|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 3 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 4 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 5 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 6 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients显示文摘Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2018 | Journal of Nutritional Oncology2018，3，4： | 5 |
| 7 | Benefit of infusions with ibandronate treatment in children with osteogenesis imperfecta显示文摘背景成骨 imperfecta (OI ) 是稀罕骨头疾病,它的有效治疗是相对缺乏的。我们试着估计新 bisphosphonate 的效果,有在这开标签的、未来的、控制研究的 OI.Methods 的孩子上的 ibandronate,有 OI 的 30 个孩子被注册。他们在每三个月或口头的 calcitriol 内收到了 ibandronate (2 mg ) 的任何一个注入为 24 个月的 0.25 g 日报。所有病人每天一起加 200 U 维生素 D 拿了 500 mg 钙。端点是年度新破裂率的变化(由病历和脊骨的 X 光线电影观察了),骨头矿物质密度( BMD ,由双精力X光检查 absortiometry 测量了),类型骨胶原的 carboxy-telopeptide 交叉结合的浆液集中( CTX ,骨头再吞标记)并且碱的磷酸酶(高山,骨头形成标记)在在 ibandronate 的周期的注入以后的 follow-up.Results 期间,年度新破裂率显著地从 1.9~0.13 次被减少,显然更低的 t 在 ibandronate 组的 BMD 的增加比 calcitriol 组(P 0.001 ) 的大。高山和 CTX 的集中显然在 ibandronate 组被减少,并且 CTX 的减小比高山(P 0.001 ) 的更重要。到 ibandronate 的孩子们的忍耐相当好。温和发烧和肌肉疼痛在 ibandronate 的第一注入以后在 1-3 天以内在 9 种情况中被发现,没有到有 OI 的孩子的 ibandronate 的周期的注入的好处是的特殊 management.Conclusions ,它能在 1-2 以后减轻天重要因为 ibandronate 能显著地减少年度骨头骨折,评价,增加腰部、新潮的 BMD ,通过骨头再吞的抑制保存病人的脊椎的 morphometry 。 | LI Mei XIA Wei-bo XING Xiao-ping YU Wei HU Ying-ying JIANG Yan WANG Ou LIU Hai-juan HAN Lan-wen MENG Xun-wu XU Ling | 2011 | Chinese Medical Journal2011，，19： | 4 |
| 8 | Improvement of hydrogen isotope exchange reactions on Li_4SiO_4 ceramic pebble by catalytic metals显示文摘Li4SiO4 ceramic pebble is considered as a candidate tritium breeding material of Chinese Helium Cooled Solid Breeder Test Blanket Module(CH HCSB TBM) for the International Thermonuclear Experimental Reactor(ITER).In this paper,Li4SiO4 ceramic pebbles deposited with catalytic metals,including Pt,Pd,Ru and Ir,were prepared by wet impregnation method.The metal particles on Li4SiO4 pebble exhibit a good promotion of hydrogen isotope exchange reactions in H 2-D 2 O gas system,with conversion equilibrium temperature reduction of 200-300 8C.The out-of-pile tritium release experiments were performed using 1.0 wt% Pt/Li4SiO4 and Li 4 SiO 4 pebbles irradiated in a thermal neutron reactor.The thermal desorption spectroscopy shows that Pt was effective to increase the tritium release rate at lower temperatures,and the ratio of tritium molecule(HT) to tritiated water(HTO) of 1.0 wt% Pt/Li4SiO4 was much more than that of Li4SiO4,which released mainly as HTO.Thus,catalytic metals deposited on Li4SiO4 pebble may help to accelerate the recovery of bred tritium particularly in low temperature region,and increase the tritium molecule form released from the tritium breeding materials. | Cheng Jian Xiao Chun Mei Kang Xiao Jun Chen Xiao Ling Gao Yang Ming Luo Sheng Hu Xiao Lin Wang | 2012 | Chinese Chemical Letters2012，23，8： | 4 |
| 9 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 10 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 11 | Evaluating the Quality of Case-control Studies involving the Association between Tobacco Exposure and Diseases in a Chinese Population based on the Newcastle-Ottawa Scale and Post-hoc Power显示文摘According to the 2017 Global Burden of Disease Study,smoking is among the four leading risk factors contributing to deaths and disability-adjusted life years(DALYs)in China.In the past 20 years,there has been a substantial increase in the number of studies focusing on the association between tobacco exposure and disease. | SHI Yu Lin ZHAO Jian AI Fei Ling WANG Yu Tong HU Kui Ru WANG Xue Wei YANG Wen Yi WANG Jing Xin AI Li Mei WAN Xia | 2022 | Biomedical and Environmental Sciences2022，35，9： | 2 |
