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| 1 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 2 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 3 | Study on Antireflection SiO_2 Coatings Fabricated by Layer-by-Layer Deposition显示文摘Multifunctional(poly(diallyldimethyl ammonium chloride)/sodium poly(4-styrene sulfonate)) n((PDDA/PSS) n) thin films were fabricated by layer-by-layer assembled on the glass substrate.The monolayer silica nanoparticles were prepared on the(PDDA/PSS) n films.The SiO 2-polyelectrolyte coatings exhibit antireflection properties with low refractive index(as low as 1.22).Interestingly,wavelengths of maximum transmittance could be well tailored by simply changing the particle size of SiO 2.A maximum transmittance of 97.03% in the visible spectral range is achieved for the particle size of 100 nm SiO 2 films.The coatings also show excellent mechanical stability and good adhesion to substrates.The easy availability of the raw materials and simplicity of the fabrication method for such films might make them be potentially useful for various applications. | WANG Cong HU Qingwei FANG Pengfei HE Chunqing | 2013 | Wuhan University Journal of Natural Sciences2013，18，3： | 2 |
| 4 | Characterization of polymer films using a slow positron beam显示文摘 | He Chunqing Suzuki T Hamada E | 2003 | Matrial Research Innovations2003，7，1： | 1 |
| 5 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 6 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 7 | Free volume expan- sion and nanofoaming of supercritical carbon dioxide treated polystyrene 显示文摘 | OKA T ITO K HE Chunqing | 2008 | J Phys Chem B2008，112，12： | 1 |
| 8 | High-rate crystallization of polycarbonate in spincast thinfilm显示文摘 | Seisuke A Toshitaka 0 He Chunqing | 2010 | Polym Sci B:Polym Phys2010，48，20： | 1 |
| 9 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 10 | Rheological behaviour of ethylene glycol based titania nanofluids显示文摘 | Haisheng Chen Yulong Ding Yurong He Chunqing Tan | 2007 | Chemical Physics Letters2007，，4： | 1 |
| 11 | Two case studies of thermal maturity and thermal modelling within the overpressured Jurassic rocks of the Barrow Sub-basin, North West Shelf of Australia显示文摘 | He Sheng Middleton M Kaiko A Jiang Chunqing Li Maowen | 2002 | Mar Pet Geol2002，19，2： | 1 |
| 12 | Positron annihilation in hypercrosslinked polystyrenes 显示文摘 | He Chunqing Suzuki T Shantarovich V P | 2003 | Chem Phys2003，286，： | 1 |
| 13 | AbInitio Calculation of Structure and Raman and Infrared Spectra of Trifluoromethylthiosulphenyl Chloride显示文摘AbInitioCalculationofStructureandRamanandInfraredSpectraofTrifluoromethylthiosulphenylChlorideZouXianwu,LiuHaoyang,LuHongwenZ... | Wang Shaojie Wang Bo Li Shiqing Dai Yiqun He Chunqing Zhang Shaoping | 1997 | Wuhan University Journal of Natural Sciences1997，2，2： | 0 |
| 14 | Status of transjugular intrahepatic portosystemic shunt for portal hypertension in China:A national survey analysis显示文摘Aim:The transjugular intrahepatic portosystemic shunt(TIPS)procedure has been performed in China for 30 years,but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete.This study aims to investigate the current situation of the use of TIPS for portal hypertension,which should aid the development of TIPS in China.Methods:This study involved a questionnaire survey,initiated by the China Portal Hypertension Alliance(CHESS)to investigate the use of TIPS for portal hypertension in China.Questionnaires were released on the Internet between August 16,2022 and September 16,2022.Detailed information was collected from 545 hospitals contracted by the CHESS in China,which performed TIPS surgery in 2021.Results:The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention.In the survey,a total of 13,527 TIPS interventions were carried out with 94.1%(498/545)of them had a system of routine follow‐up after TIPS.The majority(42.6%[232/545])believed that the main indication of TIPS was the control of acute bleeding.Overall,48.1%(262/545)carried out early or pre‐emptive TIPS,53.0%(289/545)carried out TIPS for cavernous transformation of the portal vein,and 81.0%(441/545)chose routine embolization of collateral circulation during operation.Most used coils(97.0%[475/490])and biological glue(72.0%[353/490])as embolic materials,and 78.5%(428/545)routinely performed intraoperative portal pressure gradient measurements.When selecting TIPS stents,57.1%(311/545)chose viator‐specific stents,and 57.2%(312/545)chose conventional anticoagulation after TIPS.Conventional anticoagulation after TIPS is over a time interval of 3–6 months(55.4%[173/312]).The limitation of TIPS surgery is mainly its cost(72.3%[394/545])and insufficient understanding of the procedure by doctors in other related departments(77.4%[422/545]).Most of the hospital teams accept the use of domestic instruments in TIPS surgery(92.7%[505/545]).Conclusions:This survey shows that TIPS is an essential part of the treatment of portal hypertension in China.TIPS is widely used in Chinese patients with portal hypertension,and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS.In the future,it is necessary to promote TIPS technology and further standardize surgical indications,routine operations,and instrument application. | Haibo Shao Xinwei Han Jianbo Zhao Junhui Sun Zhuting Fang Bin Xiong Xiaoli Zhu Weixin Ren Min Yuan Shiping Yu Meng Niu Weifu Lv Xueqiang Zhang Chunqing Zhang Lei Li Xuefeng Luo Yusheng Song Yilong Ma Tong Dang Hua Xiang Yun Jin Hui Xue Guiyun Jin Xiao Li Jiarui Li Shi Zhou Changlu Yu Song He Lei Yu Hongmei Zu Jun Ma Yanming Lei Ke Xu Xiaolong Qi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
