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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 4 | Experimental study on hydrodynamic behaviors of high-speed gas jets in still water显示文摘现在的纸在流动模式和水动力学效果上描述试验性的调查在水下从超声、声音的嘴的煤气的喷气操作了在正确 -- 并且有瑕疵的扩大条件。流动可视化证明 jetting 是为以在在考虑下面的参数范围的高速度的沉没煤气的注射的流动政体。获得的结果显示静止的水里的高速度的煤气的喷气在过去膨胀、下面膨胀的喷气导致嘴出口和吃惊房间结构的存在在上游的大压力跳动在导致喷气的水动力学压力的紧张导致增加。 | Zhenqing Dai Boyi Wang Longxi Qi Honghui Shi | 2006 | Acta Mechanica Sinica2006，22，5： | 28 |
| 5 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 6 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 7 | Smart manufacturing systems for Industry 4.0: Conceptual framework, scenarios, and future perspectives显示文摘 | Pai ZHENG Honghui WANG Zhiqian SANG Ray Y. ZHONG Yongkui LIU Chao LIU Khamdi MUBAROK Shiqiang YU Xun XU | 2018 | Frontiers of Mechanical Engineering2018，13，2： | 19 |
| 8 | Cas9-NG Greatly Expands the Targeting Scope of the Genome-Editing Toolkit by Recognizing NG and Other Atypical PAMs in Rice显示文摘CRISPR technologies enabling precise genome manipulation are valuable for gene function studies and molecular crop breeding. However, the requirement of a protospacer adjacent motif (PAM)y such as NGG and TTN, for Cas protein recognition restricts the selection of targetable genomic loci in practical applications of CRISPR technologies. Recently Cas9-NG, which recognizes a minimal NG PAM, was reported to expand the targeting space of genome editing in human cells, but it remains unclear whether this Cas9 variant can be used in plants. In this study, we evaluated the nuclease activity of Cas9-NG toward various NGN PAMs by targeting endogenous genes in transgenic rice. We found that Cas9-NG edits all NGG, NGA, NGT, and NGC sites with impaired activity, while the gene-edited plants were dominated by monoallelic mutations. Cas9-NG-engineered base editors were then developed and used to generate O s B Z R I gainof- function plants that can not be created by other available Cas9-engineered base editors. Moreover, we showed that a Cas9-NG-based transcriptional activator efficiently upregulated the expression of endogenous target genes in rice. In addition, we discovered that Cas9-NG recognizes NAC, NTG, NTT, and NCG apart from NG PAM. Together, these findings demonstrate that Cas9-NG can greatly expand the targeting scope of genome-editing tools, showing great potential for targeted genome editing, base editing, and genome regulation in plants. | Bin Ren Lang Liu Shaofang Li Yongjie Kuang Jingwen Wang Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2019 | Molecular Plant2019，12，7： | 18 |
| 9 | Lightweight Design of Automobile Drive Shaft Based on the Characteristics of Low Amplitude Load Strengthening显示文摘There are two kinds of internationally recognized approaches in terms of lightweight design.One is based on fatigue accumulated damage theory to achieve better reliability by optimal structural design;another is to use high performance lightweight materials.The former method takes very few considerations on the structural strengthening effects caused by the massive small loads in service.In order to ensure safety,the design is usually conservative,but the strength potential of the component is not fully exerted.In the latter method,cost is the biggest obstacle to lightweight materials in automotive applications.For the purpose of light weighting design on a fuel cell vehicle,the new design method is applied on drive shafts.The method is based on the low amplitude load strengthening characteristics of the material,and allows the stress,corresponding to test load,to enter into the strengthened range of the material.Under this condition,the light weighting design should assure that the reliability of the shaft is not impaired,even maximizes the strength potential of machine part in order to achieve the weight reduction and eventually to reduce the cost.At last,the feasibility of the design is verified by means of strength analysis and modal analysis based on the CAD model of light weighted shaft.The design applies to the load case of half shaft in independent axle,also provides technological reference for the structural lightweight design of vehicles and other machineries. | ZHENG Songlin XU Honghui FENG Jinzhi ZHENG Zuanxi WANG Youtao LU Leilei | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 16 |
