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| 1 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 2 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 3 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 4 | Effectiveness and safety of moxibustion in treatment of lumbar disc herniation: a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the effectiveness and safety of moxibustion therapy in the treatment of lumbar disc herniation (LDH). METHODS: Four Chinese databases and three English databases were searched from their inception to April 2018.Randomized controlled trials (RCTs) were included if moxibustion was used as the sole treatment or as a part of combination therapy with other treatments in patients with LDH. Two reviewers independently extracted the data and assessed the methodological quality using the Cochrane criteria for the risk of bias. The Meta-analysis was performed using Review Manager 5.3 software. RESULTS: In total, 16 RCTs including 1186 patients with LDH were analyzed. The Meta-analysis showed favorable effects of moxibustion in combination with massage therapy on the visual analog scale score compared with massage therapy alone [mean difference (MD)=? 1.32, 95% confidence interval (CI)(? 2.12,? 0.51), P = 0.001]. The subgroup Meta-analysis failed to show favorable effects of electro-acupuncture plus moxibustion on the efficacy rate compared with electro-acupuncture alone [relative risk (RR)= 1.06, 95% CI (0.98, 1.14), P = 0.15]. However, acupuncture or massage therapy plus moxibustion improved the efficacy rates compared with acupuncture or massage therapy alone [RR = 1.33, 95% CI (1.18, 1.49), P < 0.000 01][χ^2 = 2.76, P = 0.25, I2 = 27%],[RR = 1.15, 95% CI (1.06, 1.25), P = 0.001][χ^2 = 0.00, P = 0.95, I2 = 0%]. With respect to the Japanese Orthopaedic Association (JOA) scores, acupuncture or massage therapy in addition to moxibustion produced results different from those of acupuncture or massage therapy alone [MD = 5.58, 95% CI (4.15, 7.00), P < 0.000 01][χ^2 = 0.58, P = 0.45, I2 = 0%],[MD = 3.61, 95% CI (3.01, 4.21), P < 0.000 01]. There were no significant differences in the JOA score for subjective symptoms, objective symptoms, daily living ability, and other parameters. In six RCTs, no adverse reactions occurred during moxibustion. CONCLUSION: Whether moxibustion is an effective intervention for LDH is unclear because of the small sample size of qualified RCTs and the high risk of bias. More high-quality RCTs that overcome the methodological shortcomings of the existing evidence are needed. | Wang Yang Zhang Huiling Xia Liping Sun Zhiling Xu Xiao Du Shizheng | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 11 |
| 5 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 6 | Concurrent intracranial and extracranial artery stenosis and the prognosis of transient ischaemic symptoms or imaging-negative ischaemic stroke显示文摘Background and purpose Transient ischaemic attack(TIA),transient symptoms with infarction(TSI)and diffusion-weighted imaging(DWI)-negative acute ischaemic stroke(AIS)share similar aetiologies but are considered to have a rather benign prognosis.We intended to investigate the association between intracranial atherosclerotic stenosis(ICAS),extracranial atherosclerotic stenosis(ECAS)and the prognosis of patients with TIA,TSI and DWI-negative AIS.Methods Clinical and imaging data of eligible participants were derived from the Chinese Intracranial Atherosclerosis study,according to symptom duration,acute infarction on DWI and discharge diagnosis.Based on the severity and location of arterial atherosclerosis,we categorised the study population into four groups:no or<50% ICAS and no ECAS;≥50% ICAS but no ECAS;no or<50%ICAS with ECAS;and concurrent≥50% ICAS and ECAS.Using multivariable Cox regression models,we analysed the relationship between the severity and distribution of large artery atherosclerosis and the prognosis of TIA,TSI and DWI-negative AIS.Results A total of 806 patients were included,67.3% of whom were male.The median age of the study participants was 63 years.Patients in the concurrent≥50% ICAS and ECAS subgroup had both a significantly higher 1-year recurrence rate(adjusted HR 3.4(95%CI 1.15 to 10.04),p=0.027)and a higher risk of composite vascular events(adjusted HR 3.82(95%CI 1.50 to 9.72),p=0.005).Conclusions Concurrent ICAS and ECAS is associated with a higher possibility of 1-year recurrent stroke or composite vascular events.Large artery evaluation is necessary to assess patients with transient ischaemic symptoms or DWI-negative AIS.Progress in shortening the time interval between symptom onset and large vessel evaluation is needed. | Yue Suo Jing Jing Yuesong Pan Weiqi Chen Hongyu Zhou Hao Li Yuehua Pu Liping Liu Xingquan Zhao Yilong Wang Xia Meng Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 10 |
