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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 4 | Determination of abscisic acid based on the fluorescent quenching of quantum dots显示文摘The quenching mechanism of the fluorescence of quantum dots by abscisic acid has been systematically investigated.The quenching constant KSV = 5.1 × 1011 / M was obtained under the optimized condition.On the basis of that,a very sensitive method for the determination of abscisic acid has been developed.The linear equation was F0/F = 0.9309 + 0.5072 C(pmol/L) and its linear range was 0.2-3.0 pmol/L with a correlation coefficient of 0.9939.The limit of detection was 0.09 pmol/L. | ZHANG Lei,GUAN HongLiang & HE ZhiKe Key Laboratory of Analytical Chemistry for Biology and Medicine,Ministry of Education College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China | 2010 | Science China Chemistry2010，53，1： | 4 |
| 5 | Immunomagnetic assay combined with CdSe/ZnS amplification of chemiluminescence for the detection of abscisic acid显示文摘Abscisic acid (ABA) is an important plant hormone. It plays a key role in regulating plant responses to abiotic stress and in controlling seed germination, growth, and stomatal aperture. A rapid, sensitive analytical method for the ABA detection is urgently required for further investigation of ABA signaling. In this work, an immunomagnetic assay combined with CdSe/ZnS amplification of chemiluminescence has been developed for the detection of ABA. The result could be read out in 30 min at least, with the simplified procedure of immunomagnetic assay. Under the optimized condition, a linear range from 1 pM to 10 nM was obtained. An unexpected result induced by the dose hook effect was discussed. This method provided the high selectivity for ABA over other components that might be contained in real samples. | ZHOU GuoHua, WANG Ping, YUAN Ju, QIU Ting & HE ZhiKe Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China | 2011 | Science China Chemistry2011，54，8： | 3 |
| 6 | Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics显示文摘The nanoplatforms based on upconversion nanoparticles(UCNPs)have shown great promise in amplified photodynamic therapy(PDT)triggered by near-infrared(NIR)light.However,their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence(UCL)by photosensitizers.To solve these defects,core-satellite metal-organic framework@UCNP superstructures,composed of a single metal-organic framework(MOF)NP as the core and Nd3+-sensitized UCNPs as the satellites,are designed and synthesized via a facile electrostatic self-assembly strategy.The superstructures realize a high co-loading capacity of chlorin e6(Ce6)and rose bengal(RB)benefitted from the highly porous nature of MOF NPs,showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs.The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal(magnetic resonance(MR)/UCL/fluorescence(FL))imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation,avoiding the laser irradiation-induced overheating issue.This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics. | Zhike Li Xi Qiao Guihua He Xin Sun Danhua Feng Liefeng Hu Hua Xu Hai-Bing Xu Shengqian Ma Jian Tian | 2020 | Nano Research2020，13，12： | 2 |
| 7 | Functionalized CdSe quantum dots as selective silver ion chemodosimeter显示文摘 | LIANG Jiangong AI Xinping HE Zhike | 2004 | Analyst2004，129，7： | 1 |
| 8 | Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl 4 -induced liver damage in rats via the Nrf2 pathway显示文摘 | Shuangchan Wu Yuan Yue Hui Tian Zhike Li Xiaofei Li Wei He Hong Ding | 2013 | Journal of Ethnopharmacology2013，，2： | 1 |
| 9 | DNA Functionalized Fluorescent Quantum Dots for Bioanalytical Applications显示文摘作为一最新发展了荧光灯探查,有唯一的光性质的 DNA functionalized 量点(QD ) 在 bioanalytical 应用程序起一个关键作用。现在的评论在 DNA 的变化形式技术上提供概述给 QD,包括静电的吸引力,共有原子价附件,特定的效果和直接合成。另外,我们在 bioapplications 在 DNA functionalized QD 上总结最近的进展,例如指向 nucleic 酸,离子,小分子和蛋白质察觉,房间成像和疾病诊断。最后,我们在 DNA functionalized 上有关当前的挑战想象方面荧光灯 QD。 | Cuiling Zhang Caiping Ding Dongshan Xiang Li Li Xinghu Ji Zhike He Yuezhong Xian | 2016 | Chinese Journal of Chemistry2016，34，3： | 1 |
| 10 | Quantum Dot-Mediated Detection of γ-Aminobutyric Acid Binding Sites on the Surface of Living Pollen Protoplasts in Tobacco显示文摘 | Guanghui Yu Jiangong Liang Zhike He | 2006 | Chemistry & Biology2006，13，7： | 1 |
| 11 | Vibration signal analysis and feature extraction based on reassigned wavelet scalogram显示文摘 | Peng Zhike Chu Fulei Yu He | 2002 | Journal of Sound and Vibration2002，253，5： | 1 |
