|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Numerical Prediction and Performance Experiment in a Deep-well Centrifugal Pump with Different Impeller Outlet Width显示文摘The existing research of the deep-well centrifugal pump mainly focuses on reduce the manufacturing cost and improve the pump performance,and how to combine above two aspects together is the most difficult and important topic.In this study,the performances of the deep-well centrifugal pump with four different impeller outlet widths are studied by the numerical,theoretical and experimental methods in this paper.Two stages deep-well centrifugal pump equipped with different impellers are simulated employing the commercial CFD software to solve the Navier-Stokes equations for three-dimensional incompressible steady flow.The sensitivity analyses of the grid size and turbulence model have been performed to improve numerical accuracy.The flow field distributions are acquired and compared under the design operating conditions,including the static pressure,turbulence kinetic energy and velocity.The prototype is manufactured and tested to certify the numerical predicted performance.The numerical results of pump performance are higher than the test results,but their change trends have an acceptable agreement with each other.The performance results indicted that the oversize impeller outlet width leads to poor pump performances and increasing shaft power.Changing the performance of deep-well centrifugal pump by alter impeller outlet width is practicable and convenient,which is worth popularizing in the engineering application.The proposed research enhances the theoretical basis of pump design to improve the performance and reduce the manufacturing cost of deep-well centrifugal pump. | SHI Weidong ZHOU Ling LU Weigang PEI Bing LANG Tao | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 20 |
| 3 | Unilateral sacrospinous ligament fixation for treatment of genital prolapse显示文摘背景生殖器的脱垂影响中的 30% 个中年并且老妇人并且正在成为一颗主要公共健康担心。Sacrospinous 系带固定是为有低复发和复杂并发症率的阴道拱顶 prolaps 的一个有效、安全的过程。这研究试图为骨盆的机关脱垂(流行音乐) 的管理调查单方的 sacrospinous 系带固定(SSLF ) 的功效和安全有经历单方的 SSLF 的骨盆的机关的严重脱垂的四十个病人是的 .Methods 回顾地 studied.In 这研究,所有病人被 POP-Q 的价值上演。所有过程被一位高级医生执行。这些病人和他们的立即、短期的手术后的结果的特征被记录。所有病人六个星期和六个月在外科以后被看见。包括的评估由一 physician.Results 标准化了问询表和地点特定的阴道检查平均操作时间 65-92 分钟。平均的血损失是 83-188 ml。平均住院时间是 6.1 天。平均支出是 5885 元。在操作以后的尿道的导管移动的平均的天是 2.1 天。手术后的病态的发生是 17.1% 。(2.4%) 病人在权利有 hematoma 骨盆。为 35 个病人的手术后的后续的吝啬的长度是 13.1 个月。后续的率是 87.5% 。(2.9%) 病人在外科以后显示出周期性的阴道拱顶脱垂六月。骨盆的机关脱垂的客观成功率是 85%(34/40 ) 。在操作(P 0.001 ) 前后的 Aa, Ba, Ap, Bp,和 D 的 POP-Q 之间有重要差别。五(14.3%) 病人们抱怨腰骶部疼痛,臀的疼痛或正确腹股沟伤害。三(8.6%) 病人们开发了 de novo 应力不能自制。阴道 disabsorbable 缝术在三被发现(8.6%) 病人。(2.9%) 病人让 de novo 主张单方的 SSLF 是的 incontinence.Conclusions 费用和治疗为严重骨盆的机关脱垂的有效管理,特别为严重 ovaginae 流行音乐的前面的脱垂和子宫脱垂,或。从这个过程的主要复杂并发症包括了腰骶部疼痛,臀并且腹股沟疼痛和应力的新发作不能自制。 | PENG Ping ZHU Lan LANG Jing-he WANG Wen-yan SHI Hong-hui | 2010 | Chinese Medical Journal2010，，15： | 14 |
| 4 | dentification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis显示文摘 | Xiao-Xuan Xu Shuang-Zheng Jia Yi Dai Jun-Ji Zhang Xiao-Yan Li Jing-Hua Shi Jin-Hua Leng Jing-He Lang | 2018 | Chinese Medical Journal2018，，5： | 14 |