| 7 | Tribological properties of conductive lubricating greases显示文摘Three kinds of new conductive lubricating greases were prepared using lithium ionic liquids as the base oil and the polytetrafluoroethylene(PTFE)as the thickener.These lithium ionic liquids([Li(PEG)X])were obtained by blending lithium salts(LiBF4,LiPF6 and LiNTf2)with poly(ethylene glycol)(PEG)because lithium salts have an extremely high solubility in PEG.The conductivities and contact resistances of the prepared lubricating greases were investigated using the DDSJ‐308A conductivity meter and the reciprocating ball‐on‐disk UMT‐2MT sliding tester.In addition,their tribological properties were investigated in detail.Scanning electron microscopy and X‐ray photoelectron spectroscopy were employed to explore the friction mechanisms.The results suggest that the prepared lubricating greases have high conductivities and excellent tribological properties.The high conductivities are attributed to ion diffusion or migration of the lithium ionic liquids with an external electric field,and the excellent tribological properties depend on the formation of boundary protective films. | Xiaoqiang FAN Yanqiu XIA Liping WANG | 2014 | Friction2014，2，4： | 10 |
| 8 | Spatial and temporal variation in magnetic properties of street dust in Lanzhou City,China显示文摘Urban environmental problems are of increasing concern. Lanzhou is a large industrial city in North-west China. Street dust samples representing different temporal and spatial scales were collected for magnetic properties study. Magnetic measurements indicate a high concentration of magnetic minerals in Lanzhou street dust, dominated by pseudo-single domain (PSD) magnetite. The concentration of magnetic materials is distinctly high in winter and spring, low in autumn. Similarly, higher concentra-tions associated with heavy industry, concentrated residential development, and vehicular traffic sug-gest mixed contributions of magnetic material from both anthropogenic and natural sources. χ_lf and SOFT% are effective magnetic parameters that denote seasonal differences among magnetic proper-ties in street dust, convenient and economical methods for monitoring street dust pollution. | WANG Guan XIA DunSheng LIU XiuMing CHEN FaHu YU Ye YANG LiPing CHEN JianHui ZHOU AiFeng | 2008 | Chinese Science Bulletin2008，53，12： | 7 |
| 9 | Risk factors associated with 90-day recurrent stroke in patients on dual antiplatelet therapy for minor stroke or high-risk TIA:a subgroup analysis of the CHANCE trial显示文摘Objective Many patients receiving dual antiplatelet therapy still had recurrent strokes.We aimed to identify factors associated with recurrent stroke at 90 days in patients receiving dual antiplatelet therapy in Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Methods Patients with transient ischaemic attack or minor stroke receiving clopidogrel and aspirin in the trial were analysed in the study.The primary outcome was recurrent stroke within 90 days after the index event.Cox proportional hazard model with backward selection was used to identify factors associated with stroke.results Among 2584 patients,212(8.2%)had a recurrent stroke,216(8.4%)had a composite of stroke,myocardial infarction,or vascular death and 204(7.9%)had ischaemic stroke within 90 days.Multivariate analysis identified the following factors associated with stroke:history of hypertension with poor blood pressure control(HR,1.92;95%CI 1.22 to 3.03),the high baseline National Institute of Health Stroke Scale(NIHSS)score of 2 and 3(2.12(1.07 to 4.21)and 4.11(2.05 to 8.22),respectively),time from onset to randomisation of<12 hours(1.47(1.12 to 1.94)),the lipid-lowering therapy(0.61(0.47 to 0.83)),the open-label aspirin dose at day 1 of≥300 mg(1.98(1.45 to 2.69)).Intracranial arterial stenosis(ICAS)was significantly associated with stroke in the sensitivity analysis(2.17(1.16 to 4.04)).conclusions The high baseline NIHSS score,hypertension with poor blood pressure control,ICAS,time from onset to randomisation of less than 12 hours and no lipid-lowering therapy were associated with stroke,suggesting that patients with identified predictors still remain to be at high risk of recurrent stroke although being under the dual antiplatelet therapy. | Runqi Wangqin Xianwei Wang Yilong Wang Ying Xian Xingquan Zhao Liping Liu Hao Li Xia Meng Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，4： | 6 |