| 12 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 13 | CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development显示文摘尽管 HCO 3− 被知道为早胚胎开发被要求,它的准确角色留下逃犯。这里,我们报导 HCO 3− 在在 preimplantation 胚胎开发期间通过调停 CFTR 的流入调整 miR-125b 表示充当环境暗示。结果证明在 preimplantation 胚胎开发的 HCO 3− 的效果能被介入压制一条 HCO 3−-conducting 隧道的函数, CFTR,由一个特定的禁止者或基因大美人。细胞外的 HCO 3− 的移动或 CFTR 的抑制在 2 个房间阶段老鼠胚胎减少 miR-125b 表示。miR-125b 击倒模仿 HCO 3− 移动和 CFTR 抑制的效果,当 miR-125b 先锋的注射颠倒它时。在人和老鼠胚胎的 miR-125b upregulates p53 串联的 Downregulation。miR-125b 的激活被显示被 sAC/PKA-dependent 调停 NF-κ 的原子 shuttling; B。这些结果在在 preimplantation 胚胎开发期间连接环境 HCO 3− 到 miR-125b 的激活的信号 transduction 揭示了 CFTR 的一个关键角色并且在 miRNAs 的规定显示了离子隧道的重要性。 | Yong Chao Lu Hui Chen Kin Lam Fok Lai Ling Tsang Mei Kuen Yu Xiao Hu Zhang Jing Chen Xiaohua Jiang Yiu Wa Chung Alvin Chun Hang Ma Anskar Yu Hung Leung He Feng Huang Hsiao Chang Chan | 2012 | Cell Research2012，22，10： | 2 |
| 14 | Interventional treatment experience in multiple injury with major abdominal or pelvic injuries: 160 cases analysis显示文摘PurposeTo 与一个学生一起与 160 个多重损伤病人的主要腹或骨盆的 injury.MethodsData 在多重损伤病人观察 interventional embolization 和出血控制的治疗学的效果腹或骨盆的损害回顾地被分析。他们从 2013 年 10 月被同意进入 Zunyi 医学院的首先隶属于的医院的紧急情况的部门到 2016 年 4 月。为 embolization 和出血控制收到了突现的干预的 87 个病人被放作为组 A,包括 72 男性和 15 女性,与平均年龄(39.32 ? 瑩 ?睳慥 吗? | Tian-Xi Zhang Mei Han Peng Ye Quan Hu Jia-Lin Li Ling Yin An-Yong Yu | 2018 | Chinese Journal of Traumatology2018，21，1： | 1 |
| 15 | Pathogenic Pseudorabies Virus, China, 2012显示文摘 | Yu XIU LING ZHOU ZHI HU DONG MEI | 2014 | Emerg Infect Dis2014，20，： | 1 |
| 16 | The effect of SARS-CoV-2 infection on human embryo early development:a multicenter prospective cohort study显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection has swept the globe for 3 years(Zhou et al.,2020).With the nationwide relaxation of controls on the coronavirus disease 2019(COVID-19)epidemic since December 2022 in China,fertility and in vitro fertilization(IVF)centers are receiving increasing numbers of infected patients. | Xiaolei Chen Huangcong Shi Cheng Li Wanxia Zhong Linlin Cui Wenjun Zhang Ling Geng Kuona Hu Mei Fang Daimin Wei Junhao Yan Yun Sun Keliang Wu Han Zhao Zi-Jiang Chen | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 17 | Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis显示文摘 | Jiao Qin Yan‐yun Xie Ling Huang Qiong‐jing Yuan Wen‐Juan Mei Xiang‐ning Yuan Gao‐yun Hu Guang‐jie Cheng Li‐jian Tao Zhang‐zhe Peng | 2013 | Nephrology2013，，10： | 1 |
| 18 | Preparation and properties of nanosize silicone resin显示文摘 | Gong Shuling Mei Gongxiong Meng Lingzhi Hu Ling Zhang Xianliang Zhang Qunchao Chen Shenyun Liao Jun | 2002 | Youiigui Cailiao2002，16，5： | 1 |
| 19 | Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis显示文摘 | Jiao Qin Yan‐yun Xie Ling Huang Qiong‐jing Yuan Wen‐Juan Mei Xiang‐ning Yuan Gao‐yun Hu Guang‐jie Cheng Li‐jian Tao Zhang‐zhe Peng | 2013 | Nephrology2013，，10： | 1 |
| 20 | Use of iron oxide nanomaterials in wastewater treatment: A review显示文摘 | Piao Xu Guang Ming Zeng Dan Lian Huang Chong Ling Feng Shuang Hu Mei Hua Zhao Cui Lai Zhen Wei Chao Huang Geng Xin Xie Zhi Feng Liu | 2012 | Science of the Total Environment2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员