|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plant abiotic stress response and nutrient use efficiency显示文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies. | Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu | 2020 | Science China(Life Sciences)2020，63，5： | 94 |
| 2 | Fracture development in shale and its relationship to gas accumulation显示文摘有高石英,长石和碳酸盐的页岩,将有低泊松比率,高幼仔模量和高易碎物。作为结果,页岩是导致的在外部力量下面生产自然、导致的破裂。一般来说,在在页岩和在场的易碎的矿物质的体积的破裂开发之间有好关联。有高 TOC 或反常地高的压力的页岩开发得好破裂。页岩破裂开发也与全部的煤气的累积和免费煤气的体积显示出积极关联,即,页岩破裂越更好被开发,越 greater 煤气的累积并且因此越多更高煤气的生产。破裂为天然气和形成水提供迁居水管和累积空格,它为免费天然气的容量的增加是有利的。在页岩的更宽的破裂导致煤气的损失。在北美洲,从在页岩的高角度的破裂地区有页岩气体探索和高煤气的生产的高成功比率。在在四川盆的更低的古生代的海洋的器官的充满事的岩石中的好天然气表演或低收益制片人是仔细与在易碎的页岩的破裂开发的度有关。 | Wenlong Ding Chao Li Chunyan Li Changchun Xu Kai Jiu Weite Zeng Liming Wu | 2012 | Geoscience Frontiers2012，3，1： | 32 |
| 3 | Effects of ultrasonic pretreatment on sludge dewaterability and extracellular polymeric substances distribution in mesophilic anaerobic digestion显示文摘Effect of ultrasonic pretreatment on sludge dewaterability was determined and the fate of extracellular polymeric substances (EPS) matrix in mesophilic anaerobic digestion after ultrasonic pretreatment was studied. Characteristics of proteins (PN), polysaccharides (PS), excitation-emission matrix (EEM) fluorescence spectroscopy and molecular weight (MW) distribution of dissolved organic matters (DOM) in different EPS fractions were evaluated. The results showed that after ultrasonic pretreatment, the normalized capillary suction time (CST) decreased from 44.4 to 11.1 (sec·L)/g total suspended solids (TSS) during anaerobic digestion, indicating that sludge dewaterability was greatly improved. The normalized CST was significantly correlated with PN concentration (R2 = 0.92, p < 0.01) and the PN/PS ratio (R2 = 0.84, p < 0.01) in the loosely bound EPS (LB-EPS) fraction. Meanwhile, the average MW of DOM in the LB- EPS and tightly bound EPS (TB-EPS) fractions also had a good correlation with the normalized CST (R2 > 0.66, p < 0.01). According to EEM fluorescence spectroscopy, tryptophan-like substances intensities in the slime, LB-EPS and TB-EPS fractions were correlated with the normalized CST. The organic matters in the EPS matrix played an important role in influencing sludge dewaterability. | Liming Shao Guanzhao Wang Huacheng Xu Guanghui Yu Pinjing He | 2010 | Journal of Environmental Sciences2010，22，3： | 29 |
| 4 | Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases显示文摘Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic disorders.Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte apoptosis.In addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate conditions.Although remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in detail.Furthermore,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials.This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases. | Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi Fu-Sheng Wang | 2011 | Cellular & Molecular Immunology2011，8，1： | 26 |
| 5 | Dek35 Encodes a PPR Protein that Affects cis-Splicing of Mitochondrial nad4 Intron 1 and Seed Development in Maize显示文摘 | Xinze Chen Fan Feng Weiwei Qi Liming xu Dongsheng Yao Qun Wang Rentao Song | 2017 | Molecular Plant2017，10，3： | 24 |
| 6 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 7 | Recovery of phosphorus as struvite from sewage sludge ash显示文摘Phosphorus(P) is an element vital for all living organisms,yet the world's reserves of phosphate rock are becoming depleted.This study investigated an effective P recovery method from sludge ash via struvite precipitation.Results showed that more than 95% of the total P content was extracted from sludge ash by applying 0.5 mol/L HCl at a liquid/solid ratio of 50 mL/g.Although heavy metal leaching also occurred during P extraction,cation exchange resin efficiently removed the heavy metals from the P-rich solution.Orthogonal tests showed that the optimal parameters for P precipitation as struvite would be a Mg:N:P molar ratio of 1.6:1.6:1 at pH 10.0.X-ray diffraction analysis validated the formation of struvite.Further investigations revealed that the harvested precipitate had a high struvite content(97%),high P bioavailability(94%),and low heavy metal content,which could be considered a high quality fertilizer. | Huacheng Xu Pinjing He Weimei Gu Guanzhao Wang Liming Shao | 2012 | Journal of Environmental Sciences2012，24，8： | 15 |