| 5 | Morphological analysis on adhesion and invasion involved in endometriosis with tissue culture显示文摘背景子宫内膜增生(他们) 是主要在繁殖 age.However 的女人发现的良性的妇科的疾病,它的致病仍然糟糕被理解。我们的实验被设计为子宫内膜和腹膜的 coculture 建立一个马厩和可靠文化环境,在 laparoscopy 期间与 endometriois 从 6 个女人被取样以便从病人观察子宫内膜的粘附 / 侵略能力与或没有能分泌的阶段和腹膜的 EM.Methods Endometria。六作为控制与卵巢的 teratoma 或简单卵巢的包囊被拿。我们进四的 cocultured 子宫内膜和腹膜组织(从与从他们的腹膜有教养的他们的子宫内膜,从与从控制的腹膜有教养的控制的子宫内膜,从与从非他们的腹膜有教养的他们的子宫内膜和从与从他们的腹膜有教养的控制的子宫内膜)在煤气液体的表面文化和在里面中等的文化观察粘附/侵略进程。标本为组织学在 1 个小时 6 个小时 12 个小时 24 个小时, 2 天, 3 天, 4 天, 5 天, 6 天和 7 天被收集, cytokeratin 上的 immunofluorescence 和 immunohistochemical 分析 8 ( CK8 )并且 CD10.Results 煤气液体的表面文化比为织物形态学和子宫内膜的幸存的维护的在里面中等的文化优异。CK8 immunoflurescence 没有或没有他们在在病人之间的粘附过程表明显著差别。 CD10 免疫化学从他们病人表明了子宫内膜的 stromal 房间的经常的侵略进多达 3 天文化的腹膜,当从非他们病人的 endometriotic 房间没入侵煤气液体的表面进 peritoneum.Conclusions 时,文化是为观察到在从有他们的病人的他们损害 formation.Endometrium 的早事件在 coculture 期间显示出增加的侵略能力的一个合适的模型,它可能帮助解释子宫内膜增生的病原学。 | SHI Jing-hua YANG Yan-jun DONG Zhe LANG Jing-he LENG Jin-hua | 2011 | Chinese Medical Journal2011，，1： | 11 |
| 6 | Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease显示文摘 | Yun-Dai CHEN Wei-Yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI Zhu-Jun SHEN Jing WANG Yi-Ning WANG Lei XU Li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI | 2018 | Journal of Geriatric Cardiology2018，15，1： | 10 |
| 7 | Is tailored therapy based on antibiotic susceptibility effective?A multicenter,open-label,randomized trial显示文摘An effective eradication therapy of Helicobacter pylori(H.pylori)should be used for the first time.In this study,we assessed whether tailored therapy based on antibiotic susceptibility testing is more effective than traditional therapy.We also evaluated the factors that cause treatment failure in high-resistance areas.For this multicenter trial,we recruited 467 H.pylori-positive patients.The patients were randomly assigned to receive tailored triple therapy(TATT),tailored bismuth-containing quadruple therapy(TABQT),or traditional bismuthcontaining quadruple therapy(TRBQT).For the TATT and TABQT groups,antibiotic selection proceeded via susceptibility testing using an agar-dilution test.The patients in the TRBQT group were given amoxicillin,clarithromycin,esomeprazole,and bismuth.Successful eradication was defined as a negative 13C-urea breath test at least eight weeks after the treatment ended.Susceptibility testing was conducted using an agar-dilution test.The eradication rate was examined via intention-to-treat(ITT)and per-protocol(PP)analyses.The clarithromycin,levofloxacin,and metronidazole resistance rates were 26.12%,28.69%,and 96.79%,respectively.Resistance against amoxicillin and furazolidone was rare.The eradication rates for TATT,TRBQT,and TABQT were 67.32%,63.69%,and 85.99%in the ITT analysis(P<0.001)and 74.64%,68.49%,and 91.22%in the PP analysis(P<0.001),respectively.The efficacy of TABQTwas affected by clarithromycin resistance,and bismuth exerted a direct influence on TATT failure.TABQT was the most efficacious regimen for use in high-resistance regions,especially among clarithromycin-susceptible patients. | Jie Pan Zhengchao Shi Dingsai Lin Ningmin Yang Fei Meng Lang Lin Zhencheng Jin Qingjie Zhou Jiansheng Wu Jianzhong Zhang Youming Li | 2020 | Frontiers of Medicine2020，14，1： | 10 |
