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| 1 | Novel Strategy for Synthesis of High Quality CdTe Nanocrystals in Aqueous Solution显示文摘A novel aqueous route for the synthesis of high-quality CdTe nanocrystals(NCs) is presented in this article. With both glutathione(GSH) and cysteine[n(GSH):n(cysteine)=1:3] as stabilizers, high-quality CdTe NCs with controllable photoluminescence(PL) wavelength from 500 to 630 nm can be prepared within 4 h. As-prepared CdTe NCs show higher photoluminescence quantum yields(PLQY) compared with CdTe NCs prepared via other aqueous methods. When the fluorescent emission peak appeared in orange-red window, the PLQY reaches 70% or above at room temperature without any post-preparative treatment. | YAN Yu-xi MU Ying FENG Guo-dong ZHANG Lei ZHU Lin-lin XU Ling YANG Rui JIN Qin-han | 2008 | Chemical Research in Chinese Universities2008，24，1： | 21 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Plasmakinetic enucleation of prostate versus 160-W laser photoselective vaporization for the treatment of benign prostatic hyperplasia显示文摘与前列腺(PVP ) 的 160-W 锂 triboride 激光 photoselective 蒸发相比为征兆的良性的 prostatic 增生(BPH ) 的治疗评估前列腺(PKEP ) 的 plasmakinetic enucleation 的安全和功效。从 2011 年 2 月到 2012 年 7 月,未来的 nonrandomized 研究被执行。一个 -- 101 个病人经历了 PKEP,并且 110 经历了 PVP。没有严重 intraoperative 复杂并发症被记录,并且任何一个都没在任何一个组的病人要求输血。更短的 catheterization 时间(38.14 ±23.64 h 对 72.54 ±28.38 h, P <0.001 ) 并且住院(2.32 ±1.25 天对 4.07 ±1.23 天, P <0.001 ) 在 PVP 组被记录。在 12 月手术后地,有的 PKEP 组一维持并且统计上在国际前列腺症状 20 的改进(IPSS )(4.07 ±2.07 对 5.00 ±2.10;P <0.001 ) ,生活(QoL ) 的质量(1.08 ±0.72 对 1.35 ±0.72;P = 0.007 ) ,最大的尿流动率(Q 最大 )(24.75 ±5.87 ml s −1 对 22.03 ±5.04 ml s −1 ;P <0.001 ) , postvoid 剩余尿体积(PVR )(14.29 ±6.97 ml 对 17.00 ±6.11 ml;P = 0.001 ) ,并且前列腺特定的抗原(PSA ) 价值(0.78 ±0.57 ng ml −1 对 1.27 ±1.07 ng ml −1 ;P <0.001 ) 。PKEP 和 PVP 与低复杂并发症率由于 BPH 减轻低尿道症状(LUTS ) 。当 PVP 移开的织物的全部的数量是时, PKEP 能完全移开 prostatic 腺瘤不到那能被 PKEP 移开。基于我们后续的学习, PKEP 比 PVP 提供更好手术后的结果。 | Si-Jun Wang Xiao-Nan Mu Ji Chen Xun-Bo Jin Shi-Bao Zhang Long-Yang Zhang | 2017 | Asian Journal of Andrology2017，19，1： | 19 |
| 4 | Modeling and Operation of the Power-to-Gas System for Renewables Integration: A Review显示文摘Power-to-Gas(P2G)plays an important role in enhancing large-scale renewable energy integration in power systems.As an emerging inter-disciplinary subject,P2G technology requires knowledge in electrochemistry,electrical engineering,thermodynamic engineering,chemical engineering and system engineering.Aiming at P2G modeling and operational problems concerning the research field of power systems and the energy internet,this paper briefly reviews the main technologies and application potentials of the P2G system,and makes systematic summaries of major progresses related to P2G’s integration into the power grid in a bottom-top manner,including the modeling of high/room-temperature electrolysis cells,steady-state/dynamic optimization control of the P2G system,P2G’s integrated model and operational strategies at the grid level.In the final part of this paper,suggestions are put forward on future research directions of P2G systems from the aspects of modeling and operational optimization. | Xuetao Xing Jin Lin Yonghua Song You Zhou Shujun Mu Qiang Hu | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 15 |