| 8 | Antioxidant and immunomodulatory activities of a polysaccharide from Flammulina velutipes显示文摘OBJECTIVE: To evaluate the antioxidant and immunomodulatory activities of a unique polysaccharide from the medicinal fungus Flammulina velutipes in vitro.METHODS: Using water extraction and alcohol precipitation, crude polysaccharides were obtained. After purification by DEAE-cellulose 52 ion exchange chromatography and Sephacryl S-300 HR gel filtration chromatography, High performance liquid chromatography equipped with evaporative light-scattering detector, Infrared radiation and Nuclear magnetic resonance were used to evaluate the structure of the polysaccharide. Its immunomodulatory activity was measured by examining the production of nitric oxide(NO) and cytokine secretion, and via lymphocyte proliferation experiments. Its effects on the scavenging activities of hydroxyl radical, superoxide anion and reducing power were also measured.RESULTS: A water-soluble polysaccharide, Flammulina velutipes polysaccharide I-A(FVP I-A), was obtained with a molecular mass of 8.14×104Da determined by high performance gel permeation chromatography. An in vitro antioxidant assay indicated that FVP I-A could scavenge hydroxyl radical, superoxide anion and possessed reducing power and could largely promote NO production and augment the interleukin-1β, interleukin-6, and tumor necrosis factor-α secretion by RAW264.7 macrophages(P<0.05). Moreover, FVP I-A could promote lymphocyte proliferation(P<0.05), and synergistically enhance the augmentation of the proliferation of mouse lymphocytes by concanavalin A and lipopolysaccharides(P<0.01, P<0.05).CONCLUSION: The FVP I-A obtained from Flammulina velutipes possessed antioxidant activity and could enhance non-specific and specific immune responses in vitro. | Ming Wu Xia Luo Xiaoyan Xu Wei Wei Mengyao Yu Nan Jiang Liming Ye Zhirong Yang Xiaofan Fei | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 14 |
| 9 | Effect of ultrasonic pretreatment on anaerobic digestion and its sludge dewaterability显示文摘To investigate the effect of ultrasonic pretreatment on anaerobic digestion and sludge dewaterability and further to probe into the influencing factors on sludge dewaterability,sludge flocs were stratified into four fractions: (1) slime;(2) loosely bound extracellular polymeric substances (LB-EPS);(3) tightly bound EPS (TB-EPS);and (4) EPS-free pellets.The results showed that ultrasonic pretreatment increased the anaerobic digestion efficiency by 7%–8%.Anaerobic digestion without ultrasonic pretreatment deteriorated the sludge dewaterability,with the capillary suction time (CST) increased from 1.42 to 47.3 (sec·L)/g-TSS.The application of ultrasonic pretreatment firstly deteriorated the sludge dewaterability (normalized CST increased to 44.4 (sec·L)/g-TSS),while subsequent anaerobic digestion offset this effect and ultimately decreased the normalized CST to 23.2 (sec·L)/g-TSS.The dewaterability of unsonicated sludge correlated with protein (p = 0.003) and polysaccharide (p = 0.004) concentrations in the slime fraction,while that of sonicated sludge correlated with protein concentrations in the slime and LB-EPS fractions (p < 0.05).Fluorescent excitationemission matrix analysis showed that the fluorescence matters in the LB-EPS fraction significantly correlated with sludge dewaterability during anarobic digestion. | Huacheng Xu Pinjing He Guanghui Yu Liming Shao | 2011 | Journal of Environmental Sciences2011，23，9： | 13 |