| 10 | The efficacy and safety of nimodipine in acute ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial显示文摘Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain. | Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang | 2019 | Science Bulletin2019，64，2： | 5 |
| 11 | Characteristic analysis of phospholipid fatty acids (PLFAs) in typical nutrient polluted lake sediment in Wuhan显示文摘The process of urbanization aggravates the endogenous pollution of urban lake sediment,and polluted sediment may seriously affect the quality of the water in lakes.At present,it is difficult to distinguish the difference between sediment that is heavily polluted by nitrogen(N)and phosphorus(P)when using an analysis based on a physicochemical index classification.The current study applied phospholipid fatty acid(PLFA)technology to further analyze the sediment characteristics from the perspective of microbiology.Surface sediment from five urban lakes that are heavily polluted with N and P in Wuhan were sampled.Statistical approaches were used to analyze the microbial community structure in the sampled sediment,and to determine the correlations between the microorganisms and physicochemical indices.The most severely polluted lake sediment had similar PLFA structures,the highest saturated fatty-acid content,and bacteria as the dominant microorganism.However,there were differences between the microbial biomass of the various sediment samples,which may have been related to the degree of N and P pollution.Analysis of the microbial diversity in the sediment samples indicated that the bacteria were experiencing starvation and nutrient pressure,which may have been due to the dissolved oxygen concentration of the heavily polluted lake sediment.A correlation analysis showed that the endogenous N and P had different effects on the microbes of the polluted sediment.A redundancy analysis(RDA)demonstrated that the N/P ratio had the greatest influence on the PLFA species,accounting for 83%of the cumulative interpretation.To effectively promote the role of sediment microorganisms on circulating elements,it is necessary to regulate the N/P ratio of the sediment to some extent.When the N/P ratio in sediment exceeds 6,N pollution should be prioritized. | Xia Zhang Qianru Chen Chuan Wang Hongpei Zhang Yuqing Zhao Liping Zhang Biyun Liu Zhenbin Wu Qiaohong Zhou | 2021 | International Journal of Sediment Research2021，36，2： | 5 |
| 12 | Effects of Jiawei Wendan decoction on hippocampal p-CREB protein expression in a rat model of depression显示文摘BACKGROUND:Jiawei Wendan decoction can elevate hippocampal brain-derived neurotrophic factor(BDNF) protein expression in rats with depression.It has been hypothesized that Jiawei Wendan decoction can exhibit antidepressant effects through the hippocampal signal transduction pathway of cyclic adenosine monophosphate response element binding protein(CREB)-BDNF.OBJECTIVE:Using phosphorylated-CREB(p-CREB) as an entry point,the present study was designed to observe intervention effects of Jiawei Wendan decoction compared with fluoxetine.DESIGN,TIME AND SETTING:A randomized,controlled,cellular biology experiment was performed at the Central Laboratory of Guangxi University of Traditional Chinese Medicine.MATERIALS:A total of 40 healthy,male,Sprague-Dawley rats were included in the present study.Rhizoma Acori Talarinowii(Shichangpu),Flos Albiziae(Hehuanhua),Rhizoma Pinelliae(Banxia),Caulis Bambusae in Taeniam(Zhuru),Fructus Aurantii Immaturus(Zhishi),Poria(Fuling),and Radix Bupleuri(Chaihu),the primary ingredients of Jiawei Wendan decoction,were purchased from First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine.The raw drug was decocted at a concentration of 1.5 g/mL.Fluoxetine capsules were purchased from Shanghai Zhongxi Pharmaceutical Co.,Ltd.,China.METHODS:Following behavioral testing,36 rats were selected from the initial 40 rats according to similar behavioral scores,and were randomly divided into 4 groups:model(n = 8),Jiawei Wendan decoction-treated(n = 10),fluoxetine-treated(n = 10),and normal control(n = 8).All rats,except for those in the normal control group,were separately raised in a chronic and unpredictable,mild-stimulation environment for 21 days to establish a depression model.The Jiawei Wendan decoction-treated and fluoxetine-treated groups