| 8 | Icariside Ⅱ inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway显示文摘β-amyloid(Aβ)is one of the inducing factors of astrocytes activation and neuroinflammation,and it is also a crucial factor for the development of Alzheimer’s disease(AD).Icariside II(ICS II)is an active component isolated from a traditional Chinese herb Epimedium,which has shown to attnuate lipopolysaccharide(LPS)-induced neuroinflammation through regulation of NF-κB signaling pathway.In this study we investigated the effects of ICS II on LPS-induced astrocytes activation and Aβaccumulation.Primary rat astrocytes were pretreated with ICS II(5,10,and 20μM)or dexamethasone(DXMS,1μM)for 1 h,thereafter,treated with LPS for another 24 h.We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),inducible nitric oxide synthase(iNOS),cyclooxygenase-2(COX-2)in the astrocytes.Moreover,ICS II not only exerted the inhibitory effect on LPS-induced IκB-αdegradation and NF-κB activation,but also decreased the levels of Aβ1–40,Aβ1–42,amyloid precursor protein(APP)and beta secretase 1(BACE1)in the astrocytes.Interestingly,molecular docking revealed that ICS II might directly bind to BACE1.It is concluded that ICS II has potential value as a new therapeutic agent to treat neuroinflammation-related diseases,such as AD. | Yong Zheng Yan Deng Jian-mei Gao Chun Lv Ling-hu Lang Jing-shan Shi Chang-yin Yu Qi-hai Gong | 2020 | Acta Pharmacologica Sinica2020，41，2： | 8 |
| 9 | Effects of Jian Pi Qu Shi Formula on intestinal bacterial flora in patients with idiopathic membranous nephropathy:A prospective randomized controlled trial显示文摘Background:The incidence of idiopathic nlembranous nephropathy(IMN)has recently increased remarkably.Immune dysfunction caused by disordered intestinal flora might be an important factor affecting IMN.The Jian Pi Qu Shi Formula(JPQSF)shows promise in treating IMN.Here,we sequenced 16S rRNA genes to compare intestinal flora between patients with IMN and healthy persons.We also conducted a randomized controlled clinical trial to further compare the intestinal flora of patients with IMN treated with traditional Chinese medicine(TCM)and western medicine(WM).Methods:Among 40 patie nls with IMN treated at Department of Nephrology in Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine between July 2016 and December 2018,we compared 30 of them with 10 healthy persons(controls).The IMN group was randomly assigned to receive JPQSF(TCM)or immunosuppressant WM therapy in(n=15 per group)for 6 months.Intestinal microbiota diversity was analyzed using alpha diversity and beta diversity.Intestinal flora that significantly differed between the groups was analyzed using MetaStat.The effects and safety of the therapies were determined based on the values for plasma albumin,24-h urine protein excretion,serum creatinine,urea nitrogen,estimate glomerular filtration rate(eGFR),complete blood count,and liver enzymes.All data were statistically analyzed using Statistical Package for the Social Sciences(SPSS)20.0 statistical software.Results:Baseline characteristics did not significanlly differ between the IMN and healthy groups,or the TCM and WM groups.After six months of treatment,24-h urinary protein significantly declined in the TCM and WM groups(before and after treatment:3.24±1.74 vs.1.73±1.85 g,P<0.05 and 3.94±1.05 vs.1.91±1.18 g,P<0.05,respectively).Plasma albumin was significantly increased in the TCM group(before vs.after treatment:32.44±9.04 vs.39.99±7.03 g/L,P<0.05),but did not significantly change in the WM group(31.55±4.23 vs.34.83±9」4 g/L,P>0.05).Values for urea nitrogen,serum creatinine,and eGFR did not