| 10 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 11 | Thermal entanglement in a mixed-spin Heisenberg XXZ model under a nonuniform external magnetic field显示文摘The thermal entanglement in (1/2,1) mixed-spin Heisenberg XXZ model is investigated under an external nonuniform magnetic field. In the uniform magnetic field system,the critical magnetic field Bc and critical temperature Tc are increased by increasing the anisotropic parameter k. The degree of magnetic field b plays an important role in improving the critical temperature and enlarging the region of entan-glement in the nonuniform magnetic field system. | WANG Fei JIA HongHui ZHANG HaiLiang ZHANG XueAo CHANG ShengLi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 13 |
| 12 | Short-range ordering and its effects on mechanical properties of high-entropy alloys显示文摘In this letter,we briefly summarize experimental and theoretical findings of fo rmation and characterization of short-range orderings(SROs)as well as their effects on the defo rmation behavior of high-entropy alloys(HEAs).We show that existence of SROs is a common yet key structural feature of HEAs,and tuning the degree of SROs is an effective way for optimizing mechanical properties of HEAs.In additional,the challenges concerning about formation mechanism and characterization of SROs in HEAs are discussed,and future research activities in this regard are also proposed. | Yuan Wu Fei Zhang Xiaoyuan Yuan Hailong Huang Xiaocan Wen Yihan Wang Mengyuan Zhang Honghui Wu Xiongjun Liu Hui Wang Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，3： | 8 |
| 13 | Study on Mach stems induced by interaction of planar shock waves on two intersecting wedges显示文摘The properties of Mach stems in hypersonic corner flow induced by Mach interaction over 3D intersecting wedges were studied theoretically and numerically.A new method called 'spatial dimension reduction' was used to analyze theoretically the location and Mach number behind Mach stems. By using this approach, the problem of 3D steady shock/shock interaction over 3D intersecting wedges was transformed into a 2D moving one on cross sections, which can be solved by shock-polar theory and shock dynamics theory. The properties of Mach interaction over 3D intersecting wedges can be analyzed with the new method,including pressure, temperature, density in the vicinity of triple points, location, and Mach number behind Mach stems.Theoretical results were compared with numerical results,and good agreement was obtained. Also, the influence of Mach number and wedge angle on the properties of a 3D Mach stem was studied. | Gaoxiang Xiang Chun Wang Honghui Teng Yang Yang Zonglin Jiang | 2016 | Acta Mechanica Sinica2016，32，3： | 6 |
| 14 | Electrical transport properties of Fe Se single crystal under high magnetic field显示文摘Understanding the normal electronic state is crucial for unveiling the mechanism of unconventional superconductivity(SC). In this paper, by applying a magnetic field of up to 37T on FeSe single crystals, we could reveal the normal-state transport properties after SC was completely suppressed. The normal-state resistivity exhibited a Fermi liquid behavior at low temperatures. Large orbital magnetoresistance(MR) was observed in the nematic state with H//c, whereas MR was negligible with H//ab. The magnitude of the orbital MR showed an unusual reduction, and Kohler’s rule was severely violated below 10-25 K;these were attributable to spin fluctuations. The results indicated that spin fluctuations played a paramount role in the normalstate transport properties of FeSe albeit the Fermi liquid nature was at low temperature. | HongHui Wang ZhaoHui Cheng MengZhu Shi DongHui Ma WeiZhuang Zhuo ChuanYing Xi Tao Wu JianJun Ying XianHui Chen | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 6 |
| 15 | Shock/shock interactions between bodies and wings显示文摘This paper examines the Shock/Shock Interactions(SSI)between the body and wing of aircraft in supersonic flows.The body is simplified to a flat wedge and the wing is assumed to be a sharp wing.The theoretical spatial dimension reduction method,which transforms the 3D problem into a 2D one,is used to analyze the SSI between the body and wing.The temperature and pressure behind the Mach stem induced by the wing and body are obtained,and the wave configurations in the corner are determined.Numerical validations are conducted by solving the inviscid Euler equations in 3D with a Non-oscillatory and Non-free-parameters Dissipative(NND)finite difference scheme.Good agreements between the theoretical and numerical results are obtained.Additionally,the effects of the wedge angle and sweep angle on wave configurations and flow field are considered numerically and theoretically.The influences of wedge angle are significant,whereas the effects of sweep angle on wave configurations are negligible.This paper provides useful information for the design and thermal protection of aircraft in supersonic and hypersonic flows. | Gaoxiang XIANG Chun WANG Honghui TENG Zonglin JIANG | 2018 | Chinese Journal of Aeronautics2018，31，2： | 5 |
