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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair显示文摘Schwann cell proliferation in peripheral nerve injury(PNI)enhances axonal regeneration compared to central nerve injury.However,even in PNI,long-term nerve damage without repair induces degeneration of neuromuscular junctions(NMJs),and muscle atrophy results in irreversible dysfunction.The peripheral regeneration of motor axons depends on the duration of skeletal muscle denervation.To overcome this difficulty in nerve regeneration,detailed mechanisms should be determined for not only Schwann cells but also NMJ degeneration after PNI and regeneration after nerve repair.Here,we examined motor axon denervation in the tibialis anterior muscle after peroneal nerve transection in thy1-YFP mice and regeneration with nerve reconstruction using allografts.The number of NMJs in the tibialis anterior muscle was maintained up to 4 weeks and then decreased at 6 weeks after injury.In contrast,the number of Schwann cells showed a stepwise decline and then reached a plateau at 6 weeks after injury.For regeneration,we reconstructed the degenerated nerve with an allograft at 4 and 6 weeks after injury,and evaluated functional and histological outcomes for 10 to 12 weeks after grafting.A higher number of pretzel-shaped NMJs in the tibialis anterior muscle and better functional recovery were observed in mice with a 4-week delay in surgery than in those with a 6-week delay.Nerve repair within 4 weeks after PNI is necessary for successful recovery in mice.Prevention of synaptic acetylcholine receptor degeneration may play a key role in peripheral nerve regeneration.All animal experiments were approved by the Institutional Animal Care and Use Committee of Tokyo Medical and Dental University on 5 July 2017,30 March 2018,and 15 May 2019(A2017-311C,A2018-297A,and A2019-248A),respectively. | Leyang Li Hiroyuki Yokoyama Hidetoshi Kaburagi Takashi Hirai Kunikazu Tsuji Mitsuhiro Enomoto Yoshiaki Wakabayashi Atsushi Okawa | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 3 | Nondoped-Type White Organic Electroluminescent Devices Utilizing Complementary Color and Exciton Diffusion 显示文摘 | TOSHIE TSUJI SHIGEKI NAKA HIROYUKI OKADA | 2002 | Appl Phys Lett2002，81，18： | 1 |
| 4 | Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity显示文摘 | Yuki Kawakami Tomoko Hosokawa Tomoko Morinaka Shioka Irino Shiori Hirano Hirokazu Kobayashi Akiko Yoshioka Toshiko Suzuki-Yamamoto Miyuki Yokoro Masumi Kimoto Hideaki Tsuji Hiromi Yamashita Shinobu Doi Chikao Yutani Rina Kato Hiroyuki Itabe Teruyuki Kanad | 2011 | Food Chemistry2011，，4： | 1 |
| 5 | Fuel consumption-derived CO 2 emissions under conventional and reduced tillage cropping systems in northern Japan显示文摘 | Nobuhisa Koga Haruo Tsuruta Hiroyuki Tsuji Hiroshi Nakano | 2003 | Agriculture Ecosystems and Environment2003，，1： | 1 |
| 6 | Multimode Horn Antenna with Both High Efficiency and Low Cross Polarization 显示文摘 | Hiroyuki Deguchi Mikio Tsuji Hiroshi Shigesawa | 2003 | Electronics and Communications in Japan2003，86，1： | 1 |
| 7 | Prognostic Factors in Hepatic Metastases of Colorectal Carcinoma显示文摘 | Atsushi Nanashima Hiroyuki Yamaguchi Terumitsu Sawai Eiichiro Yamaguchi Hideo Kidogawa Seiji Matsuo Toru Yasutake Takashi Tsuji Masaaki Jibiki Tohru Nakagoe Hiroyoshi Ayabe | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 8 | Identification of genes expressed during spore germination of Mycosphaerella pinodes显示文摘 | Hiroyuki Takahara Kazuhiro Toyoda Gento Tsuji Yasuyuki Kubo Yoshishige Inagaki Yuki Ichinose Tomonori Shiraishi | 2005 | Journal of General Plant Pathology2005，，3： | 1 |
