analysis of target triazine herbicides from lake,canal and moat in real-world water samples.The recoveries of target analytes were in the range from 87.0 to 110.9%and the relative standard deviation was lower than 7.3%. | Shiqian Gao Gege Wu Xiaomeng Li Jie Chen Youyi Wu Junxia Wang Zhanen Zhang | 2018 | Journal of Analysis and Testing2018，2，4： | 0 |
| 10 | The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis:Therapeutic implications显示文摘Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of asthma.Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung function.In this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial asthma.Furthermore,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma. | Dan Huang Gege Liu Zhiyi Xu Shushu Chen Cuili Wang Dewei Liu Jiahao Cao Junfen Cheng Bin Wu Dong Wu | 2023 | Genes & Diseases2023，10，4： | 0 |
| 11 | An overview on CV2/CRMP5 antibody-associated paraneoplastic neurological syndromes显示文摘Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years. | Sai Wang Haiman Hou Yao Tang Shuang Zhang Gege Wang Ziyan Guo Lina Zhu Jun Wu | 2023 | Neural Regeneration Research2023，18，11： | 0 |
| 12 | Huoxue Jiedu Huayu recipe(活血解毒化瘀方)alleviates contralateral renal fibrosis in unilateral ureteral obstruction rats by inhibiting the transformation of macrophages to myofibroblast显示文摘OBJECTIVE:To investigate the action and underlying mechanisms of Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)against unilateral ureteral obstruction(UUO)-induced injury in the contralateral kidney.METHODS:Forty-eight male Sprague-Dawley rats weighing(200±10)g were used in this study and randomly assigned to 4 groups:a sham group,a UUO group,a UUO+eplerenone(EPL)group,and a UUO+HJHR group.The contralateral kidneys were harvested for further study 180 d after surgery.Histological analysis,immunohistochemistry and immunofluorescence were used to study the fibrosis of the contralateral kidneys obtained from UUO rats.Contralateral kidney damagerelated pathway proteins were detected by real-time polymerase chain reaction and Western blot analysis.RESULTS:HJHR significantly inhibited fibrosis of the contralateral kidney in UUO rats by attenuating the UUOinduced macrophage-to-myofibroblast transition(MMT)in the contralateral kidney.Moreover,HJHR attenuated fibrosis in the contralateral kidney of UUO rats by preventing MMT through the aldosterone/mineralocorticoid receptor/serum/glucocorticoid regulated kinase 1 pathway.CONCLUSIONS:Our findings suggest that HJHR may be a potential treatment for renal interstitial fibrosis of obstructive nephropathy. | XIONG Yunzhao LIU Lingjin LIU Ziqian CHEN Gege HAO Juan GAO Xiaomeng QIANG Panpan WANG Zheng XU Qingyou | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 13 | A novel silicone derivative of natural osalmid(DCZ0858)induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway显示文摘Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous malignant tumor characterized by diffuse growth.DCZ0858 is a novel small molecule with excellent antitumor effects in DLBCL.This study explored in depth the inhibitory effect of DCZ0858 on DLBCL cell lines.Cell Counting Kit-8(CCK-8)and plate colony formation assays were used to evaluate cell proliferation levels.Flow cytometry was employed to analyze apoptosis and the cell cycle,and western blotting was used to quantify the expression of cell cycle regulators.The results indicated that DCZ0858 inhibited cell growth in a concentration-dependent and time-dependent manner while inducing no significant toxicity in normal cells.Moreover,DCZ0858 initiated cell apoptosis via both internal and external apoptotic pathways.DCZ0858 also induced cell cycle arrest in the G0/G1 phase,thereby controlling cell proliferation.Further investigation of the molecular mechanism showed that the JAK2/STAT3 pathway was involved in the DCZ0858-mediated antitumor effects and that JAK2 was the key target for DCZ0858 treatment.Knockdown of JAK2 partly weakened the DCZ0858-mediated antitumor effect in DLBCL cells,while JAK2 overexpression strengthened the effect of DCZ0858 in DLBCL cells.Moreover,a similar antitumor effect was observed for DCZ0858 and the JAK2 inhibitor ruxolitinib,and combining the two could significantly enhance cancer-suppressive