| 12 | CdSe quantum dots as luminescent probes for spironolactone determination显示文摘 | Jiangong Liang Shan Huang Danyun Zeng Zhike He Xinghu Ji Xinping Ai Hanxi Yang | 2005 | Talanta2005，，1： | 1 |
| 13 | High-performance liquid chromatographic determination of oxalic acid in tea using tris ( 1,10-phenanthroline )-ruthenium (Ⅱ) chemiluminescence 显示文摘 | Wu Fengwu He Zhike Luo Qingyao | 1998 | Analytical Sciences1998，14，： | 1 |
| 14 | In-situ photoisomerization of azobenzene to inhibit ion-migration for stable high-efficiency perovskite solar cells显示文摘Ion migration is a notorious problem in perovskite solar cells(PSCs)that severely mutilates device performance.Herein,a strategy to inhibit ion migration in situ is developed by using photoisomerization of azobenzene(AZO)to immobilize cations in the lattice.During the nucleation process,the photoisomerized cis-AZO reacts with FA^(+),MA^(+)and Pb2+cations in the perovskite precursor by synergistic cation-πinteraction and Lewis base coordination,leading to heterogeneous nucleation to produce uniform perovskite film.Meanwhile,it accelerates conversion of intermediate yellowδ-phase to desired black aphase of FAPb I3for improved crystallinity with well-passivated grain surface.Consequently,defect density is effectively reduced for the perovskite film to demonstrate suppressed carrier recombination and enhanced carrier extraction.Subsequently,the solar cell efficiency is elevated from 21.29%to 23.58%with negligible J-V hysteresis.Long-term stability is also improved,with the bare device without any encapsulation retaining 84%of its initial efficiency after aging 744 hours in ambient. | Xuejiao Zuo Yiyang He Hongyu Ji Yong Li Xiuying Yang Binxun Yu Tao Wang Zhike Liu Wenliang Huang Jing Gou Ningyi Yuan Jianning Ding Shengzhong Frank Liu | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 15 | Determina- tion of Clenbuterol by CE with Chemluminescen detec- tion显示文摘 | Ji Xinghu He Zhike Xu Chuanlai | 2006 | Talanta2006，70，2： | 1 |
| 16 | Polargraphic determina-tion of fluoride using the adsorption wave of the Ce ( Ⅲ )-alizarin complexone-fluoride complex 显示文摘 | Lu Guanghan He Zhike | 1991 | Talanta1991，38，9： | 1 |
| 17 | Vibration signal analysis and feature extraction based on reassigned wavelet scalogram显示文摘 | Peng Zhike Chu Fulei Yu He | 2002 | Journal of Sound and Vibration2002，253，5： | 1 |
| 18 | Probing the cytotoxicity of CdSe quantum dots with surface modification显示文摘 | Guoning Guo Wei Liu Jiangong Liang Zhike He Huibi Xu Xiangliang Yang | 2006 | Materials Letters2006，，8： | 1 |
| 19 | Inter-specific and Inter-generic Hybridization Compatibility of Eriobotrya Species (Loquat) and Related Genera显示文摘We studied the cross-compatibility among 91 inter-specific combinations and 21 inter-generic combinations in 7 Eriobotrya plants and 2 related genera(Raphiolepis indica Lindl. and Photinia serrulata Lindl.) using emasculation, bagging, and artificial pollination. Our results showed that28 of the 91 inter-specific combinations set no fruit, which means nearly 30% of the combinations were incompatible. In the remaining 63 combinations, most showed partial cross-compatibility, and a few showed complete cross compatibility. Eriobotrya plants were incompatible with plants from their related genera(R. indica Lindl. and P. serrulata Lindl.). Backcrossing produced 5 compatible combinations, which could set fruits and produce F1 progeny but only after embryo rescue. Fruit setting ratios varied among various species used as male or female parents.E. prinoides Rehd. & Wils., common loquat(E. japonica) and Eriobotrya × daduheensis, used as female parents resulted in an average fruitsetting ratio of 36.2%–58.2%. E. deflexa Nakai and its two forms, and E. elliptica Lindl. as female parents resulted in 2.9%–16.3% average fruitsetting ratio; however, the fruit set ratio was higher(22.4%–43.1%) if they were used as male parents. Failure of E. deflexa f. koshunensis Nakai × E.prinoides Rehd. & Wils. hybrids to set fruit could be attributed to sporophytic incompatibility. | LI Guifen ZHANG Zhike YANG Xianghui QIAO Yanchun HE Xiaolong GAO Yongshun JIANG Yuanyuan LIN Shunquan | 2016 | Horticultural Plant Journal2016，2，6： | 1 |
| 20 | CdSe quantum dots as luminescent probes for spironolactone determination 显示文摘 | Jiangong Liang Shan Huang Danyun Zeng Zhike He Xinghu Ji Xinping Ai Hanxi Yang | 2006 | Talanta2006，69，： | 1 |
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