| 10 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 11 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 12 | Study on the morphology, crystalline structure and thermal properties of yam starch acetates with different degrees of substitution显示文摘This study was carried out to understand and establish the changes in physicochemical properties of starch extracted from Chinese yam (Dioscorea opposita Thunb.) after acetylation. Yam starch acetates with different degrees of substitution (DS) were prepared by the reaction of yam starch with glacial acetic acid/acetic anhydride using sulfuric acid as the catalyst. Their formation was confirmed by the presence of the carbonyl signal around 1750 cm-1 in the Fourier transform infrared (FT-IR) spectra. The thermal behavior of the native starch and starch acetate were investigated using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results reveal that the starch acetates are more thermally stable than the native starch. The starch esters showed 50% weight loss at tem- peratures from 328℃ to 372 ℃ , while the native starch underwent 50% weight loss at 325℃ . The glass transition temperature (Tg) of the starch decreased from 273℃ to 226℃. The X-ray diffraction (XRD) patterns could be classified as typical of the C-type for yam starch. X-ray diffraction also showed the loss of the ordered C-type starch crystalline structure and the degree of crystallinity of starch de- creased from 36.10% to 10.96% with the increasing DS. The scanning electron microscopy (SEM) sug- gested that the most of the starch granules disintegrated with many visible fragments with the in- creasing DS. | WANG Xu GAO WenYuan ZHANG LiMing XIAO PeiGen YAO LiPing LIU Yi LI KeFeng XIE WeiGuang | 2008 | Science China Chemistry2008，51，9： | 11 |
| 13 | Postoperative mortality and morbidity in octogenarians and nonagenarians with hip fracture: an analysis of perioperative risk factors显示文摘 | MA Ren-shi GU Gui-shan HUANG Xu ZHU Dong ZHANG Yu LIMing YAO Hai-yu | 2011 | Chinese Journal of Traumatology2011，14，6： | 10 |
| 14 | Modeling the Hook Depth Distribution of Pelagic Longlining in the Equatorial Area of Indian Ocean显示文摘A survey was conducted in the equatorial area of Indian Ocean for a better understanding of the dynamics of hook depth distribution of pelagic longline fishery.We determined the relationship between hook depth and vertical shear of current coefficiency,wind speed,hook position code,sine of wind angle,sine of angle of attack and weight of messenger weight.We identified the hook depth models by the analysis of covariance with a general linear model.The results showed that the wind effect on the hook depth can be ignored from October to November in the survey area;the surface current effect on the hook depth can be ignored;the equatorial undercurrent is the key factor for the hook depth in Indian Ocean;and there is a negative correlation between the hook depth and vertical shear of current and angle of attack.It was also found that the deeper the hook was set,the higher hook depth shoaling was.The proposed model improves the accuracy of the prediction of hook depth,which can be used to estimate the vertical distribution of pelagic fish in water column. | SONG Liming LI Jie GAO Panfeng ZHOU Ji XU Liuxiong | 2012 | Journal of Ocean University of China2012，11，4： | 10 |
| 15 | Enhanced anaerobic digestion and sludge dewaterability by alkaline pretreatment and its mechanism显示文摘To investigate the influences of alkaline pretreatment on anaerobic digestion(AD) and sludge dewaterability after AD,waste activated sludge was adjusted to different pH values(8,9,10,11,12) and placed at ambient temperature for 24 hr.The samples were then adjusted to the initial pH and subjected to 25 days of AD.The results showed that,when compared with the control(pH 6.8),total suspended solids(TSS) and volatile suspended solids(VSS) reduction following pretreatment at pH 9-11 increased by 10.7%-13.1% and 6.5%-12.8%,respectively,while biogas production improved by 7.2%-15.4%.Additionally,significant enhancement of sludge dewaterability after AD occurred when pretreatment at pH 8-9 was conducted.The proteins and carbohydrates transferred from the pellet and tightly bound extracellular polymeric