significanlly change in either group.The alpha diversity index for intestinal flora differed between the IMN and healthy groups,and the TCM and WM groups.Comparisons of multiple samples(beta diversity)revealed differences in intestinal flora between the IMN and healthy groups,and the TCM and WM groups.The Metastat analysis findings showed that the main genera that differed between the IMN group before treatment and the healthy group were Christensenellaceae_R-7_group,Bifidobacterium(77),Dorea,Escherichia-Shigella,Parabacteroides,Bifidobacterium,and Coprococcus_3.AfterTCM therapy,the main differential genera were Butyricimonas,Bacteroides,Alistipes,and Lachnospira,and after WM therapy,these were Ruminococcus_2,Lachnospiraceae_ND3007_group,Lachnospira,Bifidobacterium,Alistipes,and[Eubacterium]_ventriosum_group.Conclusion:Patients with IMN might have disordered intestinal flora,and JPQSF can regulate intestinal flora in patienls with IMN. | Rui Lang Xin-Hui Wang Ai-Feng Li Ying Liang Bao-Chen Zhu Bin Shi Yong-Qiu Zheng Ren-Huan Yu | 2020 | Chronic Diseases and Translational Medicine2020，6，2： | 8 |
| 10 | Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China显示文摘 | Fei Zhu Sen-Yang Lang Xiang-Qing Wang Xiao-Bing Shi Yun-Feng Ma Xu Zhang Ya-Nan Chen Jia-Tang Zhang | 2015 | Chinese Medical Journal2015，，22： | 8 |
| 11 | The Research of Indoor Positioning Based on Visible Light Communication显示文摘The key techniques in indoor positioning based on visible light communication and the state of the art of this research were surveyed. First, the significance of indoor positioning based on visible light communication from two aspects of the limitations of current indoor positioning technology and the advantages of visible light communication was discussed; And then, the main four technology of indoor positioning based on visible light communication were summarized and the triangulation of RSS method and the principle of image positioning were introduced in detail; Next, the performance characteristics of various typical algorithms were compared and analyzed; In the end, several suggestions on future research of indoor positioning based on visible light communication were given. | WANG Chunyue WANG Lang CHI Xuefen LIU Shuangxing SHI Wenxiao DENG Jing | 2015 | China Communications2015，12，8： | 7 |
| 12 | Evaluating the feasibility and safety of vaginal myomectomy in China显示文摘背景古典主义地, myomectomy 经由剖腹术,而是 laparoscopic myomectomy 被执行了当一个最小的侵略过程也被评估了,现在成为了珍贵处理 option.Vaginal myomectomy;然而,它的可行性和安全与很少临床的试用 published.This 学习是争论的被设计在中国评估阴道 myomectomy 的可行性并且与征兆的肌瘤从2005年1月记录任何联系 complications.Methods 到12月2010,43日病人为阴道 myomectomy 被同意进入北京联合医学院医院( PUMCH ) .The 指示,这些病人的起作用的性能,手术后的复杂并发症和结果是分析 retrospectively. | YU Xin ZHU Lan LI Lei SHI Hong-hui LANG Jing-he | 2011 | Chinese Medical Journal2011，，21： | 7 |
| 13 | 雷帕霉素对小鼠百草枯中毒导致肺纤维化的治疗作用(英文)显示文摘目的:评估雷帕霉素(RAPA)对小鼠百草枯(PQ)中毒导致肺纤维化的治疗作用,并初步探讨其作用机制。创新点:首次在小鼠PQ中毒的模型中证明RAPA可明显抑制肺纤维化,且此作用与转化生长因子-β1(TGF-β1)的抑制相关。方法:将C57BL/6J雄鼠分为对照组(腹腔注射生理盐水)和实验组(腹腔注射10 mg/kg PQ)。实验组根据采用的治疗不同,可分为以下四组:PQ组、PQ+RAPA组、PQ+MP(甲强龙)组和PQ+MP+RAPA组。用苏木精-伊红染色法(H&E)和马松(Masson)三色染色法观察肺组织病理结构变化,用酶联免疫吸附测定(ELISA)试剂盒检测肺组织中的羟脯氨酸(HYP)含量,用免疫组化和免疫印迹的方法检测TGF-β1和α-平滑肌肌动蛋白(α-SMA)的表达水平。结论:本实验中小鼠的肺组织病理染色结果显示,RAPA治疗能缓解肺纤维化导致的病理改变(图3)。ELISA实验结果显示,RAPA治疗28天后可显著降低肺组织中HYP的含量(图4)。免疫组化和免疫印迹实验结果显示,RAPA治疗能明显下调肺组织中TGF-β1和α-SMA的高表达(图5和6)。综上所述,RAPA在治疗PQ中毒导致的肺纤维化中有重要价值。 | Xue SHAO Meng LI Chong LUO Ying-ying WANG Ying-ying LU Shi FENG Heng LI Xia-bing LANG Yu-cheng WANG Chuan LIN Xiu-jin SHEN Qin ZHOU Hong JIANG Jiang-hua CHEN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 7 |