signaling.Tumor xenograft models showed that DCZ0858 inhibited tumor growth in vivo and had low toxicity in important organs,findings that were consistent with the in vitro data.In summary,DCZ0858 is a promising drug for the treatment of DLBCL. | Kang Lu Bo Li Hui Zhang Zhijian Xu Dongliang Song Lu Gao Haiguo Sun Liping Li Yingcong Wang Qilin Feng Gege Chen Liangning Hu Rong Wei Yongsheng Xie Dandan Yu Xiaosong Wu Weiliang Zhu Jumei Shi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 14 | Surface engineering of carbon dots for highly sensitive α-glucosidase assay and inhibition evaluation显示文摘Monitoringα-glucosidase(α-Glu)activity is of great significance for the early diagnosis of typeⅡdiabetes.Here the blue fluorescent carbon dots(CDs)were integrated with two different recognizing molecules,β-cyclodextrin and phenylboronic acid,for assembling a multifunctional CDs(mCDs)nanoplatform for sensitively analyzingα-Glu and its inhibitors.The hydrolyzed product of 4-nitrophenyl-α-D-glucopyranoside(α-Glu substrate),p-nitrophenol,could efficiently quench the fluorescence of mCDs due to its cooperative molecular recognition withβ-cyclodextrin and phenylboronic acid.The mCDs could be utilized for the detection ofα-Glu activity with the limit of detection of 0.030 U/L.Moreover,the presentα-Glu detection platform revealed a high selectivity,and other natural enzymes showed scarcely any effect on the present mCDs system.The proposed method could be facilely used to screenα-Glu inhibitors with satisfying performance.The rational mCDs is expected to supplement more comprehensive biosensing platforms for highly sensitive and specific recognition of disease-relevant biomarkers with clinical importance. | Meijuan Liang Gege Song Yeqing Wan Yingying Chen Fuan Wang Xiaoqing Liu | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 15 | Two stream skeleton behavior recognition algorithm based on Motif-GCN显示文摘Compared with RGB videos and images,human bone data is less vulnerable to external factors and has stronger robustness.Therefore,behavior recognition methods based on skeletons are widely studied.Because graph convolution network(GCN)can deal with the irregular topology data of hu-man skeletons very well,more and more researchers apply GCN to human behavior recognition.Tra-ditional graph convolution methods only consider the joints with physical connectivity or the same type when building the behavior recognition model based on human skeletons structure,which cannot capture higher-order information better.To solve this problem,Motif-GCN is used in this paper to ex-tract spatial features.The relationship between the joints with natural connection in the human body is encoded by the first Motif-GCN,and the possible relationship between the unconnected joints in the human skeleton is encoded by the second Motif-GCN.In this way,the relationship between non-physical joints can be strengthened.Then a two stream framework combining joint and bone informa-tion is used to capture more action information.Finally,experiments are conducted on two subdata-sets X-Sub and X-View of NTU-RGB+D,and the accuracy shown in Top-1 classification results is 89.5%and 95.4%respectively.The experimental results are 1.0%and 0.3%higher than those of the 2S-AGCN model respectively.The superiority of this method is also proved by the experimental results. | 吴进 WANG Lei FENG Haoran CHONG Gege | 2023 | High Technology Letters2023，29，4： | 0 |
| 16 | Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation显示文摘Multiple myeloma(MM)is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow.Previously,we synthesized an innovative molecule named dihydrocelastrol(DHCE)from celastrol,a triterpene purified from medicinal plant Tripterygium wilfordii.Herein,we explore the therapeutic properties and latent signal transduction mechanism of DHCE action in bortezomib(BTZ)-resistant(BTZ-R)MM cells.In this study,we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells.We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest.In addition,inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect.Simultaneously,DHCE acts synergistically with BTZ on BTZ-R cells.PSMB5,a molecular target of BTZ,is overexpressed in BTZ-R MM cells compared with BTZ-S MM cells and is