| 5 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 6 | Development and validation of a prediction model for microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Microvascular invasion(MVI)is an important prognostic factor affecting early recurrence and overall survival in hepatocellular carcinoma(HCC)patients after hepatectomy and liver transplantation,but it can be determined only in surgical specimens.Accurate preoperative prediction of MVI is conducive to clinical decisions.AIM To develop and validate a preoperative prediction model for MVI in patients with HCC.METHODS Data from 454 patients with HCC who underwent hepatectomy at the First Affiliated Hospital of Nanjing Medical University between May 2016 and October 2019 were retrospectively collected.Then,the patients were nonrandomly split into a training cohort and a validation cohort.Logistic regression analysis was used to identify variables significantly associated with MVI that were then included in the nomogram.We evaluated the discrimination and calibration ability of the nomogram by using R software.RESULTS MVI was confirmed in 209(46.0%)patients by a pathological examination.Multivariate logistic regression analysis identified four risk factors independently associated with MVI:Tumor size[odds ratio(OR)=1.195;95%confidence interval(CI):1.107–1.290;P<0.001],number of tumors(OR=4.441;95%CI:2.112–9.341;P<0.001),neutrophils(OR=1.714;95%CI:1.036–2.836;P=0.036),and serumα-fetoprotein(20–400 ng/mL,OR=1.955;95%CI:1.055–3.624;P=0.033;>400 ng/mL,OR=3.476;95%CI:1.950–6.195;P<0.001).The concordance index was 0.79(95%CI:0.74–0.84)and 0.81(95%CI:0.74–0.89)in the training and validation cohorts,respectively.The calibration curves showed good agreement between the predicted risk by the nomogram and real outcomes.CONCLUSION We have developed and validated a preoperative prediction model for MVI in patients with HCC.The model could aid physicians in clinical treatment decision making. | Lin Wang Yue-Xinzi Jin Ya-Zhou Ji Yuan Mu Shi-Chang Zhang Shi-Yang Pan | 2020 | World Journal of Gastroenterology2020，26，14： | 12 |
| 7 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 8 | Inflammatory biomarkers and cerebral small vessel disease:a community-based cohort study显示文摘Background and purpose Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease(CSVD),previous findings remain largely inconclusive and vary according to disease status and study designs.The present study aimed to investigate possible associations between inflammatory biomarkers and MRI markers of CSVD.Methods A group of 15 serum inflammatory biomarkers representing a variety of those putatively involved in the inflammatory cascade was grouped and assessed in a cross-sectional study involving 960 stroke-free subjects.The biomarker panel was grouped as follows:systemic inflammation(high-sensitivity C reactive protein(hsCRP),interleukin 6 and tumour necrosis factorα),endothelial-related inflammation(E-selectin,P-selectin,intercellular adhesion molecule 1,vascular cell adhesion molecule 1(VCAM-1),CD40 ligand,lipoprotein-associated phospholipase A2,chitinase-3-like 1 protein and total homocysteine(tHCY))and media-related inflammation(matrix metalloproteinases 2,3 and 9,and osteopontin).The association(s)between different inflammatory groups and white matter hyperintensity(WMH),lacunes,cerebral microbleeds(CMBs),enlarged perivascular space(PVS)and the number of deep medullary veins(DMVs)were investigated.Results High levels of serum endothelial-related inflammatory biomarkers were associated with both increased WMH volume(R^(2)=0.435,p=0.015)and the presence of lacunes(R^(2)=0.254,p=0.027).Backward stepwise elimination of individual inflammatory biomarkers for endothelial-related biomarkers revealed that VCAM-1 was significant for WMH(β=0.063,p=0.005)and tHCY was significant for lacunes(β=0.069,p<0.001).There was no association between any group of inflammatory biomarkers and CMBs or PVS.Systemic inflammatory biomarkers were associated with fewer DMVs(R^(2)=0.032,p=0.006),and backward stepwise elimination of individual systemic-related inflammatory biomarkers revealed that hsCRP(β=−0.162,p=0.007)was significant.Conclusion WMH and lacunes were associated with endothelial-related inflammatory biomarkers,and fewer DMVs were associated with systemic inflammation,thus suggesting different underlying inflammatory processes and mechanisms. | Ding-Ding Zhang Yuan Cao Jing-Yu Mu Yi-Ming Liu Feng Gao Fei Han Fei-Fei Zhai Li-Xin Zhou Jun Ni Ming Yao Ming-Li Li Zheng-Yu Jin Shu-Yang Zhang Li-Ying Cui Yong Shen Yi-Cheng Zhu | 2022 | Stroke & Vascular Neurology2022，7，4： | 11 |