| 16 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 17 | An improved imaging algorithm for fixed-receiver bistatic SAR显示文摘Based on the signal model of fixed-receiver bistatic SAR, this paper analyzes the characteristics of azimuth-variant, which includes variation of range migration curve and variation of Doppler rate caused by different azimuth position of targets. Then, an extended nonlinear chirp scaling (NLCS) algorithm is proposed, with its flowchart and phase compensation functions being provided. Simulation results show that the algorithm is available for the characteristics of azimuth-variant of fixed-receiver bistatic SAR, and good focused radar images could be acquired. | GENG XuPu HU YingHui YAN HongHui WANG YanFei | 2010 | Science China(Information Sciences)2010，53，7： | 5 |
| 18 | Oxidation behavior of Mo-Si-B alloys at medium-to-high temperatures显示文摘Continuous exploration of high-temperature structural materials is being driven by the needs of gasturbine engines capable of withstanding the high-temperature environment.Relatively low melting points of currently applied superalloys restrain the further improvement of service tempe ratures.With higher melting tempe ratures above 2000℃,Mo-Si-B alloys are regarded as a new generation of ultrahightemperature structural materials.However,oxidation is a concern for the industrial application of Mo-Si-B alloys.Therefore,an in-depth understanding of the oxidation mechanisms may contribute to solving this issue,whereas relevant reviews about their recent advances are lacking.In the current work,a comprehensively systematic review about the oxidation behaviors of Mo-Si-B alloys is described for this purpose. | Kunming Pan Yanping Yang Shizhong Wei Honghui Wu Zhili Dong Yuan Wu Shuize Wang Laiqi Zhang Junping Lin Xinping Mao | 2021 | Journal of Materials Science & Technology2021，，1： | 5 |
| 19 | Synchrotron radiation X-ray powder diffraction techniques applied in hydrogen storage materials--A review显示文摘Synchrotron radiation is an advanced collimated light source with high intensity. It has particular advantages in structural characterization of materials on the atomic or molecular scale. Synchrotron radiation X-ray powder diffraction(SR-XRPD) has been successfully exploited to various areas of hydrogen storage materials. In the paper, we will give a brief introduction on hydrogen storage materials, X-ray powder diffraction(XRPD), and synchrotron radiation light source. The applications of ex situ and in situ time-resolved SR-XRPD in hydrogen storage materials, are reviewed in detail. Future trends and proposals in the applications of the advanced XRPD techniques in hydrogen storage materials are also discussed. | Honghui Cheng Chen Lu Jingjing Liu Yongke Yan Xingbo Han Huiming Jin Yu Wang Yi Liu Changle Wu | 2017 | Progress in Natural Science:Materials International2017，27，1： | 5 |
| 20 | Role of VEGF in the growth and metastasis of a murine bladder carcinoma显示文摘Bladder transitional cell carcinoma is the most common form of carcinoma in the urinary system. Although overexpression of VEGF has been identified in tissue, serum, and urine of patients with bladder cancer, the role of VEGF in transitional cell carcinoma of the bladder has not beenclearly elucidated. Here, we dissected the effect of VEGFduring bladder tumor growth and progression by modifying a BBN (N-butyl-N-(4-hydroxybutyl) nitrosamine) induced mouse bladder transitional cell carcinoma cell lineBTT-T739 by stable transfection of antisense VEGF121 cDNA. The transfection resulted in more than 80% reduction inVEGF production. The growth of the transduced tumor cells in vitro was not affected, however, these cells formed small or no tumors in vivo. Even in the tumors formed, there were mini- mal vascularization, extensive necrosis and longerlatency compared to those formed by parental cells. Thepermeability of tumor vasculature and metastatic tumor growth were also significantly suppressed in antisense VEGFcDNA trans- fected cells. In addition, the transfer ofanti-angiogenic gene in a combination of sFlk-1 and ExTekwith electroporation can suppress the tumor growthefficiently. Taken together, these results demonstrated thatVEGF plays an important role in bladder tumorangiogenesis and angiogenesis plays an important role in bladder tumor growth and metastasis. | WANG Feng WU Jihong TIAN Yuhua CHEN Xiafang HU Honghui WU Wensen LI Chuanyuan | 2003 | Chinese Science Bulletin2003，48，22： | 4 |
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