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| 1 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 2 | Index of convexity:A novel liver function index using Tc-GSA scintigraphy显示文摘AIM:To investigate the clinical usefulness of a newly developed index,the 'index of convexity(IOC)',for evaluating liver functional reserve using technetium99m-diethylenetriaminepentaacetic acid-galactosylhuman serum albumin(Tc-GSA scintigraphy).METHODS:In total,349 patients underwent Tc-GSA scintigraphy.Dynamic planner images were obtained,and time activity curves of the liver and heart were generated and analyzed.Our focus was on the convex shape of the liver accumulation curve.We developed a method for evaluating the extent of convexity and calculated an index that we named the IOC.Clearance index and receptor index were also calculated.The correlations between each GSA index with other liver function tests and liver histopathology were evaluated.RESULTS:Among the 3 indices generated by TcGSA,the IOC had the highest correlation with all other liver function tests(indocyanine green R15,albumin,prothrombin time,cholinesterase level,platelet count,and total bilirubin level).IOC can also differentiate between normal liver,chronic hepatitis,and liver cirrhosis with highest F ratio among GSA indices as determined by one-way analysis of variance.Receiver operating characteristic analysis demonstrated high diagnostic performance of IOC in the diagnosis of cirrhosis.CONCLUSION:IOC is a very simple and reliable index for assessing liver functional reserve,which may prove to be useful in combination with the indocyanine green test for preoperative assessment of hepatic resection. | Kenji Miki Yuichi Matsui Masanori Teruya Michio Kaminishi Norihiro Kokudo | 2013 | World Journal of Gastroenterology2013，19，1： | 4 |
| 3 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 4 |
| 4 | Hydroperoxy-arachidonic acid mediated n-hexanal and (Z)-3- and ( E )-2-nonenal formation in Laminaria angustata 显示文摘 | Kangsadan Boonprab Kenji Matsui Yoshihiko Akakabe | 2003 | Phytochemistry2003，64，3： | 1 |
| 5 | Tolerance to various environmental stresses conferred by the salt-responsive rice gene ONAC063 in transgenic Arabidopsis显示文摘 | Naoki Yokotani Takanari Ichikawa Youichi Kondou Minami Matsui Hirohiko Hirochika Masaki Iwabuchi Kenji Oda | 2009 | Planta2009，，5： | 1 |
| 6 | Expression of Osteopontin in Kupffer Cells and Hepatic Macrophages and Stellate Cells in Rat Liver after Carbon Tetrachloride Intoxication: A Possible Factor for Macrophage Migration into Hepatic Necrotic Areas显示文摘 | Rumiko Kawashima Satoshi Mochida Atsushi Matsui YuSuFu YouLuTuZ Keiko Ishikawa Keiko Toshima Fumio Yamanobe Mie Inao Hitoshi Ikeda Akihiko Ohno Sumiko Nagoshi Toshimitsu Uede Kenji Fujiwara | 1999 | Biochemical and Biophysical Research Communications1999，，3： | 1 |
| 7 | Development of consensus statements for the diagnosis and management of intestinal Beh?et’s disease using a modified Delphi approach显示文摘 | Kenji Kobayashi Fumiaki Ueno Seiji Bito Yasushi Iwao Tsuneo Fukushima Nobuo Hiwatashi Masahiro Igarashi Bun-ei Iizuka Takahide Matsuda Toshiyuki Matsui Takayuki Matsumoto Akira Sugita Mitsuhiro Takeno Toshifumi Hibi | 2007 | Journal of Gastroenterology2007，，9： | 1 |