| 9 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 10 | Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer显示文摘To flourish,cancers greatly depend on their surrounding tumor microenvironment(TME),and cancer-associated fibroblasts(CAFs)in TME are critical for cancer occurrence and progression because of their versatile roles in extracellular matrix remodeling,maintenance of sternness,blood vessel formation,modulation of tumor metabolism,immune response,and promotion of cancer cell proliferation,migration,invasion,and therapeutic resistance.CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming growth factor-beta,phosphoinositide 3-kinase/AKT/mammalian target of rapamycin,mitogen-activated protein kinase,Wnt,Janus kinase/signal transducers and activators of transcription,epidermal growth factor receptor,Hippo,and nuclear factor kappa-light-chain-enhancer of activated B cells,etc.,signaling pathways.These signals in CAFs exhibit their own special characteristics during the cancer progression and have the potential to be targeted for anticancer therapy.Therefore,a comprehensive understanding of these signaling cascades in interactions between cancer cells and CAFs is necessary to fully realize the pivotal roles of CAFs in cancers.Herein,in this review,we will summarize the enormous amounts of findings on the signals mediating crosstalk of CAFs with cancer cells and its related targets or trials.Further,we hypothesize three potential targeting strategies,including,namely,epithelial-mesenchymal common targets,sequential target perturbation,and crosstalk-directed signaling targets,paving the way for CAF-directed or host cell-directed antitumor therapy. | Fanglong Wu Jin Yang Junjiang Liu Ye Wang Jingtian Mu Qingxiang Zeng Shuzhi Deng Hongmei Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 9 |
| 11 | Human hair follicle-derived mesenchymal stem cells:Isolation,expansion,and differentiation显示文摘Hair follicles are easily accessible skin appendages that protect against cold and potential injuries.Hair follicles contain various pools of stem cells,such as epithelial,melanocyte,and mesenchymal stem cells(MSCs)that continuously self-renew,differentiate,regulate hair growth,and maintain skin homeostasis.Recently,MSCs derived from the dermal papilla or dermal sheath of the human hair follicle have received attention because of their accessibility and broad differentiation potential.In this review,we describe the applications of human hair follicle-derived MSCs(hHF-MSCs)in tissue engineering and regenerative medicine.We have described protocols for isolating hHF-MSCs from human hair follicles and their culture condition in detail.We also summarize strategies for maintaining hHF-MSCs in a highly proliferative but undifferentiated state after repeated in vitro passages,including supplementation of growth factors,3D suspension culture technology,and 3D aggregates of MSCs.In addition,we report the potential of hHF-MSCs in obtaining induced smooth muscle cells and tissue-engineered blood vessels,regenerated hair follicles,induced red blood cells,and induced pluripotent stem cells.In summary,the abundance,convenient accessibility,and broad differentiation potential make hHF-MSCs an ideal seed cell source of regenerative medical and cell therapy. | Bo Wang Xiao-Mei Liu Zi-Nan Liu Yuan Wang Xing Han Ao-Bo Lian Ying Mu Ming-Hua Jin Jin-Yu Liu | 2020 | World Journal of Stem Cells2020，12，6： | 8 |