substances(TB-EPS) fractions to the slime and loosely bound EPS(LB-EPS) fractions after pretreatment and during the AD process,and the concentrations of proteins and carbohydrates in the slime fraction had a good linear relationship with the normalized capillary suction time(CST).During the AD process,the normalized CST was positively correlated with the organic materials in the loosely bound fraction of the sludge matrix(R 2 0.700,p < 0.01),while it was negatively correlated with the organic materials in the tightly bound fraction(R 2 0.702,p < 0.01).These results suggest that alkaline pretreatment could break the EPS matrix and release inner organic materials,thus influencing the efficiency of the AD process and dewaterability after AD. | Liming Shao Xiaoyi Wang Huacheng Xu Pinjing He | 2012 | Journal of Environmental Sciences2012，24，10： | 10 |
| 16 | Design and performance analysis of position-based impedance control for an electrohydrostatic actuation system显示文摘Electrohydrostatic actuator(EHA) is a type of power-by-wire actuator that is widely implemented in the aerospace industry for flight control, landing gears, thrust reversers, thrust vector control, and space robots. This paper presents the development and evaluation of positionbased impedance control(PBIC) for an EHA. Impedance control provides the actuator with compliance and facilitates the interaction with the environment. Most impedance control applications utilize electrical or valve-controlled hydraulic actuators, whereas this work realizes impedance control via a compact and efficient EHA. The structures of the EHA and PBIC are firstly introduced. A mathematical model of the actuation system is established, and values of its coefficients are identified by particle swarm optimization. This model facilitates the development of a position controller and the selection of target impedance parameters. A nonlinear proportional-integral position controller is developed for the EHA to achieve the accurate positioning requirement of PBIC. The controller compensates for the adverse effect of stiction, and a position accuracy of 0.08 mm is attained.Various experimental results are presented to verify the applicability of PBIC to the EHA. The compliance of the actuator is demonstrated in an impact test. | Yongling FU Xu HAN Nariman SEPEHRI Guozhe ZHOU Jian FU Liming YU Rongrong YANG | 2018 | Chinese Journal of Aeronautics2018，31，3： | 10 |
| 17 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 18 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 19 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 20 | Microwave Absorption and Shielding Property of Composites with FeSiAl and Carbonous Materials as Filler显示文摘Silicone rubber composites filled with FeSiAl alloys and multi-walled carbon nanotubes(MWCNT)/graphite have been prepared for the first time by a coating process.The complex permittivity and permeability of the composites were measured with a vector network analyzer in a 1-4 GHz frequency range,and the DC electric conductivity was measured by a standard four-point contact method.These parameters were then used to calculate the reflection loss(RL) and shielding effectiveness(SE) of the composites.The results showed that the added MWCNT increased the permittivity and permeability of composites in the L-band,while the added graphite increased only the permittivity.The variation lies in the interactions between two carbonous absorbents.Addition of 1 wt% MWCNT enhanced the RL in the L-band(minimum 5.7 dB at 1 mm,7.3 dB at 1.5 mm),while the addition of graphite did not.Addition of MWCNT as well as graphite reinforced the shielding property of the composites(maximum SE 13.3 dB at 1 mm,18.3 dB at 1.5 mm) owing to the increase of conductivity.The addition of these carbonous materials could hold the promise of enforcing the absorption and shielding property of the absorbers. | Wenqiang Zhang Yonggang Xu Liming Yuan Jun Cai Deyuan Zhang | 2012 | Journal of Materials Science & Technology2012，28，10： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员