| 8 | Biosynthesis of fatty acid derived aldehydes is induced upon mechanical wounding and its products show fungicidal activities in cucumber显示文摘 | Kenji Matsui Akari Minami Ellen Hornung Hidetoshi Shibata Kyutaro Kishimoto Volker Ahnert Helmut Kindl Tadahiko Kajiwara Ivo Feussner | 2006 | Phytochemistry2006，，7： | 1 |
| 9 | Efficacy of Covered Metallic Stents in the Treatment of Unresectable Malignant Biliary Obstruction显示文摘 | Shiro Miyayama Osamu Matsui Yukari Akakura Toru Yamamoto Hiroto Nishida Kenji Yoneda Keiichi Kawai Daisyu Toya Nobuyoshi Tanaka Takeshi Mitsui Yasuyuki Asada | 2004 | CardioVascular and Interventional Radiology2004，，： | 1 |
| 10 | Cloning of a thermostable xylanase from Actinomadura sp. S14 and its expression in Escherichia coli and Pichia pastoris显示文摘 | Thayat Sriyapai Peechapack Somyoonsap Kenji Matsui Fusako Kawai Kosum Chansiri | 2010 | Journal of Bioscience and Bioengineering2010，，5： | 1 |
| 11 | SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C显示文摘 | Masashi Naito Atsushi Matsui Mie Inao Sumiko Nagoshi Makoto Nagano Nobuko Ito Tohru Egashira Michie Hashimoto Shunji Mishiro Satoshi Mochida Kenji Fujiwara | 2005 | Journal of Gastroenterology2005，，4： | 1 |
| 12 | A molecular dynamics study of thermal conductivity of zirconium hydride显示文摘 | Kenji Konashi Tamio Ikeshoji Yoshiyuki Kawazoe Hideki Matsui | 2003 | Journal of Alloys and Compounds2003，，： | 1 |
| 13 | Antimicrobial Browning-Inhibitory Effect of Flavor Compounds in Seaweeds显示文摘 | Tadahiko Kajiwara Kenji Matsui Yoshihiko Akakabe Takushi Murakawa Chikako Arai | 2006 | Journal of Applied Phycology (-)2006，，3： | 1 |
| 14 | Effect of orientation on tensile ductility of electrodeposited bulk nanocrystalline Ni–W alloys显示文摘 | Isao Matsui Yorinobu Takigawa Tokuteru Uesugi Kenji Higashi | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 15 | Hydroperoxy-arachidonic acid mediated n -hexanal and ( Z )-3- and ( E )-2-nonenal formation in Laminaria angustata显示文摘 | Kangsadan Boonprab Kenji Matsui Yoshihiko Akakabe Norishige Yotsukura Tadahiko Kajiwara | 2003 | Phytochemistry2003，，6： | 1 |
| 16 | Increased cytoprotective function in the liver of transgenic mice expressing osteopontin in hepatocytes显示文摘 | Hea Saeng Koh Atsushi Matsui Sumie Mimura Mie Inao Eiko Saitoh Akihiko Ohno Sumiko Nagoshi Takayuki Yoshimoto Satoshi Mochida Kenji Fujiwara | 2005 | Hepatology Research2005，，1： | 1 |
| 17 | Green leaf volatiles: hydroperoxide lyase pathway of oxylipin metabolism显示文摘 | Kenji Matsui | 2005 | Current Opinion in Plant Biology2005，，3： | 1 |
| 18 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Tadashi Yoshino Shigeo Nakamura Shigeyuki Kawa Hideaki Hamano Terumi Kamisawa Toru Shimosegawa Akira Shimatsu Seiji Nakamura Tetsuhide Ito Kenji | 2012 | Modern Rheumatology2012，，1： | 1 |
| 19 | Synthesis of optically active trans-chrysanthemic acid from optically active pantolactone显示文摘 | Takashi Matsuo Kenji Mori Masanao Matsui | 1976 | Tetrahedron Lett1976，23，： | 1 |
| 20 | Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis显示文摘 | Yoshikazu Kinoshita Kenji Furuta Norihisa Ishimaura Shunji Ishihara Shuichi Sato Riruke Maruyama Shuichi Ohara Takayuki Matsumoto Choitsu Sakamoto Toshiyuki Matsui Satoshi Ishikawa Tsutomu Chiba | 2013 | Journal of Gastroenterology2013，，3： | 1 |
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