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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Phylogenetic constrains on mycorrhizal specificity in eight Dendrobium(Orchidaceae) species显示文摘Plant phylogeny constrains orchid mycorrhizal(OrM) fungal community composition in some orchids. Here, we investigated the structures of the OrM fungal communities of eight Dendrobium species in one niche to determine whether similarities in the OrM fungal communities correlated with the phylogeny of the host plants and whether the Dendrobium-OrM fungal interactions are phylogenetically conserved. A phylogeny based on DNA data was constructed for the eight coexisting Dendrobium species,and the OrM fungal communities were characterized by their roots. There were 31 different fungal lineages associated with the eight Dendrobium species. In total, 82.98% of the identified associations belonging to Tulasnellaceae, and a smaller proportion involved members of the unknown Basidiomycota(9.67%). Community analyses revealed that phylogenetically related Dendrobium tended to interact with a similar set of Tulasnellaceae fungi. The interactions between Dendrobium and Tulasnellaceae fungi were significantly influenced by the phylogenetic relationships among the Dendrobium species. Our results provide evidence that the mycorrhizal specificity in the eight coexisting Dendrobium species was phylogenetically conserved. | Xiaoke Xing Xueting Ma Jinxin Men Yanhong Chen Shunxing Guo | 2017 | Science China(Life Sciences)2017，60，5： | 10 |
| 3 | SwordDTA: A Dynamic Taint Analysis Tool for Software Vulnerability Detection显示文摘Software vulnerabilities are the root cause of various information security incidents while dynamic taint analysis is an emerging program analysis technique. In this paper, to maximize the use of the technique to detect software vulnerabilities, we present Sword DTA, a tool that can perform dynamic taint analysis for binaries. This tool is flexible and extensible that it can work with commodity software and hardware. It can be used to detect software vulnerabilities with vulnerability modeling and taint check. We evaluate it with a number of commonly used real-world applications. The experimental results show that Sword DTA is capable of detecting at least four kinds of software vulnerabilities including buffer overflow, integer overflow, division by zero and use-after-free, and is applicable for a wide range of software. | CAI Jun ZOU Peng MA Jinxin HE Jun | 2016 | Wuhan University Journal of Natural Sciences2016，21，1： | 3 |
| 4 | Effect of Chinese Herbal Medicines on Helicobacter pylori-associated gastroduodenal ulcers: a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the effect and safety of Chinese herbal medicines on Helicobacter pylori(HP)-associated gastroduodenal ulcers.METHODS: All randomized controlled trials(RCTs)listed in the PubMed, EMBASE, Cochrane Library,China National Knowledge Infrastructure Database,WanFang, China Science and Technology Journal Database and SinoMed databases that were published in English or Chinese were searched, and the retrieval time range was from database inception to December 31, 2018. A comprehensive Meta-analysis of all publications was performed with RevMan 5.3 software, and the quality of the evidence report-ed in the results of Meta-analysis was analyzed with GRADE profiler software(version 3.6.1). Dichotomous data were analyzed by calculating odds ratios and 95% confidence intervals(CIs). Outcome measures included the HP clearance rate and percentage of adverse effects.RESULTS: Eight trials with 919 participants were included in this Meta-analysis. Compared with the effects of single drug therapy on HP-associated gastroduodenal ulcers, according to the statistical analysis, odds ratios for the HP clearance rate and percentage of adverse effects of Chinese herbal medicines administered as complementary medicines combined with drugs were 3.10 [95% CI(2.21, 4.36),P < 0.01] and 0.28 [95% CI(0.15, 0.52), P < 0.01], respectively, and the differences were statistically significant. According to the GRADE analysis, the quality of evidence for the HP clearance rate and percentage of adverse effects were both very low.CONCLUSION: Compared with using the drug therapy only, the combination of Chinese herbal medicines with the drug therapy more effectively eliminates HP and alleviates adverse reactions. However,the available studies were of low quality, and therefore more well-designed studies are required to further confirm the findings. | Shi Xiaoshuang Wu Haomeng Ma Xiangxue Yin Xiaolan Li Xia Ma Jinxin Wang Fengyun Tang Xudong | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 2 |