| 15 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
| 16 | Absence seizures in lesion‑related epilepsy显示文摘Background In the new International League Against Epilepsy(ILAE)classification of seizure types,generalized seizures such as absence seizures(ASs)may originate from a focal point and rapidly spread to the bilaterally distributed brain network.Increasing evidence from animal and clinical studies has indicated that focal changes may occur prior to ASs;however,the relationship of ASs with epileptogenic lesions remains unclear.Methods We retrospectively collected and analyzed the clinical,imaging,and electrophysiological data of 16 patients who had ASs and structural lesions with seizure-free outcomes after lesion resection.Results In semiology analysis,nine patients displayed focal onset;only two patients showed simple ASs,and seizure types other than ASs were observed in the remaining patients.On ictal electroencephalography(EEG),four patients showed bilateral synchronous symmetric 3 Hz generalized spike-wave discharges(GSWDs),and the remaining patients showed bilateral 1.5–2.5 Hz GSWDs.Moreover,most patients(13/16,81.3%)exhibited focal features in addition to ASs,while interictal EEG was the same in 12 patients.Furthermore,on stereoelectroencephalogram(SEEG),2/5 patients showed focal discharges before bilateral burst GSWDs.Additionally,all patients had structural lesions on imaging.In four typical AS patients,the lesions were located in deep brain regions.Notably,in 9 patients(9/16,56%),the lesions were located in the posterior cortex.All patients underwent lesion resection and had seizure-free outcomes during follow-up,and intelligence quotient(IQ)also improved by 10.71±3.90 one year after surgery.Conclusions Patients with lesion-related epilepsy may present with ASs that have a focal onset and are associated with good surgical outcomes. | Xiaoqin Sun Miao Wang Zeng He Lihong Liu Xianjun Shi Chunqing Zhang Ning An Meihua Yang Zhifeng Wu Ruodan Wang Li Wang Zhongke Wang Hui Yang Xiaolin Yang Shiyong Liu | 2023 | Acta Epileptologica2023，6，3： | 0 |
| 17 | Positronium Annihilation in Oxygen and Nitrogen Mixture显示文摘Formed in silica aerogels, positronium annihilation in oxygen and nitrogen mixture is studied by a simple and convenient method. The results show that ortho-positronium (o-Ps) lifetime is significantly shortened when some oxygen is introduced into nitrogen gas and that the o-Ps collisional quenching rate for an oxy-gen molecule is (28.0±0.4) μs-1·amagat-1 (1 amagat = 2.69×1025m-3). It is found that the o-Ps annihilation rate in oxygen of 1atm at room temperature is (25.5±0.5) μs-1 and that the effective number of electrons per oxygen molecule available for 2γ annihilation of positron in the o-Ps is (34.6±0.4). | WANG Juncheng HE Chunqing DAI Yiqun WANG Shaojie | 2013 | Wuhan University Journal of Natural Sciences2013，18，2： | 0 |
| 18 | Extracting Lotus Fields Using the Spectral Characteristics of GF-1 Satellite Data显示文摘The lotus(Nelumbo nucifera Gaertn.)is an aquatic plant that grows in shallow water and has long been cultivated in South China.It can improve the incomes of farmers and plays an important role in alleviating poverty in rural China.However,a modern method is required to accurately estimate the area of lotus fields.Lotus has spectral characteristics similar to those of rice,grassland,and shrubs.The features surrounding areas where it is grown are complex,small,and fragmented.Few studies have examined the remote sensing extraction of lotus fields,and automatic extraction and mapping are still challenging methods.Here,we compared the spectral characteristics of lotus fields and other ground objects and devised a remote sensing method for the rapid extraction of lotus fields.Using this method,the extraction accuracy of lotus was 96.3%.The Kappa coefficient was 0.926,which is higher than those of the unsupervised K-means classification,Mahalanobis distance,and support vector machine supervised classification,and demonstrates the potential of this method for extracting and mapping lotus fields by remote sensing. | Dongping Zha Haisheng Cai Xueling Zhang Qinggang He Liting Chen Chunqing Qiu Shufang Xia | 2022 | Phyton-International Journal of Experimental Botany2022，91，10： | 0 |
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