| 12 | ZIF-8/LiFePO4 derived Fe-N-P Co-doped carbon nanotube encapsulated Fe2P nanoparticles for efficient oxygen reduction and Zn-air batteries显示文摘Iron-based oxygen reduction reaction(ORR)catalysts have been the focus of research,and iron sources play an important role for the preparation of efficient ORR catalysts.Here,we successfully use LiFePO4 as ideal sources of Fe and P to construct the heteroatom doped Fe-based carbon materials.The obtained Fe-N-P co-doped coral-like carbon nanotube arrays encapsulated Fe2P catalyst(C-ZIF/LFP)shows very high half-wave potential of 0.88 V in alkaline electrolytes toward ORR,superior to Pt/C(0.85 V),and also presents a high half-wave potential of 0.74 V in acidic electrolytes,comparable to Pt/C(0.8 V).When further applied into a home-made Zn-air battery as cathode,a peak power density of 140 mW·cm^-2 is reached,exceeds commercial Pt/C(110 mW·cm^-2).Besides,it also presents exceptional durability and methanol resistance compared with Pt/C.Noticeably,the preparation method of such a high-performance catalyst is simple and easy to optimize,suitable for the large-scale production.What’s more,it opens up a more sustainable development scenario to reduce the hazardous wastes such as LiFePO4 by directly using them for preparing high-performance ORR catalysts. | Huihui Jin Huang Zhou Pengxia Ji Chengtian Zhang Jiahuan Luo Weihao Zeng Chenxi Hu Daping He Shichun Mu | 2020 | Nano Research2020，13，3： | 8 |
| 13 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 14 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 15 | Data Analysis of Chang'E-1 Gamma-Ray Spectrometer and Global Distribution of U,K,and Th Elemental Abundances显示文摘Gamma 光线分光计(GRS ) 是 Chang'E-1 (CE-1 ) 上的主要收费载重之一月亮的探查,主要试图在月亮的表面上检测元素的丰富和分布。在 03:58 在 2007 年 11 月 28 日,它执行了月亮的 gamma 光线的第一观察。2008 年 10 月 24 日,有效 gamma 光线系列的 2105 h 被 CE-1 GRS 获得了,它盖住月亮的整个表面。这份报纸主要描述处理由使用导出元素的丰富的过程和 CE-1 GRS 时间系列改正了系列的方法的数据:首先,到进为印射的象素的箱数据;然后,执行累积系列的背景扣除并且获得元素的一个山峰区域;并且最后,当模特儿使用元素的丰富倒置生产元素的丰富。在这些上基于比 EPR 在 5s 处理方法, U 的全球丰富地图, K,和 Th。在在 near-EPR 海底山下面的岩浆结晶化压力和融化的条件之间的关联暗示来源吗? | ZOU Yongliao ZHANG Liyan LIU Jianzhong MU Lingli REN Xin ZHANG Guangliang CHANG Jin YAN Jun ZHANG Nan ZHANG Hongbo LU Chang LIU Jianjun ZUO Wei SU Yan WEN Weibin BIAN Wei WANG Min XU Chun LI Chunlai OUYANG Ziyuan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 6 |
| 16 | New technique: Design and implementation of the highly-reliable, low-cost housekeeping system in the ZDPS-1A pico-satellite显示文摘The ZDPS-1A pico-satellite designed in Zhejiang University with a mass of 3.5 kg and a power consumption of less than 3.5 W is the smallest satellite in China up to now. The housekeeping system (HKS) is the core part of ZDPS-1A. The reliability of HKS has an important influence on the safety of the satellite. Traditional fault-tolerant methods do not apply to ZDPS-1A due to such pico-satellite characteristics as light weight, compactness in size, energy saving, and high integration. This paper deals with a highly-reliable, low-cost design for HKS using industrial devices. The reliable strategies of HKS include a dual modular redundancy scheme, CPU warm backup, a static triple modular redundancy scheme, and two-level watchdogs. Recursive experiments, special tests, and environmental tests show that this system meets the design target. This design has already been applied to ZDPS-1A, which was launched to execute in-orbit tasks on Sept. 22, 2010. To date, the satellite has been in a proper state for more than 15 months. | Yu ZHANG Yang-ming ZHENG Mu YANG Hui LI Zhong-he JIN | 2012 | Journal of Zhejiang University-Science C(Computers and Electronics)2012，13，2： | 6 |