were intragastrically administered Jiawei Wendan decoction(12 g/kg/d) and fluoxetine(1.8 mg/kg/d),respectively.The model and normal control groups received double-distilled water(2 mL/kg/d) once a day for a total of 21 days.MAIN OUTCOME MEASURES:Prior to depression induction and subsequent to administration,memory and degree of depression were measured by open field and tail suspension tests,respectively.At 24 hours after administration,p-CREB expression in the hippocampal CA3 region was analyzed by the immunohistochemical SABC method.RESULTS:Two rats from the Jiawei Wendan decoction-treated group,and one from the fluoxetine-treated group,died of unknown causes.The remaining rats in each group,except for one rat that was randomly selected from the fluoxetine-treated group,were included in the final analysis.Following administration,the model group exhibited significantly decreased numbers of hippocampal p-CREB-positive cells,horizontal and vertical movements,and significantly prolonged duration of immobility in tail-suspension test,compared with the normal control group(P < 0.01).The numbers of p-CREB-positive cells,as well as horizontal and vertical movements,were significantly greater,and the duration of immobility was significantly shorter,in the Jiawei Wendan decoction and fluoxetine groups,compared with the model group(P < 0.05-0.01).There was no significant difference in the above-mentioned three indices between the Jiawei Wendan decoction and fluoxetine groups(P > 0.05).CONCLUSION:Jiawei Wendan decoction increased hippocampal p-CREB expression by influencing the rat hippocampal signal transduction pathway of CREB-BDNF.Jiawei Wendan decoction exhibited antidepressant effects equivalent to fluoxetine. | Liping Zhang Meng Xia Li Wu Boli Zhang | 2008 | Neural Regeneration Research2008，3，9： | 4 |
| 13 | Optimal fusion estimation for stochastic systems with cross-correlated sensor noises显示文摘This paper is concerned with the optimal fusion of sensors with cross-correlated sensor noises.By taking linear transformations to the measurements and the related parameters, new measurement models are established, where the sensor noises are decoupled. The centralized fusion with raw data, the centralized fusion with transformed data, and a distributed fusion estimation algorithm are introduced, which are shown to be equivalent to each other in estimation precision, and therefore are globally optimal in the sense of linear minimum mean square error(LMMSE). It is shown that the centralized fusion with transformed data needs lower communication requirements compared to the centralized fusion using raw data directly, and the distributed fusion algorithm has the best flexibility and robustness and proper communication requirements and computation complexity among the three algorithms(less communication and computation complexity compared to the existed distributed Kalman filtering fusion algorithms). An example is shown to illustrate the effectiveness of the proposed algorithms. | Liping YAN Yuanqing XIA Mengyin FU | 2017 | Science China(Information Sciences)2017，60，12： | 3 |
| 14 | 竹格填料与PVC填料在冷却塔中的节能效率与环境影响研究显示文摘本研究针对电厂冷却塔领域的能源成本及水资源短缺等问题,系统分析了新兴竹格淋水填料的节能效率及对环境影响等特性,并与市场占有率最高的PVC填料进行了对比。结果发现,竹格填料的阻力性能优于PVC填料,而热力性能较差;在6个月实际应用试验中,使用竹格填料的电厂,比使用PVC填料节约529.2 t标煤;生命周期评价结果显示,PVC填料的能源需求总量(CED)为3420 MJ,竹格填料的能源需求总量仅为561 MJ,比PVC填料减少6倍;从环境影响指数(BEES)看,PVC填料替换为竹格填料后,各主要影响指标降低了1.5~10.5倍不等。结果表明,竹格填料是替换PVC填料的良好选择,具有很好的推广价值。 | 马欣欣 陈礼生 费本华 鲁继平 Liping Cai Changlei Xia Su Shiung Lam | 2021 | 世界竹藤通讯2021，19，2： | 3 |
| 15 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 16 | Comparative study on microstructure of β-Ni(OH)_(2) as cathode material for Ni-MH battery显示文摘Microstructures such as micro-strain, crystallite as well as stacking faults can result in broadening of X-ray diffraction lines. Based on least square principle, new com- putation method and programs, which can separate the two-fold broadening effect caused by crystallite/stacking faults and which can separate the three-fold broadening effect caused by crystallite/residual stress/stacking faults, have been proposed. As a result, mi- cro-strain and crystallite sizes as well as stacking fault probability can be calculated re- spectively and investigated in detail. Then the microstructures of β-Ni(OH)2 are investi- gated by means of these methods. The main results are as follows: 1) The shape and size of crystallite as well as stacking fault probability of raw β-Ni(OH)2 are dependent on its preparation technique. 