| 14 | Clinical assessment for three routes of hysterectomy显示文摘背景子宫切除是在妇科学的一个很普通的手术。为子宫切除的理想的外科是有很少复杂并发症的 microinvasive。有当前被使用的子宫切除的三条主要线路。这研究的目的是在经历了过程由 laparoscopic 执行了的为有的肌瘤的 101 个女人经历子宫切除帮助了的三不同 approaches.Methods 的病人之中识别仙子起作用的结果的差别阴道的子宫切除( LAVH ),在使随机化的研究总计阴道子宫切除( TVH )或全部的腹的子宫切除( TAH )。我们为三条不同途径比较了仙子起作用、手术后的结果的功课。结果被线性回归分析, Fishers 准确测试和学生评估是为独立 samples.Results 的 t 测试在三个过程之中的操作时间不是显著地不同的(P > 0.05 ) 。在 TVH 组的血损失的数量是不到在里面 LAVH 和 TAH 组(P < 0.05 ) 。在在 LAVH 的操作以后的 3 个小时组织的疼痛分数比在 TAH 和 TVH 组显著地低(P < 0.001 ) 。在 LAVH 和 TVH 组的疼痛分数是比在在在操作以后的 24 和 48 个小时的 TAH 组低的(P < 0.01 ) 。经历了 LAVH 和 TVH 的女人有更短的住院停留(P < 0.001 ) 。在在 TAH 组的操作以后的最高的身体温度在 LAVH 和 TVH 组比那高(P < 0.001 ).Conclusions LAVH 和 TVH 是为要求的女人的更好的过程子宫切除。TVH 的仙子起作用、手术后的功课比 LAVH 好,排除疼痛分数在操作以后的 3 个小时。阴道子宫切除是最划算的途径,但是为子宫切除的线路的最后的选择能取决于象妇产科的疾病,病人的健康地位和妇科医生的经验那样的许多因素。 | ZHU Lan LANG Jing-he LIU Chun-yan SHI Hong-hui SUN Zhi-jing FAN Rong | 2009 | Chinese Medical Journal2009，，4： | 7 |
| 15 | Chemical vapor deposition of monolayer WS2 nano- sheets on Au foils toward direct application in hydrogen evolution显示文摘Monolayer tungsten disulfide (WS2), a typical member of the semiconducting transition metal dichalcogenide family has drawn considerable interest because of its unique properties. Intriguingly the edge of WS2 exhibits an ideal hydrogen binding energy which makes WS2 a potential alternative to Pt-based electrocatalysts for the hydrogen evolution reaction (HER). Here, we demonstrate for the first time the successful synthesis of uniform monolayer WS2 nanosheets on centimeter- scale Au foils using a facile, low-pressure chemical vapor deposition method. The edge lengths of the universally observed triangular WS2 nanosheets are tunable from -100 to N1,000 nm. The WS2 nanosheets on Au foils featuring abundant edges were then discovered to be efficient catalysts for the HER, exhibiting a rather high exchange current density of -30.20 μA/cm2 and a small onset potential of Nl10 mV. The effects of coverage and domain size (which correlate closely with the active edge density of WS2) on the electrocatalytic activity were investigated. This work not only provides a novel route toward the batch-production of monolayer WS2 via the introduction of metal foil substrates but also opens up its direct application for facile HER. | Yanshuo Zhang Jianping Shi Gaofeng Han Minjie Li Qingqing Ji Donglin Ma Yu Zhang Cong Li Xingyou Lang Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，9： | 7 |
| 16 | Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences显示文摘AIM:To evaluate the efficacy of centralized culture and possible influencing factors.METHODS:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(H.pylori) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal endoscopy.Gastric mucosal biopsies were taken from the antrum for culture.These biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 h.The culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 test.An additional 5736 biopsies from H.pylori-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory setting.RESULTS:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the H.pylori-positive quality