| 17 | SF_6断路器的热开断性能的数值预测(英文)显示文摘The design technology for HV SF6 gas circuit breakers is very demanding.A numerical method for prediction of the thermal interruption capability of SF6 gas circuit breakers is established based on the two-dimensional magneto-hydrodynamic(MHD) model and a commercial CFD(computational fluid dynamics) software,FLUENT.Nozzle ablation effect is considered by introducing an independent mass conservation equation for the ablated material to the overall conservation equations of mass,momentum,and energy.The ohmic heating and the radiation of the electric arc are considered in the model by adding relevant source terms.To predict the thermal interruption capability,the arc conductance 200 ns before current zero is used as an indicator.The CFD model is applied for the high current arcing phase,and Mayr arc model is used near the current zero period.The arc conductance at 200 ns before current zero(G200) for various arcing periods are computed by the present method.It shows that there exist a limit of the G200.For those whose arcing periods are within the arcing window,the related G200 are below the limit,therefore result a successful current interruption,and vice versa.The validation of the developed computer simulation tool is therefore verified.The numerical prediction by the simulation tool is verified by the direct interrupting test of 550 kV gas circuit breaker(GCB).The developed computer simulation tool was applied in the design of a 550 kV GCB.Significant benefits have been achieved in terms of both the cost saving and shorten of the development cycle. | MU Jingwei GUO Jin DENG Xiang'e | 2013 | 高电压技术2013，39，4： | 6 |
| 18 | Catalytic combustion of methane over nano ZrO_2-supported copper-based catalysts显示文摘nano 为甲烷燃烧的支持 ZrO2 的基于铜的催化剂借助于 N2 吸附, TEM, XRD, H2-TPR 技术和甲烷氧化的测试被调查。二种 ZrO2 被用作支持,(ZrO2-1 ) 从商业 ZrO2 被获得,其它(ZrO2-2 ) 从锆硝酸盐的热解被发出。CuO/ZrO2-2 催化剂比 CuO/ZrO2-1 更活跃,这被发现。N2 吸附, H2-TPR 和 XRD 大小比 CuO/ZrO2-1 的为 CuO/ZrO2-2 显示出那更大的表面积,更好的减小性质,四角形的 ZrO2 的存在和活跃部件的更高的分散。这些因素能是为它为甲烷燃烧的更高的活动的统治原因。 | Fen Fen Qua Wei Chu Li Min Shi Mu Hua Chen Jin Yan Hu | 2007 | Chinese Chemical Letters2007，18，8： | 6 |
| 19 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 20 | Space Flight Validation of Design and Engineering of the ZDPS-1A Pico-satellite显示文摘The ZDPS-1A pico-satellites are the first satellites in China within the 1-10 kg mass range that are successfully operated on orbit. Unlike common pico-satellites, they are designed to be 'larger but stronger' with more powerful platforms and unique payloads so as to bear a better promise for real applications. Through their space flight mission, the functionality and performance of the two flight models are tested on orbit and validated to be mostly normal and in consistency with design and ground tests with only several inconforming occasions. Moreover, they have worked properly on orbit for one year so far, well exceeding their life expectancy of three months. Therefore, the space flight mission has reached all its goals, and verified that the design concept and the engineering process of the picosatellites are sufficient in allowing them the desired functionality and performance in, and the adaption to the launch procedure and the low-Earth orbit space environment. In the foreseeable future, the platform together with the design concept and the engineering process of the pico-satellites are expected to be applied to more complicated real space applications. | YANG Mu WANG Hao WU Changju WANG Chunhui DING Licong ZHENG Yangming JIN Zhonghe | 2012 | Chinese Journal of Aeronautics2012，25，5： | 5 |
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