2) Activation changes the microstructure of β-Ni(OH)2. It transforms the crystallite shape from short-fat cylinder into polyhedrons or nearly equiaxial grains. Activation also alters the residual strain states and stacking fault probability. 3) After charge-discharge and cycle-lifetime testing, the crystallites of β-Ni(OH)2 are fined further and its residual strain and fault probability were alternated. The extent of these effects are dependent on circulating conditions. 4) Calcium additive in β-Ni(OH)2 restrains grain fining process and turns twin fault into deformation fault. 5) Comprehensive analysis reveals that micro structural parameters of β-Ni(OH)2 are correlated with some performance of Ni-MH battery. | LOU Yuwan YANG Chuanzheng ZHANG Xigui MA Liping XIA Baojia | 2006 | Science China(Technological Sciences)2006，49，3： | 3 |
| 17 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 18 | Comparison of outcome of patients with acute minor ischaemic stroke treated with intravenous t-PA, DAPT or aspirin显示文摘Background Whether to treat minor stroke with intravenous tissue plasminogen activator(t-PA)treatment or antiplatelet therapy is a dilemma.Our study aimed to explore whether intravenous t-PA treatment,dual antiplatelet therapy(DAPT)and aspirin have different efficacies on outcomes in patients with minor stroke.Methods A post hoc analysis of patients with acute minor stroke treated with intravenous t-PA within 4.5 hours from a nationwide multicentric electronic medical record and patients with acute minor stroke treated with DAPT and aspirin from the Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack Database.Minor stroke was defined by a score of 0-3 on the National Institutes of Health Stroke Scale at randomisation.Favourable functional outcome(defined as modified Rankin Scale(mRS)score of 0-1 or 0-2 at 3 months).Results Compared with those treated with intravenous t-PA,no significant association with 3-month favourable functional outcome(defined as mRS score of 0-1)was found neither in patients treated with aspirin(87.8%vs 89.4%;OR,0.83;95% CI,0.46 to 1.50;p=0.53)nor those treated with DAPT(87.4%vs 89.4%;OR,0.84;95% CI,0.46 to 1.52;p=0.56).Similar results were observed for the favourable functional outcome defined as mRS score of 0-2 at 3 months.Conclusions In our study,no significant advantage of intravenous t-PA over DAPT or aspirin was found.Due to insufficient sample size,our study is probably unable to draw such a conclusion that that intravenous t-PA was superior or non-superior to DAPT. | Peng Wang Mengyuan Zhou Yuesong Pan Xia Meng Xingquan Zhao Liping Liu Hao Li Yongjun Wang Zhimin Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 19 | China Antihypertensive Trial in Acute Ischemic Stroke II (CATIS-2): rationale and design显示文摘Backgrounds Increased blood pressure(BP)for patients who had an acute ischaemic stroke is associated with poor functional outcome,however the optimal timing of antihypertensive therapy is unknown.Aims We aim to compare early antihypertensive treatment to delayed antihypertensive treatment for reducing the risk of composite major disability and mortality at 3 months in acute ischaemic stroke.Design The China Antihypertensive Trial in Acute Ischemic Stroke II(CATIS-2)trial is a multicentre,randomised,open-label,blinded-endpoints trial that will be conducted in 100 hospitals in China.The primary outcome is the composite of death and major disability(modified Rankin Scale score≥3)at 3 months of randomisation.Antihypertensive treatment will be received immediately after randomisation in the early treatment group,aimed at average systolic BP by 10%-20%reduction within the first 24 hours,and achieving an average BP level of<140/90 mm Hg within 5 days.Patients in the delayed treatment group will discontinue any antihypertension medications for the first 7 days of randomisation,and will receive antihypertensive therapy achieving a BP goal of<140/90 mm Hg after 7 days.Conclusion The CATIS-2 trial will be testing the hypotheses that early BP lowering leads to improved functional outcome without any other harms,and developing clinical guidelines of the BP management for patients who had an acute ischaemic stroke. | Liping Liu Yilong Wang Xuewei Xie Dacheng Liu Aili Wang Penglian Wang Suwen Shen Chongke Zhong Yufei Wei Tan Xu Yuesong Pan Yong Jiang Xia Meng David Wang Yonghong Zhang Jiang He Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 20 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
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