| 9 | 显示文摘 | Chino Hiroyuki Tsuji Hirokazu | 1997 | Chemosphere1997，35，7： | 1 |
| 10 | Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts显示文摘 | Masakazu Ishii Chika Koike Akira Igarashi Katsuyuki Yamanaka Haiou Pan Yukihito Higashi Hiroyuki Kawaguchi Masaru Sugiyama Nobuyuki Kamata Tomoyuki Iwata Takehiro Matsubara Kozo Nakamura Hidemi Kurihara Koichiro Tsuji Yukio Kato | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 11 | Health‐related quality of life after carbon‐ion radiotherapy for prostate cancer: A 3‐year prospective study显示文摘 | Hiroyuki Katoh Hiroshi Tsuji Hitoshi Ishikawa Tadashi Kamada Masaru Wakatsuki Naoki Hirasawa Hiroyoshi Suzuki Koichiro Akakura Takashi Nakano Jun Shimazaki Hirohiko Tsujii | 2014 | Int J Urol2014，，： | 1 |
| 12 | Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats显示文摘 | Akari Ishisaka Satomi Ichikawa Hiroyuki Sakakibara Mariusz K. Piskula Toshiyuki Nakamura Yoji Kato Mikiko Ito Ken-ichi Miyamoto Akira Tsuji Yoshichika Kawai Junji Terao | 2011 | Free Radical Biology and Medicine2011，，7： | 1 |
| 13 | Prognostic Factors in Hepatic Metastases of Colorectal Carcinoma显示文摘 | Atsushi Nanashima Hiroyuki Yamaguchi Terumitsu Sawai Eiichiro Yamaguchi Hideo Kidogawa Seiji Matsuo Toru Yasutake Takashi Tsuji Masaaki Jibiki Tohru Nakagoe Hiroyoshi Ayabe | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 14 | Autocalibration algorithm for robust capon beamforming显示文摘 | Shohei Kikuchi Hiroyuki Tsuji Akira Sano | 2006 | IEEE Antennas and Wireless Propagation Letters2006，，5： | 1 |
| 15 | Laparoscopic Splenectomy for a Lymphangioma of the Spleen: Report of a Case显示文摘 | A-Hon Kwon Hiroyuki Inui Katsushige Tsuji Soichiro Takai Atsushi Imamura Yasuo Kamiyama | 2001 | Surgery Today2001，，3： | 1 |
| 16 | Microwave surgery: Hepatectomy using a microwave tissue coagulator显示文摘 | Katsuyoshi Tabuse M.D. Masaharu Katsumi M.D. Yasuhito Kobayashi M.D. Hiroyuki Noguchi M.D. Hiromu Egawa M.D. Osamu Aoyama M.D. Hideo Kim M.D. Yugo Nagai M.D. Hiroki Yamaue M.D. Kazunari Mori M.D. Yoshinori Azuma M.D. Takeshi Tsuji M.D | 1985 | World Journal of Surgery1985，，1： | 1 |
| 17 | Perfusion CT is superior to angiography in predicting pancreatic necrosis in patients with severe acute pancreatitis显示文摘 | Yoshihisa Tsuji Kyoko Hamaguchi Yuji Watanabe Akira Okumura Hiroyoshi Isoda Naoki Yamamoto Osamu Kikuchi Hiroyuki Yamamoto Kazuhiro Matsueda Kenji Ueno Shinsuke Tada Kaori Togashi Hiroshi Yamamoto Tsutomu Chiba | 2010 | Journal of Gastroenterology2010，，11： | 1 |
| 18 | Agrobacterium tumefaciens-mediated transformation as a tool for random mutagenesis of Colletotrichum trifolii显示文摘 | Hiroyuki Takahara Gento Tsuji Yasuyuki Kubo Mikihiro Yamamoto Kazuhiro Toyoda Yoshishige Inagaki Yuki Ichinose Tomonori Shiraishi | 2004 | Journal of General Plant Pathology2004，，2： | 1 |
| 19 | Relationship of lower uterine segment cancer with Lynch syndrome: Anovel case with an hMLH1 germline mutation显示文摘 | Kenta Masuda Kouji Banno Akira Hirasawa Megumi Yanokura Kosuke Tsuji Yusuke Kobayashi Iori Kisu Arisa Ueki Hiroyuki Nomura Eiichiro Tominaga Nobuyuki Susumu Daisuke Aoki | 2012 | Oncology Reports2012，，5： | 1 |
| 20 | Perfusion Computerized Tomography Can Predict Pancreatic Necrosis in Early Stages of Severe Acute Pancreatitis显示文摘 | Yoshihisa Tsuji Hiroshi Yamamoto Shujiro Yazumi Yuji Watanabe Kazuhiro Matsueda Hiroyuki Yamamoto Tsutomu Chiba | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 1 |
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