control specimens.In the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport group.In contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter H.pylori samples. | Ya-Nan Gong You-Ming Li Ning-Min Yang Hong-Zhang Li Feng Guo Lang Lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-Chao Shi Wu-Heng Tang Xin-Jian Zhu Wei Shao Xiao-Feng Zhang Xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng Wu Xu-Peng Chen Qiu-Long Ding Hong Ouyang Feng-Zhe Jin Yan-Li Xu Jian-Zhong Zhang | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 17 | Metabonomics delineates allergic reactions induced by Shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry显示文摘Shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,etc.At the same time,its allergic reactions have also emerged,which limits clinical applications.However,few scholars pay attention to the mechanism of allergic reactions.In this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic reactions.The levels of serum histamine and tryptase were examined and changes in histomorphology were also observed.Based on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of SHLI.Our results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways. | GU Yuan-Yuan SHI Lang ZHANG Dan-Dan HUANG Xin CHEN Da-Zhong | 2018 | Chinese Journal of Natural Medicines2018，16，8： | 5 |
| 18 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 19 | Improving the performance of all-solid-state supercapacitors by modifying ionic liquid gel electrolytes with graphene nanosheets prepared by arc-discharge显示文摘Ionic liquid gel polymers have widely been used as the electrolytes in all-solid-state supercapacitors,but they suffer from low ionic conductivity and poor electrochemical performance.Arc discharge is a fast,low-cost and scalable method to prepare multi-layered graphene nanosheets,and as-made graphene nanosheets(denoted as ad-GNSs) with few defects,high electrical conductivity and high thermal stability should be favorable conductive additive materials.Here,a novel ionic liquid gel polymer electrolyte based on an ionic liquid(EMIMNTF_2) and an copolymer(P(VDF-HFP)) was modified by the addition of ad-GNSs as an ionic conducting promoter.This modified gel electrolyte shows excellent thermal stability up to 400℃ and a wide electrochemical window of 3 V.An all-solid-state supercapacitor based on commercial activated carbon was fabricated using this modified ionic liquid gel polymer electrolyte,which shows obviously improved electrochemical behaviors compared with those of the corresponding all-solid-state supercapacitor using pure ionic liquid gel polymer electrolyte.Specially,smaller internal resistance,higher specific capacitance,better rate performance and cycling stability are achieved.These results indicate that the ionic liquid gel polymers modified by ad-GNSs would be promising and suitable gel electrolytes for high performance all-solid-state electrochemical devices. | Min-Jie Shi Sheng-Zhong Kou Bao-Shou Shen Jun-Wei Lang Zhi Yang Xing-Bin Yan | 2014 | Chinese Chemical Letters2014，25，6： | 4 |
| 20 | Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over显示文摘 | Zheng-Xing He Ting-Ting Sun Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu Jin-Hua Leng Da-Wei Sun Jian Sun Jing-He Lang | 2018 | Chinese Medical Journal2018，，11： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员