| 5 | Scanning electron microscopy of Chinese (mainland) strain Schistosorna japonicum 显示文摘 | Ma Jinxin He Yixun | 1981 | Chin Med J1981，94，1： | 1 |
| 6 | Behavior of corrosion damaged circular reinforced concrete columns under cyclic loading显示文摘 | Ying Ma Yi Che Jinxin Gong | 2011 | Construction and Building Materials2011，，： | 1 |
| 7 | Scanning electron microscopy of Chinese (mainland) strain Schistosorna japonicum 显示文摘 | Ma Jinxin He Yixun | 1981 | Chin Med J1981，94，1： | 1 |
| 8 | 3,4-Dinitrobenzamide Functionalized CdTe/ZnTe Quantum Dots as a Nanoprobe for Imaging Glutathione S-Transferase in Living Cells显示文摘一篇小说荧光灯为谷胱甘肽 S-transferase (GST ) 的 nanoprobe 被合并 3,4-dinitrobenzamide (GST 的特定的底层) 到 CdTe/ZnTe 量点上开发了。探查本身在量点上由于 3,4-dinitrobenzamide 的撤退电子的单位的强壮的熄灭效果显示一个低背景信号。然而, GST 能高效地在 nanoprobe 的 p-nitro 组上催化减少的谷胱甘肽的亲核的替换,导致大荧光改进。最尤其是,这改进向 GST 显示出高选择和敏感而不是另外的生物物质。与这 nanoprobe,为细胞内部的 GST 的一个简单荧光成像方法被建立了,并且它的适用性成功地在不同生活房间为成像 GST 被表明了,它表明 A549 房间表示大约 3 比 NIH-3T3 和 Hela 房间高预定的 GST。 | Jinxin Lu Yanchao Song Wen Shi Xiaohua Li Huimin Ma | 2013 | Chinese Journal of Chemistry2013，31，4： | 0 |
| 9 | Construction of alkyl-substituted 7-norbornenones through Diels-Alder cycloaddition of electron-deficient olefins and a cyclopentadienone derivative generated in situ显示文摘Dimeric sesquiterpenoids possessing densely substituted 7-norbornenone/7-norbornenol motifs pose a considerable challenge for chemical synthesis. From a strategic perspective, one could envision intermolecular Diels-Alder cycloaddition as a straightforward method for assembling alkyl-substituted 7-norbornenones. However, this approach is hindered by lability of the required dienes, namely alkylsubstituted cyclopentadienones. Here we report a one-pot protocol for construction of alkyl-substituted7-norbornenones from electron-deficient olefins and a cyclopentenone derivative. DDQ was found to be an effective oxidant for generating a cyclopentadienone intermediate in situ from the enone. A series of sterically congested 7-norbornenone-containing polycyclic compounds were prepared by using this protocol. | Shanxiang Liu Jinxin Wang Yuyong Ma Xin Cao Wei-Dong Zhang Ang Li | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 10 | Dppa3 is critical for Lin28a-regulated ES cells na?ve–primed state conversion显示文摘Lin28a is a pluripotent factor that promotes somatic cell reprogramming. Unlike other pluripotent factors, Lin28a expression is transient and accumulated in primed embryonic stem (ES) cells, but its exact function and mechanism in the conversion of ES cells from naive to primed state remain unclear. Here, we present evidence for Dppa3, a protein originally known for its role in germ cell development, as a downstream target of Lin28a in naive–primed conversion. Using rescue experiment, we demonstrate that Dppa3 functions predominantly downstream of Lin28a during naive–primed state conversion. Higher level of Lin28a prevents let-7 maturation and results in Dnmt3a/b (target of let-7) upregulation, which in turn induces hypermethylation of the Dppa3 promoter. Dppa3 demarcates naive versus primed pluripotency states. These results emphasize that Lin28a plays an important role during the naive–primed state conversion of ES cells, which is partially mediated by a Lin28a–let-7–Dnmt3a/b–Dppa3 axis. | Hui Sang Dan Wang Shuang Zhao Jinxin Zhang Yan Zhang Jia Xu Xiaoniao Chen Yan Nie Kaiyue Zhang Shuaiqiang Zhang Yuebing Wang Na Wang Fengxia Ma Ling Shuai Zongjin Li Na Liu | 2019 | Journal of Molecular Cell Biology2019，11，6： | 0 |
| 11 | Research on the Measurement of Urban Sprawl with a Multi-Factor Indicator in the Context of Rapid Urbanization in China显示文摘This paper attempts to create a multi-factor urban sprawl indicator containing population, economy, land use, and infrastructure by using statistical data, and empirically measures the urban sprawl level of 69 cities in China between 2000 to 2014. It then analyzes the results from regional and periodic perspectives, and divides urban sprawl into four types as well as discusses their characteristics. The main conclusions are:(1) the multi-factor indicator is applicable to measure China’s current urban sprawl level;(2) urban sprawl of large and medium-sized cities is becoming serious, while this trend has been eased in recent years;(3) the urban sprawl level and trend of large and medium-sized cities obviously differ from each other in regional perspective;(4) different types of urban sprawl present different sprawl structural characteristics. | Wang Jiating Xie Yu Ma Hongfu Cai Siyuan Liu Jinxin(译) Liu Jiayan(校) | 2021 | China City Planning Review2021，30，3： | 0 |
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