demonstrated to be a target of STAT3.Moreover,DHCE downregulates PSMB5 overexpression in BTZ-R MM cells,which illustrates that DHCE overcomes BTZ resistance through increasing the sensitivity of BTZ in resistant MM via inhibiting STAT3-dependent PSMB5 regulation.Overall,our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM. | Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 17 | Accumulation of glycolipids in wheat grain and their role in hardness during grain development显示文摘Grain hardness is an important parameter for wheat quality. To understand the role of glycolipids in the formation of grain hardness, the glycolipid contents in wholegrain wheat flour and the starch granule surfaces of oven-dried and freeze-dried hard and soft wheat grain were analyzed. Changes in endosperm structure and amyloplast membrane integrity during grain development were also examined by electron microscopy. The monogalactosyldigylcerol(MGDG) and digalactosyldigylcerol(DGDG) contents of the starch surface were significantly higher in soft wheat than in hard wheat, regardless of the drying method or developmental stage. Throughout grain development, MGDG content was significantly higher in the starch surface of freeze-dried hard wheat than in the starch surface of oven-dried hard wheat. In contrast, the MGDG content of the starch surface was significantly higher in freeze-dried soft grain at 14 and 35 days after anthesis. No significant difference was observed in puroindoline protein(PIN) accumulation in wholegrain flour from wheat that was dried using the two methods, whereas PIN accumulation on the starch surface of freeze-dried grain was lower than that on the starch surface of oven-dried grain.The gap between the amyloplast membrane and starch granules was larger in hard wheat than in soft wheat, as shown by transmission electron microscopy. For the same wheat cultivar, this gap was larger for oven-dried than for freeze-dried grain. The content of polar lipids in the starch surface was closely related to grain hardness, and the breakdown of the amyloplast membrane may determine the location of polar lipids on the starch surface. | Haixia Qin Dongyun Ma Xin Huang Jie Zhang Wan Sun Gege Hou Chenyang Wang Tiancai Guo | 2019 | The Crop Journal2019，7，1： | 0 |
| 18 | Optimal Culture Capacity of White Shrimp (Litopenaeus vannamei) and Razor Clam (Sinonovacula constricta) in a New Series-Connection Culture Model显示文摘To construct an effective circular mix-culture model and investigate its culture capacity,we established one small and one large systems,with white shrimp(Litopenaeus vannamei)and razor clam(Sinonovacula constricta)cultured in separate ponds.The culture water from the L.vannamei was pumped to the S.constricta,and the culture water from the S.constricta overflowed back into the L.vannamei via gravity.In trial I,we tested four culture densities(groups 1–4),and monitored water quality,growth indices,and digestive and immune enzyme activities.From the results,the nitrogen and phosphorus levels generally increased then declined after 56 days,and were lower in groups 1 and 2.The specific growth rate of group 2 was the highest.After 56 days,activities of four digestive enzymes were increased in group 2,and lysozyme activity was significantly decreased in S.constricta in groups 1–4;Alkaline phosphatase activity of L.vannamei was increased in group 3,but decreased in S.constricta in groups 2–4;Acid phosphatase activity was significantly higher in groups 1–3(P<0.05),while SOD and CAT activities were significantly elevated in group 2(P<0.05).Thus,we applied group 2 density for trial II.In trial II,nitrogen and phosphorus concentrations declined significantly during the latter stages,and growth indices were higher than the control(P<0.05).The yields of L.vannamei and S.constricta were significantly higher than the control(P<0.05).The results revealed a good circular mix-culture system with the optimal culture capacity for L.vannamei(40 ind m^(−2))and S.constricta(300 ind m^(−2)),which provided a reference for the future culture of them. | HU Jiabao ZHAO Chunpu BAO Gege LUO Yunhui WANG Danli XU Jilin XU Shanliang | 2022 | Journal of Ocean University of China2022，21，6： | 0 |
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